Editor's Choice | Page 18 of 113 | Links Medicus Content Curation & Alerts in Medicine

Phase 2b RCT | Danuglipron, an oral GLP-1R agonist, reduces body weight and improves glycemic control in type 2 diabetes

1 Jun, 2023 | 12:17h | UTC

Efficacy and Safety of Oral Small Molecule Glucagon-Like Peptide 1 Receptor Agonist Danuglipron for Glycemic Control Among Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA Network Open

Commentary: What is the efficacy, safety, and tolerability of novel danuglipron in adults with type two diabetes? – News Medical

SR | Systematic review finds 16.4-36.18 severe bleedings, 7.62-8.5 perforations per 10,000 colonoscopies

1 Jun, 2023 | 12:15h | UTC

An Estimate of Severe Harms Due to Screening Colonoscopy: A Systematic Review – The Journal of the American Board of Family Medicine

RCT | Prophylactic platelet transfusion reduces CVC-related bleeding in patients with platelets 10-50 K/mm³

31 May, 2023 | 14:20h | UTC

Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Research from Amsterdam UMC shows that the bottom has been reached in restrictive blood transfusion policy – Amsterdam University Medical Centers

Commentary on Twitter

Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.

— NEJM (@NEJM) May 27, 2023

RCT | Early initiation of DOACs not statistically superior to later use in atrial fibrillation-related stroke

31 May, 2023 | 14:17h | UTC

Early versus Later Anticoagulation for Stroke with Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

ELAN: Early DOACs Safe, May Help After Ischemic Stroke in AF Patients – TCTMD

Early Versus Late Initiation of Direct Oral Anticoagulants in Post-Ischemic Stroke Patients With Atrial Fibrillation – ELAN – American College of Cardiology

Commentary on Twitter

Late breaking at #ESOC2023: In the ELAN trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants. Full results:

— NEJM (@NEJM) May 24, 2023

RCT | Ketamine non-Inferiority to ECT for nonpsychotic resistant depression

31 May, 2023 | 14:15h | UTC

Ketamine versus ECT for Nonpsychotic Treatment-Resistant Major Depression – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study Finds Ketamine is at Least as Effective as ECT for Treating Major Depression – Mass General Brigham

Commentary: Expert reaction to trial looking at ketamine versus ECT for nonpsychotic treatment-resistant major depression – Science Media Centre

RCT | P2Y12 inhibitors don’t improve outcomes in critically ill COVID-19 patients

31 May, 2023 | 14:13h | UTC

Effect of P2Y12 Inhibitors on Organ Support–Free Survival in Critically Ill Patients Hospitalized for COVID-19: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

Proposing a new five-type classification for glomerulonephritis based on pathogenesis, activity, and chronicity

31 May, 2023 | 14:11h | UTC

The five types of glomerulonephritis classified by pathogenesis, activity, and chronicity (GN-AC) – Nephrology Dialysis Transplantation

Commentary on Twitter

The five types of glomerulonephritis classified by pathogenesis, activity & chronicity (GN-AC)
🔓https://t.co/NYKBde4L1I
📸The major entities of GN
📸Autoantigens in autoimmune GN
📸Multilevel diagnostic algorithm of GN
📸Proposed GN-AC classification & reporting system for GN pic.twitter.com/shmLLhCfJk

— NDT (@NDTsocial) May 24, 2023

M-A | Labor induction at 39 weeks: improved outcomes but increased shoulder dystocia for nulliparous women

31 May, 2023 | 14:10h | UTC

Comparison of Maternal Labor-Related Complications and Neonatal Outcomes Following Elective Induction of Labor at 39 Weeks of Gestation vs Expectant Management: A Systematic Review and Meta-analysis – JAMA Network Open

The WHO AWaRe (Access, Watch, Reserve) antibiotic book

30 May, 2023 | 12:09h | UTC

The WHO AWaRe (Access, Watch, Reserve) antibiotic book – World Health Organization

RCT | Sulbactam-durlobactam non-inferior to colistin in reducing 28-day mortality from carbapenem-resistant ABC

30 May, 2023 | 12:08h | UTC

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) – The Lancet Infectious Diseases (link to abstract – $ for full-text)

News Release: Novel antibiotic succeeds in trial against hospital-acquired pneumonia – Rutgers University

RCT | Microdosed incisional clindamycin reduces infection rate in skin cancer surgery

30 May, 2023 | 12:03h | UTC

Effect of Microdoses of Incisional Antibiotics on the Rate of Surgical Site Infections in Skin Cancer Surgery: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: Microdosed Incisional Clindamycin Cuts SSI After Skin Cancer Surgery – HealthDay

RCT | Care bundle with intensive blood pressure control improves outcomes in acute cerebral hemorrhage

30 May, 2023 | 12:04h | UTC

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial – The Lancet

News Release: Tens of thousands of lives a year could be saved by new treatment protocol for brain hemorrhage – George Institute for Global Health

Cohort Study | Amiodarone linked to higher bleeding risk vs. flecainide or sotalol in atrial fibrillation patients on anticoagulants

30 May, 2023 | 12:01h | UTC

Risk for Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients With Atrial Fibrillation: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Amiodarone used with anticoagulant therapy linked to more bleeding-related hospitalizations than flecainide or sotalol – American College of Physicians

Commentary: Amiodarone increases bleeding compared with flecainide or sotalol in patients on anticoagulant therapy – ACP Internist

Commentary on Twitter

A study of older adults with #AFib who were treated with #anticoagulants found #amiodarone during apixaban/rivaroxaban use was associated with greater risk for bleeding-related #hospitalizations compared to flecainide or sotalol: https://t.co/cFb1rgGqjt pic.twitter.com/gKlgLXBdb2

— Annals of Int Med (@AnnalsofIM) May 25, 2023

ACC/AHA Multimodality appropriate use criteria for the detection and risk assessment of chronic coronary disease

29 May, 2023 | 11:18h | UTC

ACC/AHA/ASE/ASNC/ASPC/HFSA/HRS/SCAI/SCCT/SCMR/STS 2023 Multimodality Appropriate Use Criteria for the Detection and Risk Assessment of Chronic Coronary Disease – Journal of the American College of Cardiology

Commentaries:

New Multimodality AUC Address Detection and Risk Assessment of Chronic Coronary Disease – American College of Cardiology

2023 Multimodality Appropriate Use Criteria for Chronic Coronary Disease: Key Points – American College of Cardiology

Commentary on Twitter

New multimodality AUC released by @ACCinTouch, key specialty & subspecialty societies, provides guidance on the appropriate use of stress testing & anatomic diagnostic procedures for risk assessment & evaluation of known or suspected CCD. https://t.co/56ewQWqW13 #JACC pic.twitter.com/WIqPyEDwfC

— JACC Journals (@JACCJournals) May 25, 2023

AHA/ASA Guideline for the management of patients with aneurysmal subarachnoid hemorrhage

29 May, 2023 | 11:16h | UTC

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke

Top Things to Know: 2023 Aneurysmal Subarachnoid Hemorrhage Guideline – American Heart Association

Commentary on Twitter

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association https://t.co/IHZRkTR25t @American_Heart @American_Stroke @AHAScience @BrianHoh1 @drdangayach @CPDerdeyn pic.twitter.com/I2JdXnHuXp

— Stroke AHA/ASA (@StrokeAHA_ASA) May 23, 2023

RCT | Group support and skill-based learning reduce opioid use in chronic pain, but leads to no effect on pain perception

29 May, 2023 | 11:14h | UTC

Reducing Opioid Use for Chronic Pain With a Group-Based Intervention: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

News Release: New treatment helps people stop addictive opioid painkillers used for chronic pain – University of Warwick

RCT | Communication-priming intervention boosts goals-of-care discussions for seriously ill patients

29 May, 2023 | 11:12h | UTC

Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Conversations on Goals of Care With Hospitalized, Seriously Ill Patients – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Some Surrogate Endpoints Are Fine – By Dr John Mandrola

Review | Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship

29 May, 2023 | 11:08h | UTC

Mitigating long-term and delayed adverse events associated with cancer treatment: implications for survivorship – Nature Reviews Clinical Oncology (if the link is paywalled, try this one)

Commentary on Twitter

In a Review now published online, @maryam_lustberg @NicoleKuderer @ADesaiMD @crisbergerot and @gary_lyman discuss the mitigation of long-term toxicities from cancer treatment, including financial toxicity and psychosocial needs: https://t.co/Gu08RtT0nO pic.twitter.com/OX9tUZyuY5

— NatureRevClinOncol (@NatRevClinOncol) May 25, 2023