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Case series: Vaccine-induced thrombocytopenia with severe headache may precede cerebral venous sinus thrombosis by several days – patients with severe headache 5 to 20 days after adenovirus vector vaccination against Covid-19 should undergo immediate testing for thrombocytopenia and d-dimer levels and, if available, testing for anti–PF4–heparin IgG antibodies.

16 Sep, 2021 | 10:14h | UTC

Vaccine-Induced Thrombocytopenia with Severe Headache – New England Journal of Medicine

 

Commentary on Twitter

 

COVID vaccine effects wane over time but still prevent death and severe illness.

16 Sep, 2021 | 10:10h | UTC

COVID vaccine effects wane over time but still prevent death and severe illness – The Conversation

Related:

Perspective | What we actually know about waning immunity.

Another study shows Pfizer mRNA vaccine immunity is reduced over time.

[Press release – not published yet] Study shows vaccine protection wanes over time, but vaccines still offer good protection against severe disease.

Studies: COVID vaccine protection waning against infection but not hospitalization.

Pfizer says it’s time for a Covid booster; FDA and CDC say not so fast.

 

An observational study in Israel suggests additional protection from a 3rd dose of the Pfizer vaccine in individuals 60 years of age or older.

16 Sep, 2021 | 10:13h | UTC

Protection of BNT162b2 Vaccine Booster against Covid-19 in Israel – New England Journal of Medicine

 

Perspective | Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain.

16 Sep, 2021 | 10:06h | UTC

Schools have begun mass testing for COVID-19. But hurdles and uncertainties remain – Science

Related: Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

 

State of the Art Review: Eosinophils in Health and Disease.

16 Sep, 2021 | 09:59h | UTC

Eosinophils in Health and Disease: A State-of-the-Art Review – Mayo Clinic Proceedings

 

Review: Is there an optimal antiplatelet strategy after gastrointestinal bleeding in patients with coronary artery disease?

16 Sep, 2021 | 09:57h | UTC

Is There an Optimal Antiplatelet Strategy after Gastrointestinal Bleeding in Patients with Coronary Artery Disease? – Cardiology

 

State of the Art Review: Screening and prevention of colorectal cancer.

16 Sep, 2021 | 10:01h | UTC

Screening and prevention of colorectal cancer – The BMJ (free for a limited period)

Related:

USPSTF Statement: Start colorectal cancer screening at 45 years for most patients.

ACG Clinical Guidelines: Start colorectal cancer screening at 45

 

Systematic Review: Can electronic cigarettes help people stop smoking, and do they have any unwanted effects when used for this purpose?

16 Sep, 2021 | 09:55h | UTC

Summary: Can electronic cigarettes help people stop smoking, and do they have any unwanted effects when used for this purpose? – Cochrane Library

Original Study: Electronic cigarettes for smoking cessation – Cochrane Library

 

Commentary on Twitter

 

A guide to the treatment of cellulitis and other soft-tissue infections.

16 Sep, 2021 | 09:47h | UTC

A guide to the Tx of cellulitis and other soft-tissue infections – Journal of Family Practice

 

Cluster RCT: Daily contact testing of school-based contacts was non-inferior to self-isolation for control of COVID-19 transmission.

15 Sep, 2021 | 10:01h | UTC

Daily testing for contacts of individuals with SARS-CoV-2 infection and attendance and SARS-CoV-2 transmission in English secondary schools and colleges: an open-label, cluster-randomised trial – The Lancet

Invited commentary: Daily antigen testing to reduce disruption when schools return – The Lancet

 

Review | Prevention of host-to-host transmission by SARS-CoV-2 vaccines.

15 Sep, 2021 | 09:16h | UTC

Prevention of host-to-host transmission by SARS-CoV-2 vaccines – The Lancet Infectious Diseases

Related:

Study ties COVID vaccines to lower transmission rates.

Effect of Vaccination on Household Transmission of SARS-CoV-2 in England – “the likelihood of household transmission was approximately 40 to 50% lower in households of index patients who had been vaccinated 21 days or more before testing positive than in households of unvaccinated index patients”.

Study in England showed one dose of COVID-19 vaccine can cut household transmission by up to half – This protection is on top of the reduced risk of a vaccinated person developing symptomatic infection, which is around 60 to 65% after the first dose

Covid-19 vaccination prevents transmission from vaccinated to unvaccinated household members.

 

Ivermectin: Cochrane’s most talked about review so far, ever. Why?

15 Sep, 2021 | 09:07h | UTC

Ivermectin: Cochrane’s most talked about review so far, ever. Why? – Cochrane Library

Original review: Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

 

Commentary on Twitter

 

Supplement: FIGO Working Group for Preterm Birth – Good Practice Recommendations.

15 Sep, 2021 | 08:56h | UTC

Homepage: FIGO Working Group for Preterm Birth – Good Practice Recommendations – International Journal of Gynecology & Obstetrics

Editorial: FIGO good practice recommendations for reducing preterm birth and improving child outcomes

FIGO good practice recommendations on the importance of registry data for monitoring rates and health systems performance in prevention and management of preterm birth

FIGO good practice recommendations on modifiable causes of iatrogenic preterm birth

FIGO good practice recommendations on reduction of preterm birth in pregnancies conceived by assisted reproductive technologies

FIGO good practice recommendations on progestogens for prevention of preterm delivery

FIGO good practice recommendations on cervical cerclage for prevention of preterm birth

FIGO good practice recommendations on the use of pessary for reducing the frequency and improving outcomes of preterm birth

FIGO good practice recommendations on the use of prenatal corticosteroids to improve outcomes and minimize harm in babies born preterm

FIGO good practice recommendations on magnesium sulfate administration for preterm fetal neuroprotection

FIGO good practice recommendations on delayed umbilical cord clamping

 

CDC report finds unvaccinated people are 11 times more likely to die of COVID-19.

15 Sep, 2021 | 09:09h | UTC

Unvaccinated People Are 11 Times More Likely To Die Of COVID-19, New Research Finds – NPR

Original study: Monitoring Incidence of COVID-19 Cases, Hospitalizations, and Deaths, by Vaccination Status — 13 U.S. Jurisdictions, April 4–July 17, 2021 – CDC Morbidity and Mortality Weekly Report

 

Commentary on Twitter

 

The USPSTF maintains the recommendation to screen for chlamydia and gonorrhea in all sexually active women 24 years or younger and in women 25 years or older who are at increased risk for infection.

15 Sep, 2021 | 08:57h | UTC

Final Recommendation Statement: Screening for Chlamydia and Gonorrhea – U.S. Preventive Services Task Force

Editorial: Screening for Chlamydia and Gonorrhea – JAMA

Evidence Report : Screening for Chlamydial and Gonococcal Infections: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Author Interview: USPSTF Recommendation: Screening for Chlamydia and Gonorrhea

JAMA Patient Page: Screening for Chlamydia and Gonorrhea

 

Report: Fully vaccinated people account for 1.2% of England’s Covid-19 deaths.

14 Sep, 2021 | 10:07h | UTC

Fully vaccinated people account for 1.2% of England’s Covid-19 deaths – The Guardian

Original Report: Deaths involving COVID-19 by vaccination status, England: deaths occurring between 2 January and 2 July 2021 – Office for National Statistics

 

COVID-19 vaccine efficacy does not support boosters for general population, review concludes.

14 Sep, 2021 | 10:08h | UTC

News release: COVID-19 vaccine efficacy does not support boosters for general population, review concludes – The Lancet

Original article: Considerations in boosting COVID-19 vaccine immune responses – The Lancet

Commentaries:

FDA experts among group opposing US booster shot plan – Associated Press

FDA vaccine regulators argue against Covid-19 vaccine boosters in new international review – STAT

Global experts pan wider use of COVID vaccine booster dose – CIDRAP

Expert reaction to viewpoint article on COVID-19 booster vaccines for general populations – Science Media Centre

Boosters Are ‘Not Appropriate’ – Reach Unvaccinated First – Health Policy Watch

Data Doesn’t Support Need for COVID-19 Vaccine Boosters: Experts – HealthDay

In a new review, some F.D.A. scientists and others say boosters aren’t needed for the general population. – The New York Times

 

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors.

14 Sep, 2021 | 10:05h | UTC

Covid: Single jab recommended for 12 to 15-year-olds by UK’s top doctors – BBC

See also: Covid-19: Children aged 12-15 should be offered vaccine, say UK’s chief medical officers – The BMJ

 

Blood Glucose Monitoring in Adults and Children with Diabetes: Update 2021.

14 Sep, 2021 | 08:57h | UTC

Blood Glucose Monitoring in Adults and Children with Diabetes: Update 2021 – Canadian Journal of Diabetes

 

M-A: Study shows significant risk of major bleeding during extended oral anticoagulant therapy for first unprovoked venous thromboembolism.

14 Sep, 2021 | 08:55h | UTC

Long-Term Risk for Major Bleeding During Extended Oral Anticoagulant Therapy for First Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries:

Long-term Anticoagulation After Unprovoked VTE: New Insights – TCTMD

Extended Anticoagulation Tied to Major Bleeding Risk – HealthDay

 

Commentary on Twitter

 

‘Do not resuscitate’ decision recorded for only 1 in 5 very sick hospitalized older patients, study finds

14 Sep, 2021 | 08:40h | UTC

‘Do not resuscitate’ decision recorded for only 1 in 5 very sick older patients, study finds – News Medical

Original study: Do not attempt cardiopulmonary resuscitation (DNACPR) decisions for older medical inpatients: a cohort study – BMJ Supportive & Palliative Care

 

Four factors that increase the risk of vaccinated people getting COVID.

12 Sep, 2021 | 22:02h | UTC

Four factors that increase the risk of vaccinated people getting COVID – The Conversation

Original study: Risk factors and disease profile of post-vaccination SARS-CoV-2 infection in UK users of the COVID Symptom Study app: a prospective, community-based, nested, case-control study – The Lancet Infectious Diseases

 

What’s the evidence for COVID-19 booster shots?

12 Sep, 2021 | 22:05h | UTC

What’s the evidence for COVID-19 booster shots? – Canadian Medical Association Journal

 

Risk of severe breakthrough Covid-19 higher for seniors and people with underlying conditions.

12 Sep, 2021 | 22:03h | UTC

Risk of severe breakthrough Covid-19 higher for seniors and people with underlying conditions – CNN

Original study: Hospitalisation among vaccine breakthrough COVID-19 infections – The Lancet Infectious Diseases

News release: Study examines severe breakthrough cases of COVID-19 – YaleNews

 

Commentary on Twitter

 

Cohort study: long term follow-up showed most patients with post–COVID-19 Multisystem Inflammatory Syndrome in Children had good outcomes with no significant medium- or long-term sequelae.

12 Sep, 2021 | 21:54h | UTC

One-Year Outcomes of Critical Care Patients Post–COVID-19 Multisystem Inflammatory Syndrome in Children – JAMA Pediatrics

Commentary: Outcome Good at One Year for Majority of PIMS-TS Patients – HealthDay

 

Commentary on Twitter

 

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