General Interest
Study: Persistence of Coronaviruses on Inanimate Surfaces and Their Inactivation with Biocidal Agents
26 Mar, 2020 | 02:06h | UTCCommentaries: Coronavirus: household cleaning products can kill the virus – an expert on which ones to use – The Conversation AND One graphic shows how long the coronavirus lives on surfaces like cardboard, plastic, and steel – Business Insider
Related Study: Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1 – New England Journal of Medicine
COVID Ethics: Should clinicians see patients without appropriate PPE?
26 Mar, 2020 | 01:48h | UTCCOVID Ethics: Should clinicians see patients without appropriate PPE? – First10EM
See also: COVID-19: Updates in Bioethics
Hydroxychloroquine: Small Study Shows No Benefit
26 Mar, 2020 | 01:39h | UTCCommentary: Chloroquine Use For COVID-19 Shows No Benefit In First Small—But Limited—Controlled Trial – Forbes
Related: Coronavirus treatment hype can lead to harm – Lown Institute AND No, These Medicines Cannot Cure Coronavirus – The New York times
See also: Chloroquine for COVID-19: Cutting Through the Hype
Study Estimates Impact of Social Distancing on Reducing Spread of COVID-19
25 Mar, 2020 | 02:51h | UTCCommentaries: Singapore modelling study estimates impact of physical distancing on reducing spread of COVID-19 – The Lancet AND Scientific and ethical basis for social-distancing interventions against COVID-19 – The Lancet Infectious Diseases AND Study: Social distancing might reduce COVID-19 spread by as much as 99% – UPI
Pill Splitting: Making the Most of Meds in a Time of Need
25 Mar, 2020 | 02:29h | UTC
Fair Allocation of Scarce Medical Resources in the Time of Covid-19
24 Mar, 2020 | 11:42h | UTCCommentary: Life, or death? Experts guide pandemic medical equipment decisions – CIDRAP
Related Perspective: The Toughest Triage — Allocating Ventilators in a Pandemic – New England Journal of Medicine
COVID-19: What About Prisons?
24 Mar, 2020 | 11:16h | UTC- Prisons and custodial settings are part of a comprehensive response to COVID-19 – The Lancet Public Health
- Preventing COVID-19 outbreak in prisons: a challenging but essential task for authorities – WHO/Europe
- COVID-19: prisons and other prescribed places of detention guidance – Public Health England
- A coronavirus outbreak in jails or prisons could turn into a nightmare – Vox
- ‘A Storm Is Coming’: Fears of an Inmate Epidemic as the Virus Spreads in the Jails – The New York Times
- ‘Everyone will be contaminated’: prisons face strict coronavirus controls – The Guardian
CEBM Estimates Infection Rate Fatality (IFR) of COVID-19 at 0,20%
23 Mar, 2020 | 01:16h | UTCGlobal Covid-19 Case Fatality Rates – Centre for Evidence-Based Medicine, University of Oxford (free)
IDSA Statement: COVID-19 Prioritization of Diagnostic Testing
20 Mar, 2020 | 11:01h | UTCCOVID-19 Prioritization of Diagnostic Testing – Infectious Diseases Society of America (free PDF)
Summary: IDSA Statement On COVID-19 Testing Recommendations – Infectious Diseases Society of America (free)
Editorial by John P.A. Ioannidis: COVID-19: The Harms of Exaggerated Information and Non‐evidence‐based Measures
23 Mar, 2020 | 01:08h | UTCRelated Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT (free)
Rebuttal 1: We know enough now to act decisively against Covid-19. Social distancing is a good place to start – STAT (free)
Rebuttal 2: A Rebuttal to “A Fiasco in the Making?” – Hilda Bastian (Free)
New Preliminary Studies with Hydroxychloroquine:
20 Mar, 2020 | 10:57h | UTCThis was an open-label study with only 42 patients without patient-relevant endpoints. The 6 patients that received Hydroxychloroquine + Azithromycin achieved more efficient virus elimination than control patients.
New in Vitro Study: Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro – Cell Discovery (free)
Related Articles: In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) – Clinical Infectious Diseases (free PDF) AND New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19? – International Journal of Antimicrobial Agents (free) AND A systematic review on the efficacy and safety of chloroquine for the treatment of COVID-19 – Journal of Critical Care (free) AND Of chloroquine and COVID-19 – Antiviral Research (free)
Video: Coronavirus Update with Anthony Fauci, MD
19 Mar, 2020 | 11:04h | UTCCoronavirus Update with Anthony Fauci, MD – March 18, 2020 – JAMA (free)
Podcast: New Research on Possible Treatments for Covid-19
19 Mar, 2020 | 10:57h | UTC
Report: Impact of Non-pharmaceutical Interventions to Reduce COVID19 Mortality and Healthcare Demand
18 Mar, 2020 | 09:53h | UTCSummary: Report 9 – Imperial College London (free)
Commentaries: US, UK coronavirus strategies shifted following UK epidemiologists’ ominous report – CNN (free) AND New Analysis Suggests Months Of Social Distancing May Be Needed To Stop Virus – NPR (free)
“…in an unmitigated epidemic, we would predict approximately 510,000 deaths in GB and 2.2 million in the US, not accounting for the potential negative effects of health systems being overwhelmed on mortality.”
‘A Ticking Time Bomb’: Scientists Worry About Coronavirus Spread in Africa
17 Mar, 2020 | 08:48h | UTC‘A ticking time bomb’: Scientists worry about coronavirus spread in Africa – Science (free)
Related: Managing COVID-19 in Low- and Middle-Income Countries – JAMA (free) AND Inside the Efforts to Prepare African Countries for COVID-19 – TIME (free) AND Looming threat of COVID-19 infection in Africa: act collectively, and fast – The Lancet (free) AND Is the Africa prepared for tackling the COVID-19 (SARS-CoV-2) epidemic? – lessons from past outbreaks, ongoing pan-African public health efforts, and implications for the future – International Journal of Infectious Diseases (free PDF)
COVID-19: Undocumented Infections are the Infection Source for 79% of Documented Cases
17 Mar, 2020 | 08:51h | UTCCommentaries: 80% of COVID-19 spreads from people who don’t know they are sick – UPI (free) AND Coronavirus Is Hiding in Plain Sight – The New York Times (10 articles per month are free)
Related: COVID-19: Who Is Infectious? – Forbes (free) AND Infected people without symptoms might be driving the spread of coronavirus more than we realized – CNN (free)
WHO Guidance: Mental Health and Psychosocial Considerations During COVID-19 Outbreak
16 Mar, 2020 | 07:57h | UTCMental Health and Psychosocial Considerations During COVID-19 Outbreak – World Health Organization (free PDF)
Related: The psychological impact of quarantine and how to reduce it: rapid review of the evidence – The Lancet (free) AND Behavioural scientists form new front in battle against coronavirus – The Guardian (free)
“Minimize watching, reading or listening to news that causes you to feel anxious or distressed; seek information only from trusted sources and mainly to take practical steps to prepare your plans and protect yourself and loved ones.”
When Guidelines Recommend Shared Decision-making
16 Mar, 2020 | 07:45h | UTCWhen Guidelines Recommend Shared Decision-making – JAMA (free)
Author Interview: When Guidelines Recommend Shared Decision-making (free audio)
Case Report: Second Patient Has Been Cured of HIV After Stem Cell Transplantation from Donors with an HIV-resistant Gene
13 Mar, 2020 | 07:56h | UTCCommentaries: A cure for HIV: how would we know? – The Lancet HIV (free) AND Second patient has been cured of HIV, study suggests – The Lancet (free) AND Second Patient Cured of HIV Still Clear – Science-Based Medicine (free) AND Second patient cured of HIV, say doctors – BBC (free)
Systematic Review: Alcoholics Anonymous Very Effective for Alcohol Use Disorder
12 Mar, 2020 | 08:10h | UTCAlcoholics Anonymous and other 12‐step programs for alcohol use disorder – Cochrane Library (free)
Author Interview: Alcoholics Anonymous and other 12-step programs for alcohol use disorder (free)
News Release: New Cochrane Review finds Alcoholics Anonymous and 12-Step Facilitation programs help people to recover from alcohol problems (free)
Commentaries: A new, big review of the evidence found that Alcoholics Anonymous works — for some – Vox (free) AND Alcoholics Anonymous validated by meta-analysis: ‘It absolutely does work’ – Stanford Medicine (free)
Doctors Working While Sick is Bad Enough in Ordinary Times. During the Covid-19 Outbreak it Could be Catastrophic
10 Mar, 2020 | 08:37h | UTCRelated Systematic Review: Working While Sick: A Systematic Review of Infectious Illness Presenteeism (free)
Related Study: Which healthcare workers work with acute respiratory illness? Evidence from Canadian acute-care hospitals during 4 influenza seasons: 2010–2011 to 2013–2014 – Infection Control & Hospital Epidemiology (free) AND Commentary: Sick hospital workers often expose patients to contagious illness – Reuters (free)
Improving Physician Communication About Treatment Decisions: Reconsideration of “Risks vs Benefits”
10 Mar, 2020 | 10:20h | UTCImproving Physician Communication About Treatment Decisions: Reconsideration of “Risks vs Benefits” – JAMA (free for a limited period)
Perspective – Can You Sue an Algorithm for Malpractice? It Depends
10 Mar, 2020 | 10:19h | UTCCan you sue an algorithm for malpractice? It depends – STAT (free)
[Abstract Only] Cohort Study: Sleep Irregularity Linked to Increased Risk of Cardiovascular Events
8 Mar, 2020 | 20:33h | UTCSleep Irregularity and Risk of Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Sleep Irregularity and Risk of Cardiovascular Events – American College of Cardiology (free) AND Better Sleep Linked With Reduced Risk of CVD, Improved Weight Loss – AJMC (free) AND Poor Sleepers at Higher Risk of CVD, MESA Data Suggest – TCTMD (free) AND Irregular sleep may increase risk of cardiovascular events – Brigham and Women’s Hospital (free) AND Irregular sleep may increase risk of cardiovascular problems – Medical News Today (free)
Ten Simple Rules to Becoming a Principal Investigator
8 Mar, 2020 | 20:37h | UTCTen Simple Rules to becoming a principal investigator – PLOS Computational Biology (free)
Related Commentary on Twitter
Read this article if you are wondering what is wrong in academia.
Spoiler: research integrity didn't make the 10 most important rules for becoming a PIhttps://t.co/BjhuaFuJGb pic.twitter.com/IJxBmouIBd
— Maarten van Smeden (@MaartenvSmeden) March 6, 2020