Editor's Choice
WHO: 2nd COVID booster for most vulnerable offers benefits.
18 May, 2022 | 11:10h | UTCWHO: 2nd COVID booster for most vulnerable offers benefits – World Health Organization
Scent dogs in detection of COVID-19: triple-blinded randomized trial and operational real-life screening in airport setting.
18 May, 2022 | 11:06h | UTCNews Release: Trained sniffer dogs accurately detect people infected with SARS-CoV-2 – BMJ Newsroom
Commentary: Trained scent dogs detect airline travelers with COVID-19 – CIDRAP
Management of drug interactions with Nirmatrelvir/Ritonavir (Paxlovid).
18 May, 2022 | 11:03h | UTCCommentary: IDSA offers guidance on managing drug interactions with nirmatrelvir/ritonavir – ACP Internist
Related:
Yes, Relapses After Paxlovid Happen — Now What? – HIV and ID Observations
Covid-19: What is the evidence for the antiviral Paxlovid? – The BMJ
Yes, Relapses After Paxlovid Happen — Now What? – HIV and ID Observations
A living WHO guideline on drugs for covid-19 – The BMJ
[Preprint] Effectiveness of a second COVID-19 vaccine booster on all-cause mortality in long-term care facility residents and in the oldest old: a nationwide, retrospective cohort study in Sweden.
18 May, 2022 | 11:05h | UTC
Commentary on Twitter
Confirmation of the 2nd booster protection from death in people age 80+ in Sweden, with a relative vaccine effectiveness 42% (compared w/ the 1st booster)https://t.co/Dq1x00J3Tr pic.twitter.com/fyXJPEcQzC
— Eric Topol (@EricTopol) May 17, 2022
WHO Report: Almost one billion children and adults with disabilities and older persons in need of assistive technology denied access.
17 May, 2022 | 11:10h | UTCReport: Global report on assistive technology – World Health Organization
Commentary on Twitter (thread – click for more)
More than 2.5 billion people – or 1 in 3 people – need one or more assistive products, such as wheelchairs, hearing aids, or apps that support communication and cognition: New WHO & @UNICEF report https://t.co/yMVjdOdREU pic.twitter.com/qpAUegL0K1
— World Health Organization (WHO) (@WHO) May 16, 2022
Guideline Synopsis: Antithrombotic therapy for venous thromboembolism.
17 May, 2022 | 11:12h | UTCAntithrombotic Therapy for Venous Thromboembolism – JAMA (free for a limited period)
Original Guideline: Antithrombotic Therapy for VTE Disease
Second Update of the CHEST Guideline and Expert Panel Report
Clinical update on COVID-19 for the emergency clinician: Cardiac arrest in the out-of-hospital and in-hospital settings.
17 May, 2022 | 11:05h | UTCRelated:
Cohort Study: Venous or arterial thrombosis and deaths among COVID-19 cases.
17 May, 2022 | 11:02h | UTCInvited Commentary: Risk of arterial and venous thromboses after COVID-19 – The Lancet Infectious Diseases
News Release: COVID-19’s high blood clot risk – University of Oxford
Commentary on Twitter
Clots with Covid: Multi-national report of over 900,000 people indicates propensity of risk for arterial and venous thrombi is in men, with increasing age, and association with fatalities (4-fold in non-hospitalized) https://t.co/muGnDld4Um pic.twitter.com/6bLiHPLInm
— Eric Topol (@EricTopol) May 13, 2022
Under a Creative Commons Attribution (CC BY 4.0) license
RECOVERY Trial: Due to safety concerns, recruitment to higher dose corticosteroids closed for patients with hypoxia on no oxygen or receiving simple oxygen.
17 May, 2022 | 11:04h | UTC
Cohort Study: The risk of death or unplanned readmission after discharge from a COVID-19 hospitalization.
17 May, 2022 | 11:01h | UTCCommentary: Study: Readmission rate for COVID-19 is 11% – CIDRAP
RCT: Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy.
17 May, 2022 | 10:59h | UTCCommentary: E-cigarettes ‘as safe as nicotine patches’ for pregnant smokers trying to quit – The Guardian
Commentary on Twitter (thread – click for more)
New paper in @NatureMedicine.
Results from a @NIHRresearch funded multi-centre UK trial of #ecigarettes for smoking cessation in pregnancy 🤰
Found that ECs for smoking cessation in pregnancy may be more effective than NRT.
Led by colleagues @QMUL 1/8. https://t.co/OUZxfZB4Cc— Linda Bauld (@LindaBauld) May 16, 2022
RCT: Effect of robot-assisted radical cystectomy with intracorporeal urinary diversion vs. open radical cystectomy on 90-day morbidity and mortality among patients with bladder cancer.
16 May, 2022 | 02:35h | UTCEditorial: Robotic Surgery for Bladder Cancer – JAMA
Commentary on Twitter
In this trial, robot-assisted surgery vs open surgery for radical cystectomy among patients with #bladdercancer resulted in a statistically significantly greater number of days alive and out of the hospital. https://t.co/icPLiKH0Lf
— JAMA (@JAMA_current) May 15, 2022
RCT: Albuterol–budesonide fixed-dose combination rescue inhaler for asthma.
16 May, 2022 | 02:33h | UTCAlbuterol–Budesonide Fixed-Dose Combination Rescue Inhaler for Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
The risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 μg of albuterol and 160 μg of budesonide than with albuterol alone. #ATS2022 https://t.co/MRGaUaGVwj pic.twitter.com/6BZX9Q6WxX
— NEJM (@NEJM) May 15, 2022
RCT: Effect of awake prone positioning on endotracheal intubation in patients with COVID-19 and acute respiratory failure.
16 May, 2022 | 02:37h | UTCRelated:
RCT: Prone positioning of patients with moderate hypoxia due to COVID-19 – medRxiv
Commentary on Twitter
In this trial, in patients with acute hypoxemic respiratory failure from #COVID19, prone positioning, compared with usual care without prone positioning, did not significantly reduce endotracheal intubation at 30 days. https://t.co/1RyYRtcrYj
— JAMA (@JAMA_current) May 15, 2022
Trial of a preferential Phosphodiesterase 4B Inhibitor for idiopathic pulmonary fibrosis.
16 May, 2022 | 02:32h | UTCTrial of a Preferential Phosphodiesterase 4B Inhibitor for Idiopathic Pulmonary Fibrosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/NEJM/status/1525878684380430343
RCT: Comparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults.
16 May, 2022 | 02:30h | UTCComparison of 8 versus 15 days of antibiotic therapy for Pseudomonas aeruginosa ventilator-associated pneumonia in adults: a randomized, controlled, open-label trial – Intensive Care Medicine (free article here)
Commentary on Twitter
🧫 8 vs 15 days ABT for Pseudomonas aeruginosa VAP in adults, iDIAPASON RCT: no differences in composite or separate outcomes (90-day mortality/VAP recurrence) between short & long duration treatment.
📢 @yourICM ground-breaking release #LIVES40 #FOAMcc
🖇 https://t.co/LfoUWxCkkl pic.twitter.com/XaWkQ5R6wT— Intensive Care Medicine (@yourICM) May 13, 2022
Test-negative, case-control study: Association of prior BNT162b2 COVID-19 vaccination with symptomatic SARS-CoV-2 infection in children and adolescents during Omicron predominance.
16 May, 2022 | 02:25h | UTCEditorial: Protecting Children Against Omicron – JAMA
Commentary on Twitter (thread – click for more)
This new JAMA study is worth discussing. It found that, this winter, vax effectiveness in 12-15 yos dropped to 0% after 3-5 months & vaccinated were MORE likely to test+ at month 7. May be confounded (see🧵)
But I don't see this as good reason for boostershttps://t.co/zpkIDdZhnn pic.twitter.com/bxAIDmiR8s— Tracy Høeg, MD, PhD (@TracyBethHoeg) May 14, 2022
ESC Position Paper: Integrated care for optimizing the management of stroke and associated heart disease.
16 May, 2022 | 02:29h | UTC
Commentary on Twitter
Integrated care for optimizing the management of stroke and associated heart disease: a position paper of the European Society of Cardiology Council on Strokehttps://t.co/L7dPxM6dZx#EHJ #stroke @escardio @ESC_Journals #CardioTwitter pic.twitter.com/MB6mIqzdui
— EHJ Editor-in-Chief (@ehj_ed) May 14, 2022
Under a https://creativecommons.org/licenses/by-nc/4.0/ license
Hypotheses | Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.
16 May, 2022 | 02:22h | UTCRelated:
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Commentary on Twitter
A solid hypothesis for the basis of the mysterious, severe acute hepatitis in children: superantigen formation from prior Covid viral reservoir in the GI tract with superimposed adenovirus infection https://t.co/1eehyQmlhi @LancetGastroHep pic.twitter.com/UqCAh3igMH
— Eric Topol (@EricTopol) May 14, 2022
Clinical Report: Health supervision for children and adolescents with Down Syndrome.
16 May, 2022 | 02:15h | UTCHealth Supervision for Children and Adolescents With Down Syndrome – Pediatrics
International evidence-based recommendations for point-of-care lung ultrasound.
16 May, 2022 | 02:20h | UTCInternational evidence-based recommendations for point-of-care lung ultrasound – Intensive Care Medicine (if the link is paywalled, try this one)
RCT: Multicomponent intervention to prevent mobility disability in frail older adults.
13 May, 2022 | 11:41h | UTCEditorial: Preserving community mobility in vulnerable older people – The BMJ
News Release: Regular exercise with dietary advice linked to better mobility in frail older people – BMJ Newsroom
Commentary on Twitter
A programme of regular exercise along with expert dietary advice is linked to a reduction in mobility problems among frail older people living in the community, finds this trial by @Emanuel00962649 and colleagueshttps://t.co/xT44sTwe4k
— The BMJ (@bmj_latest) May 12, 2022
Review of thoracic imaging manifestations of COVID-19 and other pathologic Coronaviruses.
13 May, 2022 | 11:36h | UTC
Explaining the unexplained hepatitis in children.
13 May, 2022 | 11:39h | UTCExplaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Related:
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
New versions of Omicron are masters of immune evasion.
13 May, 2022 | 11:37h | UTCNew versions of Omicron are masters of immune evasion – Science
Commentary on Twitter
"Based on its immunological profile, it [Omicron & its subvariants] should be called SARS-3"https://t.co/zxV3T2SKIB@gretchenvogel @NewsfromScience
w/ @K_G_Andersen @Tuliodna @linfa_wang pic.twitter.com/ToKDqNGH74— Eric Topol (@EricTopol) May 12, 2022