Family Medicine
CDC Study: Suspected SARS-CoV-2 reinfections in a skilled nursing facility
28 Feb, 2021 | 21:55h | UTCCommentaries: Possible SARS-CoV-2 Reinfection Described at Skilled Nursing Facility – HealthDay AND Reinfections could be more likely among those with a mild first case of COVID-19: case study – CTV News
Commentary on Twitter (thread – Click for more)
📌CDC report: Asymptomatic or mildly symptomatic infections don't always produce sufficient immune response to prevent reinfection. Report of nursing facility found 5 people reinfected ~3 months after initial infection. All 5 had more severe symptoms 2nd time around, one death🧵 pic.twitter.com/m9ix9XJolA
— Dr. Ali Nouri (@AliNouriPhD) February 28, 2021
Short Review: SARS-CoV-2 Vaccines
28 Feb, 2021 | 21:52h | UTCAuthor interview: Coronavirus Vaccines—An Overview
Check out the Table ins this #SARSCoV2 Vaccine Overview – everything you wanted to know about upcoming vaccines – Oxford/AZ, Sputnik, Sinovac, more! https://t.co/TWbgfSKBIP
— JAMA (@JAMA_current) February 26, 2021
Studies: Single dose of vaccine acts as ‘booster’ in those with prior COVID-19 infection
28 Feb, 2021 | 21:49h | UTCStudy 1: Antibody response to first BNT162b2 dose in previously SARS-CoV-2-infected individuals – The Lancet
Commentary on Twitter (thread – click for more)
New on 1-dose @Pfizer vaccine after prior covid
"We show that individuals with previous #SARSCoV2 infection generate strong humoral and cellular responses to one dose of BNT162b2 vaccine, with evidence of high titres of in-vitro live virus neutralisation"https://t.co/2G7TRu57OI pic.twitter.com/sIdB0VarqB— Eric Topol (@EricTopol) February 25, 2021
Spain to give just one vaccine dose to under 55-year olds who had COVID-19
28 Feb, 2021 | 21:47h | UTCSpain to give just one vaccine dose to under 55-year olds who had COVID-19 – Reuters
Related: Is One Vaccine Dose Enough After COVID-19 Infection? – NIH Director’s Blog AND France’s health authority recommends single vaccine shot for people who have had COVID-19
2 Case Series and Guidance| Lymphadenopathy in COVID-19 Vaccine Recipients
28 Feb, 2021 | 21:42h | UTCCase series: Lymphadenopathy in COVID-19 Vaccine Recipients: Diagnostic Dilemma in Oncology Patients – Radiology
Related case series in women without cancer: Coronavirus Disease (COVID-19) Vaccination Associated Axillary Adenopathy: Imaging Findings and Follow-Up Recommendations in 23 Women – American Journal of Roentgenology
Related guidance 1: Multidisciplinary Recommendations Regarding Post-Vaccine Adenopathy and Radiologic Imaging: Radiology Scientific Expert Panel – Radiology
Related guidance 2: Mitigating the Impact of Coronavirus Disease (COVID-19) Vaccinations on Patients Undergoing Breast Imaging Examinations: A Pragmatic Approach – American Journal of Roentgenology AND Commentary: What to do when a mammogram shows swollen lymph nodes in women just vaccinated for COVID – Massachusetts General Hospital
Commentary: COVID-19 vaccine affects imaging results, researchers warn – AuntMinnie (free registration required)
Improving lung health in low-income and middle-income countries: from challenges to solutions
28 Feb, 2021 | 21:23h | UTCImproving lung health in low-income and middle-income countries: from challenges to solutions – The Lancet (free registration required)
Commentary on Twitter
LMICs bear a high burden of global morbidity & mortality from chronic respiratory diseases (CRDs). Read this review on improving lung health in LMICs—challenges in prevention, diagnosis, management, & pathways to universal health coverage: https://t.co/u8ToWFzwUl pic.twitter.com/gJQbO8B0Zk
— The Lancet (@TheLancet) February 24, 2021
RCT: similar outcomes in patients with heart failure with preserved ejection fraction randomized to high-intensity interval training vs. moderate continuous training vs. guideline-based physical activity advice
28 Feb, 2021 | 21:06h | UTCEffect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: Hold Off on HIIT for Patients with Heart Failure with Preserved EF – Physician’s Weekly
Commentary on Twitter
In this RCT, high-intensity interval training was no better at improving peak V̇O₂ at 3 months vs moderate continuous or guideline control training, in patients with #HFpEF https://t.co/CZzAcQESLg @TUMSportMedizin @jamacardiology @jamainternalmed #VisualAbstract
— JAMA Cardiology (@JAMACardio) February 22, 2021
Clinical Update: Enteric Fever
28 Feb, 2021 | 21:02h | UTCEnteric fever – The BMJ (free for a limited period)
Commentary on Twitter
Diagnosis of enteric fever is complicated as symptoms overlap with other causes of fever and early investigations are inconclusive. Here's what you need to know about its presentation, diagnosis, and treatment #BMJEducationhttps://t.co/1mvbNb7peS pic.twitter.com/Z7YxngHanl
— The BMJ (@bmj_latest) February 28, 2021
Cognitive behavioral therapy for a variety of conditions: an overview of systematic reviews and panoramic meta-analysis
28 Feb, 2021 | 20:50h | UTC
Bioethics | Should clinical guidelines incorporate cost pathways for persons with financial hardship?
28 Feb, 2021 | 20:54h | UTC
Joint Statement: Hydroxychloroquine use with respect to retinal toxicity
28 Feb, 2021 | 20:41h | UTCCommentary: Societies Agree on Eye Safety for HCQ – MedPage Today (free registration required) AND ACR, medical societies reach consensus on hydroxychloroquine retinopathy – Healio (free registration required)
Commentary on Twitter
🆕 Joint statement on #Hydroxychloroquine use with respect to retinal toxicity 👀 by several #rheumatology and #opthtalmology societies. #ocular #toxicity relates to #HCQ dosage and duration of use and is seen in 4.3% to 13.8% of patients 🔎#Lupus #SLEhttps://t.co/ocFSCmgVsN
— Laurent ARNAUD (@Lupusreference) February 18, 2021
U.S. Guidelines panel recommendation for long-acting injectable antiretroviral regimen in adults and adolescents with HIV
28 Feb, 2021 | 20:34h | UTCWhat’s New in the Guidelines? Panel’s Recommendation for Long-Acting Injectable Cabotegravir and Rilpivirine in Persons with HIV
Indian Guidelines for pediatric skin care in neonates, infants, and children
28 Feb, 2021 | 20:37h | UTCIndian Academy of Pediatrics Guidelines for Pediatric Skin Care
WHO Report: Preparing for Long COVID 2021
26 Feb, 2021 | 08:46h | UTCIn the wake of the pandemic: preparing for Long COVID (2021) – World Health Organization
Commentaries: Long COVID sufferer still has disease’s debilitating symptoms nearly a year after first falling ill – EuroNews AND Debilitating ‘long-COVID’ may have severe health, social impacts: WHO – Reuters
Related: Dr. Fauci says new data suggests ‘long’ Covid symptoms can last up to 9 months – CNBC
New protocol tested SARS-CoV-2 positivity on day 9 among quarantined student contacts of confirmed cases, resulting in safe reduction in loss of instructional time
26 Feb, 2021 | 08:42h | UTCCommentary: Is the CDC 10-day COVID-19 quarantine guideline enough? – News Medical
Commentary on Twitter
In this study of a 9-day testing protocol for student contacts of confirmed #COVID19 cases in 1 Florida county, a reduction in loss of instructional time was found that was less than what would have occurred with 14-day quarantine https://t.co/YPft2oAvYk
— JAMA (@JAMA_current) February 19, 2021
Differences in characteristics and outcomes of children and adolescents with Multisystem Inflammatory Syndrome in Children (MIS-C) vs. severe acute COVID-19
26 Feb, 2021 | 08:43h | UTCCommentary: Studies help discern severe COVID from related kids’ syndrome – CIDRAP
Commentary on Twitter
In this case series using national MIS-C registry data, kids w MIS-C were younger (6-12 y), more likely to be non-Hispanic Black, & have severe CV or mucocutaneous involvement and more extreme inflammation vs kids w severe #COVID19 https://t.co/jmCCDPXLmf @BostonChildrens
— JAMA (@JAMA_current) February 25, 2021
COVID-19 hospitalizations attributable to cardiometabolic conditions
26 Feb, 2021 | 08:40h | UTCCommentary: Study estimates two-thirds of COVID-19 hospitalizations due to four conditions – Tufts University
Commentary on Twitter
https://twitter.com/Dmozaffarian/status/1364993823370338312
RCT: Effect of screening by clinical breast examination on breast cancer incidence and mortality after 20 years
26 Feb, 2021 | 08:34h | UTCCommentaries: The story of the Mumbai breast screening study – The BMJ Opinion
This trial found that regular breast examination by trained female health workers in Mumbai led to earlier diagnosis and reduced deaths from breast cancer in women aged 50 and olderhttps://t.co/TQCHLbVO8L
— The BMJ (@bmj_latest) February 25, 2021
Decreasing patient-reported burden of treatment: A systematic review of quantitative interventional studies
26 Feb, 2021 | 08:21h | UTC
Drains, germs, or steel: Multidisciplinary management of acute colonic diverticulitis
26 Feb, 2021 | 08:17h | UTC
Study: Unhealthy alcohol use common after bariatric surgery
26 Feb, 2021 | 08:14h | UTCCommentaries: Unhealthy Alcohol Use—A Common Iatrogenic Complication of Bariatric Surgery – JAMA Network Open AND Bariatric Surgery May Increase Risk of Unhealthy Alcohol Use – Psychiatric News Alert AND Bariatric Surgery Ups Risk of Alcohol Abuse – Physician’s Weekly
Commentary on Twitter
Our team’s analysis of VA bariatric surgery outcomes. Alcohol use increased 3–8 years after surgery. The benefits far outweigh the risks, but we need to support our patients long-term. @davearterburn @NeilFlochMD https://t.co/QpGHeRrI9l via @JAMANetworkOpen part of @JAMANetwork
— Luke Funk, MD, MPH (@lmfunk2) December 26, 2020
Guidelines for the treatment of irritable bowel syndrome
26 Feb, 2021 | 08:15h | UTC
Series of n-of-1 trials show no difference in muscle symptoms in patients receiving placebo or statins
25 Feb, 2021 | 08:54h | UTCCommentary: Do statins cause muscle symptom side effects? – The BMJ Opinion AND Study: Muscle Symptoms Didn’t Differ Between Statin and Placebo Periods – NEJM Journal Watch
Related study: #AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo (study and commentaries)
RCT: Effect of high-dose subcutaneous Semaglutide vs. placebo in adults with overweight or obesity
25 Feb, 2021 | 08:52h | UTCRelated study: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults – New England Journal of Medicine (study and commentary)
Commentary on Twitter
In this RCT, once-weekly subcutaneous semaglutide used as an adjunct to intensive behavioral therapy & low-calorie diet led significantly greater weight loss vs placebo over 68 weeks among adults w #overweight or #obesity w/o #diabetes https://t.co/xFedvckUUj @PennMedicine #STEP3
— JAMA (@JAMA_current) February 24, 2021
Cohort study: High glycemic index diets are linked to increased risk of cardiovascular disease and death
25 Feb, 2021 | 08:49h | UTCCommentaries: Study finds diet high in poor quality carbohydrates increases heart disease and death – McMaster University AND High Glycemic Index Diets Linked to CVD and Mortality – TCTMD