Gastroenterology (all articles)
Guideline – Management of Crohn’s disease
7 Jul, 2017 | 14:06h | UTC
Guideline – Management of ulcerative colitis
7 Jul, 2017 | 14:06h | UTC
Cases of recurrent Clostridium difficile infection are increasing
7 Jul, 2017 | 14:04h | UTCCommentaries: Cases of recurrent Clostridium difficile infection are soaring – University of Pennsylvania School of Medicine, via EurekAlert (free) AND Multiply Recurrent C difficile Infection Rates Sharply Rise – Medscape (free registration required) AND Demand for FMT likely to increase with rise in multiply recurrent C. difficile cases – 2 Minute Medicine (free) AND Marked increase seen in multiply recurrent C diff – CIDRAP (free)
Multidisciplinary approach of colorectal cancer liver metastases
7 Jul, 2017 | 13:36h | UTCReview: Multidisciplinary approach of colorectal cancer liver metastases – World Journal of Clinical Oncology (free)
Current Status of Immune Checkpoint Inhibitors in Gastrointestinal Cancers
7 Jul, 2017 | 13:38h | UTCReview: Current Status of Immune Checkpoint Inhibitors in Gastrointestinal Cancers – Journal of Cancer (free)
Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer
7 Jul, 2017 | 13:36h | UTC
Immunotherapy in pancreatic cancer
7 Jul, 2017 | 13:35h | UTCReview: Immunotherapy in pancreatic cancer: Unleash its potential through novel combinations – World Journal of Clinical Oncology (free)
Non-alcoholic fatty liver disease: An expanded review
7 Jul, 2017 | 13:31h | UTCReview: Non-alcoholic fatty liver disease: An expanded review – World Journal of Hepatology (free)
Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy
7 Jul, 2017 | 13:24h | UTCReview: Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy – Nutrients (free)
Updates in Mirizzi syndrome
7 Jul, 2017 | 13:21h | UTCReview: Updates in Mirizzi syndrome – Hepatobiliary Surgery and Nutrition (free)
Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies
7 Jul, 2017 | 13:17h | UTCReview: Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies – International Journal of Molecular Sciences (free)
Risk of death among users of Proton Pump Inhibitors
5 Jul, 2017 | 15:31h | UTCCommentaries: Proton pump inhibitors associated with raised mortality – OnMedica (free) AND Longtime use of heartburn drugs linked to increased risk of death – NewsMedical (free) AND People taking heartburn drugs could have higher risk of death, study claims – The Guardian (free) AND Some heartburn drugs linked with higher risk of death – CBS News (free) AND PPIs Linked to Higher Risk for Death – Medscape (free registration required)
In a large observational study, PPI use was associated with increased mortality (HR 1.25; CI 1.23 to 1.28). PPIs were also associated with increased risk compared to H2 blockers (HR 1.24; CI 1.21 to 1.27). See more on the trade-offs of PPI therapy in our July 3rd issue (see #10)
Obesity and microbiota: an example of an intricate relationship
3 Jul, 2017 | 17:59h | UTCObesity and microbiota: an example of an intricate relationship – Genes & Nutrition (free)
Treatment of severe alcoholic hepatitis
3 Jul, 2017 | 17:17h | UTCSource: Critical Care Reviews Newsletter
Functional Dyspepsia: Advances in Diagnosis and Therapy
3 Jul, 2017 | 17:04h | UTCFunctional Dyspepsia: Advances in Diagnosis and Therapy – Gut and Liver (free)
Commentary: Diagnosis and Treatment of Functional Dyspepsia – PracticeUpdate (free registration required)
Related guideline: ACG and CAG Clinical Guideline: Management of Dyspepsia – American College of Gastroenterology and Canadian Association of Gastroenterology (free PDF)
Complications of Proton Pump Inhibitor Therapy
30 Jun, 2017 | 15:20h | UTCComplications of Proton Pump Inhibitor Therapy – Gastroenterology (free)
Commentary: Complications of Proton Pump Inhibitor Therapy – PracticeUpdate (free registration required)
Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (link to abstract – registration required for full text) AND Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (link to abstract – subscription required for full text)
The authors of this review argue that the observational studies that brought up the safety issues associated with PPIs (above studies, for example) are insufficient to establish causation and suggest a more balanced approach to PPI prescribing.
Colorectal polypectomy and endoscopic mucosal resection
29 Jun, 2017 | 15:38h | UTC
Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection
26 Jun, 2017 | 17:52h | UTCSource: EvidenceAlerts (free resource to find articles of interest)
In this meta-analysis including 19 randomized trials, probiotics given within 2 days of the first antibiotic dose (more effective than if started later) reduced the risk of Clostridium difficile infection (CDI) by >50% in hospitalized adults. 1 case of CDI would be prevented for every 23−144 patients treated with probiotics when antibiotics are started. “There was no convincing evidence of superior efficacy for any of the tested probiotic formulations, delivery methods (drink or capsule), or probiotic doses”.
Spotlight on FODMAPs for IBS
25 Jun, 2017 | 16:55h | UTCSpotlight on FODMAPs – ACP Gastroenterology Monthly (free)
Original article 1: The low FODMAP diet: recent advances in understanding its mechanisms and efficacy in IBS – Gut (link to abstract – $ for full-text)
Original article 2: Diet Low in FODMAPs Reduces Symptoms in Patients with Irritable Bowel Syndrome and Probiotic Restores Bifidobacterium Species: a Randomized Controlled Trial – Gastroenterology (link to abstract – $ for full-text)
“2 studies look at FODMAPs for irritable bowel” (RT @acpinternist see Tweet)
Diagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer
25 Jun, 2017 | 14:57h | UTCDiagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer: A Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Fecal immunochemical testing demonstrates good diagnostic accuracy for high-risk individuals – 2 minute medicine (free) AND Mixed Results with FIT Screen for High-Risk Colon Cancer – MedPage Today (free registration required)
Interview with the author: Fecal Testing Better At Detecting Colon Cancer Than Advanced Atypical Changes – MedicalResearch.com (free)
“FIT is the best alternative screening strategy for pts at increased risk for CRC who refuse to use colonoscopy” (RT @JAMAInternalMed see Tweet)
ACG and CAG Clinical Guideline: Management of Dyspepsia
23 Jun, 2017 | 18:40h | UTCACG and CAG Clinical Guideline: Management of Dyspepsia – American College of Gastroenterology and Canadian Association of Gastroenterology (free PDF)
Guidelines for the Management of Cancer of the Colon, Rectum and Anus
23 Jun, 2017 | 18:32h | UTCSpecial Issue – Homepage: Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017)
1 – Introduction (free)
2 – Diagnosis, Investigations and Screening (free)
3 – Surgical Management (free)
4 – Multidisciplinary Management (free)
5 – Follow Up, Lifestyle and Survivorship (free)
6 – Audit and Outcome Reporting (free)
7 – Pathology Standards and Datasets (free)
8 – Anal Cancer (free)
Clinical effects of antivirals for hepatitis C: context is critical
23 Jun, 2017 | 13:56h | UTCEditorial: Clinical effects of antivirals for hepatitis C: context is critical – The Lancet Gastroenterology & Hepatology (free)
Original Cochrane review: Direct-acting antivirals for chronic hepatitis C – Cochrane Library (link to summary – $ for full-text)
Commentary in The Guardian: ‘Miracle’ hepatitis C drugs costing £30k per patient ‘may have no clinical effect’ (free)
Update on anti-TNF agents and other new drugs for IBD
23 Jun, 2017 | 13:27h | UTCClinical Review: Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease – The BMJ (free)
Aspirin and other NSAIDs and colorectal cancer survival
21 Jun, 2017 | 18:01h | UTCTiming of Aspirin and Other Nonsteroidal Anti-Inflammatory Drug Use Among Patients With Colorectal Cancer in Relation to Tumor Markers and Survival – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentary: Study Informs NSAID Benefit in Colon Cancer – MedPage Today (free registration required)
Observational data suggests a benefit for individuals with KRAS wild-type tumors