Editor's Choice
Heart failure with preserved ejection fraction: recent concepts in diagnosis, mechanisms and management.
4 May, 2022 | 11:02h | UTCPodcast: A comprehensive review on heart failure with preserved ejection fraction (HFpEF)
Randomized Trials: Neither detection nor control of high blood pressure improved by self-monitoring during pregnancy.
4 May, 2022 | 11:06h | UTCNews Release: Neither detection nor control of high blood pressure improved by self-monitoring during pregnancy – University of Oxford
Study 1: Effect of Self-monitoring of Blood Pressure on Diagnosis of Hypertension During Higher-Risk Pregnancy: The BUMP 1 Randomized Clinical Trial – JAMA (free for a limited period)
Study 2: Effect of Self-monitoring of Blood Pressure on Blood Pressure Control in Pregnant Individuals With Chronic or Gestational Hypertension: The BUMP 2 Randomized Clinical Trial – JAMA (free for a limited period)
Author Interview: Effect of Self-monitoring of Blood Pressure on Detection and Assessment of Hypertension During Higher-Risk Pregnancy: The BUMP 1 and BUMP 2 Trials
Editorial: Self-monitoring of Blood Pressure During Pregnancy – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, among pregnant individuals at higher risk of preeclampsia, self-monitoring of #bloodpressure with telemonitoring did not lead to earlier clinic-based detection of #hypertension. https://t.co/YKEQxpASA9 @RichardJMcManus pic.twitter.com/33Bf0gk59g
— JAMA (@JAMA_current) May 3, 2022
Paxlovid’s failure as a preventative measure raises questions, but doctors still back it as a therapeutic.
4 May, 2022 | 10:57h | UTC
Brief Review: Management of chronic hypertension during pregnancy.
4 May, 2022 | 11:03h | UTCManagement of Chronic Hypertension During Pregnancy – JAMA (free for a limited period)
Cluster RCT: A village doctor-led multifaceted intervention for blood pressure control in rural China.
4 May, 2022 | 10:53h | UTCA village doctor-led multifaceted intervention for blood pressure control in rural China: an open, cluster randomised trial – The Lancet (link to abstract – $ for full-text)
Preventing asthma deaths in school children: 3 things to know.
4 May, 2022 | 10:59h | UTCPreventing asthma deaths in school children: 3 things to know – Evidently Cochrane
Related video: Preventable
Commentary on Twitter
https://twitter.com/CochraneUK/status/1521478814349631489
Cluster RCT: Algorithm-based care vs. usual care for the early recognition and management of complications after pancreatic resection.
4 May, 2022 | 10:55h | UTCAlgorithm-based care versus usual care for the early recognition and management of complications after pancreatic resection in the Netherlands: an open-label, nationwide, stepped-wedge cluster-randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
New research @TheLancet – Smits et al – Algorithm-based care vs usual care for early recognition and management of complications after pancreatic resection in the Netherlands: a stepped-wedge, cluster-randomised trialhttps://t.co/8BeKhtk0mV#SoMe4Surgery #pancsm @DPCG_official pic.twitter.com/atPcJk4O8r
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) April 29, 2022
Remdesivir and three other drugs for hospitalized patients with COVID-19: final results of the WHO Solidarity randomized trial and updated meta-analyses.
3 May, 2022 | 11:18h | UTCInvited Commentary: When and which patients should receive remdesivir? – The Lancet
RCT: Effects of an online breathing and wellbeing program for people with persistent symptoms following COVID-19.
3 May, 2022 | 11:16h | UTCInvited Commentary: Treating COVID-19-related breathlessness with novel interventions – The Lancet Respiratory Medicine
News Release: Singing techniques can improve quality of life and breathlessness after COVID-19 – Imperial College London
Commentary on Twitter
https://twitter.com/LancetRespirMed/status/1519572126772064256
Atherosclerosis: Recent developments.
3 May, 2022 | 11:03h | UTCAtherosclerosis: Recent developments – Cell
Commentary on Twitter
We've learned a lot about atherosclerosis in recent years, including new genomic underpinnings, role of aging, clonal hematopoiesis, and the gut microbiome. A new, excellent review covers all of the progress and the many residual questionshttps://t.co/nF59sqiB6P @CellCellPress pic.twitter.com/oXVzf4J5XT
— Eric Topol (@EricTopol) May 2, 2022
Under a CC BY 4.0 license
Systematic Review: Telerehabilitation improves physical function and reduces dyspnea in people with COVID-19 and post-COVID-19 conditions.
3 May, 2022 | 11:05h | UTC
Point/Counterpoint: Should therapeutic heparin be administered to acutely ill hospitalized patients with COVID-19?
3 May, 2022 | 11:04h | UTCCOUNTERPOINT: Should Therapeutic Heparin Be Administered to Acutely Ill Hospitalized Patients With COVID-19? No – CHEST
See also: Rebuttal From Dr Tritschler et al – CHEST
Related:
Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library
M-A of randomized trials: association of influenza vaccination with cardiovascular risk.
3 May, 2022 | 10:58h | UTCAssociation of Influenza Vaccination With Cardiovascular Risk: A Meta-analysis – JAMA Network Open
Commentary on Twitter
In this meta-analysis, seasonal flu vaccine was associated with a 34% reduced risk of major adverse cardiovascular events in 1 year, with the biggest difference in patients with recent acute coronary syndrome. @WCHResearch @PMunkCardiacCtr https://t.co/SPrXNfMQJS
— JAMA Network Open (@JAMANetworkOpen) April 29, 2022
CDC reports the first case and issues recommendations for highly pathogenic avian Influenza A(H5N1) virus.
3 May, 2022 | 11:00h | UTCSee also: U.S. Case of Human Avian Influenza A(H5) Virus Reported – Centers for Disease Control and Prevention
Commentary: Alaska, Oklahoma report first avian flu outbreaks in poultry – CIDRAP
Perspective: Less pharmacotherapy is more in delirium.
3 May, 2022 | 10:56h | UTCLess pharmacotherapy is more in delirium – Intensive Care Medicine (if the link is paywalled, try this one)
Related:
Effectiveness of Bundle Interventions on ICU Delirium: A Meta-Analysis – Critical Care Medicine
Commentary on Twitter
⬇️ 💉Less medications (& ⬆️ awareness of behavioural interventions) is more in #delirium, common, challenging/costly (but often preventable) in #ICU. Despite lacking evidence, medications widely used.
Prevent/minimize addressing suspected contributors!
📎 https://t.co/fYWAsIcuiZ pic.twitter.com/DyC3agSP7w— Intensive Care Medicine (@yourICM) April 30, 2022
AAP Guidance for pediatric end-of-life care.
2 May, 2022 | 00:51h | UTCGuidance for Pediatric End-of-Life Care – Pediatrics
Related Guidance: End of life care for infants, children and young people with life-limiting conditions: planning and management – National Institute for Health and Care Excellence
CDC Report: Acute hepatitis and adenovirus infection among children.
2 May, 2022 | 00:46h | UTCCommentaries:
CDC releases new clinical details in cases of unusual hepatitis in children – CNN
CDC report finds no Covid link in children’s hepatitis cases in Alabama – NBC News
Related:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentaries on Twitter
Report from Alabama of acute hepatitis & adenovirus infection in young kids, Oct 21-Feb 22. 9 cases, all had adenovirus, 5/5 tested +ve for Adenovirus type 41. No epi links found. All under 6 yrs of age, immunocompetent, & no significant comorbidities. https://t.co/DcgcfN3KHo
— Andrew Lee is heading to @andrewleedr.bsky.social (@andrewleedr) April 29, 2022
New report from @CDCMMWR on the 9 episodes of severe acute hepatitis in children from Alabama
All 9 positive for Adenovirus on whole blood PCR (all 5 samples sequences were type 41)
None PCR positive for #SARSCoV2
HT @tonisoriano66 https://t.co/h9LmHeVHEf
— Alasdair Munro (@apsmunro) April 29, 2022
ATS/ERS/JRS/ALAT Guideline: Idiopathic pulmonary fibrosis and progressive pulmonary fibrosis in adults.
2 May, 2022 | 00:53h | UTC
Commentary on Twitter (thread – click for more)
🔥Finally out online: the latest multisocietal guidance defining progression in fibrotic lung disease🫁 has arrived!
These long-awaited guidelines help better clarify disease definition and guide treatmenthttps://t.co/LVuoVdZRj2
What does this mean? Hang on to your hats! 🧵1/n pic.twitter.com/3jvFGSfSuI
— Deji Adegunsoye, MD, PhD (@drdayjee) April 29, 2022
ECDC publishes Rapid Risk Assessment – Increase in severe acute hepatitis cases of unknown etiology in children.
2 May, 2022 | 00:44h | UTCRelated:
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Pfizer says COVID treatment Paxlovid fails to prevent infection of household members.
2 May, 2022 | 00:43h | UTCPfizer says COVID treatment Paxlovid fails to prevent infection of household members – Reuters
Commentary on Twitter
Pfizer Inc on Friday said a large trial found that its COVID-19 oral antiviral treatment Paxlovid was not effective at preventing coronavirus infection in people living with someone who had been exposed to the virus. https://t.co/95zphEYaxc
— Reuters Health (@Reuters_Health) April 29, 2022
RCT: Phentermine/Topiramate for the treatment of adolescent obesity.
2 May, 2022 | 00:41h | UTCPhentermine/Topiramate for the Treatment of Adolescent Obesity – NEJM Evidence
Commentary on Twitter
This RCT evaluated phentermine/topiramate in adolescents ages 12 to <17 yrs with high BMIs over a 56 week period. At both mid- and top-doses, treatment significantly reduced BMI and waist circumference compared to placebo. https://t.co/HbCZOAlZPf@PedsEndoSociety #PedsEndo2022 pic.twitter.com/nB5juqxyA0
— NEJM Evidence (@NEJMEvidence) April 30, 2022
RCT: Digital remote monitoring plus usual care vs. usual care in patients treated with oral anticancer agents.
2 May, 2022 | 00:37h | UTCDigital remote monitoring plus usual care versus usual care in patients treated with oral anticancer agents: the randomized phase 3 CAPRI trial – Nature Medicine (if the link is paywalled, try this one)
Commentary on Twitter
A phase 3 clinical trial evaluating the impact of a digital nurse navigator-led system in patients receiving oral #cancer treatment shows that remote monitoring with a smartphone results in improved patient experience & optimizes resources @GustaveRoussy https://t.co/N8fEXb00r7
— Nature Medicine (@NatureMedicine) April 26, 2022
RCT: Efficiency of electronic health record assessment of patient-reported outcomes after cancer immunotherapy.
2 May, 2022 | 00:36h | UTCInvited Commentary: An Assistive Electronic Patient-Reported Outcome Monitoring Intervention for Management of Immune-Related Toxic Effects—Moving Toward Efficiency and Scale – JAMA Network Open
Commentary on Twitter
This RCT aimed to compare the efficiency between ePRO and traditional follow up models in cancer immunotherapy among 278 patients from 28 hospitals, finding that an ePRO model can improve safety & QOL, and is less time consuming. https://t.co/KtpcNz0keb pic.twitter.com/EsmNyTkdfB
— JAMA Network Open (@JAMANetworkOpen) March 31, 2022
RCT: Extended vs. standard antibiotic course duration in children below 5 years of age hospitalized with community-acquired pneumonia in high-risk settings.
29 Apr, 2022 | 11:16h | UTCRelated:
Treatment of UTIs in Infants <2 Months: A Living Systematic Review – Hospital Pediatrics
Commentary on Twitter
15th RCT of short course therapy for CAP just published, this one another peds study (3 mo to <5 yr). 5-6 d vs. 14 days. Guess what the outcome was??? Updated tables will be tweeted out soon!@ABsteward @DoctorRachael @medrants https://t.co/br4WAEXAzJ
— Brad Spellberg (@BradSpellberg) April 28, 2022
Review: Nutrition, longevity and disease: From molecular mechanisms to interventions.
29 Apr, 2022 | 11:18h | UTCNutrition, longevity and disease: From molecular mechanisms to interventions – Cell
Commentary on Twitter
What is the optimal diet to promote healthspan and lifespan? A mechanistic review https://t.co/pNrwxGjget @CellCellPress @AndersonRozalyn pic.twitter.com/8JVtAanxh5
— Eric Topol (@EricTopol) April 28, 2022
Under a CC BY-NC-ND 4.0 license