Family Medicine

“Among the 1,473 patients with a renal indication for dose reduction, 43.0% were potentially overdosed, which was associated with a higher risk of major bleeding”

Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex for Iron-Deficiency Anemia

15 Jun, 2017 | 00:48h | UTC

Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the Media: Treating Nutritional Iron-Deficiency Anemia in Children (free)

Commentaries: Ferrous Sulfate Drops Tied to Higher Hemoglobin Increases in Kids with Anemia – Physician’s First Watch (free) AND Traditional treatment is better for iron-deficiency anaemia in children – OnMedica (free) AND Ferrous Sulfate Effective for Iron-Deficiency Anemia in Kids – Medscape (free registration required)

Researchers expected that Iron Polysaccharide Complex would restore hemoglobin more effectively, because it is designed to be tolerated better, but the proportion of infants and children with a complete resolution of iron-deficiency anemia was higher in the ferrous sulfate group (29 percent vs 6 percent).

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

14 Jun, 2017 | 00:43h | UTC

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes – New England Journal of Medicine (free)

Commentary: CANVAS: Canagliflozin Reduces CV Events, but at Cost of Amputations – Medscape (free registration required)

Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation and fractures. The benefits and harms were likely small. See interesting commentaries on the trade-offs by @AnilMakam, see Tweet 1; Tweet 2; Tweet 3; Tweet 4; Tweet 5; Tweet 6; Tweet 7; Tweet 8; and Tweet 9.

Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks

14 Jun, 2017 | 00:35h | UTC

Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks – NIHR Signal (free)

Original article: Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma – Cochrane Library(link to abstract – $ for full-text)

Guidelines for the Management of Hypertension

13 Jun, 2017 | 20:03h | UTC

The 2017 Focused Update of the Guidelines of the Taiwan Society of Cardiology (TSOC) and the Taiwan Hypertension Society (THS) for the Management of Hypertension (free)

Drugs may help people pass larger kidney stones

13 Jun, 2017 | 20:00h | UTC

Drugs may help people pass larger kidney stones – NIHR Signal (free)

Original article: Alpha blockers for treatment of ureteric stones: systematic review and meta-analysis – The BMJ (free)

Is the finger-stick blood test necessary for type 2 diabetes treatment?

12 Jun, 2017 | 19:58h | UTC

Glucose Self-monitoring in Non–Insulin-Treated Patients With Type 2 Diabetes in Primary Care Settings: A Randomized Trial – JAMA Internal Medicine (free)

Editorial: The Need to Test Strategies Based on Common Sense (free)

The JAMA Network – For the Media: Home Monitoring of Blood Sugar Did Not Improve Glycemic Control After 1 Year (free)

Commentary: Is the finger-stick blood test necessary for type 2 diabetes treatment? – University of North Carolina Health Care, via EurekAlert(free)

“Another RCT showing no benefit for Glucose Self-monitoring in Non–Insulin-Treated Patients with Type 2 Diabetes” (RT @PaulGlasziou see Tweet)

‘How long have I got?’: Why many cancer patients don’t have answers

12 Jun, 2017 | 19:55h | UTC

‘How long have I got?’: Why many cancer patients don’t have answers – USA Today (free)

See more on Standardized Criteria for Palliative Care Consultation in our April 24 issue, see #8

“ASCO now recommends that everyone with advanced cancer receive palliative care within eight weeks of diagnosis.” (RT @cancerassassin1 see Tweet)

Timing of food introduction and development of food sensitization

12 Jun, 2017 | 19:53h | UTC

Timing of food introduction and development of food sensitization in a prospective birth cohort – Pediatric Allergy and Immunology (link to abstract – $ for full-text)

Commentary: Delayed food introduction may increase likelihood of allergy in later childhood – McMaster University, via News Medical (free)

Working while sick

12 Jun, 2017 | 19:50h | UTC

Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (link to abstract – $ for full-text)

Commentaries: Working while sick – ACP Internist (free) AND Health worker survey reveals many work during flu illness – CIDRAP (free)

Over 40% of surveyed health care personnel worked with self-reported influenza-like illness. “To reduce levels of health-worker–associated flu transmission, the researchers said that misconceptions about working while sick and sick leave policies both need to be addressed” (from CIDRAP)

Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors?

12 Jun, 2017 | 19:52h | UTC

Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)

Commentaries: Risk of HF and Death in Patients on SGLT-2 Inhibitors – American College of Cardiology, Latest in Cardiology (free) AND SGLT2 inhibitors may have class effect for reduction of cardiac risk – ACP Diabetes Monthly (free)

Observational data suggests these class of drugs may be associated with lower risk of heart failure and deaths compared to other drugs.

Canagliflozin will receive new boxed warning about amputation risks

12 Jun, 2017 | 19:51h | UTC

Canagliflozin will receive new boxed warning about amputation risks – ACP Internist (free)

FDA Drug Safety Communication: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) (free)

Commentary: ACR Releases Guideline on prevention & treatment of glucocorticoid-induced osteoporosis – American College of Rheumatology, via EurekAlert (free)

Why are doctors killing themselves

PSA Test for Prostate Cancer

Family planning, assisted reproduction, pregnancy and menopause in patients with SLE and/or antiphospholipid syndrome

Guidelines for the Chronic Use of Opioid Analgesics

Hundreds died while taking an arthritis drug, but nobody alerted patients

Managing epilepsy in women of childbearing age

Pain and Opioids in Cancer Care: Benefits, Risks, and Alternatives

Chronic Myeloid Leukemia: What Every Practitioner Needs to Know in 2017

American Society of Health-System Pharmacists – Five Things Physicians and Patients Should Question

Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events

Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction