Evidence-based Medicine
Study: Textbooks Used to Train Physicians Lack of Conflict of Interest Transparency
24 Jan, 2020 | 08:13h | UTCTextbooks Used to Train Physicians Lack of Conflict of Interest Transparency – MedicalResearch.com (free)
Original Study: A Quantitative and Narrative Evaluation of Goodman and Gilman’s Pharmacological Basis of Therapeutics – Pharmacy (free)
Related: Authors of premier medical textbook didn’t disclose $11 million in industry payments (free commentary) AND Study: Undisclosed Financial Ties Between Guideline Writers and Pharmaceutical Companies (several resources on the subject)
Meta-Analysis: Industry Funding of Patient and Health Consumer Organizations
24 Jan, 2020 | 08:11h | UTCEditorials: Corporate sponsorship of patient groups: It’s time for mandatory disclosure (free for a limited period) AND The prevalence of industry funding of patient groups – BMJ Opinion (free)
Perspective – Childhood Obesity Is a Major Problem. Research Isn’t Helping.
22 Jan, 2020 | 09:20h | UTCChildhood Obesity Is a Major Problem. Research Isn’t Helping. – The New York Times (10 articles per month are free)
“Something is missing with many study methods.”
Synthesis Without Meta-analysis (SWiM) in Systematic Reviews: Reporting Guideline
21 Jan, 2020 | 03:11h | UTCSynthesis without meta-analysis (SWiM) in systematic reviews: reporting guideline – The BMJ (free)
Commentary: Hilary Thomson: Grasping the nettle of narrative synthesis – The BMJ Opinion (free)
Alex Nowbar’s weekly research review—17 January 2020
21 Jan, 2020 | 02:59h | UTCAlex Nowbar’s weekly research review, 17 January 2020 – BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
Perspective: Is Defending Science-Based Medicine Worth It?
21 Jan, 2020 | 01:31h | UTCIs defending science-based medicine worth it? – Science-Based Medicine (free)
Study: Possible Bias in Recent Major Studies with Drugs for Type 2 Diabetes
17 Jan, 2020 | 02:24h | UTCCommentary: Have the Blockbuster Diabetes Drug Trials Been Biased? – Medscape (free registration required)
Four Major Studies in Critical Care to be Presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study
16 Jan, 2020 | 08:59h | UTCFour major results to be presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study – More Info on the Critical Care Reviews Website
Commentary: Clinical trial results in critical care medicine to be unveiled at leading UK conference – EurekAlert (free)
1 – Thursday January 16th (09:00 to 10:30) – 65 Results Presentation Session – https://vimeo.com/383967830
See Study Protocol: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial – Journal of the Intensive Care Society (free)
2 – Thursday January 16th (16:35 to 17:40 – IHME Sepsis Study Results – https://vimeo.com/383968757
3 – Friday January 17th (09:00 to 10:30) – PEPTIC Trial Results Session – https://vimeo.com/383968980
See Study Protocol: A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. – Critical Care and Resuscitation (free PDF)
4 – Friday January 17th (11:00 to 12:30) – VITAMINS Trial Results – https://vimeo.com/383969217
Report: What Researchers Think About the Culture they Work In
16 Jan, 2020 | 08:57h | UTCReport Summary: What researchers think about the culture they work in – Wellcome Trust (free)
Full Report: What researchers think about the culture they work in – Wellcome Trust (free PDF)
Commentary: Researchers facing ‘shocking’ levels of stress, survey reveals – The Guardian (free)
Viewpoint: Incidental Imaging Findings in Clinical Trials
15 Jan, 2020 | 01:08h | UTCIncidental Imaging Findings in Clinical Trials – JAMA (free for a limited period)
Perspective: FDA and NIH Let Clinical Trial Sponsors Keep Results Secret and Break the Law
14 Jan, 2020 | 00:21h | UTCFDA and NIH let clinical trial sponsors keep results secret and break the law – Science (a few articles per month are free)
Related Commentary on Twitter
Shameful lack, non-compliance of reporting of clinical trials by academic medical centershttps://t.co/dmbSeUNJur #openaccess@sciencemagazine by @cpiller
comparison with industry striking pic.twitter.com/5aXMIvjGvQ— Eric Topol (@EricTopol) January 13, 2020
Yes, Size Does Matter! Sample Size Calculations for Randomized Trials
14 Jan, 2020 | 00:06h | UTC
JAMA Guide to Statistics and Methods: Using Propensity Score Methods to Create Target Populations in Observational Clinical Research
12 Jan, 2020 | 21:07h | UTCUsing Propensity Score Methods to Create Target Populations in Observational Clinical Research – JAMA (free for a limited period)
Perspective – Flattening the Hierarchies in Academic Medicine: The Importance of Diversity in Leadership, Contribution, and Thought
9 Jan, 2020 | 23:41h | UTC
‘Evidence-Based Medicine’ and the Expulsion of Peter Gøtzsche
9 Jan, 2020 | 23:40h | UTC‘Evidence-Based Medicine’ and the Expulsion of Peter Gøtzsche – Undark (free)
Related Commentary on Twitter (Thread – Click for more)
Had a chance to read this article about Cochrane and Peter Gotzsche, and, since I care about EBM, have some thoughts
[THREAD] https://t.co/s4J7jUPz5O
— Vinay Prasad (@VPrasadMDMPH) January 1, 2020
Alex Nowbar’s weekly review—8 January 2020
9 Jan, 2020 | 01:23h | UTCAlex Nowbar’s weekly review, 8 January 2020 – The BMJ Opinion (free)
Collection: The Year in Cardiology 2019
8 Jan, 2020 | 08:47h | UTCCollection Homepage: The Year in Cardiology 2019 – European Heart Journal (free articles)
– The Year in Cardiology: Acute Coronary Syndromes
– The Year in Cardiology: Aorta and Peripheral Circulation
– The Year in Cardiology: Arrhythmias and Pacing
– The Year in Cardiology: Imaging
– The Year in Cardiology: Cardiovascular Prevention
– The Year in Cardiology: Interventional Cardiology
– The Year in Cardiology: Valvular Heart Disease
– The Year in Cardiology: Heart Failure
Randomized Trial: Effect of Teaching Bayesian Methods Using Learning by Concept vs Learning by Example on Medical Students’ Ability to Estimate Probability of a Diagnosis
6 Jan, 2020 | 23:15h | UTCInvited Commentary: The Pursuit of Diagnostic Excellence – JAMA Network Open (free)
See also: Concept Teaching Video (free)
The Altmetric TOP 100 Articles of 2019
5 Jan, 2020 | 14:24h | UTCThe Altmetric TOP 100 Articles of 2019
See the 54 articles in the List Related to Medical and Health Sciences
“In the past 12 months, Altmetric has tracked over 62.5 million mentions of 2.7 million research outputs. Here, we’ve highlighted the 100 most-discussed works of 2019 – those that have truly captured the public imagination.”
Related Commentary on Twitter
It’s finally here! Explore the list of the most discussed and shared research of 2019 https://t.co/vfy3LUPCFt #AltmetricTop100 pic.twitter.com/t3zJmC3aiS
— Altmetric (@altmetric) December 17, 2019
Analysis: Doctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It
5 Jan, 2020 | 14:17h | UTCDoctors Prescribe More of a Drug If They Receive Money from a Pharma Company Tied to It – ProPublica (free)
Commentary: We’ve Been Tracking Pharma Payments to Doctors For Nearly A Decade. We Just Made A Big Breakthrough – ProPublica (free)
Working 9 to 5, Not the Way to Make an Academic Living: Observational Analysis of Manuscript and Peer Review Submissions Over Time
5 Jan, 2020 | 13:32h | UTCCommentaries: Study busts 9 to 5 model for academic work – Queensland University of Technology (free) AND There’s No Winter Break From ‘Publish or Perish’ – The New York Times (a few articles per month are free)
Related Commentary on Twitter
The “weekend” is a misnomer for many researchers, concludes this study by @aidybarnett et al, which found that levels of out of hours work were high among researchershttps://t.co/LPQ3HgbQgq
— The BMJ (@bmj_latest) December 29, 2019
Predatory Journals: No Definition, No Defense
12 Dec, 2019 | 08:19h | UTCPredatory journals: no definition, no defence – Nature (free)
Related: Many Academics Eager to Publish in Worthless Journals – The New York Times (10 articles per month are free) AND Predatory Journals Are Such a Big Problem It’s Not Even Funny – HIV and ID Observations (free)
“Leading scholars and publishers from ten countries have agreed a definition of predatory publishing that can protect scholarship. It took 12 hours of discussion, 18 questions and 3 rounds to reach.”
Related Commentary on Twitter
Define what predatory journals actually are in order to combat them. https://t.co/c4e2oCqt89
— Nature News & Comment (@NatureNews) December 11, 2019
Perspective: How Twitter is Changing Medical Research
11 Dec, 2019 | 08:22h | UTCHow Twitter is Changing Medical Research – Nature (free)
Related: Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD (free) AND Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free) AND Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)
“From online journal clubs to ‘tweetorials’ to conference updates, social media is changing the dissemination and discussion of biomedicine.”
BBC Investigation on the Reporting of the EXCEL Trial Raises Concerns Over the Safety of Stents for Left Main Disease in Patients at Low Risk for Surgery
11 Dec, 2019 | 08:19h | UTCSurgeons withdraw support for heart disease advice – BBC (free)
YouTube Video: European guidelines on heart disease under review – BBC Newsnight (free)
See also: EACTS responds to BBC Newsnight’s investigation on the EXCEL trial – European Association for Cardio-Thoracic Surgery (free)
Commentary: EACTS Pulls Out of Left Main Guidelines After BBC Bombshell Alleging EXCEL Trial Cover-up – TCTMD (free)
Related Commentary on Twitter
Wow! Super ???? breaking story!
Reanalysis of EXCEL using Universal Definition of MI would have changed results substantially.
Taggart may be vindicated.
H/t @MedCrisis @drjohnm https://t.co/Yu7qKuiBdV
— Venk Murthy (@venkmurthy) December 9, 2019
Editorial – Cochrane Sustainable Healthcare: Evidence for Action on Too Much Medicine
9 Dec, 2019 | 01:32h | UTCCochrane Sustainable Healthcare: evidence for action on too much medicine – Cochrane Library (free)
News Release: Launch of new Cochrane Sustainable Healthcare Field – Cochrane Library (free)
See Website: Cochrane Sustainable Healthcare (free)
Related Commentary on Twitter
Cochrane Sustainable Healthcare: evidence for action on too much medicine https://t.co/w2vIv67sUN Less is more: @CochraneLibrary editorial on reducing unnecessary tests & treatment and launch of @Cochrane_SH pic.twitter.com/5sqyXm6My4
— The Cochrane Library (@CochraneLibrary) December 7, 2019