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USPSTF Draft Statement: Postmenopausal women should not use hormone therapy to prevent chronic health problems.

20 Apr, 2022 | 10:15h | UTC

Draft Recommendation Statement: Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Persons – U.S. Preventive Services Task Force

News Release: Task Force Issues Draft Recommendation Statement on Hormone Therapy for Preventing Chronic Conditions in Postmenopausal People – U.S. Preventive Services Task Force

Commentary: USPSTF Advises Against Hormone Therapy to Prevent Chronic Conditions – HealthDay

 

Studies highlight meningitis vaccine’s potential against gonorrhea.

20 Apr, 2022 | 10:06h | UTC

Commentary: Studies highlight meningitis vaccine’s potential against gonorrhea – CIDRAP

News Release: Threat of untreatable gonorrhoea could be tackled using an existing meningitis vaccine – The Lancet

Study 1: Effectiveness of a serogroup B outer membrane vesicle meningococcal vaccine against gonorrhoea: a retrospective observational study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Study 2: Effectiveness and impact of the 4CMenB vaccine against invasive serogroup B meningococcal disease and gonorrhoea in an infant, child, and adolescent programme: an observational cohort and case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Study 3: Public health impact and cost-effectiveness of gonorrhoea vaccination: an integrated transmission-dynamic health-economic modelling analysis – The Lancet Infectious Diseases

 

An observational study suggests coprescription of Phosphodiesterase Type 5 Inhibitors (i.e., sildenafil) and oral Nitrates is not associated with increased risk of adverse cardiovascular outcomes in male patients with ischemic heart disease.

20 Apr, 2022 | 10:11h | UTC

Adverse Events Associated With Coprescription of Phosphodiesterase Type 5 Inhibitors and Oral Organic Nitrates in Male Patients With Ischemic Heart Disease: A Case-Crossover Study – Annals of Internal Medicine

Commentaries:

PDE5 inhibitors didn’t increase cardiovascular events in men on nitrates for heart disease – ACP Internist

PDE5 Inhibitors Prescribed for Men on Oral Nitrates for IHD – HealthDay

 

Big Tech in Healthcare: Here’s who wins and loses as Alphabet, Amazon, Apple, and Microsoft target niche sectors of healthcare.

20 Apr, 2022 | 09:59h | UTC

BIG TECH IN HEALTHCARE: Here’s who wins and loses as Alphabet, Amazon, Apple, and Microsoft target niche sectors of healthcare – Insider Intelligence

 

Covid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel.

20 Apr, 2022 | 09:57h | UTC

Covid hasn’t given up all its secrets. Here are 6 mysteries experts hope to unravel – STAT

 

Expert Guidance: Strategies to prevent central line-associated bloodstream infections in acute-care hospitals.

20 Apr, 2022 | 10:13h | UTC

Strategies to prevent central line-associated bloodstream infections in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

 

Commentary on Twitter

Article under a http://creativecommons.org/licenses/by/4.0/ license

 

FDA warns of risks associated with non-invasive prenatal screening tests – inappropriate interpretation of results may lead to potentially improper medical decisions.

20 Apr, 2022 | 09:52h | UTC

FDA Warns of Risks Associated with Non-Invasive Prenatal Screening Tests – U.S. Food & Drug Administration

See also: Genetic Non-Invasive Prenatal Screening Tests May Have False Results: FDA Safety Communication – U.S. Food & Drug Administration

 

A nonrandomized controlled study found awake prone position (median of 4.2 hours per day) may not benefit hospitalized adults with Covid-19.

20 Apr, 2022 | 09:56h | UTC

Assessment of Awake Prone Positioning in Hospitalized Adults With COVID-19: A Nonrandomized Controlled Trial – JAMA Internal Medicine

Commentaries:

Prone Positioning for Nonintubated Patients With COVID-19—Potential Dangers of Extrapolation and Intermediate Outcome Variables – JAMA Internal Medicine

Study suggests worse outcomes for awake COVID patients in prone position – CIDRAP

Putting Hospitalized COVID Patients on Their Belly May Not Be a Good Idea After All – HealthDay

Related:

Awake prone positioning for non-intubated patients with COVID-19-related acute hypoxaemic respiratory failure: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Prone positioning of patients with moderate hypoxaemia due to covid-19: multicentre pragmatic randomised trial (COVID-PRONE) – The BMJ

RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv

Awake prone positioning for COVID-19 acute hypoxaemic respiratory failure: a randomised, controlled, multinational, open-label meta-trial – The Lancet Respiratory Medicine

Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19: the PROFLO multicenter randomized clinical trial – Critical Care

Prone Positioning of Nonintubated Patients With Coronavirus Disease 2019—A Systematic Review and Meta-Analysis – Critical Care Medicine

 

Commentary on Twitter (thread – click for more)

 

Opinion | Low-grade prostate cancer (Gleason score 6): time to stop calling it cancer.

19 Apr, 2022 | 02:29h | UTC

Low-Grade Prostate Cancer: Time to Stop Calling It Cancer – Journal of Clinical Oncology

Commentary: Doctors suggest new names for low-grade prostate cancer – Associated Press

 

AAOS Guideline: Prevention of surgical site infections after major extremity trauma.

19 Apr, 2022 | 02:35h | UTC

Prevention of Surgical Site Infections After Major Extremity Trauma: Evidence-Based Clinical Practice Guideline – American Academy of Orthopaedic Surgeons

Evidence Review: Prevention of Surgical Site Infection After Extremity Trauma (2022)

 

Video: Here’s what we know about COVID-19’s impact on the brain.

19 Apr, 2022 | 02:22h | UTC

Here’s what we know about COVID-19’s impact on the brain – Science

Related:

SARS-CoV-2 is associated with changes in brain structure in UK Biobank – Nature

Nervous system consequences of COVID-19 – Science

The COVID generation: how is the pandemic affecting kids’ brains? – Nature

Fatigue and cognitive impairment in Post-COVID-19 Syndrome: A systematic review and meta-analysis – Brain, Behavior, and Immunity

Assessment of Cognitive Function in Patients After COVID-19 Infection – JAMA Network Open

 

Omicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial.

19 Apr, 2022 | 02:25h | UTC

Omicron-specific Sinopharm, Sinovac COVID vaccine candidates cleared for clinical trial – Reuters

 

Commentary on Twitter

 

M-A: Global prevalence of post COVID-19 condition or long COVID.

19 Apr, 2022 | 02:18h | UTC

Global Prevalence of Post COVID-19 Condition or Long COVID: A Meta-Analysis and Systematic Review – The Journal of Infectious Diseases

Commentary: Global data reveal half may have long COVID 4 months on – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

Opinion | Learning the art and science of diagnosis.

19 Apr, 2022 | 02:12h | UTC

Learning the Art and Science of Diagnosis – JAMA (free for a limited period)

 

A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease.

19 Apr, 2022 | 02:14h | UTC

A systematic review of COVID-19 vaccine efficacy and effectiveness against SARS-CoV-2 infection and disease – Open Forum Infectious Diseases

 

Commentary on Twitter

 

AHA Scientific Statement: Management of hypertension in patients with ventricular assist devices.

19 Apr, 2022 | 02:09h | UTC

Management of Hypertension in Patients With Ventricular Assist Devices: A Scientific Statement From the American Heart Association – Circulation: Heart Failure

 

Public health doctors and scientists are investigating 74 cases of hepatitis in children living in the UK that were not caused by hepatitis A to E virus.

18 Apr, 2022 | 10:56h | UTC

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

Commentaries:

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

Commentary on Twitter (thread – click for more)

 

RCT: In patients with acute Achilles’ tendon rupture, a nonoperative strategy resulted in similar outcomes compared with routine surgical treatment.

18 Apr, 2022 | 10:53h | UTC

Nonoperative or Surgical Treatment of Acute Achilles’ Tendon Rupture – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Heal Thyself: Most who tear Achilles tendon can skip surgery – Associated Press

 

Review: Covid-19: virology, variants, and vaccines.

18 Apr, 2022 | 10:50h | UTC

Covid-19: virology, variants, and vaccines – BMJ Medicine

 

Commentary on Twitter

 

Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study.

18 Apr, 2022 | 10:52h | UTC

Household transmission of SARS-CoV-2 from unvaccinated asymptomatic and symptomatic household members with confirmed SARS-CoV-2 infection: an antibody-surveillance study – CMAJ Open

Commentary: COVID-19 household transmission is high, with children being a significant source of spread: study – CHEO

 

Commentary on Twitter (thread – click for more)

 

Analysis: Changing the assortment of available food and drink for leaner, greener diets.

18 Apr, 2022 | 10:39h | UTC

Changing the assortment of available food and drink for leaner, greener diets – The BMJ

News Release: Changing products on offer in shops and restaurants can lead to leaner, greener diets – BMJ

 

EBM Analysis: Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomized studies.

18 Apr, 2022 | 10:48h | UTC

Factors influencing estimated effectiveness of COVID-19 vaccines in non-randomised studies – BMJ Evidence-Based Medicine

 

Commentary on Twitter

 

RCT: A 12-months oral itraconazole regimen is superior to 6-months of treatment to prevent relapses of chronic pulmonary aspergillosis.

18 Apr, 2022 | 10:36h | UTC

Efficacy of 12-months oral itraconazole versus 6-months oral itraconazole to prevent relapses of chronic pulmonary aspergillosis: an open-label, randomised controlled trial in India – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

Cohort Study: Changes in the incidence of retinal vascular occlusions after COVID-19 diagnosis.

18 Apr, 2022 | 10:34h | UTC

Changes in the Incidence of Retinal Vascular Occlusions After COVID-19 Diagnosis – JAMA Ophthalmology

Commentaries:

COVID-19 Diagnosis and Incidence of Retinal Thromboembolism – JAMA Ophthalmology

Threatening Eye Condition Rare After COVID Infection – HealthDay

 

M-A: Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination.

18 Apr, 2022 | 10:32h | UTC

Myopericarditis following COVID-19 vaccination and non-COVID-19 vaccination: a systematic review and meta-analysis – The Lancet Respiratory Medicine

Commentaries:

Myopericarditis following COVID-19 vaccination is rare, finds international study – The Lancet

Myopericarditis after COVID-19 vaccination: unexpected but not unprecedented – The Lancet Respiratory Medicine

Study explores myopericarditis incidence and COVID-19 vaccination – News Medical

 

Commentary on Twitter

 

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