Evidence-based Medicine
Opinion | A strategy to reduce the carbon footprint of clinical trials.
24 Jun, 2021 | 09:45h | UTCA strategy to reduce the carbon footprint of clinical trials – The Lancet
Interactive Infographic | Interpreting a lateral flow SARS-CoV-2 antigen test – “This calculator demonstrates how interpreting a covid-19 lateral flow device (LFD) result varies according to the pre-test probability, and the sensitivity and specificity of the LFD used”.
23 Jun, 2021 | 10:29h | UTCInterpreting a lateral flow SARS-CoV-2 antigen test – The BMJ
Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”.
22 Jun, 2021 | 10:08h | UTCIvermectin is the new hydroxychloroquine, take 2 – Science-Based Medicine
Related: [Preprint] Meta-analysis of RCT: Ivermectin for the treatment of COVID-19 – no effect on all-cause mortality, length of stay, or viral clearance AND M-A: Prophylaxis against Covid-19: 1 – no benefit from Hydroxychloroquine; 2 – as studies on ivermectin so far have been small, it remains very uncertain whether ivermectin reduces SARS-CoV-2 infection AND Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials AND EMA advises against use of ivermectin for the prevention or treatment of COVID-19 outside randomized clinical trials AND FDA: Why you should not use Ivermectin to treat or prevent COVID-19 AND RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19 AND NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19” AND Video (5min): Ivermectin for COVID-19 | A Doctor Explains
Guidelines for reporting trial protocols and completed trials modified due to the COVID-19 pandemic and other extenuating circumstances: The CONSERVE 2021 Statement.
22 Jun, 2021 | 10:04h | UTC
Commentaries on Twitter
CONSERVE offers guidance that could help improve the transparency, quality, and completeness of reporting important modifications to trials in extenuating circumstances https://t.co/IiWgs7dtpQ
— JAMA (@JAMA_current) June 21, 2021
https://twitter.com/DrSherryPagoto/status/1407102563191824384
Concerned about the latest AstraZeneca news? These 3 graphics help you make sense of the risk – “Two people in Australia have died from thrombosis with thrombocytopenia after 3.8 million doses of the AstraZeneca vaccine delivered”.
21 Jun, 2021 | 08:48h | UTC
Opinion | Causation or confounding: why controls are critical for characterizing long COVID – “Many of the self-reported symptoms, such as intermittent headaches or tiredness, are nonspecific and prevalent in the general population”.
18 Jun, 2021 | 08:29h | UTCCausation or confounding: why controls are critical for characterizing long COVID – Nature
Study commentary: a history of hypothermia for cardiac arrest, 2002-2021 (RIP).
18 Jun, 2021 | 08:20h | UTCA history of hypothermia for cardiac arrest, 2002-2021 (RIP) – PulmCrit
Original study: RCT: In patients with coma after out-of-hospital cardiac arrest, targeted hypothermia did not improve outcomes.
Commentary on Twitter
A history of hypothermia for cardiac arrest, 2002-2021 (RIP)🪦
🥶2002 studies supporting hypothermia were weak
🥶robust studies refute benefit (TTM1 & TTM2)
🥶growing evidence of iatrogenic harm
🥶post-arrest hypothermia should be restricted to within RCTshttps://t.co/GZbpgHXWoD pic.twitter.com/ILUAiqqLQl— 𝙟𝙤𝙨𝙝 𝙛𝙖𝙧𝙠𝙖𝙨 💊 (@PulmCrit) June 17, 2021
The authorship rows that sour scientific collaborations.
17 Jun, 2021 | 09:34h | UTCThe authorship rows that sour scientific collaborations – Nature
Opinion | The future of pandemic preparedness: agile coordination around clinical trials.
11 Jun, 2021 | 08:27h | UTCThe future of pandemic preparedness: agile coordination around clinical trials – STAT
Perspective | How COVID changed science.
9 Jun, 2021 | 08:24h | UTCHow COVID Changed Science – Scientific American
Opinion | Scientific publishing’s new weapon for the next crisis: the rapid correction.
9 Jun, 2021 | 08:14h | UTCScientific publishing’s new weapon for the next crisis: the rapid correction – STAT
FDA approvement of Alzheimer’s drug sparks controversy among doctors.
9 Jun, 2021 | 08:18h | UTCNews release: FDA Grants Accelerated Approval for Alzheimer’s Drug – U.S. Food & Drug Administration
Commentaries: ICER Issues Statement on the FDA’s Approval of Aducanumab for Alzheimer’s Disease – Institute for Clinical and Economic Review AND Landmark Alzheimer’s Drug Approval Confounds Research Community – Nature AND FDA approves Alzheimer’s drug from Biogen, against experts’ advice – NBC News AND F.D.A. Approves Alzheimer’s Drug Despite Fierce Debate Over Whether It Works – The New York Times (a few articles per month are free) AND Alzheimer’s drug approved despite doubts about effectiveness – Science (a few articles per month are free) AND The FDA Has Approved A New Alzheimer’s Drug — Here’s Why That’s Controversial – NPR AND Opinion: Bad medicine: aducanumab is a lackluster drug with a high price tag – STAT
JAMA editor-in-chief stepping down after backlash from podcast that questioned racism in medicine.
2 Jun, 2021 | 08:28h | UTCSee also: JAMA editor in chief steps down over tweet that questioned racism in medicine – MarketWatch AND The Editor Of A Top Medical Journal Is Leaving After The Publication Said “No Physician Is Racist” – Buzzfeed News
JAMA Editorial: To Howard Bauchner, MD, Visionary Editor in Chief of JAMA—A Sincere Thank You and a Fond Farewell
Opinion | The Covid-19 lab leak theory is a tale of weaponized uncertainty.
31 May, 2021 | 08:19h | UTCThe Covid-19 Lab Leak Theory Is a Tale of Weaponized Uncertainty – Wired
See also: Divisive COVID ‘lab leak’ debate prompts dire warnings from researchers – Nature
Academic bullying is too often ignored. Here are some targets’ stories.
31 May, 2021 | 07:59h | UTCAcademic bullying is too often ignored. Here are some targets’ stories – Science (a few articles per month are free)
Living systematic review: The evidence is insufficient to determine the benefits and harms of vitamin D supplementation as a treatment of COVID‐19.
25 May, 2021 | 08:55h | UTCSummary: Is vitamin D an effective and safe treatment for COVID-19? – Cochrane Library
Using resources wisely in the COVID-19 pandemic: an international list of Choosing Wisely recommendations.
24 May, 2021 | 08:36h | UTC
#ACC21 – Lessons from the ACC 2021 Meeting.
24 May, 2021 | 08:29h | UTCLessons from the ACC 2021 Meeting – by John Mandrola, MD
Nonreplicable publications are cited more than replicable ones
24 May, 2021 | 08:15h | UTCNonreplicable publications are cited more than replicable ones – Science Advances
Commentary on Twitter
Not only does misinformation flow at considerably higher velocity across the Internet than truth, but science publications without replication are cited much more than those which are replicated
New @ScienceAdvances https://t.co/aNSKyv1alq @UriGneezy @m_serra_garcia pic.twitter.com/eWWc0NZwgi— Eric Topol (@EricTopol) May 21, 2021
COVID vaccines: the danger of journals being seen as substitute regulators – “the peer-review process is not adequate to evaluate a new vaccine in the way that a regulator can”.
20 May, 2021 | 08:51h | UTCCOVID vaccines: the danger of journals being seen as substitute regulators – The Conversation
Related: Covid-19: Sputnik vaccine rockets, thanks to Lancet boost
Editorial: Vaccinating children against SARS-CoV-2 – “Hard to justify right now for most children in most countries”.
14 May, 2021 | 08:39h | UTCVaccinating children against SARS-CoV-2 – The BMJ
Related: Pfizer COVID-19 shot expanded to US children as young as 12.
Large trial with over 200.000 patients finds ovarian cancer screening does not reduce deaths.
14 May, 2021 | 08:32h | UTCCommentaries: Screening for ovarian cancer did not reduce early deaths – Imperial College London AND Annual screening for ovarian cancer does not save lives, study finds – The Guardian
Perspective | How COVID broke the evidence pipeline
13 May, 2021 | 06:01h | UTCHow COVID broke the evidence pipeline – Nature
Editorial: Evidence-based medicine: how COVID can drive positive change – Nature
Related: Scientists say the rush to do Covid research led to a whole lot of waste
Commentary on Twitter
The weak pursuit of evidence-based medicine during the pandemic.
Thankfully, the #RECOVERY and #SOLIDARITY collaborative trial groups led the way in rapidly accumulating pivotal data asking the right questions with large sample size https://t.co/aSAhQvq5dz @hcpearson @nature pic.twitter.com/iM956krq0Q— Eric Topol (@EricTopol) May 12, 2021
Pfizer COVID-19 shot expanded to US children as young as 12.
12 May, 2021 | 08:53h | UTCPfizer COVID-19 shot expanded to US children as young as 12 – Associated Press
Counterpoint: Covid vaccines for children should not get emergency use authorization – The BMJ Opinion
Commentaries: Covid-19: FDA authorises Pfizer vaccine for children 12-15 – The BMJ AND Expert reaction to U.S. FDA authorising Pfizer-BioNTech COVID-19 vaccine for emergency use in adolescents – Science Media Centre
Science, Medicine, And The Anesthesiologist | May 2021: Key Papers from the Most Recent Literature Relevant to Anesthesiologists
11 May, 2021 | 09:05h | UTCScience, Medicine, And The Anesthesiologist | May 2021 – Anesthesiology