Editor's Choice
Review | Invasive respiratory fungal infections in COVID-19 critically ill patients.
15 Jul, 2022 | 12:58h | UTCInvasive Respiratory Fungal Infections in COVID-19 Critically Ill Patients – Journal of Fungi
7 of your most pressing monkeypox vaccine questions, answered – “We have safe, effective options — but in short supply”.
15 Jul, 2022 | 13:00h | UTC7 of your most pressing monkeypox vaccine questions, answered – Vox
Related:
How contagious is monkeypox—and should you get a vaccine? Here’s the latest. – National Geographic
Prevention and Treatment of Monkeypox – Drugs
Monkeypox soars in Europe, with more than 4,000 cases – CIDRAP
No room for complacency – World Health Organization
Multi-country monkeypox outbreak: situation update – World Health Organization
Monkeypox Genital Lesions – New England Journal of Medicine
Monkeypox vaccination begins — can the global outbreaks be contained? – Nature
Incubation period for monkeypox: Estimates from the Netherlands.
‘Discriminatory and stigmatizing’: Scientists push to rename monkeypox viruses – STAT
Rename monkeypox strains to remove geographic stigma, researchers say – Science
2022 Monkeypox and Orthopoxvirus Outbreak Global Map – Centers for Disease Control and Prevention
As monkeypox threat grows, scientists debate best vaccine strategy – Science
Monkeypox is a new global threat. African scientists know what the world is up against – Science
Experts highlight sexual aspect of monkeypox spread – CIDRAP
What to Know About Monkeypox – JAMA
Multi-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
Pressure ulcers (pressure injuries) | Cochrane Library evidence and resources.
14 Jul, 2022 | 13:03h | UTCPressure ulcers (pressure injuries): evidence and resources – Evidently Cochrane
RCT | Pharmacogenomic testing for drug-gene interactions provides little benefit for the remission of symptoms in major depressive disorder.
14 Jul, 2022 | 13:05h | UTCEffect of Pharmacogenomic Testing for Drug-Gene Interactions on Medication Selection and Remission of Symptoms in Major Depressive Disorder: The PRIME Care Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Pharmacogenomic Testing for Next-Step Antidepressant Selection: Still a Work in Progress – JAMA (free for a limited period)
Commentary: Does Pharmacogenomic Testing Improve Outcomes in Major Depressive Disorder? — The evidence is unclear – MedPage Today (free registration required)
Commentary on Twitter
In this randomized clinical trial, pharmacogenomic testing for drug-gene interactions in major depressive disorder reduced prescription of medications with predicted drug-gene interactions but had small and nonpersistent effects on symptom remission. https://t.co/Z2OIK3h1Bo pic.twitter.com/8eKSipfBFN
— JAMA (@JAMA_current) July 12, 2022
FDA authorizes emergency use of Novavax COVID-19 vaccine.
14 Jul, 2022 | 13:01h | UTCCommentaries:
FDA authorizes Novavax Covid vaccine, in hopes the traditional shot will convince holdouts – STAT
US regulators OK new COVID-19 shot option from Novavax – Associated Press
How to bounce back from a PhD-project failure.
14 Jul, 2022 | 12:59h | UTCHow to bounce back from a PhD-project failure – Nature
WHO Updated Report | Severe acute hepatitis of unknown etiology in children.
14 Jul, 2022 | 12:54h | UTCSevere acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Related:
Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
A case series of children with acute hepatitis and human Adenovirus infection.
14 Jul, 2022 | 12:56h | UTCA Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Related Study: Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41 — Two studies point to a suspiciously high prevalence – MedPage Today (free registration required)
Commentaries on Twitter
A majority of children admitted to a single hospital in late 2021–early 2022 with acute hepatitis of unknown cause tested positive for adenovirus. This report describes the children’s illnesses and outcomes. https://t.co/QYvi6U1jUN pic.twitter.com/auPRq1duQm
— NEJM (@NEJM) July 13, 2022
From January–April 2022, 44 children with acute hepatitis of unknown cause were referred to a liver-transplantation center in the U.K. Six underwent liver transplantation. https://t.co/CMI4KCqdxM pic.twitter.com/og72u58L5R
— NEJM (@NEJM) July 13, 2022
Nationwide cohort study | Safety of heterologous primary and booster schedules with ChAdOx1-S and BNT162b2 or mRNA-1273 vaccines.
14 Jul, 2022 | 12:52h | UTC
M-A of RCTs | Megestrol Acetate not beneficial for cancer-related anorexia/cachexia.
14 Jul, 2022 | 12:50h | UTC
RCT | Endovascular thrombectomy NOT noninferior to standard bridging thrombolytic with endovascular thrombectomy within 4.5 h of stroke onset.
13 Jul, 2022 | 11:57h | UTCEndovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Thrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
RCT | Thrombectomy alone NOT noninferior to intravenous alteplase plus thrombectomy in patients with stroke.
13 Jul, 2022 | 11:55h | UTCThrombectomy alone versus intravenous alteplase plus thrombectomy in patients with stroke: an open-label, blinded-outcome, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Related Study: Endovascular thrombectomy versus standard bridging thrombolytic with endovascular thrombectomy within 4·5 h of stroke onset: an open-label, blinded-endpoint, randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
Two new RCTs show we shouldn't skip bridging intravenous thrombolysis in eligible thrombectomy patients: DIRECT-SAFE (n=293) & SWIFT DIRECT (n=408) @TheLancet @SNISinfo@cvsection https://t.co/Tks14TlaVFhttps://t.co/WaTPn34diy pic.twitter.com/Gcddws8oDf
— Babak Jahromi MD PhD FRCSC (@babaksjahromi) July 9, 2022
RCT | Myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy.
13 Jul, 2022 | 11:52h | UTC
Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses.
13 Jul, 2022 | 11:51h | UTC
Clinical prediction models for mortality in patients with covid-19: external validation and individual participant data meta-analysis.
13 Jul, 2022 | 11:49h | UTC
M-A | Home oxygen for moderate hypoxemia in chronic obstructive pulmonary disease.
13 Jul, 2022 | 11:47h | UTCHome oxygen for moderate hypoxaemia in chronic obstructive pulmonary disease: a systematic review and meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Home oxygen probably makes little or no difference to 3-year mortality in pts with #COPD and moderate hypoxaemia
Systematic review & meta-analysis from Yves Lacasse & colleagues https://t.co/8wDrkEd1LH pic.twitter.com/UoOqW7hngT
— The Lancet Respiratory Medicine (@LancetRespirMed) July 11, 2022
RCT | Neutropenic versus regular diet for acute leukemia induction chemotherapy.
13 Jul, 2022 | 11:45h | UTCNeutropenic versus regular diet for acute leukaemia induction chemotherapy: randomised controlled trial – BMJ Supportive & Palliative Care (link to abstract – $ for full-text)
Related:
Association between the dietary regimen and infection-related complications in neutropenic high-risk patients with cancer – European Journal of Cancer (link to abstract – $ for full-text)
Neutropenic diets to prevent cancer infections: updated systematic review and meta-analysis – BMJ Supportive & Palliative Care (link to abstract – $ for full-text)
Things We Do For No Reason: Neutropenic Diet – Journal of Hospital Medicine (PDF)
Cohort Study | Risk and timing of noncardiac surgery after transcatheter aortic valve implantation.
13 Jul, 2022 | 11:43h | UTCCommentaries:
Surgery After TAVR: Waiting a Month or More Not Really Better— Prosthesis-patient mismatch, paravalvular regurgitation the bigger issues for surgical candidates – MedPage Today (free registration required)
Commentaries on Twitter
https://twitter.com/JAMANetworkOpen/status/1545120466326749186
https://twitter.com/preopconsult/status/1546167570771894272
ADA Guideline Summary | Obesity and weight management for prevention and treatment of Type 2 Diabetes.
12 Jul, 2022 | 13:06h | UTCObesity and Weight Management for Prevention and Treatment of Type 2 Diabetes – JAMA (free for a limited period)
Original Guideline: ADA 2022 Standards of Medical Care in Diabetes – American Diabetes Association
New coronavirus mutant (BA.2.75) raises concerns in India and beyond.
12 Jul, 2022 | 12:59h | UTCNew coronavirus mutant raises concerns in India and beyond – Associated Press
Perspective | Why BA.5 feels different: the latest wave of infections is a test of our pandemic priorities.
12 Jul, 2022 | 13:03h | UTCWhy BA.5 Feels Different – The Atlantic
Long-term follow up of a RCT | Physical therapy noninferior to early arthroscopic partial meniscectomy in patients with degenerative meniscal tears.
12 Jul, 2022 | 12:57h | UTC
M-A | Global changes in child and adolescent physical activity during the COVID-19 pandemic.
12 Jul, 2022 | 12:53h | UTCGlobal Changes in Child and Adolescent Physical Activity During the COVID-19 Pandemic: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
RCT | Adjunctive transdermal cannabidiol no better than placebo for drug-resistant focal epilepsy.
12 Jul, 2022 | 12:54h | UTC
Commentary on Twitter
In this randomized clinical trial, transdermal cannabidiol was well-tolerated and safe, but did not decrease seizure frequency at week 12 of the double-blind period among the placebo, 195-mg cannabidiol, and 390-mg cannabidiol treatments. https://t.co/lR3kEzPE5T
— JAMA Network Open (@JAMANetworkOpen) July 8, 2022
RCT | Leflunomide vs. azathioprine for maintenance therapy of lupus nephritis.
12 Jul, 2022 | 12:51h | UTC
Commentary on Twitter
🆕🔥Leflunomide versus azathioprine for maintenance therapy of lupus nephritis
🫘LEF=AZR in maintenance for SLE-LN
🫘Induction with NIH-CYC
🫘Chinese seem to love Lefno
🫘Generalisability difficult
Would have loved an MMF vs LEF#Rheumtwitter #Nephtwitterhttps://t.co/N2gTYISibM pic.twitter.com/nlP2LkSu8c— EnvisionRheumat (@ERheumat) July 5, 2022
Under a http://creativecommons.org/licenses/by-nc/4.0/ license