Family Medicine
Guideline: Psoriasis: assessment and management
3 Sep, 2017 | 21:20h | UTCPsoriasis: assessment and management – National Institute for Health and Care Excellence (NICE) (free)
Study: Accelerometer-assessed sedentary work, leisure time and cardio-metabolic biomarkers during one year
3 Sep, 2017 | 21:16h | UTCCommentaries: Sitting for 20 minutes less a day won’t make you ‘more muscly’ – NHS Choices (free) AND Just 21 minutes less sitting improves health – Medical News Today (free)
Cohort Study: Association between sedentary time and mortality across levels of frailty
1 Sep, 2017 | 20:57h | UTCCommentary: Prolonged sitting and frailty a deadly combination – Medical News Today (free) AND Inactivity Toll Worst for Frailest Elders – Medscape (free registration required)
New Nutrition Study Changes Nothing (commentaries on the PURE study)
3 Sep, 2017 | 21:15h | UTCNew Nutrition Study Changes Nothing – The Atlantic (free) (RT @drjohnm see Tweet)
See original article and commentaries in our August 30 issue (see #1 and #2)
“Why the science of healthy eating appears confusing – but isn’t”
Viewpoint: Diagnostic Errors and Diagnostic Calibration
1 Sep, 2017 | 20:54h | UTCDiagnostic Errors and Diagnostic Calibration – JAMA (free)
Studies: Intensive versus Standard Blood-Pressure Control
31 Aug, 2017 | 20:35h | UTCOriginal articles: Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control – New England Journal of Medicine (link to abstract – $ for full-text) AND Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Analyses from SPRINT examine cost-effectiveness, patient-reported outcomes with intensive BP control – ACP Internist (free) AND Intensive BP Management Well Tolerated, Cost-effective: SPRINT – Medscape (free registration required) AND Can SPRINT Be Used To Inform Hypertension Treatment? – Cardiobrief (free)
Be sure to measure the patient’s blood pressure in the same way it was done in the SPRINT trial before adopting this results to clinical practice (see Cardiobrief commentary)
Study: Active Surveillance for Low-Risk Papillary Thyroid Cancer May be Safe
31 Aug, 2017 | 22:34h | UTCNatural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance – JAMA Otolaryngology Head & Neck Surgery (free for a week)
Author interview audio: Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers (free)
Commentaries: Findings Support Use of Active Surveillance for Low-Risk Papillary Thyroid Cancer – The JAMA Network (free) AND Many People Can Delay Treatment For Thyroid Cancer, Study Finds – NPR (free)
Systematic Review: Pharmacotherapy for hypertension in adults aged 18 to 59 years
31 Aug, 2017 | 20:44h | UTCPharmacotherapy for hypertension in adults aged 18 to 59 years – Cochrane Library (link to abstract – $ for full-text)
Commentary: Antihypertensive Tx Analyzed in Younger, Predominantly Healthy Adults – MPR (free)
Preventing Teen Suicide: What Does the Evidence Shows
31 Aug, 2017 | 21:06h | UTCPreventing Teen Suicide: What Does the Evidence Shows – The New York Times (10 articles per month are free)
Related Guideline: Preventing Suicide: A Technical Package of Policy, Programs, and Practices – Centers for Disease Control and Prevention (free PDF)
Guidelines for the diagnosis and treatment of postmenopausal osteoporosis
31 Aug, 2017 | 19:27h | UTC
Meta-analysis: Drugs in heart failure with preserved ejection fraction
31 Aug, 2017 | 20:33h | UTCCommentary: Heart Failure with Preserved Ejection Fraction: Treatments Compared – MPR (free)
Source: ACP Journal Wise ($)
This study suggests a reduction in all-cause mortality with beta-blocker therapy in patients with heart failure with preserved ejection fraction. The authors recommend further trials to confirm the benefits of beta-blockers in this patient group.
Guideline: Vitamin D Supplementation
31 Aug, 2017 | 19:42h | UTCPublic Health Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (NICE) (free)
“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk”
Review article: hepatitis E—a concise review of virology, epidemiology, clinical presentation and therapy
31 Aug, 2017 | 16:44h | UTCReview article: hepatitis E—a concise review of virology, epidemiology, clinical presentation and therapy – Alimentary Pharmacology and Therapeutics (free)
Source: Medscape
Review: Chest CT Signs in Pulmonary Disease
31 Aug, 2017 | 15:19h | UTCChest CT Signs in Pulmonary Disease: A Pictorial Review – Chest (free)
Source: Critical Care Review Newsletter (free)
Study: effects of probiotic and peanut oral immunotherapy for peanut allergy
31 Aug, 2017 | 15:53h | UTCLong-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentaries: Benefits of Immunotherapy-Probiotic Combo for Peanut Allergy Sustained at 4 Years – Physician’s First Watch (free) AND Peanut Allergy: Is Oral Immunotherapy With Probiotic a Cure? – Medscape (free registration required) AND Peanut Allergy Tx Efficacy Examined in 4-Year Follow-Up Study – MPR (free)
Study: Comparison of recommendations for screening mammography
31 Aug, 2017 | 15:20h | UTCComparison of recommendations for screening mammography using CISNET models – Cancer (link to abstract – $ for full-text)
Commentaries: Three questions to ask about calls to widen breast cancer screening – The Conversation (free) AND Comparison of Screening Recommendations for Mammography – ASCO Post (free)
Canadian Task Force on Preventive Health Care: Risks & Benefits, Age 40–49 (free) AND Risks & Benefits, Age 50–69 (free) AND Risks & Benefits, Age 70–74 (free) AND Full Guideline and Resources (free)
This article had a lot of attention from the media and suggests an annual screening starting at age 40 would prevent more breast cancer deaths. But screening has potential harms. For a clearer picture of the benefits and harms of screening in this context have a look at The Conversation commentary above and the infographics from the Canadian Task Force.
Meta-analysis: Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment
30 Aug, 2017 | 20:37h | UTCAssociation of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)
Commentaries: Breathing Disorders During Sleep Tied to Cognitive Issues – MedPage Today (free registration required) AND Sleep-Disordered Breathing Raises Risk for Cognitive Decline – Medscape (free registration required)
This meta-analysis of observational studies suggests a possible association. Further studies are needed to examine whether the treatment of this condition can help in the prevention of dementia and in improvement of cognition.
Study: Resistance training may prevent obese older people becoming frail when losing weight
30 Aug, 2017 | 19:12h | UTCResistance training may prevent obese older people becoming frail when losing weight – NIHR Signal (free)
Original article: Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text) AND Video Summary: Exercise and Dieting in Obese Older Adults (free)
Cohort Study: Chronic cough postacute respiratory illness in children
30 Aug, 2017 | 20:12h | UTCChronic cough postacute respiratory illness in children: a cohort study – Archives of Disease in Childhood (link to abstract – $ for full-text)
Commentary: Kids often have a chronic cough after respiratory illness – Reuters (free)
Study: Medical Students Fall Short on Blood Pressure Check Challenge
30 Aug, 2017 | 20:20h | UTCMedical News & Perspectives: Medical Students Fall Short on Blood Pressure Check Challenge – JAMA (free)
Original Article: Medical students and measuring blood pressure: Results from the American Medical Association Blood Pressure Check Challenge – The Journal of Clinical Hypertension (free)
“Only 1 out of 159 medical students correctly performed all 11 elements in a BP check challenge w simulated patients” (RT @JAMA_current see Tweet)
Study: Lack of REM sleep may lead to higher risk for dementia
30 Aug, 2017 | 19:08h | UTCSleep architecture and the risk of incident dementia in the community – Neurology (link to abstract – $ for full-text)
Commentaries: Lack of REM sleep may lead to higher risk for dementia – Boston University School of Medicine, via EurekAlert (free) AND Less REM Sleep May Significantly Boost Dementia Risk – Medscape (free registration required) AND Dreaming may keep dementia at bay – Medical News Today (free) AND Lack of REM sleep tied to increased risk of dementia – Reuters (free)
#ESCCongress – Cohort Study: Fruit, vegetable, and legume intake, and cardiovascular disease and deaths
30 Aug, 2017 | 18:32h | UTC#ESCCongress – Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)
Commentaries: Reassessing the benefits of plant-based eating (PURE) – ESC Press Release (free) Fruit, Vegetable, Legume Intake and CVD Events – American College of Cardiology, Latest in Cardiology (free) AND Life-saving fruit and vegetable diet need only be three portions – study – The Guardian (free) AND Less Is More? Health Benefits of Fruits, Vegetables, and Legumes Seen at Lower Intake Levels – TCTMD (free)
#ESCCongress – Cohort Study: Associations of fats and carbohydrate intake with cardiovascular disease and mortality
30 Aug, 2017 | 18:33h | UTC#ESCCongress – Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)
Commentaries: Revisiting dietary fat guidelines? (PURE) – ESC Press Release (free) AND PURE Investigators: Rethink Diet Guidance to Plug More Fats, Fewer Carbs – TCTMD (free) AND International study shows moderate consumption of fats and carbohydrates best for health – McMaster University, via EurekAlert (free) AND PURE: Findings Could Have Implications For Global Dietary Guidelines – ACC News Story (free) AND Huge Diet Study Questions Conventional Wisdom About Carbs And Fats – Cardiobrief (free)
#ESCCongress – Study: Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
30 Aug, 2017 | 18:29h | UTCCommentaries: Anacetrapib REVEALs ‘Modest’ Effect on Cardiovascular Outcomes – Medscape (free registration required) AND Anacetrapib Finds (Modest) Success Where All Other CETP Inhibitors Failed – TCTMD (free) AND REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial – Cardiobrief (free)
Interesting new drug, but with modest benefits. During the median follow-up period of 4.1 years, the primary outcome occurred in fewer patients in the anacetrapib group than in the placebo group (10.8% vs. 11.8% / absolute risk difference = 1%, meaning 100 patients would have to be treated for 4.1 years to benefit 1 patient)
#ESCCongress – Study: Automatic external defibrillators save lives in amateur sports and fitness centres
30 Aug, 2017 | 18:28h | UTCAutomatic external defibrillators save lives in amateur sports and fitness centres (free) (the results have not been published yet)
“Neurologically intact survival was 93% for patients treated with an onsite Automatic external defibrillator (AED) compared to 9% without an AED”