Family Medicine
Russia’s Sputnik V COVID-19 vaccine candidate appears safe and is 91.6% effective
3 Feb, 2021 | 01:49h | UTCCommentaries: Sputnik V COVID-19 vaccine candidate appears safe and effective – The Lancet AND Russia’s “Sputnik V” COVID Vaccine Makes Strong 91.6 % Efficacy Showing In Peer-Reviewed Trial Results – Health Policy Watch AND Russia’s COVID vaccine 92% effective, even in those over 60 – CIDRAP AND Russia’s Sputnik V vaccine has 92% efficacy in trial – BBC AND Expert reaction to study looking at preliminary efficacy and safety results from interim analysis of Russian COVID-19 phase 3 vaccine (Sputnik) trial – Science Media Centre
Commentary on Twitter
NEW—Interim analysis of Russian #COVID19 #vaccine phase 3 trial involving nearly 20,000 participants suggests a two-dose regimen has an efficacy of 91.6% against symptomatic #COVID19. No serious adverse events were deemed to be associated with vaccination. https://t.co/40sM7f2nbS pic.twitter.com/Hzrs34uCWr
— The Lancet (@TheLancet) February 2, 2021
One in three adults report anxiety, depression related to COVID-19
3 Feb, 2021 | 01:35h | UTCOne in three adults report anxiety, depression related to COVID-19 – Duke-NUS Medical School
Podcast: Hypertension Update
2 Feb, 2021 | 01:07h | UTC#254 Hypertension Update with Dr. Wanpen Vongpatanasin – The Curbsiders Internal Medicine Podcast
AAP urges continuing obesity management
2 Feb, 2021 | 01:03h | UTCAAP urges continuing obesity management – Contemporary Pediatrics
Original Guideline: Obesity Management and Treatment During COVID-19 – American Academy of Pediatrics
Meta-analysis of longitudinal studies: Frequent or dependent cannabis use in youth linked to decline IQ
2 Feb, 2021 | 01:02h | UTC
Covid: The devastating toll of the pandemic on children
2 Feb, 2021 | 01:22h | UTCCovid: The devastating toll of the pandemic on children – BBC
Commentary on Twitter (thread – click for more)
Longtime school closures cause major psychological harm to children. School closures also affect their education, future prospects in life and cause further inequality in society. The long-term economic harm of school closures will be felt by all.
1/https://t.co/n7yhUEfXmL— Prof Francois Balloux (@BallouxFrancois) January 30, 2021
COVID-19 rarely spreads through surfaces. So why are we still deep cleaning?
2 Feb, 2021 | 01:20h | UTCCOVID-19 rarely spreads through surfaces. So why are we still deep cleaning? – Nature
COVID-19 vaccine-linked adenopathies could mimic breast malignancies
2 Feb, 2021 | 01:17h | UTCCOVID-19 Vaccine-Linked Adenopathies Could Mimic Breast Malignancies – Diagnostic Imaging
Original Study: Unilateral axillary Adenopathy in the setting of COVID-19 vaccine – Clinical Imaging
Commentaries on Twitter
Important for radiologists to consider vaccine induced hyperplastic adenopathy in unilateral axillary adenopathy seen on #breastimaging post #COVID19Vaccine #COVID19
Read here https://t.co/7IizHgIzU0@NishiMehtaMD @KatiaDodelzon @KemiMDRad @WCMRadiology @BreastImaging
— Clinical Imaging (@CI_Journal) January 19, 2021
The COVID-19 vaccine may cause swollen lymph nodes that could be mistaken for breast malignancies. However, it's important not to postpone your vaccine or breast cancer screenings, researchers from @WCMRadiology and @WCMBreastCenter say. https://t.co/jLuVbA2rXL
— Weill Cornell Medicine (@WeillCornell) January 22, 2021
[Press release – not published yet] Single-shot Janssen COVID-19 vaccine candidate met primary endpoints in interim analysis of its phase 3 trial
1 Feb, 2021 | 01:55h | UTCCommentaries: J&J’s one-shot COVID vaccine offers hope for faster protection – Nature AND Johnson & Johnson Executive Says Vaccine Works Where It Counts: Preventing Deaths – NPR AND Novavax’s COVID Vaccine Shows High Efficacy In Trials; J&J One-Dose Shot Less So – As Europe Feuds With AstraZeneca – Health Policy Watch AND Covid vaccine: Single-dose Johnson & Johnson jab is 66% effective – BBC AND Johnson & Johnson’s COVID-19 Vaccine Results Are Better Than They May Sound – TIME AND Expert reaction to Johnson & Johnson announcing that the single-shot Janssen COVID-19 vaccine candidate met primary endpoints in the interim analysis of its phase 3 ENSEMBLE Trial – Science Media Centre AND Janssen Investigational COVID-19 Vaccine: Interim Analysis of Phase 3 Clinical Data Released – NIH News Releases AND J&J one-dose Covid vaccine is 66% effective, a weapon but not a knockout punch – STAT
New coronavirus variants call for intensified surveillance, control, and vaccination efforts
29 Jan, 2021 | 01:56h | UTCNew coronavirus variants call for intensified surveillance, control, and vaccination efforts – STAT
How Covid-19 mutations are changing the pandemic
29 Jan, 2021 | 01:55h | UTCHow Covid-19 mutations are changing the pandemic – BBC
Covid-19: Cough, fatigue, sore throat ‘more common’ in new variant
28 Jan, 2021 | 01:41h | UTCCovid-19: Cough, fatigue, sore throat ‘more common’ in new variant – BBC
[Preprint] Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19
28 Jan, 2021 | 01:49h | UTCEfficacy of Colchicine in Non-Hospitalized Patients with COVID-19 – medRxiv
Commentary on Twitter
The large colchicine RCT for covid is preprint published.
It shows some consistent directional benefit for major outcomeshttps://t.co/gxtyKnMqZ5
Since this is a pill, it's safe, cheap & an early intervention (as tested here, before hospital) these findings are very encouraging pic.twitter.com/uzTSkjftFp— Eric Topol (@EricTopol) January 27, 2021
Long Covid: Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge
28 Jan, 2021 | 01:31h | UTCCommentary: Lung, mobility problems plague COVID-19 patients months after recovery – UPI
Low-dose aspirin may improve pregnancy chances for women with one or two prior miscarriages
27 Jan, 2021 | 01:09h | UTCOriginal study: The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, Pregnancy Loss, and Live Birth: Per Protocol Analysis of a Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Summary for Patients: The Effect of Preconception-Initiated Low-Dose Aspirin on Human Chorionic Gonadotropin–Detected Pregnancy, Pregnancy Loss, and Live Birth – Annals of Internal Medicine
Related (study and commentaries): Low-dose aspirin for the prevention of preterm delivery in nulliparous women with a singleton pregnancy (ASPIRIN): a randomised, double-blind, placebo-controlled trial – The Lancet
AHA Statement: Psychological health, well-being, and the mind-heart-body connection
27 Jan, 2021 | 01:11h | UTCNews release: Mental health is important to overall health, and heart disease prevention and treatment – American Heart Association
Commentary: The head is connected to the heart – and can influence health – American Heart Association
Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases
27 Jan, 2021 | 01:08h | UTCVitamin D, Calcium, Other Vitamins, and Supplements Do Not Prevent CVD – TCTMD
Original study 1: Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Original study 2: Vitamin D, Calcium Supplements, and Implications for Cardiovascular Health: JACC Focus Seminar – Journal of the American College of Cardiology (link to abstract – $ for full-text)
CDC Report: Low risk of COVID-19 transmission in schools with precautions in place
27 Jan, 2021 | 01:25h | UTCRelated viewpoint: Data and Policy to Guide Opening Schools Safely to Limit the Spread of SARS-CoV-2 Infection – JAMA
Commentary on Twitter
Important study:
While covid test + rates ranged from 7 to 40% in the community, K-12 schools were able to open with nearly no transmission linked to school.The harm of school closure will tear the fabric of society; these steps are worth it to reopen. https://t.co/q0SXpqJrqw pic.twitter.com/rsL7EkVsZZ
— Vinay Prasad MD MPH (@VPrasadMDMPH) January 26, 2021
WHO Updated Guideline: COVID-19 clinical management
27 Jan, 2021 | 01:26h | UTCCOVID-19 Clinical management: living guidance – World Health Organization
News release: WHO recommends follow-up care, low-dose anticoagulants for COVID-19 patients
Commentary: WHO issues new clinical advice on treating COVID-19 patients – Reuters
Randomized trial: Remote, online support for blood pressure management at home is effective and low-cost
26 Jan, 2021 | 00:46h | UTC
Commentary on Twitter
NEW #BMJresearch has found that a digital intervention for the management of hypertension by using self-monitored blood pressure led to better control of systolic blood pressure after one year than usual care, with low incremental costs @RichardJMcManus https://t.co/XiNCzE0t6C
— The BMJ (@bmj_latest) January 23, 2021
10-year follow up of a randomized trial shows metabolic surgery is more effective than conventional medical therapy for the control of type 2 diabetes
26 Jan, 2021 | 00:44h | UTCMetabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)
Podcast: Smoking Cessation Unfiltered
26 Jan, 2021 | 00:41h | UTC
Cohort study: Association of potent and very potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures
26 Jan, 2021 | 00:38h | UTCEditorial: Topical Corticosteroids and Glucocorticoid-Induced Osteoporosis—Cumulative Dose and Duration Matter
Commentaries: Prolonged Use of Topical Steroids Associated with Increased Risk of Osteoporosis – Physician’s Weekly AND Potent Topical Corticosteroids Tied to Increased Fracture Risk – NEJM Journal Watch
Author Interview: Association of Topical Corticosteroids and Risk of Osteoporosis and Major Osteoporotic Fractures – JAMA
Commentary on Twitter
In a cohort study of 723 251 users of potent or very potent topical #corticosteroids, use of these drugs was associated with increased risk of #osteoporosis and major osteoporotic fracture with a dose-response association for cumulative use https://t.co/m5Rp4n0NvK
— JAMA Dermatology (@JAMADerm) January 20, 2021
[Press release – not published yet] Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial
26 Jan, 2021 | 01:03h | UTC
New analysis does not support a major role of school reopening in the second COVID-19 wave in Israel
26 Jan, 2021 | 00:52h | UTC
Commentary on Twitter
Very interesting paper
Despite previous certainty about schools being the driving factor in the second wave in Israel, now looks unlikely
Easing restrictions of large gatherings in adults the predominant factor
Young adults, not children, as elsewherehttps://t.co/oWHbZynRpL
— Alasdair Munro (@apsmunro) January 25, 2021