Editor's Choice | Page 88 of 113 | Links Medicus Content Curation & Alerts in Medicine

Kids get limited COVID protection from world’s most popular vaccines – “First analyses of two Chinese-made vaccines in young children show that the shots do provide 60–65% effectiveness against hospitalization”.

10 May, 2022 | 11:04h | UTC

Kids get limited COVID protection from world’s most popular vaccines – Nature

Time to clinical benefit of intensive blood pressure lowering in patients 60 years and older with hypertension: a secondary analysis of randomized clinical trials.

10 May, 2022 | 10:57h | UTC

Time to Clinical Benefit of Intensive Blood Pressure Lowering in Patients 60 Years and Older With Hypertension: A Secondary Analysis of Randomized Clinical Trials – JAMA Internal Medicine

Rapidly progressive dementias — etiologies, diagnosis and management.

10 May, 2022 | 10:59h | UTC

Rapidly progressive dementias — aetiologies, diagnosis and management – Nature Reviews Neurology (if the link is paywalled, try this one in PMC)

WHO launches first ever global report on infection prevention and control.

9 May, 2022 | 02:19h | UTC

News Release: WHO launches first ever global report on infection prevention and control – World Health Organization

Executive Summary: Global report on infection prevention and control – World Health Organization

Commentary on Twitter

A new report from the World Health Organization (WHO) shows that good Infection Prevention and Control (IPC) programmes where good hand hygiene and other cost-effective practices are followed, 70% of those infections can be prevented #IDTwitter #MedEd https://t.co/qo954eXMm8

— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) May 6, 2022

Technical briefing 2: Investigation into acute hepatitis of unknown etiology in children in England.

9 May, 2022 | 02:18h | UTC

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

Summary on Twitter (thread – click for more)

NEW: @UKHSA Technical Briefing 2 on Paediatric acute hepatitis in England

A 🧵 ⤵️https://t.co/E9MvVTK505 pic.twitter.com/YZCHdCdt4U

— Meaghan Kall has moved to Bluesky (@kallmemeg) May 6, 2022

WHO Report: 14.9 million excess deaths associated with the COVID-19 pandemic in 2020 and 2021.

9 May, 2022 | 02:14h | UTC

News Release: 14.9 million excess deaths associated with the COVID-19 pandemic in 2020 and 2021 – World Health Organization

Original Report: Global excess deaths associated with COVID-19, January 2020 – December 2021 – World Health Organization

Commentaries:

Covid-19: True global death toll from pandemic is almost 15 million, says WHO – The BMJ

WHO: Nearly 15 million died as a result of Covid-19 in first two years of pandemic – STAT

WHO notes 15 million excess deaths over 2 COVID years – CIDRAP

Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020–21 – The Lancet

“Excess deaths” is the best metric for tracking the pandemic – The BMJ

The pandemic’s true death toll: millions more than official counts – Nature

Effects of covid-19 pandemic on life expectancy and premature mortality in 2020: time series analysis in 37 countries – The BMJ

Under-reporting of deaths limits our understanding of true burden of covid-19 – The BMJ

Quantifying impacts of the COVID-19 pandemic through life-expectancy losses: a population-level study of 29 countries – International Journal of Epidemiology

Just How Do Deaths Due to COVID-19 Stack Up? – Think Global Health

Commentary on Twitter (thread – click for more)

The total number of deaths associated with #COVID19 worldwide from 2020-2021 may be closer to 14.9 million: New estimates by WHO & @UNDESA.

That’s 9.5 million more deaths than reported https://t.co/qDvaA6t5KZ #HealthData pic.twitter.com/ZjABJzlgiZ

— World Health Organization (WHO) (@WHO) May 5, 2022

Studies show promise for 2 new COVID vaccine platforms.

9 May, 2022 | 02:12h | UTC

Commentary: Studies show promise for 2 new COVID vaccine platforms – CIDRAP

Study 1: Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine – New England Journal of Medicine

Study 2: Efficacy and Safety of the RBD-Dimer–Based Covid-19 Vaccine ZF2001 in Adults – New England Journal of Medicine

Editorial: Does the World Still Need New Covid-19 Vaccines?

Commentaries on Twitter

Efficacy of a plant-based vaccine with adjuvant was 69.5% against symptomatic #COVID19 and 78.8% against moderate-to-severe disease. https://t.co/WH54QWCBdg pic.twitter.com/BiEYpJUD7D

— NEJM (@NEJM) May 4, 2022

ZF2001 vaccine has 87% efficacy against critical or severe #COVID19 for at least 6 months after full vaccination and was safe in large cohort of adults. #IDTwitter https://t.co/wsG0AXqI4Y pic.twitter.com/45fqwVrz9a

— NEJM (@NEJM) May 4, 2022

Systematic Review: Workplace interventions to reduce the risk of SARS‐CoV‐2 infection outside of healthcare settings.

9 May, 2022 | 02:09h | UTC

Workplace interventions to reduce the risk of SARS‐CoV‐2 infection outside of healthcare settings – Cochrane Library

Summary: Interventions to reduce the risk of coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) infection among workers outside healthcare settings – Cochrane Library

Timing of invasive strategy in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials.

9 May, 2022 | 01:52h | UTC

Timing of invasive strategy in non-ST-elevation acute coronary syndrome: a meta-analysis of randomized controlled trials – European Heart Journal

Commentary on Twitter

Timing of invasive management of NSTE-ACS: is the time up for early management?

Timing of invasive strategy in #NSTEMI : a meta-analysis of randomized controlled trialshttps://t.co/XD074Lh94S @ESC_Journals @escardio @mmamas1973 @ALEX_MISCHIE @AnkurKalraMD @HeartOTXHeartMD pic.twitter.com/0XekZqvJop

— Henry Han (@HanCardiomd) May 6, 2022

Under a https://creativecommons.org/licenses/by-nc/4.0/ license

Brief Review | In search of the Holy Grail: identifying the best PEEP in ventilated patients.

9 May, 2022 | 01:50h | UTC

In search of the Holy Grail: identifying the best PEEP in ventilated patients – Intensive Care Medicine

Commentary on Twitter

Best PEEP on MV?? Individual-specific providing oxygenation (SpO2 >90%/no excessive FiO2 + acceptable PaCO2 (<50/55 mmHg) & minimal need for fluids/cardioactives. Start at 10-12 but stay alert to hemodynamic impact & as set, serially asses need/adequacy.
🖇https://t.co/wdK92bs8B9 pic.twitter.com/NlTzoxfwa5

— Intensive Care Medicine (@yourICM) May 5, 2022

Brief Review | Oxygen targets.

9 May, 2022 | 01:48h | UTC

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Commentary on Twitter

Oxygen targets in #ICU?? Supplemental O2 often required in critically ill, but balancing opposing risks hypo/hyperxaemia required to choose right amount to give. Hyperoxaemia associated with negative cellular/physiological effects: O2 can harm!#FOAMcc
🫧 https://t.co/F4r3Qg7hXg pic.twitter.com/EizwMNjjnc

— Intensive Care Medicine (@yourICM) May 7, 2022

RCT: Effect of early vs. standard approach to tracheostomy on functional outcome at 6 months among patients with severe stroke receiving mechanical ventilation.

6 May, 2022 | 11:13h | UTC

Effect of Early vs Standard Approach to Tracheostomy on Functional Outcome at 6 Months Among Patients With Severe Stroke Receiving Mechanical Ventilation: The SETPOINT2 Randomized Clinical Trial – JAMA (free for a limited period)

Commentary on Twitter

In this study, among patients with severe stroke receiving mechanical ventilation, a strategy of early tracheostomy, compared with a standard approach to tracheostomy, did not significantly improve functional outcome at 6 months. https://t.co/bLZ4b6hBxr

— JAMA (@JAMA_current) May 4, 2022

Review: SARS-CoV-2 pathogenesis.

6 May, 2022 | 11:01h | UTC

SARS-CoV-2 pathogenesis – Nature Reviews Microbiology

Commentary on Twitter

A Review published in @NatureRevMicro explores recent clinical and experimental advances in understanding SARS-CoV-2 pathogenesis, interactions with host cells and the involvement of the immune system in the development of severe disease. https://t.co/GTm0BZ3ikH pic.twitter.com/jPXFU05Pwm

— Nature Portfolio (@NaturePortfolio) April 23, 2022

RCT: Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet.

6 May, 2022 | 11:05h | UTC

Long-term secondary prevention of cardiovascular disease with a Mediterranean diet and a low-fat diet (CORDIOPREV): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Safety of ezetimibe in lipid-lowering treatment: systematic review and meta-analysis of randomized controlled trials and cohort studies.

6 May, 2022 | 10:59h | UTC

Safety of ezetimibe in lipid-lowering treatment: systematic review and meta-analysis of randomised controlled trials and cohort studies – BMJ Medicine

PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations – The BMJ

PCSK9 inhibitors and ezetimibe with or without statin therapy for cardiovascular risk reduction: a systematic review and network meta-analysis – The BMJ

Commentary on Twitter

Read a new #systematicreview and meta-analysis of RCTs and cohort studies on the safety of #Ezetimibe in lipid-lowering treatment. ▶️ https://t.co/mr4H5MfVdP #VisualAbstract #RapidRecommendations @bmj_latest @theMAGICapp pic.twitter.com/OLg0HZr8D3

— BMJMedicine (@BMJMedicine) May 5, 2022

Long COVID: aiming for a consensus.

6 May, 2022 | 11:03h | UTC

Long COVID: aiming for a consensus – The Lancet Respiratory Medicine

Commentary on Twitter

There is an urgent need for unification of terminology for the sequelae of #SARSCoV2 infection to ensure that research is directed towards and translated into interventional trials to improve outcomes

NEW Comment—#LongCOVID: aiming for a consensushttps://t.co/dZO4rBVCSY pic.twitter.com/H5ezqL0RLb

— The Lancet Respiratory Medicine (@LancetRespirMed) May 5, 2022

Ten tips to optimize vasopressors use in the critically ill patient with hypotension.

5 May, 2022 | 11:07h | UTC

Ten tips to optimize vasopressors use in the critically ill patient with hypotension – Intensive Care Medicine (if the link is paywalled, try this one)

Commentary on Twitter

Vasopressors in #ICU
1️⃣set MAP/DBP goals
2️⃣individualize
3️⃣may⬇️+ve fluid balance
4️⃣reassess fluid status/CO
5️⃣change mechanism as 2 line
6️⃣high doses?? hydrocortisone
7️⃣vasopressin in RV failure
8️⃣no MAX dose
9️⃣EN can be initiated
🔟can be safe in PVC
🖇 https://t.co/v6Q9nfy5KY pic.twitter.com/8YEDaOQBOQ

— Intensive Care Medicine (@yourICM) May 4, 2022

Variation in revascularization use and outcomes of patients in hospital with acute myocardial infarction across six high income countries: cross sectional cohort study.

5 May, 2022 | 11:04h | UTC

Variation in revascularisation use and outcomes of patients in hospital with acute myocardial infarction across six high income countries: cross sectional cohort study – The BMJ

News Release: Study finds large differences in heart attack care across six high income countries – British Medical Journal

PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations.

5 May, 2022 | 11:06h | UTC

PCSK9 inhibitors and ezetimibe for the reduction of cardiovascular events: a clinical practice guideline with risk-stratified recommendations – The BMJ

News Release: Experts recommend additional cholesterol lowering drugs for adults at high heart disease risk – British Medical Journal

Guidelines on enhanced recovery after cardiac surgery under cardiopulmonary bypass or off-pump.

5 May, 2022 | 10:57h | UTC

Guidelines on enhanced recovery after cardiac surgery under cardiopulmonary bypass or off-pump – Anaesthesia Critical Care & Pain Medicine

Controversies in enhanced recovery after cardiac surgery – Perioperative Medicine

Guidelines for Perioperative Care in Cardiac Surgery: Enhanced Recovery After Surgery Society Recommendations – JAMA Surgery

Expert Consensus of Data Elements for Collection for Enhanced Recovery After Cardiac Surgery – World Journal of Surgery

Enhanced Recovery After Cardiac Surgery (ERAS Cardiac) Recommendations: An Important First Step—But There Is Much Work to Be Done – Cardiothoracic and Vascular Anesthesia

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids.

5 May, 2022 | 10:59h | UTC

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study.

5 May, 2022 | 11:02h | UTC

Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study – The BMJ

Commentary on Twitter

In this international, registry based cohort study of patients with covid-19 associated acute respiratory failure, extracorporeal membrane oxygenation was associated with a reduction in mortality by 7.1% compared with conventional mechanical ventilation https://t.co/VkNFeRDQ3j

— The BMJ (@bmj_latest) May 4, 2022