Endocrinology (all articles)
How to rein in the widening disease definitions that label more healthy people as sick
17 May, 2017 | 20:19h | UTCViewpoint: How to rein in the widening disease definitions that label more healthy people as sick – The Conversation (free)
Menopausal Hormone Therapy for Prevention of Chronic Conditions
17 May, 2017 | 20:18h | UTCDraft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)
Source: USPSTF Recommendation Against HRT for Chronic Conditions Stands – Medscape (free registration required)
“The USPSTF recommends against the use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women”.
Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs
16 May, 2017 | 20:07h | UTCSource: Review: Sulfonylureas are associated with overall mortality and CV events vs other antihyperglycemics – ACP Diabetes Monthly (free)
Prevalence of Elevated Cardiovascular Risks in Young Adults
16 May, 2017 | 20:06h | UTCPrevalence of Elevated Cardiovascular Risks in Young Adults: A Cross-sectional Analysis of National Health and Nutrition Examination Surveys – Annals of Internal Medicine (link to abstract – $ for full-text)
Source: Study Assesses ASCVD Risk in Non-Diabetic Adults – American College of Cardiology, Latest in Cardiology (free)
In the absence of diabetes, smoking or hypertension, most adult men younger than 40 years and adult women younger than 50 years are at low risk of cardiovascular disease (defined as < 5% in 10 years, usually not eligible for statin therapy) and may not benefit from cholesterol screening.
Treatment Deintensification Is Uncommon in Adults With Type 2 Diabetes Mellitus
15 May, 2017 | 19:43h | UTCTreatment Deintensification Is Uncommon in Adults With Type 2 Diabetes Mellitus: A Retrospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (link to abstract – $ for full-text)
Source: Treatment deintensification uncommon in type 2 diabetes – ACP Internist (free)
Editorial: Diabetes Mellitus Treatment Deintensification: When Well-Controlled Diabetes Mellitus Becomes Overcontrolled (free)
Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality
10 May, 2017 | 18:27h | UTCMeta-analysis: Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies – European Journal of Epidemiology (free)
Source: Eating cheese does not raise risk of heart attack or stroke, study finds – The Guardian (free)
Dairy seems to be neutral regarding risks of cardiovascular diseases and all-cause mortality.
Mortality from different causes associated with meat, heme iron, nitrates, and nitrites
10 May, 2017 | 18:28h | UTCMeta-analysis: Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study – The BMJ (free)
High intakes of red and processed meat are associated with increased risks of all-cause mortality and death due to nine different causes.
Type 2 diabetes in adults: management – NICE Guideline
9 May, 2017 | 20:44h | UTC
Weight management programmes of extended duration
5 May, 2017 | 20:22h | UTCRandomized controlled trial: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free)
Invited commentary: Weight management programmes of extended duration – The Lancet (free)
Commentary: Give overweight patients a year of weight-loss classes, say researchers – The Guardian (free)
In this trial with 1,267 overweight or obese participants an extended weight loss program (1 year) was more effective for weight loss and seems cost-effective in the longer term.
Alternate-day fasting does not seem to lead to greater weight loss
3 May, 2017 | 17:26h | UTCCommentaries: Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It – NPR Health News (free) AND Fasting Every Other Day Does Not Lead to Greater Weight Loss – Physician’s First Watch (free) AND Same Weight Loss With Alternate-Day Fasting vs Cutting Calories – Medscape (free registration required) AND Alternate-Day Fasting Doesn’t Lead to Speedier Weight Loss – MedPage Today (free registration required)
Randomized trial with 100 patients showed no difference in weight loss between alternate-day fasting versus calorie restriction.
PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library
3 May, 2017 | 17:28h | UTCSystematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))
The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.
UK guideline for the prevention and treatment of osteoporosis
1 May, 2017 | 16:50h | UTCUK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)
Normal-Weight Central Obesity and Risk for Mortality
28 Apr, 2017 | 16:38h | UTCNormal-Weight Central Obesity and Risk for Mortality – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Waist circumference stronger predictor of death risk than BMI – Haelio (free) AND Forget Your BMI and Focus on This Measurement Instead – TIME (free) AND Central Obesity Ups Mortality Across BMI Range – Physician’s Briefing (free) AND Central obesity may increase mortality risk from cardiovascular disease – Cardiovascular Business (free) AND People with a normal BMI who carry weight around the middle at greatest risk of death – HealthCanal (free)
Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease
27 Apr, 2017 | 16:29h | UTCGuidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease – American Association Of Clinical Endocrinologists And American College Of Endocrinology (free PDF) (RT @greg_folkers)
Prevention and Management of Cardiovascular Disease Risk in Primary Care
26 Apr, 2017 | 16:09h | UTCUpdated Guideline: Prevention and Management of Cardiovascular Disease Risk in Primary Care – Toward Optimized Practice (TOP) Guidelines (free)
Practical guideline for primary care providers.
Hormone Therapy in Primary Ovarian Insufficiency
25 Apr, 2017 | 15:47h | UTCCommittee Opinion: Hormone Therapy in Primary Ovarian Insufficiency – American College of Obstetricians and Gynecologists (free)
Source: Group Offers Guidance on Treating Primary Ovarian Insufficiency with Hormone Therapy – Physician’s First Watch (free)
Effect of Weight Reduction on Hemoglobin A1c
24 Apr, 2017 | 15:27h | UTCSystematic review: Effect of Weight Reduction on Hemoglobin A1c in weight loss trials of Type 2 Diabetes Patients – Diabetes, Obesity and Metabolism (link to abstract – $ for full-text)
“Each 1kg reduction in weight loss trials associated with 0.1% reduction in HbA1c” (RT @kamleshkhunti see Tweet)
Association between active commuting and incident cardiovascular disease, cancer, and mortality
21 Apr, 2017 | 15:19h | UTCEditorial: Active commuting is beneficial for health (free)
See also: Cycling to work can cut cancer and heart disease, says study – BBC News (free) AND Cycling to work: major new study suggests health benefits are staggering – The Conversation (free)
Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes
21 Apr, 2017 | 15:22h | UTCFrequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
See also: Researchers Propose Extending Diabetic Retinopathy Screening Interval – Physician’s First Watch (free) AND Research from long-term study advocates individualized eye screenings in type 1 diabetes – Diabetes.co.uk (free)
In patients who have had type 1 diabetes for 5 years, annual retinal examinations are currently recommended. Based on their findings, the authors suggest an individualized screening schedule, with less frequent screening for patients at low risk and more frequent screening for patients at higher risk, leading to decreased cost without delaying the diagnosis of clinically significant disease.
ACC/AHA vs. USPSTF statin guidelines
19 Apr, 2017 | 14:11h | UTCComparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines – JAMA (link to abstract – $ for full-text)
See also: ACC/AHA vs. USPSTF statin guidelines – Cardiology News (free)
Although recommended by most guidelines for individuals at high risk, there is still some controversy over prescribing statins for primary prevention and over what patients benefit the most – see related commentary: Cholesterol-lowering statin therapy for healthy people is not as simple as ‘yes’ or ‘no’ – The Pharmaceutical Journal (free)
Adherence to the 2016 USPSTF recommendations for statin therapy, compared with the 2013 ACC/AHA guidelines, could lead to a lower number of individuals (an estimated difference of 9.3 million individuals in the U.S. population) recommended for primary prevention statin therapy.
Insulin pump didn’t improve glycemic control compared to training on injections
18 Apr, 2017 | 13:58h | UTCSee also: Insulin pump didn’t improve glycemic control compared to training on injections – ACP Diabetes Monthly (free)
Amsterdam’s solution to the obesity crisis: no fruit juice and enough sleep
17 Apr, 2017 | 13:55h | UTCAmsterdam’s solution to the obesity crisis: no fruit juice and enough sleep – The Guardian (free) (RT @DrAseemMalhotra see Tweet)
“The city is successfully fighting fat by promoting tap water in its schools, along with healthy cooking classes and a ban on fast food sponsorship”
Banning trans fats in New York prevented thousands of heart attacks
13 Apr, 2017 | 16:08h | UTCHospital Admissions for Myocardial Infarction and Stroke Before and After the Trans-Fatty Acid Restrictions in New York – JAMA Cardiology (link to abstract – $ for full-text)
Sources: Banning trans fats in New York prevented thousands of heart attacks, study finds – STAT News (free) AND Trans Fat Bans Tied to Fewer Heart Attacks and Strokes – The New York Times (10 articles per month are free)
Other localities might consider doing the same as well.
Screening for Endocrine Hypertension
14 Apr, 2017 | 16:27h | UTCScreening for Endocrine Hypertension: An Endocrine Society Scientific Statement (free)
Source: Screen for Endocrine Hypertension, Endocrine Society Says – Medscape (free registration required)
“The statement provides guidance on screening for 15 hormonal disorders that present with hypertension and that can be potentially cured with surgery or treated with medication” (from Medscape commentary above).
Why Are So Many People Popping Vitamin D?
11 Apr, 2017 | 15:47h | UTCWhy Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)
“Labs performing these tests are reporting perfectly normal levels of vitamin D — 20 to 30 nanograms per milliliter of blood — as “insufficient.” As a consequence, millions of healthy people think they have a deficiency”
Note: Some organizations still think appropriate levels would be above 30 nanograms per milliliter of blood, more details in the text.