Editor's Choice
Observational study suggests antidopaminergic antiemetics (domperidone, metopimazine, and metoclopramide) are associated with increased stroke risk.
24 Mar, 2022 | 09:51h | UTCNews Release: Widely used nausea drugs linked to heightened risk of stroke – BMJ
RCT: Single-dose Liposomal Amphotericin B treatment for Cryptococcal Meningitis.
24 Mar, 2022 | 09:56h | UTCSingle-Dose Liposomal Amphotericin B Treatment for Cryptococcal Meningitis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Cryptococcal meningitis is a major complication of HIV infection. Single-dose liposomal amphotericin B combined with flucytosine and fluconazole was noninferior to the WHO-recommended treatment and was associated with fewer adverse events. https://t.co/cg9DqSDhyN pic.twitter.com/SrKx4tDaph
— NEJM (@NEJM) March 23, 2022
Test-negative, case-control study: effectiveness of the Pfizer vaccine against COVID-19 in adolescents.
24 Mar, 2022 | 09:44h | UTCEffectiveness of BNT162b2 against COVID-19 in adolescents – The Lancet Infectious Diseases
Commentary on Twitter
Our paper on #COVID19 vaccine effectiveness in teenagers (12-17y) is published @TheLancetInfDis. Rapid waning of protection against symptomatic disease, esp with omicron. Vaccines did reduce delta hospitalisations but too early to assess omicron effects
— Shamez Ladhani (@ShamezLadhani) March 23, 2022
RCT: Safety and efficacy of a third dose of the Pfizer Covid-19 vaccine during the Delta wave.
24 Mar, 2022 | 09:46h | UTCSafety and Efficacy of a Third Dose of BNT162b2 Covid-19 Vaccine – New England Journal of Medicine
Commentary on Twitter
A third dose of the BNT162b2 vaccine administered a median of 10.8 months after the second dose provided 95.3% efficacy against Covid-19 as compared with two doses. #COVID19 #IDTwitter https://t.co/IeHOgVhU8a pic.twitter.com/wValXSdyHX
— NEJM (@NEJM) March 23, 2022
Systematic Review: Effectiveness and safety of pulse oximetry in remote patient monitoring of patients with COVID-19.
24 Mar, 2022 | 08:53h | UTCCommentaries:
Simple home oxygen monitors signal when to seek COVID care – CIDRAP
RCT: Awake prone positioning did not improve outcomes in patients with moderate hypoxemia due to covid-19.
24 Mar, 2022 | 09:48h | UTCEditorial: Awake prone positioning for patients with covid-19
News Release: Lying prone long enough to improve outcomes is difficult for many covid-19 patients – BMJ
Estimating overdiagnosis of melanoma using trends among black and white patients in the US.
24 Mar, 2022 | 08:52h | UTCEstimating Overdiagnosis of Melanoma Using Trends Among Black and White Patients in the US – JAMA Dermatology (link to abstract – $ for full-text)
Commentary: Deadly form of skin cancer ‘overdiagnosed’ in some patients, study finds – UPI
Commentary from the author on Twitter (thread – click for more)
The wildest thing about this paper is we wrote it in 2017, then shelved it because of the initial push back in peer review. This experience taught me A LOT about when colleagues are ready to accept ideas that challenge their thinking. 🧵
1/9 https://t.co/hXDURXkwju— Ade Adamson, MD MPP (@AdeAdamson) March 20, 2022
RCT: Multivitamins not beneficial for the prevention of cancer.
24 Mar, 2022 | 08:49h | UTCCommentary: Daily Multivitamin Does Not Cut Cancer Incidence in Older Adults – HealthDay
[News release – not published yet] RCT: Minimally invasive approach to hysterectomy in cervical cancer is associated with poorer disease-free survival than open surgery.
24 Mar, 2022 | 08:47h | UTC
Oxford Covid jab gears up for final act: saving the rest of the world.
23 Mar, 2022 | 10:35h | UTCOxford Covid jab gears up for final act: saving the rest of the world – The Guardian
WHO releases clinical management guidelines for influenza.
23 Mar, 2022 | 10:41h | UTCNews Release: WHO releases clinical management guidelines for influenza – World Health Organization
Original Report: Guidelines for the clinical management of severe illness from influenza virus infections – World Health Organization
Collaboration and shared decision-making between patients and clinicians in preventive health care decisions and US Preventive Services Task Force Recommendations.
23 Mar, 2022 | 10:39h | UTC
RCT: Among critically ill patients with Covid-19, treatment with an antiplatelet agent had a low likelihood of improving organ support–free days within 21 days.
23 Mar, 2022 | 10:38h | UTCEditorial: Thromboinflammation and Antithrombotics in COVID-19: Accumulating Evidence and Current Status – JAMA
Commentary: Aspirin may improve 3-month survival for patients critically ill with COVID-19 – Imperial College London
Commentaries on Twitter
https://twitter.com/JAMA_current/status/1506188937852858369
Cohort Study: Perinatal complications in individuals in California with or without SARS-CoV-2 infection during pregnancy.
23 Mar, 2022 | 10:33h | UTCNews Release: Coronavirus may double severe complications in pregnancy – Kaiser Permanente
Commentary: COVID-19 in pregnancy tied to poor maternal outcomes, preterm birth, fetal death – CIDRAP
Review | Psychological stress and heart disease: fact or folklore?
23 Mar, 2022 | 10:30h | UTCPsychological Stress and Heart Disease: Fact or Folklore? – The American Journal of Medicine
Cohort Study: Risks and burdens of incident diabetes in long COVID.
23 Mar, 2022 | 10:32h | UTC
Review: Broadening risk factor or disease definition as a driver for overdiagnosis.
23 Mar, 2022 | 10:28h | UTC
Choosing Wisely in clinical practice: Embracing critical thinking, striving for safer care.
23 Mar, 2022 | 10:24h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Systematic Review: Economic evaluation guidelines in low- and middle-income countries.
23 Mar, 2022 | 10:22h | UTC
ANN Guideline: Stroke prevention in symptomatic large artery intracranial atherosclerosis practice advisory.
22 Mar, 2022 | 09:51h | UTCNews Release: AAN issues guidance on preventing second stroke in those with plaque in brain arteries – American Academy of Neurology
New WHO guidelines on the management of tuberculosis in children and adolescents.
22 Mar, 2022 | 09:52h | UTC
AHA Scientific Statement: Understanding the importance of the lay responder experience in out-of-hospital cardiac arrest.
22 Mar, 2022 | 09:49h | UTCNews Release: Lay rescuers who do CPR are heroes and survivors, new statement addresses their perspective – American Heart Association
Commentary: AHA News: CPR ‘Heroes’ Need More Support, Report Says – HealthDay
Review: When to operate after SARS-CoV-2 infection?
22 Mar, 2022 | 09:44h | UTCRelated:
Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery
BJS commission on surgery and perioperative care post-COVID-19.
ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.
Position statement: Perioperative management of post-COVID-19 surgical patients.
Study shows whole-genome risk prediction of common diseases in human preimplantation embryos is feasible, leading to ethical concerns.
22 Mar, 2022 | 09:42h | UTCWhole-genome risk prediction of common diseases in human preimplantation embryos – Nature Medicine
Invited Commentaries:
Polygenic embryo testing: understated ethics, unclear utility – Nature Medicine
The uncertain science of preimplantation and prenatal genetic testing – Nature Medicine
Commentary on Twitter (thread – click for more)
Preimplantation genetic testing of human embryos is a rapidly advancing field, but scientists and ethicists are calling for caution.
We present 3 articles highlighting new research and expert commentary on this controversial topic.
THREAD 🧵— Nature Medicine (@NatureMedicine) March 21, 2022
RCT: Effect of a physical activity and behavior maintenance program on functional mobility decline in older adults.
22 Mar, 2022 | 09:47h | UTCInvited Commentary: Considerations for maintaining functional mobility in older populations – The Lancet Public Health