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Out today in @bmj_latest

We reviewed the evidence on the efficacy of antidepressants for pain in adults

We showed that antidepressants are effective for some pain conditions, but for most they are either ineffective or evidence is inconclusivehttps://t.co/E2XVQ9oGUQ
🧵 pic.twitter.com/kBo7eAyeCP

— Giovanni Ferreira (@giovanni_ef) February 1, 2023

Patients labeled as nonallergic after initial tests for penicillin allergy may develop resensitization afterwards

2 Feb, 2023 | 15:03h | UTC

Resensitization in suspected penicillin allergy – Allergy

Video summary: Resensitisation in suspected penicillin allergy

Commentary: Patients should be retested for penicillin resensitization before being deemed nonallergic – Healio (free registration required)

Improving antimicrobial stewardship with penicillin allergy testing: a review of current practices and unmet needs – JAC-Antimicrobial Resistance

Management of Patients with Suspected or Confirmed Antibiotic Allergy. Executive Summary of Guidance from the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC), the Spanish Society of Allergy and Clinical Immunology (SEAIC), the Spanish Society of Hospital Pharmacy (SEFH) and the Spanish Society of Intensive Medicine and Coronary Care Units (SEMICYUC) – Journal of Investigational Allergology and Clinical Immunology (PDF)

The prevalence of penicillin allergy labeling ranged from 0.9% to 10.2% across practices in a large pediatric cohort, raising questions regarding the validity of those labels and the unnecessary use of second-line antibiotics that may follow.

M-A: Most patients with allergy to Penicillin can be given Cefazolin

Systematic review: Safety and efficacy of de-labelling penicillin allergy in adults using direct oral challenge

Penicillin allergy labels increase second-line broad-spectrum antibiotic prescribing for pediatric respiratory tract infections

Podcast: A Clinical Pharmacologist’s Perspective on Penicillin Allergy

Study: Development and Validation of a Penicillin Allergy Clinical Decision Rule

Management of a surgical patient with a label of penicillin allergy: narrative review and consensus recommendations – British Journal of Anaesthesia

NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk

Cohort Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy

Commentary on Twitter

Doña et al. Resensitization in suspected #penicillinallergy

Read 👉 https://t.co/irMhv07kN5

Video abstract of this article 👉 https://t.co/JIzDlQROYN

Read all recent papers published in #Allergy on #drugallergies 👉 https://t.co/jUxpXPlxKB @mariajtorresj #Allergy_journal pic.twitter.com/eIB1TdDqPI

— Allergy EAACI (@AllergyEaaci) November 15, 2022

Position Paper | Exercise recommendations for people with type 1 and type 2 diabetes

2 Feb, 2023 | 14:55h | UTC

2022: Position of Brazilian Diabetes Society on exercise recommendations for people with type 1 and type 2 diabetes – Diabetology & Metabolic Syndrome

RCT | Diclofenac diethylamine 2.32% gel applied twice daily vs. 1.16% gel four times daily in patients with acute ankle sprain

2 Feb, 2023 | 14:49h | UTC

Randomized, double-blind, noninferiority study of diclofenac diethylamine 2.32% gel applied twice daily versus diclofenac diethylamine 1.16% gel applied four times daily in patients with acute ankle sprain – BMC Musculoskeletal Disorders

M-A | Effect of aspirin in patients with established asymptomatic carotid atherosclerosis

2 Feb, 2023 | 14:44h | UTC

Effect of aspirin in patients with established asymptomatic carotid atherosclerosis: A systematic review and meta-analysis – Frontiers in Pharmacology

M-A | Comparative effectiveness of prophylactic strategies for preeclampsia

2 Feb, 2023 | 14:42h | UTC

Comparative effectiveness of prophylactic strategies for preeclampsia: a network meta-analysis of randomized controlled trials – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentary: Meta‐analysis reveals effective prophylactic strategies for preeclampsia – MDEdge

RCT | Oral minocycline plus rifampicin vs. oral linezolid for complicated skin and skin structure infections caused by MRSA

2 Feb, 2023 | 14:33h | UTC

Oral minocycline plus rifampicin versus oral linezolid for complicated skin and skin structure infections caused by methicillin-resistant Staphylococcus aureus: The AIDA open label, randomized, controlled Phase 4 trial – eClinicalMedicine

The introduction of sugary drinks tax in the UK was followed by a drop in obesity cases among children

1 Feb, 2023 | 13:32h | UTC

Associations between trajectories of obesity prevalence in English primary school children and the UK soft drinks industry levy: An interrupted time series analysis of surveillance data – PLOS Medicine

News Releases:

UK soft drink taxes associated with decreased obesity in girls – PLOS

Sugary drinks tax may have prevented over 5,000 cases of obesity a year in year six girls alone – University of Cambridge

Commentaries:

Expert reaction to study looking at the UK sugary drinks tax and obesity in children – Science Media Centre

UK sugar tax ‘prevents 5,000 cases of obesity in year 6 girls annually’ – The Guardian

WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.

M-A: Outcomes following taxation of sugar-sweetened beverages.

Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics

Cutting back on sugar-sweetened beverages: What works? – Cochrane Library

Association of a Beverage Tax on Sugar-Sweetened and Artificially Sweetened Beverages With Changes in Beverage Prices and Sales at Chain Retailers in a Large Urban Setting – JAMA

Impact of sugar‐sweetened beverage taxes on purchases and dietary intake: Systematic review and meta‐analysis – Obesity Reviews

Association between tax on sugar sweetened beverages and soft drink consumption in adults in Mexico: open cohort longitudinal analysis of Health Workers Cohort Study – The BMJ

Potential impact on prevalence of obesity in the UK of a 20% price increase in high sugar snacks: modelling study – The BMJ

Changes in food purchases after the Chilean policies on food labelling, marketing, and sales in schools: a before and after study – The Lancet Planetary Health

Association of a Sweetened Beverage Tax With Soda Consumption in High School Students – JAMA Pediatrics

Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine

Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation

Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian

Commentary from the author on Twitter (thread – click for more)

📢 19 months after the UK Soft Drinks Industry Levy (sugar tax) was implemented, we found an 8% relative reduction in obesity levels in 10/11 year old girls. Greatest reductions were found in girls from schools in the most deprived areas https://t.co/pYDHZZJrur

— Dr Nina Rogers (@Nina_Tr_Rogers) January 26, 2023

Cohort Study | Associations between infant screen use, electroencephalography markers, and cognitive outcomes

1 Feb, 2023 | 13:34h | UTC

Associations Between Infant Screen Use, Electroencephalography Markers, and Cognitive Outcomes – JAMA Pediatrics

Commentaries:

Infant Screen Use Linked to Alterations in Cortical EEG Before Age 2 – HealthDay

Your child’s academic success may start with their screen time as infants, study says – CNN

Assessment of COVID-19 as the underlying cause of death among children and young people aged 0 to 19 years in the US

1 Feb, 2023 | 13:36h | UTC

Assessment of COVID-19 as the Underlying Cause of Death Among Children and Young People Aged 0 to 19 Years in the US – JAMA Network Open

News Release: COVID-19 is a leading cause of death in children and young people in the US – University of Oxford

Commentary: Expert reaction to study looking at children in the US aged 0 to 19 years whose underlying cause of death was COVID-19 – Science Media Centre

[Preprint] Risk of Hospitalization, severe disease, and mortality due to COVID-19 in children with SARS-CoV-2 infection in Germany – “overall hospitalization rate associated with SARS-CoV-2 infection was 35.9 per 10,000 children, ICU admission rate was 1.7 per 10,000 and case fatality was 0.09 per 10,000”.

Deaths in children and young people in England after SARS-CoV-2 infection during the first pandemic year – “In total, 99.995% of children and young people with a positive SARS-CoV-2 test survived”.

Review | High prevalence of geriatric conditions among older adults with cardiovascular disease

1 Feb, 2023 | 13:30h | UTC

High Prevalence of Geriatric Conditions Among Older Adults With Cardiovascular Disease – Journal of the American Heart Association

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

M-A | Comparative efficacy of exercise therapy and oral NSAIDs and paracetamol for knee or hip osteoarthritis

1 Feb, 2023 | 13:28h | UTC

Comparative efficacy of exercise therapy and oral non-steroidal anti-inflammatory drugs and paracetamol for knee or hip osteoarthritis: a network meta-analysis of randomised controlled trials – British Journal of Sports Medicine

Commentary on Twitter

Network meta-analysis of 152 RCTs (17431 pts) comparing efficacy of exercise therapy, NSAIDs, Tylenol for knee or hip osteoarthritis: Found all 3 equivalent at 4 wk, 8 wk and 24 wks. https://t.co/rKck2AacL4 pic.twitter.com/YEAMh9UxTs

— Dr. John Cush (@RheumNow) January 10, 2023

SR | Interventions to improve health and the determinants of health among sex workers in high-income countries

1 Feb, 2023 | 13:25h | UTC

Interventions to improve health and the determinants of health among sex workers in high-income countries: a systematic review – The Lancet Public Health

Editorial: Sex workers health: time to act

Commentary from the author on Twitter (thread – click for more)

New Paper! Our SR in @TheLancetPH summarises evidence for health & social interventions in sex worker populations in HICs https://t.co/TSe9qv4oKP Great team inc @DrLucypotter @MollyBradbury14 @GraceyOutreach @Kitdempsey @rob_aldridge @BintyRock @SerenaLuchenski🧵below…1/4 pic.twitter.com/P6Bx3rFfHw

— Luke Johnson, MD, MSc, FFPH (@luke_a_johnson) November 3, 2022

M-A | Blood pressure, hypertension and the risk of atrial fibrillation

1 Feb, 2023 | 13:22h | UTC

Blood pressure, hypertension and the risk of atrial fibrillation: a systematic review and meta-analysis of cohort studies – European Journal of Epidemiology

Guideline | Management of “CKD-PeriDialysis”-the periods prior to and in the early-stage of initial dialysis

1 Feb, 2023 | 13:21h | UTC

Chinese Clinical Practice Guideline for the Management of “CKD-PeriDialysis”-the Periods Prior to and in the Early-Stage of Initial Dialysis – Kidney International Reports

Cohort Study | Association between celiac disease and cardiovascular disease

1 Feb, 2023 | 13:16h | UTC

Association between coeliac disease and cardiovascular disease: prospective analysis of UK Biobank data – BMJ Medicine

News Release: Fewer known risk factors, but heightened risk of cardiovascular disease in people with coeliac disease – BMJ Newsroom

M-A | Association between autism spectrum disorders and cardiometabolic diseases

1 Feb, 2023 | 13:11h | UTC

Association Between Autism Spectrum Disorders and Cardiometabolic Diseases: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Editorial: Autism, Physical Health Conditions, and a Need for Reform – JAMA Pediatrics (free for a limited period)

Commentary on Twitter

Study results suggest that having autism may be associated with a higher risk of developing diabetes, dyslipidemia, and heart disease. https://t.co/T19VAQxdjf

— JAMA Pediatrics (@JAMAPediatrics) January 30, 2023

A2BCD: a concise guide for asthma management

1 Feb, 2023 | 13:14h | UTC

A2BCD: a concise guide for asthma management – The Lancet Respiratory Medicine (free registration required)

Commentary on Twitter

https://twitter.com/LancetRespirMed/status/1619284669379522560

M-A | Effects of GLP-1 receptor agonists on cardiovascular outcomes in patients with type 2 diabetes and CKD

1 Feb, 2023 | 13:06h | UTC

Effects of GLP-1 receptor agonists on cardiovascular outcomes in patients with type 2 diabetes and chronic kidney disease: A systematic review and meta-analysis – Pharmacology

SR | Physical interventions to interrupt or reduce the spread of respiratory viruses

31 Jan, 2023 | 14:11h | UTC

Physical interventions to interrupt or reduce the spread of respiratory viruses – Cochrane Library

Commentary on Twitter (thread – click for more)

Just out Cochrane review on Physical interventions to interrupt or reduce the spread of respiratory viruses https://t.co/fI4Ac6VbAa

— Carl Heneghan (@carlheneghan) January 30, 2023