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Family Medicine

NICE Guideline | Treatment and management of depression in adults.

4 Jul, 2022 | 13:02h | UTC

Depression in adults: treatment and management – National Institute for Health and Care Excellence


Review | Cough hypersensitivity and chronic cough.

4 Jul, 2022 | 12:59h | UTC

Cough hypersensitivity and chronic cough – Nature Reviews Disease Primers (if the link is paywalled, try this one)

See also: Infographic (if the link is paywalled, try this one)

 

Commentary on Twitter


Guideline Synopsis | Evaluation and diagnosis of chest pain.

4 Jul, 2022 | 12:49h | UTC

Evaluation and Diagnosis of Chest Pain – JAMA (free for a limited period)

Original Guideline:

2021 AHA/ACC/ASE/CHEST/SAEM/SCCT/SCMR Guideline for the Evaluation and Diagnosis of Chest Pain: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

News Release: First-Ever Guideline Focused Solely on Chest Pain Evaluation, Diagnosis Released

Guideline Hub: Guideline for the Evaluation and Diagnosis of Chest Pain

Key Points: 2021 AHA/ACC Chest Pain Guideline – American College of Cardiology

Commentary: New Chest Pain Guidelines Out at Last: Most Tests Have a Role – TCTMD


RCT | Immobilization of torus fractures of the wrist in children.

4 Jul, 2022 | 12:46h | UTC

Immobilisation of torus fractures of the wrist in children (FORCE): a randomised controlled equivalence trial in the UK – The Lancet

 

Commentary from the author on Twitter (thread – click for more)


Brief Review | Sudden onset hepatitis in children.

4 Jul, 2022 | 12:41h | UTC

Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)

Related: WHO Updated Report: Severe acute hepatitis of unknown etiology in children. (several articles on the subject)

 

Commentary on Twitter


Monkeypox soars in Europe, with more than 4,000 cases.

4 Jul, 2022 | 12:43h | UTC

Monkeypox soars in Europe, with more than 4,000 cases – CIDRAP

Original Report: European Centre for Disease Prevention and Control/WHO Regional Office for Europe. Monkeypox, Joint Epidemiological overview, 30 June, 2022

WHO Statement: No room for complacency – World Health Organization

Related:

Multi-country monkeypox outbreak: situation update – World Health Organization

Monkeypox Genital Lesions – New England Journal of Medicine

Monkeypox: Africa CDC Demands Equal Treatment in Global Allocation of Limited Vaccine Doses – Health Policy Watch

Monkeypox vaccination begins — can the global outbreaks be contained? – Nature

Incubation period for monkeypox: Estimates from the Netherlands.

‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT

Rename monkeypox strains to remove geographic stigma, researchers say – Science

Clinical management and infection prevention and control for monkeypox: Interim rapid response guidance, 10 June 2022 – World Health Organization

2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention

As monkeypox threat grows, scientists debate best vaccine strategy – Science

Monkeypox is a new global threat. African scientists know what the world is up against – Science

WHO Experts Emphasize ‘Window of Opportunity’ to Control Monkeypox Spread as Cases Outside Africa Double Again – Health Policy Watch

Genetic data indicate at least two separate monkeypox outbreaks underway, suggesting wider spread – STAT

Experts highlight sexual aspect of monkeypox spread – CIDRAP

What to Know About Monkeypox – JAMA

Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization

Principles for monkeypox control in the UK: 4 nations consensus statement – UK Health Security Agency

Monkeypox outbreaks: 4 key questions researchers have – Nature

Study reports first use of antivirals in monkeypox patients – Lancet

Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization

Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization

A Novel International Monkeypox Outbreak – Annals of Internal Medicine

EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT

Monkeypox cases increase across Europe, North America – CIDRAP

Multi-country monkeypox outbreak in non-endemic countries – World Health Organization

Monkeypox goes global: why scientists are on alert – Nature

Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ

Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT

What is monkeypox? A microbiologist explains what’s known about this smallpox cousin – The Conversation

Monkeypox: Time to worry or one to ignore? – BBC

UK, Spain, Portugal report more monkeypox cases – CIDRAP

U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT

Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization

Monkeypox cases confirmed in England – latest updates – UK Health Security Agency

Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch

European outbreak of monkeypox: what you need to know – The Conversation

Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR

Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News


Guideline | Malignancy risk stratification for solitary pulmonary nodule.

4 Jul, 2022 | 12:33h | UTC

Malignancy risk stratification for solitary pulmonary nodule: A clinical practice guideline – Journal of Evidence-Based Medicine


M-A | Antibiotics for preventing recurrent urinary tract infection.

4 Jul, 2022 | 12:17h | UTC

Antibiotics for Preventing Recurrent Urinary Tract Infection: Systematic Review and Meta-Analysis – Open Forum Infectious Diseases


Review | Lowering and raising serum urate levels: off-label effects of commonly used medications.

4 Jul, 2022 | 12:10h | UTC

Lowering and Raising Serum Urate Levels: Off-Label Effects of Commonly Used Medications – Mayo Clinic Proceedings


M-A of randomized trials | Ondansetron vs. metoclopramide for managing hyperemesis gravidarum.

4 Jul, 2022 | 12:11h | UTC

Ondansetron versus metoclopramide for managing hyperemesis gravidarum: A systematic review and meta-analysis of randomized controlled trials – Turkish Journal Of Obstetrics And Gynecology


Two new studies show no benefit of Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19.

1 Jul, 2022 | 11:49h | UTC

Study 1: Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19 (OVID): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet Haematology

Study 2: Thromboprophylactic low-molecular-weight heparin versus standard of care in unvaccinated, at-risk outpatients with COVID-19 (ETHIC): an open-label, multicentre, randomised, controlled, phase 3b trial – The Lancet Haematology

Commentaries:

Antithrombotic prophylaxis for symptomatic outpatients with COVID-19: less is consistently more – The Lancet Haematology

Antithrombotic Prophylaxis No Help in Outpatients With COVID — Two trials show no differences between patients who received enoxaparin vs standard of care – MedPage Today (free registration required)

 

Commentary on Twitter (thread – click for more)

 


Accuracy of rapid antigen vs. RT-PCR testing for SARS-CoV-2 infection in college athletes during prevalence of the Omicron variant.

1 Jul, 2022 | 11:39h | UTC

Accuracy of Rapid Antigen vs Reverse Transcriptase–Polymerase Chain Reaction Testing for SARS-CoV-2 Infection in College Athletes During Prevalence of the Omicron Variant – JAMA Network Open

 

Commentary on Twitter

 


Consensus for the definition, classification, diagnosis, and management of urticaria.

1 Jul, 2022 | 11:32h | UTC

Taiwanese dermatological association consensus for the definition, classification, diagnosis, and management of urticaria: A 2021 update – Journal of the Formosan Medical Association

 


RCT: Diclofenac–hyaluronate conjugate intra-articular injection for hip, ankle, shoulder, and elbow osteoarthritis.

1 Jul, 2022 | 10:55h | UTC

Diclofenac–hyaluronate conjugate (diclofenac etalhyaluronate) intra-articular injection for hip, ankle, shoulder, and elbow osteoarthritis: a randomized controlled trial – BMC Musculoskeletal Disorders

 


RCT: FODMAP diet vs. medication in primary care patients with irritable bowel syndrome.

1 Jul, 2022 | 10:46h | UTC

Diet or medication in primary care patients with IBS: the DOMINO study – a randomised trial supported by the Belgian Health Care Knowledge Centre (KCE Trials Programme) and the Rome Foundation Research Institute – Gut (link to abstract – $ for full-text)

 


Life’s Essential 8: Updating and enhancing the AHA construct of cardiovascular health.

30 Jun, 2022 | 11:31h | UTC

Life’s Essential 8: Updating and Enhancing the American Heart Association’s Construct of Cardiovascular Health: A Presidential Advisory From the American Heart Association – Circulation

News Release: American Heart Association adds sleep to cardiovascular health checklist

Commentary: Sleep duration matters for heart health, according to new recommendations – CNN

Related Study: Status of Cardiovascular Health in US Adults and Children Using the American Heart Association’s New “Life’s Essential 8” Metrics: Prevalence Estimates from the National Health and Nutrition Examination Survey (NHANES), 2013-2018 – Circulation

 


Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019.

30 Jun, 2022 | 11:28h | UTC

Adolescent transport and unintentional injuries: a systematic analysis using the Global Burden of Disease Study 2019 – The Lancet Public Health

News Release: The Lancet: Improving road safety measures could save half a million lives every year worldwide – Institute for Health Metrics and Evaluation

 

Commentaries on Twitter

(Thread – click for more)

(Thread – click for more)

 


Cohort Study: Pfizer vaccine effectiveness against omicron in children 5 to 11 years of age.

30 Jun, 2022 | 11:21h | UTC

BNT162b2 Vaccine Effectiveness against Omicron in Children 5 to 11 Years of Age – New England Journal of Medicine

 


Secondary analysis of a RCT: Empagliflozin for heart failure with preserved left ventricular ejection fraction with and without diabetes.

30 Jun, 2022 | 10:58h | UTC

Empagliflozin for Heart Failure With Preserved Left Ventricular Ejection Fraction With and Without Diabetes – Circulation

Original Study: Empagliflozin in Heart Failure with a Preserved Ejection Fraction – New England Journal of Medicine

 


RCT: A 2-week interruption in methotrexate treatment doubles the antibody response to a COVID-19 booster vaccine.

29 Jun, 2022 | 12:10h | UTC

Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial – The Lancet Respiratory Medicine

News Releases:

Interrupting the treatment of vulnerable people on immune-suppressing medicines, doubles their antibody response to COVID-19 booster vaccination – University of Nottingham

Interrupting immune-suppressing treatment can boost COVID vaccine response – Imperial College London

Commentaries:

Improving COVID-19 vaccine immunogenicity by interrupting methotrexate treatment – The Lancet Respiratory Medicine

Covid-19: Pausing immune suppressing drugs enhances antibody response to boosters, study shows – The BMJ

Related Study: Two-week methotrexate discontinuation in patients with rheumatoid arthritis vaccinated with inactivated SARS-CoV-2 vaccine: a randomised clinical trial – Annals of Rheumatic Diseases

 

Commentary on Twitter

 


AAP Policy Statement: Breastfeeding and the use of human milk.

29 Jun, 2022 | 12:13h | UTC

Breastfeeding and the Use of Human Milk – Pediatrics

News Release: American Academy of Pediatrics Calls for More Support for Breastfeeding Mothers Within Updated Policy Recommendations

 


M-A: Comparison of mortality and hospital readmissions among patients receiving virtual ward transitional care vs. usual postdischarge care.

29 Jun, 2022 | 12:06h | UTC

Comparison of Mortality and Hospital Readmissions Among Patients Receiving Virtual Ward Transitional Care vs Usual Postdischarge Care: A Systematic Review and Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 


Review: Common hand conditions.

29 Jun, 2022 | 11:57h | UTC

Common Hand Conditions: A Review – JAMA (free for a limited period)

Audio Clinical Review: Diagnosis and Treatment of Common Hand Conditions

 


An analysis of SARS-CoV-2 vaccine reactogenicity: variation by type, dose, and history, severity, and recency of prior SARS-CoV-2 infection.

29 Jun, 2022 | 11:52h | UTC

An Analysis of SARS-CoV-2 Vaccine Reactogenicity: Variation by Type, Dose, and History, Severity, and Recency of Prior SARS-CoV-2 Infection – Open Forum Infectious Diseases

 


ESPGHAN position paper on management and follow-up of children and adolescents with coeliac disease.

29 Jun, 2022 | 11:32h | UTC

ESPGHAN position paper on management and follow-up of children and adolescents with coeliac disease – Pediatric Gastroenterology and Nutrition

 


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