Editor's Choice
Guideline | Preventing obesity in midlife women.
3 Aug, 2022 | 14:37h | UTCCommentary: Counseling Can Prevent Obesity in Normal, Overweight Women – HealthDay
Commentary on Twitter
New guidelines aim to prevent #obesity in midlife women. @TheWPSI recommends counseling to prevent weight gain in all women at normal or overweight BMI. Full text available at https://t.co/P8VwBWIHXe @CedarsSinai @acog pic.twitter.com/YxTQVgXj59
— Annals of Int Med (@AnnalsofIM) August 2, 2022
M-A | Response to acute monotherapy for major depressive disorder in randomized, placebo controlled trials.
3 Aug, 2022 | 14:31h | UTC
RECOVERY Trial | Baricitinib in patients admitted to hospital with COVID-19.
3 Aug, 2022 | 14:34h | UTCInvited Commentary: Baricitinib in COVID-19: a coming-of-age from artificial intelligence to reducing mortality – The Lancet
Related:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
New @TheLancet
The largest trial of baricitinib, a JAK-inhibitor drug repurposed via #AI data mining, reduced Covid mortality and the overall reduction consistent with 8 previous RCTs (~20%)https://t.co/5fHDBBvm3Q pic.twitter.com/GDFzcU26H6— Eric Topol (@EricTopol) July 29, 2022
Under a Creative Commons Attribution (CC BY 4.0) license
Antivirals with activity against Monkeypox: a clinically oriented review.
3 Aug, 2022 | 14:26h | UTCRelated:
WHO chief advises men who have sex with men to reduce partners to limit exposure to monkeypox – CNN
WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch
Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases
Review | Diagnosis, treatment, and prevention of Malaria in the US.
3 Aug, 2022 | 14:27h | UTCDiagnosis, Treatment, and Prevention of Malaria in the US: A Review – JAMA (free for a limited period)
Audio Clinical Review: Diagnosis, Treatment, and Prevention of Malaria in the US – JAMA
Cohort Study | Association between gout flare and subsequent cardiovascular events among patients with gout.
3 Aug, 2022 | 14:30h | UTCAssociation Between Gout Flare and Subsequent Cardiovascular Events Among Patients With Gout – JAMA (free for a limited period)
Editorial: Cardiovascular Events and Gout Flares – JAMA (free for a limited period)
News Release: Flare-ups of gout are linked to heart attack and stroke – University of Nottingham
Commentary: Association Between Gout Flare and Subsequent Cardiovascular Events – American College of Cardiology
Cohort Study | Association of higher-dose fluoroquinolone therapy with serious adverse events in older adults with advanced chronic kidney disease.
3 Aug, 2022 | 14:22h | UTC
Evidence Synthesis | Deprescribing medicines in older people living with multimorbidity and polypharmacy.
3 Aug, 2022 | 14:20h | UTCRelated:
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
Designing Infographics | Visual representations for enhancing education, communication, and scientific research.
3 Aug, 2022 | 14:24h | UTCRelated:
As scientists take to Twitter, study shows power of ‘visual abstract’ graphics – Scienmag
See also: an open-source primer on visual abstracts
Deep learning electrocardiographic analysis for detection of left-sided valvular heart disease.
3 Aug, 2022 | 14:19h | UTC
Commentary from the author on Twitter (thread – click for more)
Out today in @JACCJournals, our ValveNet study shows a ML model can detect mod-severe left sided valve disease from ECG. This model is currently running live in our health system daily. Now let me tell you everything wrong with it! A brief 🧵 https://t.co/rjtZxxTLt9 pic.twitter.com/oZKDDnZqYU
— Pierre Elias, MD (@PierreEliasMD) August 1, 2022
WHO Guidelines on HIV, viral hepatitis and STI prevention, diagnosis, treatment and care for key populations.
2 Aug, 2022 | 12:41h | UTCNews Release: WHO publishes new guidelines on HIV, hepatitis and STIs for key populations – World Health Organization
Severe acute hepatitis of unknown etiology in children—what is known?
2 Aug, 2022 | 12:39h | UTCSevere acute hepatitis of unknown aetiology in children—what is known? – BMC Medicine
Related:
A Case Series of Children with Acute Hepatitis and Human Adenovirus Infection – New England Journal of Medicine (link to abstract – $ for full-text)
Clinical Spectrum of Children with Acute Hepatitis of Unknown Cause – New England Journal of Medicine (link to abstract – $ for full-text)
Severe acute hepatitis of unknown aetiology in children – Multi-country – World Health Organization
Sudden onset hepatitis in children – Nature Reviews Gastroenterology & Hepatology (if the link is paywalled, try this one)
Outbreak of hepatitis in children: clinical course of children with acute liver failure admitted to the intensive care unit – Intensive Care Medicine (if the link is paywalled, try this one)
Investigating Acute Hepatitis of Unknown Origin in Children – American Society for Microbiology
What’s sending kids to hospitals with hepatitis—coronavirus, adenovirus, or both? – Science
Puzzling pediatric hepatitis cases echo an earlier mysterious illness – STAT
Why COVID is a key suspect in severe hepatitis cases in kids worldwide – CBC
Hepatitis outbreak in children: What do we know so far? – Imperial College London
Explaining the unexplained hepatitis in children – The Lancet Infectious Diseases
Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP
Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization
WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT
Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch
U.S., U.K. investigating unusual cases of hepatitis in young children – STAT
Mysterious liver illness seen in kids in US, Europe – Associated Press
Burden of chronic obstructive pulmonary disease and its attributable risk factors in 204 countries and territories, 1990-2019: results from the Global Burden of Disease Study 2019.
2 Aug, 2022 | 12:37h | UTCNews Release: Chronic lung disease remains major public health problem – BMJ Newsroom
Commentary on Twitter
New research finds that despite the decreasing burden of COPD, this disease remains a major public health problem, especially in countries with a low sociodemographic index https://t.co/uUkQYCSmBY
— The BMJ (@bmj_latest) July 30, 2022
M-A | GLP1 receptor agonists are associated with increased risk of progression of retinopathy in patients with type 2 diabetes.
2 Aug, 2022 | 12:32h | UTCProgression of retinopathy with glucagon-like peptide-1 receptor agonists with cardiovascular benefits in type 2 diabetes – A systematic review and meta-analysis – Journal of Diabetes and its Complications (link to abstract – $ for full-text)
Commentary: GLP1 RA use tied to increased risk of rapidly worsening retinopathy in type 2 diabetes – Medical Dialogues
Retrospective Cohort Study | Syncope and the risk of subsequent motor vehicle crash.
2 Aug, 2022 | 12:33h | UTCSyncope and the Risk of Subsequent Motor Vehicle Crash: A Population-Based Retrospective Cohort Study – JAMA Internal Medicine (free for a limited period)
Editorial: Driving Safety After an Acute Illness—This Is Our Lane – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter
"I fainted…am I safe to drive?" Study found that 9,223 drivers with an ED visit for syncope had subsequent crash risks no different than controls, suggesting more stringent driving restrictions might not be justified. https://t.co/T0GUJ63Nci
— JAMA Internal Medicine (@JAMAInternalMed) August 1, 2022
Digital teaching in medical education: scientific literature landscape review.
2 Aug, 2022 | 12:23h | UTCNews Release: Digital teaching in medical education: A literature review – JMIR Publications
M-A | Planned delivery or expectant management in preeclampsia.
2 Aug, 2022 | 12:28h | UTC
Commentary on Twitter
Planned delivery or expectant management in preeclampsia: an individual participant data meta-analysis https://t.co/djWXjReZAM pic.twitter.com/UdjsqcXDnH
— AJOG (@AJOG_thegray) July 26, 2022
Cohort Study | Association of elevated amyloid and tau positron emission tomography signal with near-term development of Alzheimer disease symptoms in older adults without cognitive impairment.
2 Aug, 2022 | 12:26h | UTCAssociation of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment – JAMA Neurology (link to abstract – $ for full-text)
Commentary on Twitter
Study found that Aβ and tau PET positivity in cognitively unimpaired individuals was associated with near-term progression to mild cognitive impairment and, among those who do not show such categorical change, longitudinal cognitive decline. https://t.co/sKpST7e4Nh
— JAMA Neurology (@JAMANeuro) July 30, 2022
M-A | Perioperative care bundles for the prevention of surgical-site infections.
2 Aug, 2022 | 12:30h | UTC
Review | Massive Open Online Courses (MOCCs) for health worker education in low- and middle-income countries.
2 Aug, 2022 | 12:21h | UTC
RCT | Intervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden.
1 Aug, 2022 | 12:32h | UTCIntervention with methotrexate in patients with arthralgia at risk of rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a randomised, double-blind, placebo-controlled, proof-of-concept trial – The Lancet (link to abstract – $ for full-text)
News Release: Treatment before patients develop rheumatism provides lasting relief – Leiden University Medical Centre
Commentaries on Twitter:
NEW in @TheLancet—The TREAT EARLIER trial shows that #methotrexate initiated in patients with arthralgia at risk of #rheumatoidarthritis did not prevent the development of clinical arthritis, but did modify the disease course https://t.co/5zh7lqb4NJ pic.twitter.com/lJflW9Prwm
— The Lancet Rheumatology (@TheLancetRheum) July 22, 2022
🆕🔥Methotrexate,🇳🇱study
MTX in pre-arthritis stage➡️ did not prevent the development of clinical arthritis
but ➡️sustained improvement in
♦️MRI-detected inflammation,
♦️Symptoms (Pain & EMS)
♦️Related impairments (HAQ n Presentism)
Vs placebohttps://t.co/I0IdKydPME pic.twitter.com/cNi6AhO151— EnvisionRheumat (@ERheumat) July 29, 2022
RCT | Endoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity.
1 Aug, 2022 | 12:35h | UTCEndoscopic sleeve gastroplasty for treatment of class 1 and 2 obesity (MERIT): a prospective, multicentre, randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
MERIT trial suggests endoscopic sleeve gastroplasty should be considered as a synergistic weight loss intervention for patients with class 1 or class 2 obesity.
Find out more: https://t.co/FWeXeWbBF0 pic.twitter.com/W6qUKW92hR
— The Lancet (@TheLancet) July 30, 2022
Brief Review | Monitoring pain in the intensive care unit.
1 Aug, 2022 | 12:30h | UTCMonitoring pain in the intensive care unit (ICU) – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Monitoring pain in #ICU
➡️ self‐assessment tools in pts able to self‐report
➡️ observational behavioural scales in pts unable to self‐report
➡️ physiologic parameters in pts unable to self‐report nor express behaviours (deep sedaution, NMBAs)#FOAMcc
🖇 https://t.co/SaD1BBxSNw pic.twitter.com/81tNNvnTDe— Intensive Care Medicine (@yourICM) July 30, 2022
Cohort Study | Long-term leisure-time physical activity intensity and all-cause and cause-specific mortality.
1 Aug, 2022 | 12:26h | UTCLong-Term Leisure-Time Physical Activity Intensity and All-Cause and Cause-Specific Mortality: A Prospective Cohort of US Adults – Circulation (free for a limited period)
News Release: New study finds lowest risk of death was among adults who exercised 150-600 minutes/week – American Heart Association
M-A | Probiotics in critical illness.
1 Aug, 2022 | 12:28h | UTCProbiotics in Critical Illness: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Critical Care Medicine (free for a limited period)
Commentary on Twitter
#OpenAccess #VisualAbstract @SameerSharifMD et al: Sys Review & MA of #Probiotics in #CritCareMed
67 RCTs 8483 pts
⬇️VAP HAP #ICULOS, #mechvent
No effect on mortality
Low certainty evidenceLink: https://t.co/kN7FliTpbr@SCCM #CritCareMed @Bram_Rochwerg @leashgreer pic.twitter.com/pROjhq9T2J
— Critical Care Medicine (@CritCareMed) July 22, 2022