Family Medicine
Perspective: COVID-19 vaccine trials should seek worthwhile efficacy
31 Aug, 2020 | 01:45h | UTCCOVID-19 vaccine trials should seek worthwhile efficacy – The Lancet
Commentary: Covid vaccine rush could make pandemic worse, say scientists – The Guardian
Commentary on Twitter
"Although efficacy far greater than 50% would be better, efficacy of about 50% would represent substantial progress"
Philip Krause et al for the @WHO Solidarity Vaccines Trial Expert Group on why #COVID19 vaccine trials should seek worthwhile efficacy https://t.co/2VWas8YU7L pic.twitter.com/RjbeZkeAE0
— The Lancet (@TheLancet) August 28, 2020
Children might play a bigger role in COVID transmission than first thought. Schools must prepare
31 Aug, 2020 | 01:41h | UTC
#ESCCongress – [Abstract Only] Randomized trial: Cardiovascular and renal outcomes with Empagliflozin in heart failure
31 Aug, 2020 | 01:38h | UTCCommentaries: EMPEROR-Reduced: Empagliflozin Cuts Hospitalizations, CV Mortality in HFrEF – TCTMD AND EMPEROR-Reduced meets primary endpoint in heart failure with reduced ejection fraction – European Society of Cardiology AND Empagliflozin Outcome Trial in Patients With Chronic Heart Failure and a Reduced Ejection Fraction – EMPEROR-Reduced – American College of Cardiology
Related study: Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction – New England Journal of Medicine
Commentary on Twitter
Original Article: Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure (EMPEROR-Reduced Trial) #ESCCongress
— NEJM (@NEJM) August 29, 2020
#ESCCongress – [Abstract Only] SGLT2 inhibitors in patients with heart failure with reduced ejection fraction: A meta-analysis of the EMPEROR-Reduced and DAPA-HF trials
31 Aug, 2020 | 01:36h | UTC
#ESCCongress – [Abstract Only] Randomized trial: Low-dose edoxaban in very elderly patients with atrial fibrillation
31 Aug, 2020 | 01:32h | UTCCommentaries: Edoxaban Low-Dose for Elder Care Atrial Fibrillation – ELDERCARE-AF – American College of Cardiology AND ELDERCARE-AF: Edoxaban Superior to Placebo in Preventing Stroke, Systemic Embolism in Elderly Japanese AFib Patients – American College of Cardiology
Commentary on Twitter
Elderly patients with AF who were not candidates for standard doses of oral anticoagulants because of a high risk of bleeding were assigned to receive 15 mg of edoxaban or placebo once daily. Edoxaban was superior to placebo in preventing stroke or systemic embolism. #ESCCongress
— NEJM (@NEJM) August 30, 2020
#ESCCongress – 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation
31 Aug, 2020 | 01:18h | UTCNews Release: Heart rhythm disorders are best managed when patients are listened to – European Society of Cardiology
Commentary on Twitter
2020 ESC Guidelines for diagnosis & management of atrial fibrillation https://t.co/SSuQAr13TO#ESCCongress @escardio @ESC_Journals @AChoiHeart @purviparwani @DrMarthaGulati @ErinMichos @DrPascalMeier pic.twitter.com/5cLRSJbldp
— Open Heart (@Open_HeartBMJ) August 29, 2020
Updated Covid-19 Reviews: Hydroxychloroquine or Chloroquine / Masks / ACE Inhibitors or ARBs
28 Aug, 2020 | 08:54h | UTC- Update Alert 2: Hydroxychloroquine or Chloroquine for the Treatment or Prophylaxis of COVID-19
- Update Alert 2: Masks for Prevention of Respiratory Virus Infections, Including SARS-CoV-2, in Health Care and Community Settings
- Update Alert 3: Risks and Impact of Angiotensin-Converting Enzyme Inhibitors or Angiotensin-Receptor Blockers on SARS-CoV-2 Infection in Adults
Cohort study: Clinical characteristics of children and young people admitted to hospital with Covid-19
28 Aug, 2020 | 08:53h | UTCCommentaries: COVID-19 less deadly and causes milder symptoms in children – University of Liverpool AND Expert reaction to ISARIC 4C study on clinical characteristics of children admitted to hospital with COVID-19 in the UK – Science Media Centre
A Pediatric infectious disease perspective of SARS-CoV-2 and COVID-19 in children
28 Aug, 2020 | 08:51h | UTC
Individuals with obesity and COVID‐19: A global perspective on the epidemiology and biological relationships
27 Aug, 2020 | 09:57h | UTCCommentaries: Obesity increases risk of complications from Covid-19, damages vaccine efficacy, study finds – CNN AND Obesity increases risk of Covid-19 death by 48%, study finds – The Guardian AND Obesity linked with higher risk for COVID-19 complications – University of North Carolina at Chapel Hill
Systematic Review: Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection
27 Aug, 2020 | 09:55h | UTC
Commentary on Twitter (Thread – Click for more)
We have published our next Cochrane review of Covid-19 tests:
Rapid, point‐of‐care antigen and molecular‐based tests for diagnosis of SARS‐CoV‐2 infection – Dinnes, J – 2020 | Cochrane Library https://t.co/EhD0onSgH0
— Jon Deeks FMedSci (@deeksj) August 26, 2020
COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing
26 Aug, 2020 | 04:13h | UTCSee also: First Covid-19 reinfection documented in Hong Kong
Duration of SARS-CoV-2 infectivity: When is it safe to discontinue isolation?
26 Aug, 2020 | 04:14h | UTC
Post-discharge persistent symptoms and health-related quality of life after hospitalization for COVID-19
26 Aug, 2020 | 04:09h | UTCCommentary: COVID-19 symptoms can persist for months after hospital stay – CIDRAP
Two meters or one: What is the evidence for physical distancing in Covid-19?
26 Aug, 2020 | 04:08h | UTCTwo metres or one: what is the evidence for physical distancing in covid-19? – The BMJ
Commentary: Rigid social distancing rules for COVID-19 based on outdated science – British Medical Journal
Systematic review: Effect of renin-angiotensin-aldosterone system inhibitors in patients with COVID-19
26 Aug, 2020 | 04:05h | UTCCommentaries: Expert reaction to study looking at blood pressure medicines and COVID-19 – Science Media Centre AND Coronavirus Treatment: Blood Pressure Medicines May Reduce COVID-19 Severity, Deaths: Study – International Business Times
Prevalence of SARS-CoV-2 infection in children without symptoms of Covid-19
26 Aug, 2020 | 04:02h | UTCCommentary: Rate of asymptomatic kids with COVID-19 roughly equal to community rate – UPI
New drool-based tests are replacing the dreaded coronavirus nasal swab
26 Aug, 2020 | 03:59h | UTCNew drool-based tests are replacing the dreaded coronavirus nasal swab – Science
Maternal caffeine consumption and pregnancy outcomes: A narrative review with implications for advice to mothers and mothers-to-be
26 Aug, 2020 | 03:56h | UTCCommentaries: Caffeine consumption not safe during pregnancy, new study says. Some experts disagree – CNN AND Maternal caffeine consumption and pregnancy outcomes – MedicalResearch.com
Observational study: Risk of hydroxychloroquine alone and in combination with azithromycin in the treatment of rheumatoid arthritis
26 Aug, 2020 | 03:57h | UTC
Randomized trial: Vitamin D Supplementation does not prevent severe asthma exacerbations in children with asthma and low vitamin D levels
26 Aug, 2020 | 03:52h | UTCEffect of Vitamin D3 Supplementation on Severe Asthma Exacerbations in Children With Asthma and Low Vitamin D Levels: The VDKA Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: Compared to placebo, vitamin D has no benefit for severe asthma attacks, study finds – University of Pittsburgh School of Medicine AND Don’t count on vitamin D to ease childhood asthma – MedicalXpress
Commentary on Twitter
In this RCT, #vitaminD3 supplementation did not improve the time to a severe asthma exacerbation vs placebo in children with persistent asthma and low #vitaminD levels https://t.co/VfYXUrhyT7
— JAMA (@JAMA_current) August 25, 2020
First Covid-19 reinfection documented in Hong Kong
25 Aug, 2020 | 04:00h | UTCFirst Covid-19 reinfection documented in Hong Kong, researchers say – STAT
Commentaries: Some people can get the pandemic virus twice, a study suggests. That is no reason to panic – Science AND You can get reinfected with Covid-19 but still have immunity. Let’s explain – Vox AND Expert reaction to first reported case of COVID-19 re-infection in Hong Kong patient – Science Media Centre
Commentary on Twitter
In Hong Kong, researchers reported what appears to be the first confirmed case of Covid-19 reinfection in a 33-year-old man. The virus sequenced from his two infections didn't match, indicating the second one was not tied to the first. https://t.co/4GHd1lMRZ0
— STAT (@statnews) August 24, 2020
Cost of contact: Redesigning healthcare in the age of COVID
25 Aug, 2020 | 03:51h | UTCCost of contact: redesigning healthcare in the age of COVID – BMJ Quality & Safety
Commentary on Twitter
The ‘cost of contact’ associated with risks of COVID-19 is forcing redesign of healthcare. That may be a good thing. say @sacha_bhatia, @kgshojania and Wendy Levinson, but it needs to be done well. https://t.co/cq5gYtuvMT
— BMJ Quality & Safety (@BMJ_Qual_Saf) August 24, 2020
The disappearance of the primary care physical examination—losing touch
25 Aug, 2020 | 03:49h | UTCThe Disappearance of the Primary Care Physical Examination—Losing Touch – JAMA Internal Medicine (free for a limited period)
WHO says children aged 12 and over should follow the same mask guidelines for adults
24 Aug, 2020 | 00:56h | UTCWHO Q&A: Children and masks related to COVID-19
Commentaries: WHO says children aged 12 and over should wear masks like adults – Reuters AND The WHO just released specific mask guidance for kids as they gear up to return to school: children 12 and older should wear them as adults do – Business Insider