Endocrinology (all articles)
Risk of major congenital malformations in relation to maternal overweight and obesity severity
16 Jun, 2017 | 00:55h | UTCCommentaries: Risks of major birth defects greater if mother is overweight – OnMedica (free) AND Obese women more likely to have babies with serious birth defects, says study – The Guardian (free)
Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes
14 Jun, 2017 | 00:43h | UTCCommentary: CANVAS: Canagliflozin Reduces CV Events, but at Cost of Amputations – Medscape (free registration required)
Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation and fractures. The benefits and harms were likely small. See interesting commentaries on the trade-offs by @AnilMakam, see Tweet 1; Tweet 2; Tweet 3; Tweet 4; Tweet 5; Tweet 6; Tweet 7; Tweet 8; and Tweet 9.
Health Effects of Overweight and Obesity in 195 Countries over 25 Years
13 Jun, 2017 | 20:06h | UTCEditorial: Global Health Effects of Overweight and Obesity (free)
Commentaries: New study finds more than 2 billion people overweight or obese – Institute for Health Metrics and Evaluation (free) AND More Than 10 Percent of World’s Population Is Obese, Study Finds – The New York Times (free) AND Being overweight – not just obese – kills millions a year, say experts – The Guardian (free)
“High BMI accounted for 4.0 million deaths globally, nearly 40% of which occurred in persons who were not obese”
Is the finger-stick blood test necessary for type 2 diabetes treatment?
12 Jun, 2017 | 19:58h | UTCEditorial: The Need to Test Strategies Based on Common Sense (free)
The JAMA Network – For the Media: Home Monitoring of Blood Sugar Did Not Improve Glycemic Control After 1 Year (free)
Commentary: Is the finger-stick blood test necessary for type 2 diabetes treatment? – University of North Carolina Health Care, via EurekAlert(free)
Related: Self-Monitoring of Blood Glucose – Canadian Agency for Drugs and Technologies in Health (free)
“Another RCT showing no benefit for Glucose Self-monitoring in Non–Insulin-Treated Patients with Type 2 Diabetes” (RT @PaulGlasziou see Tweet)
Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors?
12 Jun, 2017 | 19:52h | UTCCommentaries: Risk of HF and Death in Patients on SGLT-2 Inhibitors – American College of Cardiology, Latest in Cardiology (free) AND SGLT2 inhibitors may have class effect for reduction of cardiac risk – ACP Diabetes Monthly (free)
Observational data suggests these class of drugs may be associated with lower risk of heart failure and deaths compared to other drugs.
Canagliflozin will receive new boxed warning about amputation risks
12 Jun, 2017 | 19:51h | UTCCanagliflozin will receive new boxed warning about amputation risks – ACP Internist (free)
FDA Drug Safety Communication: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) (free)
Prevention and Treatment of Glucocorticoid-Induced Osteoporosis
9 Jun, 2017 | 16:04h | UTCCommentary: ACR Releases Guideline on prevention & treatment of glucocorticoid-induced osteoporosis – American College of Rheumatology, via EurekAlert (free)
Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor
9 Jun, 2017 | 16:02h | UTCCommentaries: Study Warns of Diabetic Ketoacidosis With SGLT2 Inhibitors in T2D – MedPage Today (free registration required) AND SGLT2 Inhibitors Double the Risk for Diabetic Ketoacidosis – Medscape (free registration required) AND New class of type 2 diabetes drug associated with rare, life-threatening outcome – Brigham and Women’s Hospital, Via EurekAlert (free)
Related: SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System – Diabetologia (link to abstract – $ for full-text)
Serum uric acid levels and multiple health outcomes
8 Jun, 2017 | 15:57h | UTCObservational studies suggest that high serum uric acid levels are associated with multiple health outcomes, including cardiovascular and metabolic diseases. This review findings suggest there is a clear association only for gout and nephrolithiasis.
Prebiotic for Overweight or Obesity Children?
7 Jun, 2017 | 15:03h | UTCPrebiotic Reduces Body Fat and Alters Intestinal Microbiota in Children With Overweight or Obesity (free PDF)
Commentary: Prebiotics reduce body fat in overweight children – American Gastroenterological Association, via EurekAlert (free)
Small randomized trial (42 patients) suggests prebiotics might be useful for overweight and obese children.
Television in the bedroom and body fatness
4 Jun, 2017 | 19:17h | UTCCommentaries: TVs in the bedroom linked to childhood obesity, study finds – The Guardian (free) AND TVs in children’s bedrooms ‘increase risk of obesity’ – BBC News (free)
DASH diet and risk of gout
4 Jun, 2017 | 18:44h | UTCSee also: DASH Diet May Reduce Gout Risk – Medscape (free registration required)
Metformin is linked to reduced mortality in type 2 diabetes with comorbid CKD and CHF
4 Jun, 2017 | 18:43h | UTC
Diabetes – Injection and Infusion Technique Recommendations
1 Jun, 2017 | 18:31h | UTCCommentary: New Guidance Focuses on Best Injection Practices for Diabetes – Medscape (free registration required)
Related guideline: New Insulin Delivery Recommendations – Mayo Clinic Proceedings (free)
Current guidelines on prevention with a focus on dyslipidemias
30 May, 2017 | 15:33h | UTCReview: Current guidelines on prevention with a focus on dyslipidemias – Cardiovascular Diagnosis & Therapy (free)
Review comparing current recommendations for the treatment of dyslipidemia.
Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk
30 May, 2017 | 15:27h | UTCComparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe – British Journal of Cancer (free)
Commentaries: Why your waist measurement can predict cancer risk – The Guardian (free) AND Large Waist Raises Cancer Risk – Medscape (free registration required)
The Weight Loss Trap: Why Your Diet Isn’t Working
29 May, 2017 | 15:23h | UTCThe Weight Loss Trap: Why Your Diet Isn’t Working – Time (cover story) (free)
“The challenges of weight loss and obesity – really well addressed” (RT @EricTopol see Tweet)
Type 2 diabetes in adults: management – NICE Guideline
29 May, 2017 | 15:24h | UTCType 2 diabetes in adults: management – NICE Guideline (free)
See also: Algorithm for blood glucose lowering therapy in adults with type 2 diabetes (free PDF)
Source: UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance – Medscape (free registration required)
Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease
25 May, 2017 | 14:55h | UTCRecommended: New QRISK-3 2017 Calculator (free)
QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.
Eating disorders: recognition and treatment
26 May, 2017 | 15:03h | UTCEating disorders: recognition and treatment – NICE Guideline (free)
The lap band for weight loss is a tale of medicine gone wrong
25 May, 2017 | 15:02h | UTCThe lap band for weight loss is a tale of medicine gone wrong – VOX (free)
See also a recent study showing high complication rates of laparoscopic gastric band surgeries in our May 23rd issue (see #7)
Trans-fat – The Worst Fat in the Food Supply
24 May, 2017 | 14:36h | UTCThe Worst Fat in the Food Supply – The New York Times (10 articles per month are free)
See also a recent study and commentaries on the effects of trans-fat bans in our April 23rd issue (see #1)
Trans-fat bans seem to be reducing cardiovascular deaths.
Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults
23 May, 2017 | 14:32h | UTCEffect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)
Editorial: Risks of Statin Therapy in Older Adults (free)
Commentaries: Older adults may not benefit from taking statins to prevent heart disease – Medical News Today (free) AND Pravastatin Doesn’t Improve Clinical Outcomes in Seniors – Physician’s First Watch (free)
Patients > 65 years with moderate hyperlipidemia and hypertension had no benefit from pravastatin for primary prevention. “A nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older” (HR 1.34; 95% CI, 0.98-1.84; P = .07).
Reoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery
23 May, 2017 | 14:25h | UTCReoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Following gastric band surgery, device-related reoperation common, costly – Science Daily (free) AND Safety, Effectiveness of Gastric Banding Called Into Question – Medscape (free registration required) AND 1 In 5 Gastric Band Surgeries Require Corrective Operations – American Council on Science and Health (free)
Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults
19 May, 2017 | 17:52h | UTCAerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Exercise and Dieting in Obese Older Adults (free)
Commentary: Aerobic Plus Resistance Exercise Best for Obese Older Adults – MedPage Today (free)