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Cohort Study | In utero exposure to ADHD medication does not seem to result in worse offspring neurodevelopmental outcomes

14 Feb, 2023 | 10:54h | UTC

Summary: The authors conducted a study to investigate the long-term effects of in utero exposure to ADHD medication (methylphenidate, amphetamine, dexamphetamine, lisdexamphetamine, modafinil, atomoxetine, clonidine) on offspring. The study followed 1,068,073 liveborn singletons from 1998 to 2018 and compared the outcomes of children whose mothers continued or discontinued ADHD medication during pregnancy. The main outcomes were neurodevelopmental psychiatric disorders, impairments in vision or hearing, epilepsy, seizures, or growth impairment during childhood or adolescence. After adjustment for demographic and psychiatric characteristics of the mother, no increased risk of any developmental disorders was found in offspring exposed to ADHD medication compared to those not exposed. The results provide reassurance for women with ADHD who depend on medication and consider continuing it during pregnancy.

(By ChatGPT, reviewed and edited)

 

Article: In utero exposure to ADHD medication and long-term offspring outcomes – Molecular Psychiatry (link to abstract – $ for full-text)

News Release: Study: Pregnant women on ADHD medications shouldn’t worry about pediatric neurodevelopmental disorders – The Mount Sinai Hospital

 

Commentary from the author on Twitter (thread – click for more)

 

Single-arm study | Effects of SER-109 as an investigational microbiome therapeutic in recurrent C. difficile infection

14 Feb, 2023 | 10:47h | UTC

Summary: This was a phase 3, open-label, single-arm trial of 263 adults with recurrent Clostridioides difficile Infection (CDI). The trial aimed to evaluate the safety and rate of CDI recurrence after administration of the investigational microbiome therapeutic SER-109. The trial found that SER-109 was well tolerated and the overall rate of recurrent CDI was low, regardless of the number of prior recurrences, demographics, or diagnostic approach.

(By ChatGPT, reviewed and edited)

 

Article: Safety and Tolerability of SER-109 as an Investigational Microbiome Therapeutic in Adults With Recurrent Clostridioides difficile Infection: A Phase 3, Open-Label, Single-Arm Trial – JAMA Network Open

Commentary: Phase 3 trial provides more positive data for recurrent C diff microbiome drug – CIDRAP

Related:

RCT: Among patients with recurrent Clostridioides difficile infection, the use of SER-109, an oral microbiome therapy, reduced recurrence rate compared to placebo (12% vs. 40%).

Post-trial follow-up | Microbiome therapeutic SER-109 through 24 weeks for recurrent Clostridioides difficile infection.

 

Podcast | Intravenous fluids in pediatrics

14 Feb, 2023 | 10:32h | UTC

#76: IV Fluids – Salty and Sweet – The Cribsiders

 

RCT | Testing equivalence of two doses of intravenous iron to treat iron deficiency in pregnancy

14 Feb, 2023 | 10:31h | UTC

Testing equivalence of two doses of intravenous iron to treat iron deficiency in pregnancy: A randomised controlled trial – BJOG

 

Recommended adult immunization schedule, United States, 2023

13 Feb, 2023 | 13:06h | UTC

Recommended Adult Immunization Schedule, United States, 2023 – Annals of Internal Medicine

Commentary: Recommended 2023 Adult Immunization Schedule Published – HealthDay

 

Commentary on Twitter

 

RCT | Azithromycin reduces the risk of maternal sepsis or death in women planning a vaginal birth

13 Feb, 2023 | 13:02h | UTC

Azithromycin to Prevent Sepsis or Death in Women Planning a Vaginal Birth – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Single-dose antibiotic prevents maternal sepsis and death – NIH News

Commentaries:

In large study, a single antibiotic dose slashed rate of sepsis in childbirth – STAT

Dose of azithromycin found to cut risk of maternal death, sepsis in childbirth – CIDRAP

Single dose of the antibiotic azithromycin decreases sepsis and death risk during childbirth – News Medical/ University of Virginia Health System

 

Updated child and adolescent immunization schedule, United States, 2023

13 Feb, 2023 | 13:05h | UTC

Child and Adolescent Immunization Schedule by Age – Centers for Diseases Control and Prevention

See also: Recommended Childhood and Adolescent Immunization Schedule: United States, 2023 – Pediatrics

Commentary: Immunization Schedule for Children, Teens Updated for 2023 – HealthDay

 

The Lancet Series | Breastfeeding 2023

13 Feb, 2023 | 12:52h | UTC

Homepage: Breastfeeding 2023 – The Lancet

Editorial: Unveiling the predatory tactics of the formula milk industry

Breastfeeding: crucially important, but increasingly challenged in a market-driven world

Marketing of commercial milk formula: a system to capture parents, communities, science, and policy

The political economy of infant and young child feeding: confronting corporate power, overcoming structural barriers, and accelerating progress

Stemming commercial milk formula marketing: now is the time for radical transformation to build resilience for breastfeeding

Commentaries:

Expert reaction to review of formula baby milk – Science Media Centre

Lancet Series outlines baby formula companies’ exploitative marketing playbook to sell products – University of the Witwatersrand/News Medical

 

Updated Guideline | Cardiovascular disease risk assessment and reduction, including lipid modification

13 Feb, 2023 | 12:47h | UTC

Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence

Related Guidelines:

USPSTF Recommendation Statement | Statin use for the primary prevention of cardiovascular disease in adults.

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation

#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias

#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology – 2019 – Arquivos Brasileiros de Cardiologia

Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal

 

Abbreviated lipid guidelines for clinical practice

13 Feb, 2023 | 12:46h | UTC

Abbreviated lipid guidelines for clinical practice : Based on ESC lipid guidelines 2019 and ESC cardiovascular disease prevention in clinical practice guidelines 2021 – Irish Journal of Medical Science

Original Guidelines

#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias

#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.

Related:

Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence

USPSTF Recommendation Statement | Statin use for the primary prevention of cardiovascular disease in adults.

2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation

Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology – 2019 – Arquivos Brasileiros de Cardiologia

Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal

 

US infant pertussis incidence trends before and after implementation of the maternal Tdap vaccine

13 Feb, 2023 | 12:38h | UTC

US Infant Pertussis Incidence Trends Before and After Implementation of the Maternal Tetanus, Diphtheria, and Pertussis Vaccine – JAMA Pediatrics (free for a limited period)

Commentary: Maternal Tdap Vaccination Protects Youngest Infants From Pertussis – HealthDay

 

Commentary on Twitter

 

Resistant hypertension: a stepwise approach

10 Feb, 2023 | 13:58h | UTC

Resistant hypertension: A stepwise approach – Cleveland Clinic Journal of Medicine

 

Brief Review | Mpox — A rapidly evolving disease

10 Feb, 2023 | 13:56h | UTC

Mpox—A Rapidly Evolving Disease – JAMA Dermatology

Related:

Surveillance, case investigation and contact tracing for mpox (monkeypox): interim guidance, 22 December 2022 – World Health Organization

Rapid review on monkeypox policies among the G20 nations: relevance to policy and practitioner – F1000 Research

Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study – The Lancet Infectious Diseases

Monkeypox (hMPXV infection): A practical review – American Journal of Medicine

Monkeypox in pregnancy: virology, clinical presentation, and obstetric management – American Journal of Obstetrics & Gynecology

WHO renames “monkeypox” as “mpox” to help destigmatize the disease.

Monkeypox – The Lancet

Study shows there is substantial monkeypox transmission before symptoms appear.

Global monkeypox case hospitalisation rates: A rapid systematic review and meta-analysis – eClinicalMedicine

Human monkeypox virus infection in women and non-binary individuals during the 2022 outbreaks: a global case series – The Lancet

Monkeypox — A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity – New England Journal of Medicine

CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox.

Monkeypox – New England Journal of Medicine

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine

Monkeypox: disease epidemiology, host immunity and clinical interventions.

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

Opinion | Interpreting the results from the first randomized controlled trial of colonoscopy: does it save lives?

10 Feb, 2023 | 13:54h | UTC

Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives? – BMJ Evidence Based Medicine

Original Study: RCT | Effect of colonoscopy screening on risks of colorectal cancer and related death.

 

Consensus Statement | Evaluation and management of patients with diabetes and heart failure

10 Feb, 2023 | 13:51h | UTC

Evaluation and Management of Patients with Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement – Diabetes & Metabolism Journal

Related:

ACC/AHA/HFSA 2022 and ESC 2021 guidelines on heart failure comparison – ESC Heart Failure

#ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.

#ESCCongress – 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure – SGLT2 inhibitors are now recommended for patients with heart failure with reduced ejection fraction regardless of the presence of diabetes.

 

RCT | Consumption of 2 green kiwifruits daily improves constipation and abdominal comfort

10 Feb, 2023 | 13:39h | UTC

Consumption of 2 Green Kiwifruits Daily Improves Constipation and Abdominal Comfort—Results of an International Multicenter Randomized Controlled Trial – The American Journal of Gastroenterology

 

POTS and Pregnancy: a review of literature and recommendations for evaluation and treatment

10 Feb, 2023 | 13:37h | UTC

POTS and Pregnancy: A Review of Literature and Recommendations for Evaluation and Treatment – International Journal of Women’s Health

 

M-A | Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus

10 Feb, 2023 | 13:38h | UTC

Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus: A meta-analysis of randomized controlled trials – PLOS One

 

Sex differences in clinical features, treatment, and lifestyle factors in patients with cluster headache

10 Feb, 2023 | 13:33h | UTC

Sex Differences in Clinical Features, Treatment, and Lifestyle Factors in Patients With Cluster Headache – Neurology

Commentaries:

Differences ID’d Between Men, Women With Cluster Headache – HealthDay

Cluster Headaches Affect Men More Often, But It’s Women Who Are Hit Hardest – Science Alert

 

Cohort Study | Adverse pregnancy outcomes and long-term risk of ischemic heart disease in mothers

9 Feb, 2023 | 14:02h | UTC

Adverse pregnancy outcomes and long term risk of ischemic heart disease in mothers: national cohort and co-sibling study – The BMJ

News Release: Five major adverse pregnancy outcomes associated with long term risks of ischemic heart disease – News Medical/BMJ

Commentary: Complications during pregnancy linked to a higher risk of heart disease, study finds – CNN

Related:

Risk and trajectory of premature ischemic CVD in women with a history of pre-eclampsia: a nationwide register-based study

Cohort Study | Pre-eclampsia is associated with increased risk of premature-onset obstructive coronary artery stenosis.

Primary Care–Based Cardiovascular Disease Risk Management After Adverse Pregnancy Outcomes: a Narrative Review – Journal of General Internal Medicine

Pregnancy Complications and Risk of Cardiovascular Disease Later in Life: A Nationwide Cohort Study – Journal of the American Heart Association

AHA Scientific Statement | Adverse Pregnancy Outcomes and Cardiovascular Disease Risk

Consensus statement: Cardiovascular health after menopause transition, pregnancy disorders, and other gynecologic conditions

Cohort Study: Preeclampsia and Cardiovascular Disease

Cohort Study: Cardiovascular Disease After Hypertensive Disorders of Pregnancy Largely Explained by Conventional Cardiovascular Risk Factors

All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease

Gestational Hypertension and Future Risk of Cardiovascular Disease

Research: Conjoint Associations of Gestational Diabetes and Hypertension With Diabetes, Hypertension, and Cardiovascular Disease in Parents

 

Cohort Study | Outcomes of Meningococcal B disease in children after implementation of routine 4CMenB vaccination

9 Feb, 2023 | 13:57h | UTC

Outcomes of meningococcal serogroup B disease in children after implementation of routine infant 4CMenB vaccination in England: an active, prospective, national surveillance study – The Lancet Child & Adolescent Health

 

Commentary on Twitter

 

Cohort Study | Middle-age high normal serum sodium as a risk factor for chronic diseases and premature mortality

9 Feb, 2023 | 13:38h | UTC

Middle-age high normal serum sodium as a risk factor for accelerated biological aging, chronic diseases, and premature mortality – eBioMedicine

News Release: Good hydration linked to healthy aging – National Institutes of Health

Related: Cohort study: Increased middle age serum sodium levels (may correlate with low water ingestion) are linked to increased risk of left ventricular hypertrophy and heart failure after 25 years of follow up.

 

Transition from pediatric to adult healthcare: a review on the recommendations of young adults with lived experience

9 Feb, 2023 | 13:29h | UTC

Improving the transition from paediatric to adult healthcare: a scoping review on the recommendations of young adults with lived experience – BMJ Open

 

Cohort Study | The impact of population-level HbA1c screening on reducing diabetes diagnostic delay in middle-aged adults

9 Feb, 2023 | 13:28h | UTC

The impact of population-level HbA1c screening on reducing diabetes diagnostic delay in middle-aged adults: a UK Biobank analysis – Diabetologia

 

M-A | Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients

9 Feb, 2023 | 13:24h | UTC

Prevalence of polypharmacy and potentially inappropriate medication use in older lung cancer patients: A systematic review and meta-analysis – Frontiers in Pharmacology

 

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