Evidence-based Medicine
NCCN’s cancer treatment guidelines questioned
8 Mar, 2018 | 22:02h | UTCCommentaries: Vinay Prasad on the NCCN’s cancer treatment guidelines: The US system needs an audit – The BMJ Opinion (free) AND US cancer network recommending expensive drugs based on weak evidence, study finds – The Guardian (free) AND New Study Questions Evidence for NCCN Recommendations – Medscape (free registration required)
Authors of premier medical textbook didn’t disclose $11 million in industry payments
8 Mar, 2018 | 21:38h | UTCAuthors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)
“’The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)
Richard Lehman’s journal review – 5 March 2018
8 Mar, 2018 | 21:32h | UTCRichard Lehman’s journal review, 5 March 2018 – The BMJ (free)
Richard Lehman reviews the latest research in the top medical journals.
Open access, data capitalism and academic publishing
8 Mar, 2018 | 20:46h | UTCOpen access, data capitalism and academic publishing – Swiss Medical Weekly (free)
Bad results from drug trials no longer have a place to hide
8 Mar, 2018 | 20:42h | UTCBad results from drug trials no longer have a place to hide – Wired (free)
Related: Tool ‘names and shames’ hidden drug trials – BBC (free) AND Trials Tracker brings out in the open institutions that hide their drug trials – thealtweb (free)
Key design considerations for adaptive clinical trials: a primer for clinicians
8 Mar, 2018 | 20:41h | UTCResearch Methods & Reporting: Key design considerations for adaptive clinical trials: a primer for clinicians – The BMJ (free)
Scientists Aim to Pull Peer Review Out Of The 17th Century
2 Mar, 2018 | 02:03h | UTCScientists Aim to Pull Peer Review Out Of The 17th Century – NPR (free)
Related: The Future of Peer Review – Scientific American (free) AND Peer review is a black box. Let’s open it up – STAT News (free) AND Exposing peer review – Research Information (free) AND Researchers debate whether journals should publish signed peer reviews – Science (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free)
Richard Lehman’s journal review – 26 February 2018
2 Mar, 2018 | 01:00h | UTCRichard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Living network meta-analysis compared with pairwise meta-analysis
1 Mar, 2018 | 22:11h | UTC
An Overview of Meta-analysis for Clinicians
1 Mar, 2018 | 22:11h | UTCAn overview of meta-analysis for clinicians – Korean Journal of Internal Medicine (free)
Patient led PROMs must take centre stage in cancer research
1 Mar, 2018 | 22:05h | UTCPatient led PROMs must take centre stage in cancer research – Research Involvement and Engagement (free) (via @RichardLehman1 see Tweet)
Methodological quality and synthesis of case series and case reports
1 Mar, 2018 | 22:03h | UTCMethodological quality and synthesis of case series and case reports – BMJ Evidence-Based Medicine (free)
“Case reports & case series can advance knowledge sometimes: here’s an article on assessing their quality, & evidence synthesis” (via @hildabast see Tweet)
Opinion: Performance-driven culture is ruining scientific research
1 Mar, 2018 | 22:01h | UTCPerformance-driven culture is ruining scientific research – The Guardian (free)
“I was told impact metrics could make or break careers. Instead, they broke my faith in scientific research”.
Data sharing and reanalysis of randomized controlled trials in leading biomedical journals
1 Mar, 2018 | 22:02h | UTC
Reproducibility of clinical research in critical care: a scoping review
27 Feb, 2018 | 16:27h | UTCReproducibility of clinical research in critical care: a scoping review – BMC Medicine (free)
“Reproducibility in Critical Care trials from NEJM, Lancet, JAMA. Bottom line:
-Attempt to reproduce previous findings: 42%
-Original studies reported larger effects
-Inconsistency with the original: 56%” (via @otavio_ranzani see Tweet)
Routinely collected data for randomized trials: promises, barriers, and implications
27 Feb, 2018 | 15:56h | UTCRoutinely collected data for randomized trials: promises, barriers, and implications – Trials (free) (via @RasoiniR see Tweet)
Richard Lehman’s journal reviews – 19 February 2018
22 Feb, 2018 | 23:24h | UTCRichard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
EBM: What is a Guideline?
22 Feb, 2018 | 22:54h | UTCWhat is a Guideline? – Students 4 Best Evidence (free)
Researchers debate whether journals should publish signed peer reviews
22 Feb, 2018 | 22:50h | UTCResearchers debate whether journals should publish signed peer reviews – Science (free)
Source: Global Health NOW Newsletter
EBM: All Fair Comparisons and Outcomes Should be Reported
22 Feb, 2018 | 21:45h | UTCAll fair comparisons and outcomes should be reported – Students 4 Best Evidence (free)
The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles
16 Feb, 2018 | 02:12h | UTCThe state of OA: a large-scale analysis of the prevalence and impact of Open Access articles – PeerJ (free)
Opinion: Heart Stents Are Useless for Most Stable Patients
16 Feb, 2018 | 01:28h | UTCOpinion: Heart Stents Are Useless for Most Stable Patients. They’re Still Widely Used – The New York Times (10 articles per month are free)
Richard Lehman’s journal reviews – 12 February 2018
16 Feb, 2018 | 01:27h | UTCRichard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Big tobacco’s offer: $1 billion for research. Should scientists take it?
15 Feb, 2018 | 11:28h | UTCBig tobacco’s offer: $1 billion for research. Should scientists take it? – Science (free)
How to estimate the effect of treatment duration on survival outcomes using observational data
15 Feb, 2018 | 11:17h | UTCResearch Methods & Reporting: How to estimate the effect of treatment duration on survival outcomes using observational data – The BMJ (free)