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M-A | Global prevalence and incidence of tinnitus.

9 Aug, 2022 | 12:57h | UTC

Global Prevalence and Incidence of Tinnitus: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)

Commentary: Review: Global Pooled Prevalence of Tinnitus 14.4 Percent – HealthDay

 

Commentary on Twitter

 

Guideline Synopsis | Treatment of Clostridioides difficile infection.

9 Aug, 2022 | 12:54h | UTC

Treatment of Clostridioides difficile Infection – JAMA (free for a limited period)

Original Guideline: ACG Clinical Guidelines: Prevention, Diagnosis, and Treatment of Clostridioides difficile Infections – American Journal of Gastroenterology

Related Guidelines:

Clinical Practice Guideline by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA): 2021 Focused Update Guidelines on Management of Clostridioides difficile Infection in Adults – Clinical Infectious Diseases

Prevention of Clostridioides difficile in hospitals: A position paper of the International Society for Infectious Diseases – International Journal of Infectious Diseases

Clostridioides difficile infection: antimicrobial prescribing – National Institute for Health and Care Excellence

Japanese Clinical Practice Guidelines for Management of Clostridioides (Clostridium) difficile infection – Journal of Infection and Chemotherapy

 

Commentary on Twitter

 

Diagnostic Test Interpretation | Serum Cystatin C for estimation of glomerular filtration rate.

9 Aug, 2022 | 12:52h | UTC

Serum Cystatin C for Estimation of GFR – JAMA (free for a limited period)

 

Commentary on Twitter

 

Position statement | Use of albumin in liver cirrhosis.

8 Aug, 2022 | 11:58h | UTC

Position statement on the use of albumin in liver cirrhosis – Annals of Hepatology

 

ACG Clinical Guideline | Gastroparesis.

8 Aug, 2022 | 12:00h | UTC

ACG Clinical Guideline: Gastroparesis – The American Journal of Gastroenterology

Related: United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis – UEG Journal

 

RCT | Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes.

8 Aug, 2022 | 11:56h | UTC

Effect of once-weekly semaglutide versus thrice-daily insulin aspart, both as add-on to metformin and optimized insulin glargine treatment in participants with type 2 diabetes (SUSTAIN 11): A randomized, open-label, multinational, phase 3b trial – Diabetes, Obesity and Metabolism

 

RCT | Antiseptic skin agents to prevent surgical site infection after incisional surgery.

8 Aug, 2022 | 11:54h | UTC

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Related:

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

 

Two randomized trials found monoclonal antibodies are no better than placebo for Parkinson’s Disease.

8 Aug, 2022 | 11:53h | UTC

Study 1: Trial of Cinpanemab in Early Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Study 2: Trial of Prasinezumab in Early-Stage Parkinson’s Diseas – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Monoclonal Antibodies No Better Than Placebo for Early Parkinson Disease – HealthDay

 

Cochrane Collection | Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence.

8 Aug, 2022 | 11:50h | UTC

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

 

Systematic Review | Impact of low‐dose computed tomography screening on lung cancer‐related mortality.

8 Aug, 2022 | 11:52h | UTC

Impact of low‐dose computed tomography (LDCT) screening on lung cancer‐related mortality – Cochrane Library

Summary: Impact of computed tomography (CT) on lung cancer screening – Cochrane Library

Related:

Association of computed tomography screening with lung cancer stage shift and survival in the United States: quasi-experimental study – The BMJ

Screening for Lung Cancer: CHEST Guideline and Expert Panel Report.

USPSTF Statement: begin screening for lung cancer at age 50 years instead of 55 years for patients at risk

Meta-analysis: Lung cancer screening using low-dose computed tomography reduces lung cancer–specific mortality, albeit with a tradeoff of likely overdiagnosis

 

Is the contemporary care of older persons with acute coronary syndrome evidence-based?

8 Aug, 2022 | 11:48h | UTC

Is the contemporary care of the older persons with acute coronary syndrome evidence-based? – European Heart Journal Open

 

Commentary from the author on Twitter

 

M-A | Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment.

5 Aug, 2022 | 14:43h | UTC

Role of human papillomavirus (HPV) vaccination on HPV infection and recurrence of HPV related disease after local surgical treatment: systematic review and meta-analysis – The BMJ

News Release: HPV vaccination alongside surgery for cervical lesions may reduce risk of further disease – BMJ Newsroom

 

M-A | Risk factors for primary pelvic organ prolapse and prolapse recurrence.

5 Aug, 2022 | 14:42h | UTC

Risk factors for primary pelvic organ prolapse and prolapse recurrence: an updated systematic review and meta-analysis – American Journal of Obstetrics & Gynecology

 

Commentary on Twitter

 

Heavy periods: evidence to help you weigh up treatment options.

5 Aug, 2022 | 14:40h | UTC

Heavy periods: evidence to help you weigh up treatment options – Evidently Cochrane

Original Article: Interventions for heavy menstrual bleeding; overview of Cochrane reviews and network meta‐analysis – Cochrane Library

 

Cohort Study | Age at menopause and risk of heart failure and atrial fibrillation.

5 Aug, 2022 | 14:38h | UTC

Age at menopause and risk of heart failure and atrial fibrillation: a nationwide cohort study – European Heart Journal (link to abstract – $ for full-text)

Editorial: Premature menopause and cardiovascular disease: can we blame estrogen? – European Heart Journal

News Release: Premature menopause is associated with increased risk of heart problems – European Society of Cardiology

 

Phase 1 Study | Low-dose subcutaneous or intravenous monoclonal antibody can prevent malaria in a human challenge model.

4 Aug, 2022 | 14:45h | UTC

Low-Dose Subcutaneous or Intravenous Monoclonal Antibody to Prevent Malaria – New England Journal of Medicine

Editorial: Monoclonal Antibodies for Malaria – New England Journal of Medicine

 

Standardized definitions for bioprosthetic valve dysfunction following aortic or mitral valve replacement.

4 Aug, 2022 | 14:35h | UTC

Standardized Definitions for Bioprosthetic Valve Dysfunction Following Aortic or Mitral Valve Replacement: JACC State-of-the-Art Review – Journal of the American College of Cardiology

 

Commentary on Twitter

Under a http://creativecommons.org/licenses/by/4.0/ license

 

Viewpoint | Deimplementation of low-value care in surgery.

4 Aug, 2022 | 14:43h | UTC

Deimplementation of Low-Value Care in Surgery – JAMA Surgery (free for a limited period)

 

Enhancing primary stroke prevention: a combination approach.

4 Aug, 2022 | 14:42h | UTC

Enhancing primary stroke prevention: a combination approach – The Lancet Public Health

 

Commentary on Twitter

Under a Creative Commons Attribution (CC BY 4.0) license

 

Case-Control Study | Outpatient oral macrolide use is associated with increased risk of sensorineural hearing loss in children, adolescents, and young adults.

4 Aug, 2022 | 14:29h | UTC

Association of Outpatient Oral Macrolide Use With Sensorineural Hearing Loss in Children, Adolescents, and Young Adults – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentary: Kids’ Hearing Loss Associated With Common Antibiotics — Children and teens with sensorineural hearing loss more often macrolide users – MedPage Today (free registration required)

 

RCT | 72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy.

4 Aug, 2022 | 14:33h | UTC

72 weeks post-partum follow-up of dolutegravir versus efavirenz initiated in late pregnancy (DolPHIN-2): an open-label, randomised controlled study – The Lancet HIV

Related:

WHO Recommends Dolutegravir as Preferred HIV Treatment Option in All Populations

Week 96 results from a RCT: Efficacy and safety of dolutegravir or darunavir combined with lamivudine plus either zidovudine or tenofovir for second-line treatment of HIV infection.

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

RCT: Low-cost, easy to take antiretroviral treatment based on Dolutegravir as first- or second-Line therapy found to be non-inferior to standard care for treating HIV-1 infection in children.

RCT: Dolutegravir or Darunavir in combination with Zidovudine or Tenofovir to treat HIV.

Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV

Randomized Trial: Switching to Dolutegravir/Lamivudine Two-Drug Regimen Noninferior to Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1

 

Cohort Study | The risk of opioid overdose is increased with concomitant use of oxycodone and selective serotonin reuptake inhibitors that are inhibitors of oxycodone metabolism.

4 Aug, 2022 | 14:27h | UTC

Risk of Opioid Overdose Associated With Concomitant Use of Oxycodone and Selective Serotonin Reuptake Inhibitors – JAMA Network Open

Commentary from the author: Taking certain opioids while on commonly prescribed antidepressants may increase the risk of overdose – The Conversation

 

Commentary on Twitter

 

In a cohort study with a median follow‐up of 23.2 years, both very low and very high LDL‐C levels are associated with increased risk of cardiovascular mortality in the general population.

4 Aug, 2022 | 14:25h | UTC

Association of Low‐Density Lipoprotein Cholesterol Levels with More than 20‐Year Risk of Cardiovascular and All‐Cause Mortality in the General Population – Journal of the American Heart Association

 

M-A | Efficacy of Doxycycline for mild-to-moderate community-acquired pneumonia in adults.

4 Aug, 2022 | 14:17h | UTC

Efficacy of Doxycycline for Mild-to-moderate Community-acquired Pneumonia in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Clinical Infectious Diseases (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Cohort Study | Bariatric surgery linked to doubling chance of marriage or divorce.

4 Aug, 2022 | 14:16h | UTC

News Release: Bariatric Surgery Linked to Doubling Chance of Marriage or Divorce – University of Pittsburgh

Original Study: Changes in Marital Status Following Roux-en-Y Gastric Bypass and Sleeve Gastrectomy: A US Multicenter Prospective Cohort Study – Annals of Surgery Open

Commentary: Spouse Getting Weight Loss Surgery? Your Marriage Might Be in Trouble – HealthDay

 

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