Evidence-based Medicine
Perspective: What a Massive Database of Retracted Papers Reveals About Science Publishing’s ‘Death Penalty’
2 Nov, 2018 | 02:46h | UTCRelated: A huge database of scientific retractions is live. That’s great for science. – VOX (free)
The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine
26 Oct, 2018 | 02:06h | UTCPerspective: The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine – TCTMD (free)
Alex Nowbar’s Research Reviews, 22 October 2018
26 Oct, 2018 | 01:47h | UTCAlex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Antidepressant Withdrawal: Reviewing the Paper Behind the Headlines
19 Oct, 2018 | 00:07h | UTCAntidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)
Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)
“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)
Researcher Requests for Inappropriate Analysis and Reporting in a Survey of Consulting Biostatisticians
16 Oct, 2018 | 23:39h | UTCResearcher Requests for Inappropriate Analysis and Reporting: A U.S. Survey of Consulting Biostatisticians – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: When scientists want their data fudged and why you should care – CBC (free)
Perspective: I Hate Guidelines (But They Can Improve, and You Can Help)
16 Oct, 2018 | 23:36h | UTCI hate guidelines (but they can improve, and you can help) – First10EM (free) (via @srrezaie)
Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results
16 Oct, 2018 | 23:20h | UTCMany Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results – Advances in Methods and Practices in Psychological Science (free) (via @f_g_zampieri)
“This is one of most important studies published this century. 29 teams used same data set to address same research question; estimated effect sizes ranged from 0.89 to 2.93 in odds-ratio units. Dramatic implications for observational research.” (via @hmkyale see Tweet)
Ann Robinson’s Research Reviews – 15 October 2018
16 Oct, 2018 | 23:19h | UTCAnn Robinson’s research reviews, 15 October 2018 – The BMJ Opinion (free)
Ann Robinson reviews the latest research from the top medical journals.
Analysis: Treatment Burden Should be Included in Clinical Practice Guidelines
16 Oct, 2018 | 23:13h | UTCTreatment burden should be included in clinical practice guidelines – The BMJ (free for a limited period)
Opinion: Professional Societies Should Abstain From Authorship of Guidelines and Disease Definition Statements
16 Oct, 2018 | 23:12h | UTCCommentaries: Professional Societies, Clinical Specialists, and Guidelines – Circulation: Cardiovascular Quality and Outcomes (free) AND Turn Cardiology Guidelines Over to Outsiders – MedPage Today (free registration required)
John Ioannidis, MD. “questioned whether cardiovascular guidelines “homogenize biased, collective, and organized ignorance” through use of predominantly “insider” experts as authors.” (from MedPage Today)
How to Write a Thorough Peer Review
16 Oct, 2018 | 21:32h | UTCHow to write a thorough peer review – Nature (free)
Perspective: Ghost Authorship Haunts Industry-funded Clinical Trials
11 Oct, 2018 | 21:53h | UTCGhost authorship haunts industry-funded clinical trials – Nature (free)
Original Article: Collaboration Between Academics and Industry in Clinical Trials (free study and commentaries)
Methods Guide: Evidence Synthesis for Health Policy and Systems
11 Oct, 2018 | 21:46h | UTCEvidence synthesis for health policy and systems: a methods guide – World Health Organization (free PDF) (via @trishgreenhalgh)
Zackary Berger’s Journal Reviews – 8 October 2018
11 Oct, 2018 | 21:34h | UTCZackary Berger’s journal reviews, 8 October 2018 – The BMJ Opinion (free)
Zackary Berger reviews the latest research from the top medical journals.
Perspective: What the Tests Don’t Show
11 Oct, 2018 | 20:11h | UTCWhat the tests don’t show – The Washington Post (a few articles per month are free)
“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)
Outcome Reporting Bias in Trials: A Methodological Approach for Assessment and Adjustment in Systematic Reviews
11 Oct, 2018 | 20:02h | UTC
Perspective: When Conventional Wisdom Is Put on Trial
5 Oct, 2018 | 02:40h | UTCWhen Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)
“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”
Study: Collaboration Between Academics and Industry in Clinical Trials
5 Oct, 2018 | 02:37h | UTCCommentaries: Shining a light on industry collaboration – The BMJ Opinion (free) AND Industry funders involved in most aspects of funded trials – OnMedica (free)
Study: Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology
5 Oct, 2018 | 02:26h | UTCEvaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Health-related quality of life overlooked in cancer drug studies – McMaster University (free) AND Investigators Question the Use of PFS as a Surrogate End Point – Cancer Therapy Advisor (free) AND Preventing tumor spread may not improve quality of life – Reuters (free) AND Research: Consider quality of life when evaluating cancer drug studies – UPI (free)
Association is Not Causation: Treatment Effects Cannot be Estimated from Observational Data in Heart Failure
5 Oct, 2018 | 02:05h | UTC
Zackary Berger’s Journal Reviews, 1 October 2018
5 Oct, 2018 | 01:43h | UTCZackary Berger’s journal reviews, 1 October 2018 – The BMJ Opinion (free)
Perspective: More Evidence That Nutrition Studies Don’t Always Add Up
5 Oct, 2018 | 01:30h | UTCMore Evidence That Nutrition Studies Don’t Always Add Up – The New York Times (10 articles per month are free)
Opinion: No More First Authors, no More Last Authors
28 Sep, 2018 | 01:09h | UTCNo more first authors, no more last authors – Nature (free)
“The controversial suggestion that we “blow up” authorship conventions to foster team, collaborative science” (via @EricTopol see Tweet)
Scientific Advocacy and Biases of the Ideological and Industry Kinds
28 Sep, 2018 | 01:07h | UTCScientific Advocacy and Biases of the Ideological and Industry Kinds – Absolutely Maybe Blog (free)
Opinion: STAT’s Cheerleading Coverage of Prescription Fish Oil Capsule Lacks Crucial Context
28 Sep, 2018 | 01:01h | UTCOriginal Commentary: Amarin fish oil capsule shows dramatic benefit for cardiovascular patients, potentially upending market – STAT (free)