Clinical Review: Treatment and outcomes: medical and surgical treatment for intestinal Behçet’s disease (free)
Clinical Review: Optimal diagnosis and disease activity monitoring of intestinal Behçet’s disease (free)
Clinical Review: Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis – Gut and Liver (free PDF)
Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons (free)
Practical review of this common problem in the emergency department.
Association of delay of urgent or emergency surgery with mortality and use of health care resources: a propensity score–matched observational cohort study – Canadian Medical Association Journal (free)
Source: STAT News Newsletter
“Delayed operating room access for emergency surgery was associated with increased risk of inhospital mortality, longer length of stay and higher costs”.
An analysis of a large database of de-identified electronic medical records (EMRs) with over 40.000.000 patients found no association.
Commentaries: Cases of recurrent Clostridium difficile infection are soaring – University of Pennsylvania School of Medicine, via EurekAlert (free) AND Multiply Recurrent C difficile Infection Rates Sharply Rise – Medscape (free registration required) AND Demand for FMT likely to increase with rise in multiply recurrent C. difficile cases – 2 Minute Medicine (free) AND Marked increase seen in multiply recurrent C diff – CIDRAP (free)
Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer7 Jul, 2017 | 13:36h | UTC
Commentaries: Proton pump inhibitors associated with raised mortality – OnMedica (free) AND Longtime use of heartburn drugs linked to increased risk of death – NewsMedical (free) AND People taking heartburn drugs could have higher risk of death, study claims – The Guardian (free) AND Some heartburn drugs linked with higher risk of death – CBS News (free) AND PPIs Linked to Higher Risk for Death – Medscape (free registration required)
In a large observational study, PPI use was associated with increased mortality (HR 1.25; CI 1.23 to 1.28). PPIs were also associated with increased risk compared to H2 blockers (HR 1.24; CI 1.21 to 1.27). See more on the trade-offs of PPI therapy in our July 3rd issue (see #10)
Source: Critical Care Reviews Newsletter
Commentary: Complications of Proton Pump Inhibitor Therapy – PracticeUpdate (free registration required)
Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (link to abstract – registration required for full text) AND Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (link to abstract – subscription required for full text)
The authors of this review argue that the observational studies that brought up the safety issues associated with PPIs (above studies, for example) are insufficient to establish causation and suggest a more balanced approach to PPI prescribing.