Endocrinology (all articles)
Type 2 diabetes in adults: management – NICE Guideline
29 May, 2017 | 15:24h | UTCType 2 diabetes in adults: management – NICE Guideline (free)
See also: Algorithm for blood glucose lowering therapy in adults with type 2 diabetes (free PDF)
Source: UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance – Medscape (free registration required)
Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease
25 May, 2017 | 14:55h | UTCRecommended: New QRISK-3 2017 Calculator (free)
QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.
Eating disorders: recognition and treatment
26 May, 2017 | 15:03h | UTCEating disorders: recognition and treatment – NICE Guideline (free)
The lap band for weight loss is a tale of medicine gone wrong
25 May, 2017 | 15:02h | UTCThe lap band for weight loss is a tale of medicine gone wrong – VOX (free)
See also a recent study showing high complication rates of laparoscopic gastric band surgeries in our May 23rd issue (see #7)
Trans-fat – The Worst Fat in the Food Supply
24 May, 2017 | 14:36h | UTCThe Worst Fat in the Food Supply – The New York Times (10 articles per month are free)
See also a recent study and commentaries on the effects of trans-fat bans in our April 23rd issue (see #1)
Trans-fat bans seem to be reducing cardiovascular deaths.
Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults
23 May, 2017 | 14:32h | UTCEffect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)
Editorial: Risks of Statin Therapy in Older Adults (free)
Commentaries: Older adults may not benefit from taking statins to prevent heart disease – Medical News Today (free) AND Pravastatin Doesn’t Improve Clinical Outcomes in Seniors – Physician’s First Watch (free)
Patients > 65 years with moderate hyperlipidemia and hypertension had no benefit from pravastatin for primary prevention. “A nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older” (HR 1.34; 95% CI, 0.98-1.84; P = .07).
Reoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery
23 May, 2017 | 14:25h | UTCReoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Following gastric band surgery, device-related reoperation common, costly – Science Daily (free) AND Safety, Effectiveness of Gastric Banding Called Into Question – Medscape (free registration required) AND 1 In 5 Gastric Band Surgeries Require Corrective Operations – American Council on Science and Health (free)
Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults
19 May, 2017 | 17:52h | UTCAerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Exercise and Dieting in Obese Older Adults (free)
Commentary: Aerobic Plus Resistance Exercise Best for Obese Older Adults – MedPage Today (free)
How to rein in the widening disease definitions that label more healthy people as sick
17 May, 2017 | 20:19h | UTCViewpoint: How to rein in the widening disease definitions that label more healthy people as sick – The Conversation (free)
Menopausal Hormone Therapy for Prevention of Chronic Conditions
17 May, 2017 | 20:18h | UTCDraft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)
Source: USPSTF Recommendation Against HRT for Chronic Conditions Stands – Medscape (free registration required)
“The USPSTF recommends against the use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women”.
Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs
16 May, 2017 | 20:07h | UTCSource: Review: Sulfonylureas are associated with overall mortality and CV events vs other antihyperglycemics – ACP Diabetes Monthly (free)
Prevalence of Elevated Cardiovascular Risks in Young Adults
16 May, 2017 | 20:06h | UTCPrevalence of Elevated Cardiovascular Risks in Young Adults: A Cross-sectional Analysis of National Health and Nutrition Examination Surveys – Annals of Internal Medicine (link to abstract – $ for full-text)
Source: Study Assesses ASCVD Risk in Non-Diabetic Adults – American College of Cardiology, Latest in Cardiology (free)
In the absence of diabetes, smoking or hypertension, most adult men younger than 40 years and adult women younger than 50 years are at low risk of cardiovascular disease (defined as < 5% in 10 years, usually not eligible for statin therapy) and may not benefit from cholesterol screening.
Treatment Deintensification Is Uncommon in Adults With Type 2 Diabetes Mellitus
15 May, 2017 | 19:43h | UTCTreatment Deintensification Is Uncommon in Adults With Type 2 Diabetes Mellitus: A Retrospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (link to abstract – $ for full-text)
Source: Treatment deintensification uncommon in type 2 diabetes – ACP Internist (free)
Editorial: Diabetes Mellitus Treatment Deintensification: When Well-Controlled Diabetes Mellitus Becomes Overcontrolled (free)
Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality
10 May, 2017 | 18:27h | UTCMeta-analysis: Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies – European Journal of Epidemiology (free)
Source: Eating cheese does not raise risk of heart attack or stroke, study finds – The Guardian (free)
Dairy seems to be neutral regarding risks of cardiovascular diseases and all-cause mortality.
Mortality from different causes associated with meat, heme iron, nitrates, and nitrites
10 May, 2017 | 18:28h | UTCMeta-analysis: Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study – The BMJ (free)
High intakes of red and processed meat are associated with increased risks of all-cause mortality and death due to nine different causes.
Type 2 diabetes in adults: management – NICE Guideline
9 May, 2017 | 20:44h | UTC
Weight management programmes of extended duration
5 May, 2017 | 20:22h | UTCRandomized controlled trial: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free)
Invited commentary: Weight management programmes of extended duration – The Lancet (free)
Commentary: Give overweight patients a year of weight-loss classes, say researchers – The Guardian (free)
In this trial with 1,267 overweight or obese participants an extended weight loss program (1 year) was more effective for weight loss and seems cost-effective in the longer term.
Alternate-day fasting does not seem to lead to greater weight loss
3 May, 2017 | 17:26h | UTCCommentaries: Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It – NPR Health News (free) AND Fasting Every Other Day Does Not Lead to Greater Weight Loss – Physician’s First Watch (free) AND Same Weight Loss With Alternate-Day Fasting vs Cutting Calories – Medscape (free registration required) AND Alternate-Day Fasting Doesn’t Lead to Speedier Weight Loss – MedPage Today (free registration required)
Randomized trial with 100 patients showed no difference in weight loss between alternate-day fasting versus calorie restriction.
PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library
3 May, 2017 | 17:28h | UTCSystematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))
The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.
UK guideline for the prevention and treatment of osteoporosis
1 May, 2017 | 16:50h | UTCUK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)
Normal-Weight Central Obesity and Risk for Mortality
28 Apr, 2017 | 16:38h | UTCNormal-Weight Central Obesity and Risk for Mortality – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Waist circumference stronger predictor of death risk than BMI – Haelio (free) AND Forget Your BMI and Focus on This Measurement Instead – TIME (free) AND Central Obesity Ups Mortality Across BMI Range – Physician’s Briefing (free) AND Central obesity may increase mortality risk from cardiovascular disease – Cardiovascular Business (free) AND People with a normal BMI who carry weight around the middle at greatest risk of death – HealthCanal (free)
Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease
27 Apr, 2017 | 16:29h | UTCGuidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease – American Association Of Clinical Endocrinologists And American College Of Endocrinology (free PDF) (RT @greg_folkers)
Prevention and Management of Cardiovascular Disease Risk in Primary Care
26 Apr, 2017 | 16:09h | UTCUpdated Guideline: Prevention and Management of Cardiovascular Disease Risk in Primary Care – Toward Optimized Practice (TOP) Guidelines (free)
Practical guideline for primary care providers.
Hormone Therapy in Primary Ovarian Insufficiency
25 Apr, 2017 | 15:47h | UTCCommittee Opinion: Hormone Therapy in Primary Ovarian Insufficiency – American College of Obstetricians and Gynecologists (free)
Source: Group Offers Guidance on Treating Primary Ovarian Insufficiency with Hormone Therapy – Physician’s First Watch (free)
Effect of Weight Reduction on Hemoglobin A1c
24 Apr, 2017 | 15:27h | UTCSystematic review: Effect of Weight Reduction on Hemoglobin A1c in weight loss trials of Type 2 Diabetes Patients – Diabetes, Obesity and Metabolism (link to abstract – $ for full-text)
“Each 1kg reduction in weight loss trials associated with 0.1% reduction in HbA1c” (RT @kamleshkhunti see Tweet)