Family Medicine
Gabapentin for chronic neuropathic pain in adults
9 Jul, 2017 | 00:26h | UTCCochrane Review: Gabapentin for chronic neuropathic pain in adults – Cochrane Library (link to abstract – $ for full-text)
Commentary: Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain – MPR (free)
“Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy”.
Doxycycline may be a safer first option for treating a blistering skin condition
8 Jul, 2017 | 20:28h | UTCDoxycycline may be a safer first option for treating a blistering skin condition – NIHR Signal (free)
Original Article: Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial – The Lancet (free) AND Editorial: Doxycycline: a first-line treatment for bullous pemphigoid? (free)
Pictograms, Units and Dosing Tools, and Parent Medication Errors
7 Jul, 2017 | 14:08h | UTCPictograms, Units and Dosing Tools, and Parent Medication Errors: A Randomized Study – Pediatrics (link to abstract – $ for full-text)
Commentaries: Most Parents Give Kids Wrong Doses – MedPage Today (free registration required) AND Proper tools may help prevent medicine errors at home – Reuters (free)
Guideline – Management of Crohn’s disease
7 Jul, 2017 | 14:06h | UTC
Guideline – Management of ulcerative colitis
7 Jul, 2017 | 14:06h | UTC
Free online course – Easing the burden of obesity, diabetes and cardiovascular disease
7 Jul, 2017 | 14:09h | UTCFree online course, starts July 17: Easing the burden of obesity, diabetes and cardiovascular disease – University of Sidney and Coursera
Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma
7 Jul, 2017 | 14:03h | UTCEffect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Add-On Azithromycin Associated with Fewer Asthma Exacerbations – Physician’s First Watch (free)
Long-term health status and trajectories of seriously injured patients
7 Jul, 2017 | 14:01h | UTCLong-term health status and trajectories of seriously injured patients: A population-based longitudinal study – PLOS Medicine (free) (RT @karimbrohi see Tweet – “Trauma is a chronic disease”)
“The prevalence of reporting problems at 36-months postinjury was 37% for mobility, 21% for self-care, 47% for usual activities, 50% for pain/discomfort, and 41% for anxiety/depression… the prevalence of ongoing problems at 3-years postinjury is high, confirming that serious injury is frequently a chronic disorder”
Diabetes and Ramadan: Practical guidelines
7 Jul, 2017 | 13:57h | UTCDiabetes and Ramadan: Practical guidelines – Diabetes Research and Clinical Practice (free)
Rivastigmine reviewed: doubts about dementia drug
7 Jul, 2017 | 13:56h | UTCRivastigmine reviewed: doubts about dementia drug – Evidently Cochrane (free)
Related review: Rivastigmine for people with Alzheimer’s disease – Cochrane Library (link to abstract – $ for full-text)
“”Sadly, “small” and “of uncertain clinical importance” are the words chosen by the Cochrane reviewers to describe…” (RT @CochraneUK see Tweet)
Imaging and Management of Incidental Renal Lesions
7 Jul, 2017 | 13:44h | UTCReview: Imaging and Management of Incidental Renal Lesions – BioMed Research International (free)
Pharmacologic Management of Type 2 Diabetes Mellitus: Available Therapies
7 Jul, 2017 | 13:46h | UTCReview: Pharmacologic Management of Type 2 Diabetes Mellitus: Available Therapies – American Journal of Medicine (free)
Review of the Relationship between Red Meat Consumption and Cardiovascular Risk
7 Jul, 2017 | 13:41h | UTC
Non-alcoholic fatty liver disease: An expanded review
7 Jul, 2017 | 13:31h | UTCReview: Non-alcoholic fatty liver disease: An expanded review – World Journal of Hepatology (free)
The Association between the Mediterranean Dietary Pattern and Cognitive Health
7 Jul, 2017 | 13:25h | UTCReview: The Association between the Mediterranean Dietary Pattern and Cognitive Health: A Systematic Review – Nutrients (free)
Treating Anxiety in 2017: Optimizing Care to Improve Outcomes
5 Jul, 2017 | 21:49h | UTCTreating Anxiety in 2017: Optimizing Care to Improve Outcomes – JAMA (free)
“Exercise, mindfulness-based stress reduction = 1st-line treatments for anxiety; move on to SSRIs and CBT as needed” (RT @JAMA_current see Tweet)
Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure
5 Jul, 2017 | 18:24h | UTCSource: Hospital Medicine Virtual Journal Club
In this observational analysis, patients with atrial fibrillation without heart failure had increased risk of sudden cardiac death with digoxin use. Among patients with heart failure, digoxin use was associated with an increase in all‐cause death, cardiovascular death, sudden cardiac death, and death caused by HF/cardiogenic shock.
Certain OTC, less expensive hearing aids provide benefit similar to conventional hearing aid
5 Jul, 2017 | 20:48h | UTCPersonal Sound Amplification Products vs a Conventional Hearing Aid for Speech Understanding in Noise – JAMA (link to abstract – $ for full-text)
The Jama Network – For the Media: Certain OTC, less expensive hearing aids provide benefit similar to conventional hearing aid (free)
Commentaries: Less Expensive Hearing Devices May Work as Well as Traditional Hearing Aids – Physician’s First Watch (free) AND Study Boosts Case for OTC Hearing Aids – MedPage Today (free registration required) AND OTC Hearing Devices Effective Alternative for Some, Study Shows – Medscape (free registration required)
“Some over-the-counter sound amplification devices are nearly as effective as prescription hearing aids, according to a small JAMA study” (from Physician’s First Watch)
Prevalence and risk factors for HIV, hepatitis B, and hepatitis C in people with severe mental illness
5 Jul, 2017 | 18:08h | UTCInvited commentary: Ending HIV, hepatitis B, and hepatitis C: what about people with severe mental illness?
“People with severe mental illness have 3x the general pop risk of HIV & Hepatitis B, and 9x the risk of Hepatitis C” (RT @AllenFrancesMD and @in_psych see Tweet)
Arthroscopic surgery for degenerative knee arthritis and meniscal tears
5 Jul, 2017 | 15:30h | UTCWhat I Wish I’d Known About My Knees – The New York Times (10 articles per month are free)
Related guideline: Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline – The BMJ (free)
“There’s little evidence to support many of the procedures people undergo in the hopes of avoiding a knee replacement”. (RT @NYTHealth see Tweet)
Risk of death among users of Proton Pump Inhibitors
5 Jul, 2017 | 15:31h | UTCCommentaries: Proton pump inhibitors associated with raised mortality – OnMedica (free) AND Longtime use of heartburn drugs linked to increased risk of death – NewsMedical (free) AND People taking heartburn drugs could have higher risk of death, study claims – The Guardian (free) AND Some heartburn drugs linked with higher risk of death – CBS News (free) AND PPIs Linked to Higher Risk for Death – Medscape (free registration required)
In a large observational study, PPI use was associated with increased mortality (HR 1.25; CI 1.23 to 1.28). PPIs were also associated with increased risk compared to H2 blockers (HR 1.24; CI 1.21 to 1.27). See more on the trade-offs of PPI therapy in our July 3rd issue (see #10)
Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms
5 Jul, 2017 | 15:26h | UTCAllergy Testing in Children With Low-Risk Penicillin Allergy Symptoms – Pediatrics (link to abstract – $ for full-text)
Commentaries: Penicillin Allergy in Children Substantially Overreported – Medscape (free registration required) AND No Penicillin Allergy Found in Most Kids with Non-Specific Symptoms – MedPage Today (free registration required) AND Low risk allergy symptoms not linked to true penicillin allergy – 2 minute medicine (free)
Related article: Penicillin Allergy Is Not Necessarily Forever – JAMA (free)
New Choosing Wisely Canada List – Five Things Residents and Patients Should Question
5 Jul, 2017 | 15:28h | UTCNew Choosing Wisely Canada List: Medical Education: Residents: Five Things Residents and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)
See more on the Choosing Wisely initiative in our April 5 issue (see #6).
Herpes Zoster Increases the Risk of Stroke and Myocardial Infarction
5 Jul, 2017 | 15:26h | UTCHerpes Zoster Increases the Risk of Stroke and Myocardial Infarction – Journal of The American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Does Shingles Increase the Risk of Heart Attack, Stroke? – American College of Cardiology, Latest in Cardiology (free) AND Shingles may up risk of heart attack, stroke – Reuters Health (free) AND Heart attack and stroke risk higher with shingles – OnMedica (free)
Metformin May Reduce Coronary Calcium in Men
4 Jul, 2017 | 21:22h | UTCCommentary: Long-term Metformin May Reduce Coronary Calcium – Medscape (free registration required)
“Metformin may protect against atherosclerosis in men with pre-diabetes and early diabetes” (RT @CircAHA see Tweet)