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RCT: High-flow nasal oxygen is not beneficial for patients with COVID-19 pneumonia and mild hypoxemia.

23 May, 2022 | 01:51h | UTC

High-flow nasal oxygen versus conventional oxygen therapy in patients with COVID-19 pneumonia and mild hypoxaemia: a randomised controlled trial – Thorax

 

What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both?

23 May, 2022 | 01:48h | UTC

What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science

Related:

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 3 – UK Health Security Agency

Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years – Eurosurveillance

Severe acute hepatitis and acute liver failure of unknown origin in children: a questionnaire-based study within 34 paediatric liver centres in 22 European countries and Israel, April 2022 – Eurosurveillance

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens – The Lancet Gastroenterology & Hepatology

Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT

Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC

Hepatitis outbreak in children: What do we know so far? – Imperial College London

Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

 

WHO: Multi-country monkeypox outbreak in non-endemic countries.

23 May, 2022 | 01:46h | UTC

Multi-country monkeypox outbreak in non-endemic countries – World Health Organization

Monkeypox goes global: why scientists are on alert – Nature

Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ

Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT

What is monkeypox? A microbiologist explains what’s known about this smallpox cousin – The Conversation

Monkeypox: Time to worry or one to ignore? – BBC

UK, Spain, Portugal report more monkeypox cases – CIDRAP

U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT

Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization

Monkeypox cases confirmed in England – latest updates – UK Health Security Agency

Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch

European outbreak of monkeypox: what you need to know – The Conversation

Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR

Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News

 

Commentary on Twitter

 

Review: Hypothyroidism.

23 May, 2022 | 01:49h | UTC

Hypothyroidism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Hypothyroidism – Nature Reviews Disease Primers (if the link is paywalled, try this one)

 

Management of moderate to severe traumatic brain injury: an update for the intensivist.

23 May, 2022 | 01:42h | UTC

Management of moderate to severe traumatic brain injury: an update for the intensivist – Intensive Care Medicine

 

Commentary on Twitter

 

AHA Scientific Statement: Preventing and managing falls in adults with cardiovascular disease.

20 May, 2022 | 11:20h | UTC

Preventing and Managing Falls in Adults With Cardiovascular Disease: A Scientific Statement From the American Heart Association – Circulation: Cardiovascular Quality and Outcomes

News Release: Statement addresses ways to prevent heart-related risks for falling – American Heart Association

Commentary: AHA News: Falls Can Be a Serious, Poorly Understood Threat to People With Heart Disease – HealthDay

 

WHO: 2022 Progress report on the Global Action Plan for Healthy Lives and Well-being for All.

20 May, 2022 | 11:17h | UTC

2022 Progress report on the Global Action Plan for Healthy Lives and Well-being for All – World Health Organization

Full Report: Stronger collaboration for an equitable and resilient recovery towards the health-related Sustainable Development Goals, incentivizing collaboration – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

WHO validates 11th vaccine for COVID-19.

20 May, 2022 | 11:16h | UTC

WHO validates 11th vaccine for COVID-19 – World Health Organization

 

Commentary on Twitter

 

Covid-19: Second boosters may benefit at-risk groups but have “minimal” impact for others, says WHO.

20 May, 2022 | 11:08h | UTC

Covid-19: Second boosters may benefit at-risk groups but have “minimal” impact for others, says WHO – The BMJ

Original Statement: Interim statement on the use of additional booster doses of Emergency Use Listed mRNA vaccines against COVID-19 – World Health Organization

Related recommendations:

COVID-19: Joint statement from ECDC and EMA on the administration of a fourth dose of mRNA vaccines –
European Centre for Disease Prevention and Control

Coronavirus (COVID-19) Update: FDA Authorizes Second Booster Dose of Two COVID-19 Vaccines for Older and Immunocompromised Individuals – U.S. Food & Drug Administration

 

COVID-19 evidence: a Cochrane round-up.

20 May, 2022 | 11:14h | UTC

COVID-19 evidence: a Cochrane round-up – Cochrane Library

 

Systematic Review: Thoracic imaging tests for the diagnosis of COVID‐19.

20 May, 2022 | 11:13h | UTC

Thoracic imaging tests for the diagnosis of COVID‐19 – Cochrane Library

Summary: How accurate is chest imaging for diagnosing COVID-19? – Cochrane Library

Related: Review of Thoracic Imaging Manifestations of COVID-19 and Other Pathologic Coronaviruses – Radiology Clinics of North America

 

M-A: Antibiotic duration for community acquired pneumonia in outpatient children in high-income countries – treatment duration of 3–5 days is equally effective and safe vs. 7–10 days.

20 May, 2022 | 11:10h | UTC

Antibiotic treatment duration for community acquired pneumonia in outpatient children in high-income countries – a systematic review and meta-analysis – Clinical Infectious Diseases

Related:

Antibiotics for Pediatric Pneumonia: Might Less Be Enough? – Annals of Emergency Medicine

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial – JAMA

Extended Versus Standard Antibiotic Course Duration in Children <5 Years of Age Hospitalized With Community-acquired Pneumonia in High-risk Settings: Four-week Outcomes of a Multicenter, Double-blind, Parallel, Superiority Randomized Controlled Trial – The Pediatric Infectious Disease Journal

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial – JAMA Pediatrics

Appropriate Use of Short-Course Antibiotics in Common Infections: Best Practice Advice From the American College of Physicians – Annals of Internal Medicine

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics

Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy

 

Commentary on Twitter

 

Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality.

20 May, 2022 | 11:06h | UTC

Cytomegalovirus blood reactivation in COVID-19 critically ill patients: risk factors and impact on mortality – Intensive Care Medicine

 

Commentary on Twitter

 

UK, Spain, Portugal report more monkeypox cases.

19 May, 2022 | 11:15h | UTC

UK, Spain, Portugal report more monkeypox cases – CIDRAP

See also:

U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT

Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization

Monkeypox cases confirmed in England – latest updates – UK Health Security Agency

Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch

European outbreak of monkeypox: what you need to know – The Conversation

Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR

Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News

 

Commentary on Twitter

 

Pollution and health: a progress update.

19 May, 2022 | 11:12h | UTC

Pollution and health: a progress update – The Lancet Planetary Health

Commentaries:

One in six killed by pollution worldwide, study finds – CNN

Pollution responsible for one in six deaths across planet, scientists warn – The Guardian

 

Commentary on Twitter

 

The pandemic’s true health cost: how much of our lives has COVID stolen?

19 May, 2022 | 11:09h | UTC

The pandemic’s true health cost: how much of our lives has COVID stolen? – Nature

 

Commentary on Twitter

 

Discovery reveals blocking inflammation may lead to chronic pain.

19 May, 2022 | 11:06h | UTC

News Release: Discovery reveals blocking inflammation may lead to chronic pain – McGill University

Original Study: Acute inflammatory response via neutrophil activation protects against the development of chronic pain – Science Translational Medicine

 

Commentary on Twitter

 

Results of two cases of pig-to-human kidney xenotransplantation.

19 May, 2022 | 11:11h | UTC

Results of Two Cases of Pig-to-Human Kidney Xenotransplantation – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Opinion | Does Paxlovid help people who have been vaccinated against Covid-19? Show us the data!

19 May, 2022 | 11:07h | UTC

Does Paxlovid help people who have been vaccinated against Covid-19? Show us the data! – STAT

 

Review: Unexplained post-acute infection syndromes.

19 May, 2022 | 10:58h | UTC

Unexplained post-acute infection syndromes – Nature Medicine (if the link is paywalled, try this one)

 

Commentary on Twitter

 

Opinion | Bill Gates and the fate of WHO.

19 May, 2022 | 10:56h | UTC

Offline: Bill Gates and the fate of WHO – The Lancet

 

Commentary on Twitter

 

AHA/ASA Guideline: Management of patients with spontaneous intracerebral hemorrhage.

18 May, 2022 | 12:01h | UTC

2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke

Top Things to Know: 2022 Guideline for the Management of Patients With Spontaneous Intracerebral Hemorrhage – American Heart Association

News Release: New guideline refines care for brain bleeds: compression socks, some meds not effective – American Heart Association

 

Commentary on Twitter

 

RCT: Effect of transcatheter aortic valve implantation vs. surgical aortic valve replacement on all-cause mortality in patients with aortic stenosis.

18 May, 2022 | 11:12h | UTC

Effect of Transcatheter Aortic Valve Implantation vs Surgical Aortic Valve Replacement on All-Cause Mortality in Patients With Aortic Stenosis: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Treatment of Aortic Stenosis With Transcatheter Aortic Valve Implantation – JAMA (free for a limited period)

 

Commentary on Twitter

 

ASCO Guideline: Exercise, diet, and weight management during cancer treatment.

18 May, 2022 | 11:28h | UTC

Exercise, Diet, and Weight Management During Cancer Treatment: ASCO Guideline – Journal of Clinical Oncology

 

Commentary on Twitter

 

RCT: Effect of oral methylprednisolone on decline in kidney function or kidney failure in patients with IgA nephropathy.

18 May, 2022 | 11:20h | UTC

Effect of Oral Methylprednisolone on Decline in Kidney Function or Kidney Failure in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Oral Glucocorticoids for IgA Nephropathy – JAMA

Commentary: Multi-country study provides a clear treatment option for IgA nephropathy – News Medical

 

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