Family Medicine
Epilepsy ‘Not a Rare Condition’
16 Aug, 2017 | 14:23h | UTCReport: National and State Estimates of the Numbers of Adults and Children with Active Epilepsy — United States, 2015 – CDC MMWR (free)
Commentaries: Epilepsy Isn’t As Rare As Many Might Think – And Cases Are Increasing – Forbes (free) AND Epilepsy ‘Not a Rare Condition’ – MedPage Today (free registration required)
Study: diet soda can really mess with your metabolism
16 Aug, 2017 | 14:15h | UTCStudy: diet soda can really mess with your metabolism – VOX (free)
Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)
See also a related meta-analysis showing little evidence of artificial sweeteners for weight loss in our July 18th issue (see #2)
“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.
Standards for Diabetes Self-management Education and Support
16 Aug, 2017 | 13:20h | UTC2017 National Standards for Diabetes Self-management Education and Support – The Diabetes Educator (free)
Commentaries: ADA and AADE Update Standards for Diabetes Self-Management Education and Support – AJMC (free) AND Diabetes groups update standards for self-management – ACP Diabetes (free)
Occupation and Risk of Developing Rheumatoid Arthritis
16 Aug, 2017 | 14:03h | UTCOccupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study – Arthritis Care & Research (link to abstract – $ for full-text)
Commentaries: Certain occupations linked to an increased risk of rheumatoid arthritis – Willey, via EurekAlert (free) AND Occupational Exposures Increase Rheumatoid Arthritis Risk – Medscape (free registration required) AND Some jobs tied to higher risk of rheumatoid arthritis – Reuters (free)
Case-control study suggests bricklayers, concrete workers, electricians and nurses are at increased risk.
SGLT2 agents may reduce cardiovascular risk in diabetics
16 Aug, 2017 | 12:52h | UTCCardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Related article: Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)
Commentary: SGLT2 Agents Cut CV Events in ‘Real-World’ Analysis – MedPage Today (free registration required) AND Cardiovascular disease and mortality appear lower in patients on SGLT2 inhibitors – ACP Diabetes (free)
Another observational study suggests this class of drugs may reduce cardiovascular mortality and morbidity in patients with diabeties.
FDA Safety Alert: Liquid-filled Intragastric Balloon Systems
16 Aug, 2017 | 13:46h | UTCFDA Safety Alert: Liquid-filled Intragastric Balloon Systems: Letter to Healthcare Providers – Potential Risks (free)
Commentaries: Five People Die After Using Weight Loss Balloons for Obesity – Time (free) AND FDA Warns of Gastric Balloon Deaths – MedPage Today (free registration required) AND Five Deaths Tied to Intragastric Balloons, FDA Says – Medscape (free registration required)
Foot care for people with diabetes: prevention of complications and treatment
15 Aug, 2017 | 21:24h | UTCRelated guideline: Diabetic foot problems: prevention and management – National Institute for Health and Care Excellence (free)
Special issue: 60 years of metformin use
16 Aug, 2017 | 13:11h | UTCSpecial issue: 60 years of metformin use – Diabetologia (Source: ACP Diabetes Monthly)
– Editorial: 60 years of metformin use: a glance at the past and a look to the future (free)
– Metformin: historical overview (free)
– The mechanisms of action of metformin (free)
– Metformin: clinical use in type 2 diabetes (free)
– A new perspective on metformin therapy in type 1 diabetes (free)
– Metformin use in pregnancy: promises and uncertainties (free)
– Metformin and ageing: improving ageing outcomes beyond glycaemic control (free)
– Repurposing metformin for the prevention of cancer and cancer recurrence (free)
– The pharmacogenetics of metformin (free)
– Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome (free)
– The effects of metformin on gut microbiota and the immune system as research frontiers (free)
The Effects of Cannabis Among Adults With Chronic Pain
15 Aug, 2017 | 22:25h | UTCRelated article: Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review – Annals of Internal Medicine (free)
Commentaries: Evidence on cannabis for chronic pain and PTSD – American College of Physician’s, via EurekAlert (free) AND Evidence Lacking on Benefits of Cannabis for Treating Chronic Pain, PTSD – Physician’s First Watch (free) AND Limited evidence available to determine effectiveness and safety of cannabis to treat chronic pain – 2 Minute Medicine (free) AND Little evidence that marijuana helps chronic pain, PTSD, studies find – CNN (free text and video)
Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality
15 Aug, 2017 | 22:44h | UTCRelationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults – Journal of The American College of Cardiology (link to abstract and infographic – $ for full-text)
Commentaries: Consuming Alcohol in Moderation Can Lower Mortality Risks – American College of Cardiology, Latest in Cardiology (free) AND Alcohol Consumption and All-Cause, CV, and Cancer-Related Mortality – American College of Cardiology, Latest in Cardiology (free) AND Can drinking a little bit help you live longer? – Reuters (free)
Risk traumatic brain injuries associated with antidepressant use among patients with Alzheimer’s disease
15 Aug, 2017 | 20:40h | UTCCommentary: Antidepressant use increases risk of head injuries among persons with Alzheimer’s disease – University of Eastern Finland, via EurekAlert (free)
The 10-Year Prognostic Value of Zero and Minimal CAC
15 Aug, 2017 | 20:54h | UTCThe 10-Year Prognostic Value of Zero and Minimal CAC – Journal of The American College of Cardiology (no abstract – $ for full text)
Commentary: Calcium in Arteries Influences Heart Attack Risk – UT Southwestern Medical Center, via NewsWise (free) AND Study: Calcium in arteries influences heart attack risk – UPI (free)
“Half of the participants had no calcium deposits in their arteries or a zero coronary artery calcium, or CAC, score, and had less than a 3 percent chance of a cardiovascular event over a 10-year period despite having other risk factors for heart disease and stroke such as type 2 diabetes, high blood pressure and high bad cholesterol levels” (from UPI)
Longer sleep is associated with lower BMI and favorable metabolic profiles
15 Aug, 2017 | 19:45h | UTCCommentaries: Short sleep linked to body mass, waist size – Reuters (free) AND Insufficient sleep may be adding to your waistline – University of Leeds, via Science Daily (free)
Blood pressure targets for hypertension in older adults
15 Aug, 2017 | 19:55h | UTCBlood pressure targets for hypertension in older adults – Cochrane Library (free)
Full review: Blood pressure targets for hypertension in older adults – Cochrane Library (link to abstract – $ for full-text)
Related guideline: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From ACP and AAFP (free)
“At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP”
Ibuprofen versus placebo effect on acute kidney injury in ultramarathons
15 Aug, 2017 | 16:09h | UTCIbuprofen versus placebo effect on acute kidney injury in ultramarathons: a randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
Commentaries: Ibuprofen linked to slight risk of kidney damage in ultramarathoners – Reuters (free) AND Study reveals harmful effects on kidney of Ibuprofen – Stanford Daily (free)
Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment
15 Aug, 2017 | 15:41h | UTCReview: Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment – Digestive Diseases and Sciences (free)
Related guidelines: United European Gastroenterology evidence-based guidelines for the diagnosis and therapy of chronic pancreatitis (free) AND Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology (free)
Pathogenesis and management of hypoglycemia
15 Aug, 2017 | 15:41h | UTCReview: Pathogenesis and management of hypoglycemia – European Journal of Endocrinology (free)
Management of urinary tract infections in patients with neurogenic bladder
15 Aug, 2017 | 15:38h | UTCReview: Management of urinary tract infections in patients with neurogenic bladder: challenges and solutions – Research and Reports in Urology (free)
Car crashes in older adult drivers using Zolpidem
15 Aug, 2017 | 01:13h | UTC“Car crashes in older adult drivers: Zolpidem (aOR 2.27) > zolpidem + zopiclone combo (aOR 2.20)” (RT @psychopharmacol see Tweet)
Richard Lehman’s journal review, 14 August 2017
15 Aug, 2017 | 01:01h | UTC8 – Richard Lehman’s journal review, 14 August 2017 – The BMJ Blogs (free)
Richard Lehman reviews the latest research in the top medical journals
Advances in the diagnosis and management of neck pain
15 Aug, 2017 | 00:33h | UTCState of the Art Review: Advances in the diagnosis and management of neck pain – The BMJ (free)
Related guideline: Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)
Midlife Vascular Risk Factors and Incident Dementia
14 Aug, 2017 | 18:08h | UTCAssociations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text)
Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart-healthy middle age tied to lower risk of dementia – Medical News Today (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)
Effect of 0.5 mg versus 1 mg varenicline for smoking cessation
14 Aug, 2017 | 15:55h | UTCEffect of 0.5 mg versus 1 mg varenicline for smoking cessation: a randomized controlled trial – Addiction (link to abstract – $ for full-text)
“No difference in smoking cessation effectiveness between 1 mg and 0.5 mg twice daily varenicline” (46.5% vs 46.4%) (RT @JorgeMTamayo see Tweet)
Eliminating CK–MB Testing in Suspected Acute Coronary Syndrome
15 Aug, 2017 | 00:50h | UTCEliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)
Author interview: Eliminating Creatine Kinase–Myocardial Band Testing in Suspected ACS (free)
Commentaries: Eliminating CK-MB Testing in Suspected ACS – American College of Cardiology, Latest in Cardiology (free) AND Research review recommends eliminating widely ordered blood test for diagnosing heart attacks – Johns Hopkins Medicine, via Science Daily (free)
“Review is first publication from national consortium of academic medical centers working to eliminate unnecessary medical tests, treatments and procedures” (from Science Daily)
Day-to-Day Blood Pressure Variability and Risk of Dementia
14 Aug, 2017 | 16:12h | UTCCommentaries: Fluctuations in home-monitored blood pressure may raise dementia risk – Circulation Journal Report (free) AND Fluctuations in Blood Pressure Linked to Vascular Dementia – MedPage Today (free registration required) AND Fluctuating Home Blood Pressure Linked to Dementia – Medscape (free registration required) AND Blood pressure fluctuations linked to dementia – Reuters (free)