Endocrinology (all articles)
Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019
22 Feb, 2023 | 12:17h | UTC
Review | Diagnosis and management of patients with polyneuropathy
21 Feb, 2023 | 11:40h | UTCDiagnosis and management of patients with polyneuropathy – Canadian Medical Association Journal
RCT | Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease
20 Feb, 2023 | 12:27h | UTCSummary: The article reports on a randomized trial that compared the effects of alternate-day fasting (ADF) combined with exercise, fasting alone, or exercise alone in adults with obesity and non-alcoholic fatty liver disease (NAFLD). After three months, the combination of ADF and exercise significantly reduced intrahepatic triglyceride content, body weight, fat mass, waist circumference, and alanine transaminase levels compared to the control group. The intervention seems promising for patients with fatty liver disease who want to improve their health without using medications.
Article: Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial – Cell Metabolism (link to abstract – $ for full-text)
News Release: Alternate-day fasting could be a good option for patients with fatty liver disease – University of Illinois Chicago
M-A | Consumption of whole vs. refined grains and risk of cardiovascular disease and all-cause mortality
20 Feb, 2023 | 12:23h | UTCSummary: This systematic review and meta-analysis of prospective cohort studies found that consuming whole grains was associated with a reduced risk of coronary heart disease, cardiovascular disease, and all-cause mortality, while consuming refined grains had no significant influence on these outcomes. Residual confounding can’t be excluded and the association found does not necessarily imply causation.
M-A | Soluble fiber supplementation and serum lipid profile
20 Feb, 2023 | 12:18h | UTCSummary: The article presents the results of a systematic review and dose-response meta-analysis of randomized controlled trials (RCTs) that evaluated the effect of soluble fiber supplementation on blood lipid parameters in adults. The review included 181 RCTs with 220 treatment arms and 14,505 participants. The meta-analysis found that soluble fiber supplementation significantly reduced LDL cholesterol, total cholesterol, triglycerides, and apolipoprotein B concentrations. The article suggests that increasing fiber intake using soluble fiber supplementation could be an effective intervention in the prevention and management of dyslipidemia, and consequently may contribute to the risk reduction of cardiovascular diseases. However, the article also notes that because of the high between-study heterogeneity and publication bias, the findings should be interpreted cautiously.
M-A | Aspirin with or without statin in individuals without atherosclerotic CVD across risk categories
17 Feb, 2023 | 13:22h | UTCSummary: This meta-analysis examined the effects of aspirin in adults without atherosclerotic cardiovascular disease (ASCVD), stratified by statin use across different ASCVD risks. The analysis found that aspirin reduced myocardial infarction but increased major bleeding, and was not associated with total or cardiovascular survival benefits. In adults without ASCVD, concomitant statin appeared to significantly reduce absolute risk reduction for MI associated with aspirin without influencing bleeding risk. The study highlights that the risk-benefit equilibrium may be tilted towards more harm for primary prevention, and that the expected absolute risk of major bleeding exceeds absolute MI benefits by aspirin for every level of ASCVD risk. The findings have implications for the use of aspirin in those already on statin therapy for primary ASCVD prevention.*
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
Perspective | A short history of saturated fat: the making and unmaking of a scientific consensus
16 Feb, 2023 | 14:57h | UTC
Commentary from the author on Twitter (thread – click for more)
My latest: "A short history of saturated fat: the making and unmaking of a scientific consensus"
Do saturated fats cause heart disease? The science was always weak. Fear of these fats was started by American Heart Assoc. in 1961 based on a flawed study🧵https://t.co/J3cOlfzTi6— Nina Teicholz, PhD (@bigfatsurprise) December 14, 2022
Cohort Study | Associations between types and sources of dietary carbohydrates and cardiovascular disease risk
15 Feb, 2023 | 16:13h | UTCSummary: This study found that the associations between carbohydrate intake and cardiovascular disease risk depend on the type and source of carbohydrates consumed, with free sugar intake being associated with higher risk of total cardiovascular disease and stroke. Fiber intake was associated with lower risk, and replacing refined grain starch and free sugars with wholegrain starch and non-free sugars may be protective for cardiovascular disease. Free sugar intake was also associated with higher triglycerides and lipoprotein subclasses. As with all observational studies, this study cannot establish causality, but rather suggests associations between carbohydrate intake and cardiovascular disease risk, and the importance of considering the quality of carbohydrates consumed for cardiovascular health.*
News Release: Free sugars associated with higher risk of cardiovascular disease – BioMed Central
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
SR | Preoperative medical treatments and surgical approaches for acromegaly
15 Feb, 2023 | 15:48h | UTC
Position Statement | Immune checkpoint inhibitors and endocrine disorders
14 Feb, 2023 | 10:50h | UTCRelated:
Updated Guideline | Cardiovascular disease risk assessment and reduction, including lipid modification
13 Feb, 2023 | 12:47h | UTCRelated Guidelines:
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation
#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias
#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.
Abbreviated lipid guidelines for clinical practice
13 Feb, 2023 | 12:46h | UTCOriginal Guidelines
#ESCCongress – 2019 ESC/EAS Guidelines for the Management of Dyslipidaemias
#ESCCongress – 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice.
Related:
2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Circulation
Consensus Statement | Evaluation and management of patients with diabetes and heart failure
10 Feb, 2023 | 13:51h | UTCRelated:
ACC/AHA/HFSA 2022 and ESC 2021 guidelines on heart failure comparison – ESC Heart Failure
#ACC22 – 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure.
M-A | Effect of SGLT-2 inhibitors on body composition in patients with type 2 diabetes mellitus
10 Feb, 2023 | 13:38h | UTC
Cohort Study | The impact of population-level HbA1c screening on reducing diabetes diagnostic delay in middle-aged adults
9 Feb, 2023 | 13:28h | UTC
Review | Management of menopausal symptoms
8 Feb, 2023 | 12:44h | UTCManagement of Menopausal Symptoms: A Review – JAMA (free for a limited period)
Audio Clinical Review: Treatment of Menopausal Symptoms – JAMA
Research shows ad libitum meal energy intake is influenced by energy density, eating rate and hyper-palatable foods
8 Feb, 2023 | 12:36h | UTCAd libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns – Nature Food (free for a limited period)
News Release: Research shows impact of ‘hyper-palatable’ foods across four diets – University of Kansas
Commentary from one of the authors on Twitter (thread – click for more)
What determines how many calories people eat during a meal? Our new study, led by Tera Fazzino @UnivOfKansas, was just published in @NatureFoodJnl & investigated the meal characteristics that influence ad libitum energy intake. https://t.co/Of2IzddLRd
— Kevin Hall (@KevinH_PhD) January 30, 2023
RCT | Outcomes in children of women with type 2 diabetes exposed to metformin vs. placebo during pregnancy
8 Feb, 2023 | 12:32h | UTCOutcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Crossover RCT | Effects of SGLT2 inhibition on sodium in patients with chronic syndrome of inappropriate antidiuresis
8 Feb, 2023 | 12:34h | UTC
Commentary on Twitter
The syndrome of inappropriate antidiuresis (SIAD) is a major cause of hypotonic hyponatremia. This study shows the SGLT2 inhibitor empagliflozin is a promising new treatment for chronic SIAD-induced hyponatremia, possibly improving neurocognitive function https://t.co/U26RNmVM9j pic.twitter.com/8pH6xqSs7D
— JASN_News (@JASN_News) December 12, 2022
SR | Calcium and vitamin D supplements do not increase bone mineral density or prevent fractures in premenopausal women
7 Feb, 2023 | 14:18h | UTCCalcium and vitamin D for increasing bone mineral density in premenopausal women – Cochrane Library
Summary: Calcium and vitamin D for improving bone health in healthy premenopausal women – Cochrane Library
RCT | Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity
7 Feb, 2023 | 13:54h | UTC
Commentary on Twitter
Time-restricted eating (TRE) and high-intensity interval training (HIIT) both improve glucose control and reduce fat mass in people w/ obesity.
Combining TRE (<10 hour eating window) with 3 x weekly HIIT enhances these benefits.
🔗:https://t.co/m051O3AUPW pic.twitter.com/6q6mtzDwVB
— Brady Holmer (@B_Holmer) October 4, 2022
Under a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) license
Crossover RCT | Effects of liquid glucagon on preventing exercise-associated hypoglycemia in adults with Type 1 DM
6 Feb, 2023 | 13:08h | UTCEffect of Mini-Dose Ready-to-Use Liquid Glucagon on Preventing Exercise-Associated Hypoglycemia in Adults With Type 1 Diabetes – Diabetes Care (free for a limited period)
RCT | Efficacy and safety of intermittent fasting in people with insulin-treated Type 2 Diabetes
3 Feb, 2023 | 13:54h | UTCCommentary: Intermittent fasting feasible with insulin-treated type 2 diabetes – medwire News
Related:
RCT | Effect of an intermittent calorie-restricted diet on Type 2 DM remission.
Intermittent fasting may be effective weight loss strategy in patients with type 2 diabetes
Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus
Cardiometabolic multimorbidity and incident dementia: the Swedish twin registry
3 Feb, 2023 | 13:45h | UTCEditorial: Deciphering dementia in the cardiometabolic continuum – European Heart Journal
Position Paper | Exercise recommendations for people with type 1 and type 2 diabetes
2 Feb, 2023 | 14:55h | UTC