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Family Medicine

Synopsis | Updates to the Pediatrics Asthma Management Guidelines.

8 Jun, 2021 | 09:22h | UTC

Updates to the Pediatrics Asthma Management Guidelines – JAMA Pediatrics (free for a limited period)

Original Guideline: 2020 Focused Updates to the Asthma Management Guidelines: A Report from the National Asthma Education and Prevention Program Coordinating Committee Expert Panel Working Group

 

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection – there was a significant association between skin rashes and a positive swab test result (odds ratio 1.67).

8 Jun, 2021 | 09:26h | UTC

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection – British Journal of Dermatology

 

More data suggests no cardiovascular benefit from Omega-3 supplementation – secondary analysis of STRENGHT trial did not show an association between achieved Omega-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk.

8 Jun, 2021 | 09:19h | UTC

Association Between Achieved ω-3 Fatty Acid Levels and Major Adverse Cardiovascular Outcomes in Patients With High Cardiovascular Risk: A Secondary Analysis of the STRENGTH Trial – JAMA Cardiology

Original study: #AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

Commentaries: Higher blood levels of omega-3 fatty acids from prescription fish oil showed no effect on CV events – American College of Cardiology

 

Six months of COVID vaccines: what 1.7 billion doses have taught scientists.

6 Jun, 2021 | 23:57h | UTC

Six months of COVID vaccines: what 1.7 billion doses have taught scientists – Nature

See also: Coronavirus (COVID-19) Vaccinations – Our World in Data

 

Related commentary on Twitter

 

Review: Management of patients with venous thromboembolism after the initial treatment period.

8 Jun, 2021 | 09:13h | UTC

Management of Patients With Venous Thromboembolism After the Initial Treatment Period – The Journal of the American Board of Family Medicine

 

Study shows reduced neutralizing antibody activity induced by Pfizer–BioNTech vaccine against SARS-CoV-2 variants of concern B.1.617.2 (Delta) and B.1.351 (Beta).

6 Jun, 2021 | 23:59h | UTC

Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2  and B.1.351 (Beta) by BNT162b2 vaccination – The Lancet

Commentary: Pfizer-BioNTech vaccine recipients have lower antibody levels targeting the Delta variant – The Francis Crick Institute

 

Commentary on Twitter (thread – click for more)

 

More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.

6 Jun, 2021 | 23:52h | UTC

Depressive symptoms, mental wellbeing, and substance use among adolescents before and during the COVID-19 pandemic in Iceland: a longitudinal, population-based study – The Lancet Psychiatry

Commentaries: A lost generation? COVID-19 and adolescent mental health – The Lancet Psychiatry AND COVID-19 pandemic has had significant impact on the mental health of adolescents – Columbia University Mailman School of Public Health

 

Commentary on Twitter (thread – click for more)

https://twitter.com/TheLancetPsych/status/1400783180937011202

 

2 new meta-analysis detail neurologic and psychiatric conditions in COVID-19.

6 Jun, 2021 | 23:54h | UTC

Neurologic, psychiatric conditions common in COVID-19 – CIDRAP

Meta-analysis 1: Neurology and neuropsychiatry of COVID-19: a systematic review and meta-analysis of the early literature reveals frequent CNS manifestations and key emerging narratives – Journal of Neurology, Neurosurgery & Psychiatry

Meta-analysis 2: Central and peripheral nervous system involvement by COVID-19: a systematic review of the pathophysiology, clinical manifestations, neuropathology, neuroimaging, electrophysiology, and cerebrospinal fluid findings – BMC Infectious Diseases

Related: Large study finds 1 in 3 Covid-19 survivors have subsequent mental health and neurological conditions

 

Perspective | Could statins do more than lower cholesterol in patients with COVID-19? – “Don’t Start, Don’t Stop”.

6 Jun, 2021 | 23:49h | UTC

Could Statins Do More Than Lower Cholesterol in Patients With COVID-19? – JAMA

 

Another study shows a high frequency of antibiotic use among patients hospitalized with Covid-19 (85.2%), despite low rates of confirmed secondary bacterial infections.

4 Jun, 2021 | 10:43h | UTC

Co-infections, secondary infections, and antimicrobial use in patients hospitalised with COVID-19 during the first pandemic wave from the ISARIC WHO CCP-UK study: a multicentre, prospective cohort study – The Lancet Microbe

Commentaries: Very high use of antibiotics in COVID-19 treatment could be reduced – University of Glasgow AND More evidence of frequent antibiotic use noted in COVID patients – CIDRAP AND Covid-19: Antimicrobial use was high during first wave despite bacterial co-infections being rare, study finds – The BMJ

Related: Many hospitalized Covid-19 patients are given antibiotics. That’s a problem – STAT

 

Commentary on Twitter (thread – click for more)

 

Cohort study: long working hours (more than 55 h/week) linked to increased risk of recurrent coronary events.

6 Jun, 2021 | 23:32h | UTC

Long Working Hours and Risk of Recurrent Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Working long hours may increase odds of second heart attack – American College of Cardiology AND Recurrent CHD Risk Up With Long Working Hours After First MI – HealthDay AND Longer Work Hours After MI Tied to Higher Risk of Recurrent Events – TCTMD

 

In a Mendelian randomization study, researchers found no genetic evidence to support an association between Vitamin D levels and COVID-19 susceptibility, severity, or hospitalization.

4 Jun, 2021 | 10:35h | UTC

Vitamin D and COVID-19 susceptibility and severity in the COVID-19 Host Genetics Initiative: A Mendelian randomization study – PLOS Medicine

Commentary: Vitamin D may not provide protection from COVID-19 susceptibility or disease severity, study suggests – PLOS

Related: Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19. AND RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

 

RCT: Prophylactic post-exposure prophylaxis with Bamlanivimab reduced the incidence of Covid-19 among residents and staff of skilled nursing and assisted living facilities.

4 Jun, 2021 | 10:40h | UTC

Effect of Bamlanivimab vs Placebo on Incidence of COVID-19 Among Residents and Staff of Skilled Nursing and Assisted Living Facilities: A Randomized Clinical Trial – JAMA

Editorial: Bamlanivimab for Prevention of COVID-19

 

[Preprint] Covid-19 B.1.617.2 variant of concern (Delta) is associated with increased transmissibility compared to B.1.1.7 (Alpha) that will rapidly lead to B.1.617.2 becoming the prevailing variant in the UK.

4 Jun, 2021 | 10:36h | UTC

Interim estimates of increased transmissibility, growth rate, and reproduction number of the Covid-19 B.1.617.2 variant of concern in the United Kingdom – medRxiv

Related: Covid: Indian variant ‘now dominant’ in the UK – BBC

 

Countries hit hardest by COVID-19 – estimated mortality countries will have on September 1, 2021.

3 Jun, 2021 | 11:09h | UTC

Countries Hit Hardest by COVID-19 – Think Global Health

 

Commentary on Twitter (thread – click for more)

 

Cohort study showed good recovery for most children 6 months after Pediatric Inflammatory Multisystem Syndrome (PIMS-TS) associated with SARS-CoV-2.

3 Jun, 2021 | 11:06h | UTC

6-month multidisciplinary follow-up and outcomes of patients with paediatric inflammatory multisystem syndrome (PIMS-TS) at a UK tertiary paediatric hospital: a retrospective cohort study – The Lancet Child & Adolescent Health

Commentary: Most severe effects of MIS-C in children typically resolve within six months, new research suggests – CNN AND Children who developed a rare inflammation disease after COVID-19 are mostly better after 6 months, but some still suffer fatigue and anxiety, a small UK study found – Insider AND Most severe effects of PIMS-TS resolved at six months – HealthDay

 

Commentary on Twitter

 

What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – “the Delta variant may soon become the most dominant COVID strain in the world and lead to rapid outbreaks in countries without high vaccination rates”.

3 Jun, 2021 | 11:05h | UTC

What We Know About the Dangerous COVID B.1.617.2 (Delta) Variant – Intelligencer

 

Commentary on Twitter

 

RCT: Among patients with Type 2 diabetes treated with basal insulin with poor glycemic control (mean baseline HbA1c level = 9.1%), continuous glucose monitoring reduced HbA1c level by 0.4% compared to usual care (8.0% and 8.4%). Patient engagement (i.e., adherence, diet, physical activity in response to CGM readings) was the most likely source of improved glycemic control.

3 Jun, 2021 | 10:54h | UTC

Effect of Continuous Glucose Monitoring on Glycemic Control in Patients With Type 2 Diabetes Treated With Basal Insulin: A Randomized Clinical Trial – JAMA

Editorial: Broadening Access to Continuous Glucose Monitoring for Patients With Type 2 Diabetes – JAMA

Commentary: Studies support wider CGM access in type 2 diabetes – medwire News

 

Commentary on Twitter

 

AHA Statement: Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?

3 Jun, 2021 | 10:52h | UTC

Physical Activity as a Critical Component of First-Line Treatment for Elevated Blood Pressure or Cholesterol: Who, What, and How?: A Scientific Statement From the American Heart Association – Hypertension

News Release: ‘Prescription’ to sit less, move more advised for mildly high blood pressure and cholesterol – American Heart Association

Commentary: AHA: Physical Activity Should First-line Therapy as BP, LDL Tick Upwards – TCTMD

 

Doctors tell how to make the most of your telehealth visits.

3 Jun, 2021 | 10:39h | UTC

Doctors Tell How to Make the Most of Your Telehealth Visits – Kaiser Health News

 

M-A: Parenting interventions to promote early child development in the first three years of life.

3 Jun, 2021 | 10:37h | UTC

Parenting interventions to promote early child development in the first three years of life: A global systematic review and meta-analysis – PLOS Medicine

 

WHO validates Sinovac-CoronaVac COVID-19 vaccine for emergency use and issues interim policy recommendations.

2 Jun, 2021 | 08:42h | UTC

WHO validates Sinovac COVID-19 vaccine for emergency use and issues interim policy recommendations – World Health Organization

Commentary: WHO grants emergency approval to 2nd Chinese COVID vaccine – MedicalXpress

 

Commentary on Twitter (thread – click for more)

Systematic review: Driving performance under treatment of most frequently prescribed drugs for mental disorders – 31% of schizophrenic or schizoaffective patients under antipsychotics, and 18% of unipolar and bipolar patients under antidepressants showed severe impairment in skills relevant for driving.

2 Jun, 2021 | 08:24h | UTC

Driving performance under treatment of most frequently prescribed drugs for mental disorders: a systematic review of patient studies – International Journal of Neuropsychopharmacology

 

WHO renames COVID-19 variants with the Greek alphabet (i.e., Alpha, Beta, Gamma, etc), making them simple, easy to say and remember. The naming system aims to prevent calling COVID-19 variants by the places where they are detected, which is stigmatizing & discriminatory.

1 Jun, 2021 | 08:26h | UTC

Tracking SARS-CoV-2 variants – World Health Organization

Commentaries: The name game for coronavirus variants just got a little easier – STAT AND Covid: WHO renames UK and other variants with Greek letters – BBC

 

Study shows low risk of SARS-CoV-2 reinfection 1 year after primary infection.

1 Jun, 2021 | 08:23h | UTC

Assessment of SARS-CoV-2 Reinfection 1 Year After Primary Infection in a Population in Lombardy, Italy – JAMA Internal Medicine

Editorial: Protection Because of Prior SARS-CoV-2 Infection

 

Commentary on Twitter

 

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