General Interest
RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain
16 Mar, 2021 | 01:39h | UTCEffect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain
Update on the safety of COVID-19 Vaccine AstraZeneca
16 Mar, 2021 | 02:35h | UTCUpdate on the safety of COVID-19 Vaccine AstraZeneca
Related: Countries should continue AstraZeneca rollout: WHO – MedicalXpress AND Expert reaction to news that Germany has halted vaccinations with the Oxford-AstraZeneca COVID-19 vaccine – Science Media Centre AND AstraZeneca finds no evidence of increased blood clot risk from vaccine – Reuters AND Data suggest no increased risk of blood clots from the AstraZeneca vaccine. Australia shouldn’t pause its rollout – The Conversation
Commentary on Twitter
As of March 8th, Around 17 million people in the EU & UK received the vaccine , there have been 15 events of DVT & 22 events of pulmonary embolism reported among those given the vaccine,This is much lower than would be expected to occur naturally in a general population
Please RT https://t.co/tnn4brxwpp— Antibiotic Steward? Bassam Ghanem (@ABsteward) March 14, 2021
B.1.1.7 variant linked to 55% higher mortality compared to other strains of SARS-CoV-2
16 Mar, 2021 | 02:32h | UTCOriginal study: Increased mortality in community-tested cases of SARS-CoV-2 lineage B.1.1.7 – Nature
Related: Death rate 64% higher with B117 COVID variant, study finds (study and commentary)
Commentary on Twitter (thread – Click for more)
https://mobile.twitter.com/_nickdavies/status/1371441682089132032
Cartoons that explain how the COVID vaccines work
16 Mar, 2021 | 02:13h | UTCCartoons that explain how the COVID vaccines work – KevinMD
More than half of COVID-19 patients report depressive symptoms months later, study finds
16 Mar, 2021 | 02:11h | UTCOriginal study: Association of Acute Symptoms of COVID-19 and Symptoms of Depression in Adults – JAMA Network Open
Commentary on Twitter
Survey study finds 52% of individuals with prior #COVID19 met criteria for moderate or greater symptoms of depression; more likely in younger, male, and those with more severe #COVID19 @royperlis @HarvardMed @Ognyanova @RutgersU @NorthwesternU @dellavolpe https://t.co/4krNvFb29T
— JAMA Network Open (@JAMANetworkOpen) March 13, 2021
Revisiting the Ten Commandments of Emergency Medicine: A Resident’s Perspective
14 Mar, 2021 | 20:26h | UTCRevisiting the Ten Commandments of Emergency Medicine: A Resident’s Perspective – Annals of Emergency Medicine (free for a limited period)
Commentary: Ten Commandments of Emergency Medicine Revisited – Journal Feed
Perspective | New lung cancer screening guideline comes with many caveats
14 Mar, 2021 | 20:23h | UTCNew lung cancer screening guideline comes with many caveats – Lown Institute
Original Guideline: USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk (article and commentaries)
Perspective | School reopening without robust COVID-19 mitigation risks accelerating the pandemic
14 Mar, 2021 | 20:51h | UTCSchool reopening without robust COVID-19 mitigation risks accelerating the pandemic – The Lancet
Covid vaccinations: No reason to stop using AstraZeneca jab, says WHO
14 Mar, 2021 | 20:46h | UTCCovid vaccinations: No reason to stop using AstraZeneca jab, says WHO
See also: Benefits Of AstraZeneca Vaccine Outweigh Risks, Say EMA and WHO Officials – Urging Jabs To Continue While Safety Data Around Blood Clots Is Reviewed – Health Policy Watch AND COVID-19 Vaccine AstraZeneca: PRAC investigating cases of thromboembolic events – vaccine’s benefits currently still outweigh risks – Update – European Medicines Agency AND Canada says AstraZeneca vaccine is safe after Norway and Denmark suspend use – Reuters
Urgent lessons from COVID 19: why the world needs a standing, coordinated system and sustainable financing for global research and development
14 Mar, 2021 | 20:47h | UTC
Commentary on Twitter
#COVID19 vaccines—developed, trialled, manufactured & authorised in several countries within a year. @VictorDzau et al. on lessons from the pandemic to inform an end-to-end global research & development preparedness & response ecosystem. Read https://t.co/G9PA5JBuaJ pic.twitter.com/EtFORBxvTl
— The Lancet (@TheLancet) March 12, 2021
Study: Healthcare settings did not increase the risk for Covid-19 infection among health care workers in the US. Exposure outside the workplace was the strongest risk factor for SARSCoV2 seropositivity
14 Mar, 2021 | 20:41h | UTCCommentaries: Healthcare settings do not increase risk for Covid-19 infection spread – University of Maryland School of Medicine AND Did Healthcare Workers Catch Covid In Or Outside The Hospital? – MedicalResearch.com AND Community Covid-19 Risk Higher Than Workplace Risk for Health Care Personnel – Physician’s Weekly
Commentary on Twitter
Cross-sectional study finds #COVID19 exposure outside the workplace was the strongest risk factor for #SARSCoV2 seropositivity. No workplace factors were associated with seropositivity. @EmoryMedicine @UMMC @HopkinsMedicine @CDCgov https://t.co/DbdSxTEb8n
— JAMA Network Open (@JAMANetworkOpen) March 10, 2021
Perspective | Long Covid isn’t as unique as we thought
12 Mar, 2021 | 08:27h | UTCLong Covid isn’t as unique as we thought – Vox
CDC Interim Recommendations for Fully Vaccinated People: An Important First Step
12 Mar, 2021 | 08:22h | UTCCDC Interim Recommendations for Fully Vaccinated People: An Important First Step – JAMA
Original Guidance and Commentaries: New CDC Guideline for fully vaccinated individuals says people can get together indoors without masks. Precautions should continue in public.
WHO Report | Devastatingly pervasive: 1 in 3 women globally experience violence
10 Mar, 2021 | 08:21h | UTCDevastatingly pervasive: 1 in 3 women globally experience violence – World Health Organization
Commentary: Violence Against Women Is “Unequivocally Pervasive”, Reveals Largest WHO Study Ever – Health Policy Watch
Death rate 64% higher with B117 COVID variant, study finds
11 Mar, 2021 | 08:38h | UTCDeath rate 64% higher with B117 COVID variant, study finds – CIDRAP
News release: Variant B.1.1.7 of COVID-19 associated with a significantly higher mortality rate, research shows – University of Bristol
Original Study: Risk of mortality in patients infected with SARS-CoV-2 variant of concern 202012/1: matched cohort study – The BMJ
Study: Children and young people remain at low risk of COVID-19 mortality
11 Mar, 2021 | 08:28h | UTC
Attributes and predictors of long COVID
11 Mar, 2021 | 08:25h | UTCAttributes and predictors of long COVID – Nature
Commentary on Twitter
Attributes and predictors of long COVID (fatigue, headache, dyspnea and anosmia) from 4182 incident cases.
– 13.3% symptoms ≥4 wks
– 4.5% for ≥8 wks
– 2.3% for ≥12 wksBeing older, female, incr. BMI, # symptoms all appeared to predict long COVID https://t.co/xSdNtLQO4V
— Andrew Morris (@ASPphysician) March 10, 2021
Audio Interview: The implications of changes in the structural biology of SARS-CoV-2
11 Mar, 2021 | 08:20h | UTC
Lab study shows Pfizer/BioNTech COVID-19 vaccine can also neutralize B.1.351, P1 and B.1.1.7 variants
10 Mar, 2021 | 08:43h | UTCNeutralizing Activity of BNT162b2-Elicited Serum – New England Journal of Medicine
Commentaries: Expert reaction to NEJM correspondence paper looking at the neutralising activity of the Pfizer-BioNTech vaccine against SARS-CoV-2 variants in the lab – Science Media Centre AND Pfizer/BioNTech COVID-19 vaccine neutralizes Brazil variant in lab study – Reuters
Study: Home testing for COVID-19 could prevent infections and reduce deaths at justifiable cost
10 Mar, 2021 | 08:40h | UTCNews release: Home testing for COVID-19 could prevent infections and reduce deaths at justifiable cost – Yale University
Original study: Clinical and Economic Effects of Widespread Rapid Testing to Decrease SARS-CoV-2 Transmission – Annals of Internal Medicine
Commentary on Twitter
Model-based analysis by @ADPaltiel, Amy Zheng of @YaleMed and @PaulSaxMD of @BrighamWomens.
A nationwide program of frequent home testing and self-isolation could greatly reduce total #COVID19 infections and mortality at a justifiable cost https://t.co/8AglZQXpuL. pic.twitter.com/5gQV3i0NxG
— Annals of Int Med (@AnnalsofIM) March 8, 2021
New CDC Guideline for fully vaccinated individuals says people can get together indoors without masks. Precautions should continue in public.
9 Mar, 2021 | 02:56h | UTCCommentaries: You’re fully vaccinated? The CDC says you can now have friends and family over for dinner – Vox AND CDC says fully vaccinated Americans can spend time together indoors and unmasked – STAT AND CDC Says It’s Safe For Vaccinated People To Do These Activities – WBUR AND If you got the COVID-19 vaccine, here’s what the CDC says you can do – Live Science
RCT: Azithromycin provides no benefit for community treatment of patients with suspected COVID-19
7 Mar, 2021 | 20:15h | UTC
Commentary on Twitter
The PRINCIPLE trial publishes its first peer reviewed paper, showing results from the study of azithromycin as a treatment for Covid-19 in the community. @TheLancet #UrgentCovidResearch #PRINCIPLETrial
?https://t.co/qKRI5PVpQk pic.twitter.com/BVQztDSvSC— OxPrimaryCareSci (@OxPrimaryCare) March 5, 2021
[Preprint] Increased risk of hospitalization associated with infection with SARS-CoV-2 Lineage B.1.1.7 in Denmark
7 Mar, 2021 | 19:46h | UTC
Commentary on Twitter (thread – click for more)
?~64% MORE SEVERE—The already more contagious #B117 variant from ?? is now found to increase risk of #COVID19 hospitalization by 64% versus other strains, says Denmark’s ?? CDC. Denmark sequences every cases—their data is the best, & now most worrisome.? https://t.co/F6w2JYEUnM pic.twitter.com/mngJoTBZtl
— Eric Feigl-Ding (@DrEricDing) March 4, 2021
Perspective | COVID-19 in 2021—Continuing Uncertainty
5 Mar, 2021 | 08:52h | UTCCOVID-19 in 2021—Continuing Uncertainty – JAMA
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
5 Mar, 2021 | 08:53h | UTCCommentaries: Ivermectin: Yet Another Fad Runs Into The Brick Wall Known As “Actual Science” – Brief-19 AND Ivermectin doesn’t speed recovery from mild COVID-19, study shows – CIDRAP