Gastroenterology (all articles)

Observational study suggests Apixaban may be associated with a more favorable gastrointestinal safety profile. Further randomized trials are needed to confirm these findings.

Review: Drug-induced liver injury

26 Aug, 2017 | 15:48h | UTC

Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)

Guideline: serrated polyps in the colon and rectum

24 Aug, 2017 | 23:07h | UTC

British Society of Gastroenterology position statement on serrated polyps in the colon and rectum – Gut (free)

Study: Reductions in Acute Gastroenteritis–Related Hospitalizations and Associated Costs After Implementation of Rotavirus Vaccines

22 Aug, 2017 | 19:06h | UTC

National Estimates of Reductions in Acute Gastroenteritis–Related Hospitalizations and Associated Costs in US Children After Implementation of Rotavirus Vaccines – Journal of the Pediatric Infectious Diseases Society (free)

Commentary: Rotavirus vaccines continue to reduce diarrhea hospitalizations, medical costs in US kids – Medical News Today (free) AND Study: Rotavirus vaccine cuts healthcare costs in US children – CIDRAP (free)

Study: Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding

22 Aug, 2017 | 15:19h | UTC

Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial – The Lancet (link to abstract – $ for full-text)

Source: ACP Journal Club

In this study, patients at high risk of both cardiovascular and gastrointestinal events who required concomitant aspirin and NSAID, celecoxib associated with a proton pump inhibitor led to less recurrent gastrointestinal bleeding when compared to naproxen associated with a proton pump inhibitor (5.6% vs 12.3%).

Guideline: Gastrointestinal Sarcomas (GIST)

22 Aug, 2017 | 14:13h | UTC

GEIS guidelines for gastrointestinal sarcomas (GIST) – Cancer Treatment Reviews (free)

Guideline: Living Donor Liver Transplant Recipient

22 Aug, 2017 | 14:12h | UTC

The International Liver Transplantation Society Living Donor Liver Transplant Recipient Guideline – Transplantation (free)

Guideline: Management of Inherited Polyposis Syndromes

22 Aug, 2017 | 12:59h | UTC

The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes – Diseases of the Colon & Rectum (free)

Re-analysis of the USPSTF 2016 Evidence Report on Colorectal Cancer Screening

22 Aug, 2017 | 13:01h | UTC

Re-analysis of All-Cause Mortality in the U.S. Preventive Services Task Force 2016 Evidence Report on Colorectal Cancer Screening – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Flexible Sigmoidoscopy Tied to Lower Mortality Risk – Physician’s First Watch (free) AND Flexible Sigmoidoscopy Reduces All-Cause Mortality – Medscape (free registration required)

Free Online Course: Anatomy of the Abdomen and Pelvis

21 Aug, 2017 | 01:52h | UTC

Starts Today! Free Online Course: Anatomy of the Abdomen and Pelvis; a journey from basis to clinic – Leiden University Medical Center and Coursera

Study: probiotics can prevent sepsis in newborns

17 Aug, 2017 | 21:41h | UTC

A randomized synbiotic trial to prevent sepsis among infants in rural India – Nature (free PDF)

Commentaries: At Last, a Big, Successful Trial of Probiotics – The Atlantic (free) AND Probiotic Bacteria Could Protect Newborns From Deadly Infection – NPR Goats and Soda (free) AND Seeding the Gut Microbiome Prevents Sepsis in Infants – The Scientist (free)

New 8-Week Treatment Approved for All Hepatitis C Genotypes

17 Aug, 2017 | 15:42h | UTC

New 8-Week Treatment Approved for All Hepatitis C Genotypes – Physician’s First Watch (free)

Effect of scheduled second-look endoscopy on peptic ulcer bleeding

16 Aug, 2017 | 20:43h | UTC

Effect of scheduled second-look endoscopy on peptic ulcer bleeding: a prospective randomized multicenter trial – Gastrointestinal Endoscopy (link to abstract – $ for full-text)

Source: No Benefit of Second-Look Endoscopy After Endoscopic Hemostasis – Journal Watch ($)

“A single EGD with endoscopic hemostasis is not inferior to scheduled second-look endoscopy in terms of reduction in rebleeding rate of peptic ulcer bleeding. Repeat endoscopy would be helpful in the patients with unsatisfactory initial endoscopic hemostasis, use of NSAIDs, and larger amounts of transfused blood”