Editor's Choice
Survey Study | ChatGPT’s performance in simulated patient-provider interactions
19 Jul, 2023 | 14:28h | UTCPutting ChatGPT’s Medical Advice to the (Turing) Test: Survey Study – JMIR Medical Education
Related: ChatGPT’s responses to patient questions rated higher for quality and empathy than physicians
RCT | Solanezumab fails to slow cognitive decline in preclinical Alzheimer’s disease
19 Jul, 2023 | 14:26h | UTCTrial of Solanezumab in Preclinical Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Related:
RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns
RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns
Commentary on Twitter
Original Article: Trial of Solanezumab in Preclinical Alzheimer’s Disease (A4 trial) https://t.co/lCXsVoiP8i #AAIC23 pic.twitter.com/e8DplR27yd
— NEJM (@NEJM) July 18, 2023
IARC, WHO agency, identifies aspartame as potentially carcinogenic but probably safe within established acceptable daily intake
18 Jul, 2023 | 13:58h | UTCNews Release: Aspartame hazard and risk assessment results released – World Health Organization
Commentaries:
Expert reaction to IARC and JEFCA summary on aspartame – Science Media Centre
Aspartame Hazard and Risk Assessment Results Released by IARC and JECFA – The ASCO Post
AHA Scientific Statement | Cardiopulmonary impact of electronic cigarettes and vaping products
18 Jul, 2023 | 13:56h | UTCNews Releases:
Top Things to Know: Cardiopulmonary Impact of Electronic Cigarettes and Vaping Products – American Heart Association
Commentary: Vaping’s Risks to CV Health Not Yet Fully Known: AHA – CIDRAP
RCT | Direct oral challenge noninferior to skin testing followed by direct oral challenge in low-risk penicillin allergy patients
18 Jul, 2023 | 13:54h | UTCEfficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
See also: Visual Abstract
News Release: World-first clinical trial to help millions with penicillin allergies – Vanderbilt University Medical Center
Commentary: Trial supports use of direct oral challenge for penicillin allergy – CIDRAP
RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns
18 Jul, 2023 | 13:51h | UTCDonanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)
Editorials:
Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)
Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)
Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
Guideline | Antibiotic therapy in patients with suspected antibiotic allergy
17 Jul, 2023 | 13:59h | UTC
RCT | No definitive benefit of enoxaparin over placebo in preventing VTE in hospitalized older adults
17 Jul, 2023 | 13:57h | UTC
What are effective strategies to reduce low-value care? An analysis of 121 randomized deimplementation studies
17 Jul, 2023 | 13:55h | UTC
Retrospective Analysis | Inconsistencies in pediatric drug dosing found in over half of prehospital emergency drug administrations
17 Jul, 2023 | 13:50h | UTCCommentaries:
Children and Drug Dosing Variations When in Transit to the Hospital – AAP Journals Blog
Variation Seen in Dosing of Meds at Prehospital Pediatric Encounters – HealthDay
M-A | One-year usage of elastic compression stockings comparable to two for post-thrombotic syndrome prevention
17 Jul, 2023 | 13:49h | UTC
Consensus Paper | Implementing strategies to prevent infections in acute-care settings
14 Jul, 2023 | 13:03h | UTCNews Release: New guidance for infection prevention in acute care settings – Society for Healthcare Epidemiology of America
Related:
Practice Recommendation | Strategies to prevent MRSA transmission and infection in hospitals
Consensus Paper | Strategies to prevent surgical site infections in acute-care hospitals
Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals
Consensus Statement | Aerosol therapy in adult critically ill patients
14 Jul, 2023 | 13:01h | UTC
M-A | First-line thiazide diuretics show reduced cardiovascular events, comparable mortality vs. other antihypertensive drugs
14 Jul, 2023 | 12:55h | UTC
Quality Improvement Study | Improved asymptomatic bacteriuria management by reduction of unnecessary urine culture requests
14 Jul, 2023 | 12:54h | UTCRelated:
Study: Hospital Intervention Resulted in a 45% Reduction in the Urine Cultures Ordered
USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults
IDSA Guideline for the Management of Asymptomatic Bacteriuria
Commentary on Twitter
🔥🔥🔥Powerful message from our new study in @JAMAInternalMed: diagnostic stewardship (better use of diagnostic tests) was responsible for ALL the⬇️in unnecessary antibiotic use for ASB. ➕results🟰💪nudge to action. Time to👀👀upstream to improve care! https://t.co/yO4UpA6ZKK pic.twitter.com/hXZGvNmVJP
— Valerie Vaughn (@ValerieVaughnMD) July 11, 2023
AHA Policy Statement | Value-based payment for clinicians treating cardiovascular disease
13 Jul, 2023 | 13:13h | UTCNews Release: Policy guidance offers strategies to shift to value-based health care and payment – American Heart Association
Commentary: AHA Reviews Value-Based Payment Systems and Proposes Next Steps – TCTMD
Cohort Study| Childhood development delayed by 4.39 months due to COVID-19 pandemic
13 Jul, 2023 | 13:11h | UTCAssociation Between the COVID-19 Pandemic and Early Childhood Development – JAMA Pediatrics
Commentary: Studies describe pandemic’s lasting influence on children – CIDRAP
M-A | Adjunctive corticosteroids improve survival, clinical outcomes in severe community-acquired pneumonia
13 Jul, 2023 | 13:09h | UTCRelated:
Corticosteroids in Community-Acquired Bacterial Pneumonia: a Systematic Review, Pairwise and Dose-Response Meta-Analysis – Journal of General Internal Medicine (if the link is paywalled, try this one)
RCT | Hydrocortisone reduces mortality in severe community-acquired pneumonia
ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia
Review | Cushing Syndrome
13 Jul, 2023 | 13:08h | UTCCushing Syndrome: A Review – JAMA (free for a limited period)
Audio clinical review: Diagnosis and Treatment of Cushing Syndrome – JAMA
RCT | Metformin boosts effectiveness of lifestyle interventions for diabetes prevention in individuals with impaired glucose regulation
13 Jul, 2023 | 13:07h | UTCSafety and effectiveness of metformin plus lifestyle intervention compared with lifestyle intervention alone in preventing progression to diabetes in a Chinese population with impaired glucose regulation: a multicentre, open-label, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Related Study: Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin – New England Journal of Medicine (link to abstract – $ for full-text)
Practice Guidance | Six steps to better care for older people in acute hospitals
12 Jul, 2023 | 14:00h | UTCSix steps to better care for older people in acute hospitals – British Geriatrics Society
News Release: New guidance outlines ‘Six steps to better care for older people in hospital’ – British Geriatrics Society
Clinical practice guideline for deprescribing opioid analgesics
12 Jul, 2023 | 13:58h | UTCRelated:
RCT | Opioids not more effective than placebo for acute low back and neck pain
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
RCT | Self-administered intranasal etripamil superior to placebo for acute supraventricular tachycardia conversion
12 Jul, 2023 | 13:54h | UTC
WHO Guideline | Policies to protect children from the harmful impact of food marketing
12 Jul, 2023 | 13:52h | UTCNews Release: WHO recommends stronger policies to protect children from the harmful impact of food marketing – World Health Organization
Commentary: WHO Launches New Guideline for Protecting Children from Unhealthy Food Marketing – Health Policy Watch
M-A | The effect of blood pressure lowering medications on the prevention of episodic migraine
12 Jul, 2023 | 13:50h | UTCNews Release: New study shows common blood pressure meds underused for migraine – George Institute for Global Health