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Perspective: The origins, development, and context of the Lancet Commission on the Value of Death – “Death has turned from being a family, social, and cultural event to primarily a medical event”.

3 Feb, 2022 | 08:51h | UTC

The origins, development, and context of the Lancet Commission on the Value of Death – The BMJ

Related: The Lancet Commission: Experts warn of the increasing overmedicalization of death, call for radical rethink of how society cares for dying people.

 

Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.

3 Feb, 2022 | 08:53h | UTC

An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients: a stepped-wedge, cluster randomized controlled trial (TELnet@NRW) – Journal of Medical Internet Research

Related:

The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)

Infectious Diseases Society of America: Five Things Physicians and Patients Should Question

 

A nationwide study in Sweden showed the risk of death doubled in patients with chronic disease and co-occurring psychiatric disorders.

3 Feb, 2022 | 08:49h | UTC

Risk of Death Doubled in Patients with Chronic Disease and Co-occurring Psychiatric Disorders – University of Oxford

Original Study: Psychiatric comorbidity and risk of premature mortality and suicide among those with chronic respiratory diseases, cardiovascular diseases, and diabetes in Sweden: A nationwide matched cohort study of over 1 million patients and their unaffected siblings – PLOS Medicine

 

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

 

WHO Report: Global analysis of health care waste in the context of COVID-19.

2 Feb, 2022 | 08:54h | UTC

Global analysis of health care waste in the context of COVID-19 – World Health Organization

News Release: Tonnes of COVID-19 health care waste expose urgent need to improve waste management systems – World Health Organization

Commentaries:

Covid-19: Pandemic waste threatens human and environmental health, says WHO – The BMJ

Amid Mountains of COVID Waste, WHO Urges Sustainable Solutions – Health Policy Watch

 

Commentary on Twitter (thread – click for more)

 

Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.

2 Feb, 2022 | 08:50h | UTC

Therapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines

 

Commentary on Twitter

 

Editorial: Menstruation and Covid-19 vaccination.

2 Feb, 2022 | 08:46h | UTC

Menstruation and covid-19 vaccination – The BMJ

News Release: New studies provide reassuring data on menstrual changes after covid-19 vaccination – BMJ

 

Commentary on Twitter

 

Ten billion COVID vaccinations: world hits new milestone.

2 Feb, 2022 | 08:48h | UTC

Ten billion COVID vaccinations: world hits new milestone – Nature

 

Commentary on Twitter

 

As Denmark scraps COVID restrictions, WHO urges caution.

2 Feb, 2022 | 08:47h | UTC

As Denmark Scraps COVID Restrictions, WHO Urges Caution – Health Policy Watch

Related: Despite the ongoing spread of Omicron, some European countries have decided to lift Covid-19 restrictions.

 

M-A: Impact of Ketamine on analgosedative consumption in critically ill patients.

2 Feb, 2022 | 08:44h | UTC

Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis – Annals of Pharmacotherapy

Related:

RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.

RCT: In patients undergoing emergency endotracheal intubation, 7-day survival was significantly lower with etomidate vs. ketamine (77.3% versus 85.1%), but 28 survival rates were not significantly different (etomidate 64.1% vs. ketamine 66.8%, p = 0.294).

 

Perspective: Avoidance of β-blockers in patients who use stimulants is not supported by good evidence.

2 Feb, 2022 | 08:39h | UTC

Avoidance of β-blockers in patients who use stimulants is not supported by good evidence – Canadian Medical Association Journal

 

Perspective: The ongoing saga of normal saline vs. balanced fluids.

2 Feb, 2022 | 08:43h | UTC

The ongoing saga of normal saline versus balanced fluids – First10EM

Original studies:

RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

Balanced Crystalloids versus Saline in Critically Ill Adults — A Systematic Review with Meta-Analysis – NEJM Evidence

Related:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Using melatonin for sleep is on the rise, study says, despite potential health harms.

2 Feb, 2022 | 08:41h | UTC

Using melatonin for sleep is on the rise, study says, despite potential health harms – CNN

Original Study: Trends in Use of Melatonin Supplements Among US Adults, 1999-2018 – JAMA (free for a limited period)

 

WHO Recommendations: Reducing the risk of cognitive decline and dementia.

1 Feb, 2022 | 09:50h | UTC

Reducing the Risk of Cognitive Decline and Dementia: WHO Recommendations – Frontiers in Neurology

Related:

Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019.

New WHO toolkit promotes inclusion of people with dementia in society.

Dementia: number of people affected to triple in next 30 years – World Health Organization

 

SCAI SHOCK Cardiogenic Shock Classification Expert Consensus Update.

1 Feb, 2022 | 09:53h | UTC

SCAI SHOCK Stage Classification Expert Consensus Update: A Review and Incorporation of Validation Studies: This statement was endorsed by the American College of Cardiology (ACC), American College of Emergency Physicians (ACEP), American Heart Association (AHA), European Society of Cardiology (ESC) Association for Acute Cardiovascular Care (ACVC), International Society for Heart and Lung Transplantation (ISHLT), Society of Critical Care Medicine (SCCM), and Society of Thoracic Surgeons (STS) in December 2021 – JSCAI

News Release: SCAI releases updated expert consensus to SCAI SHOCK classification – Society for Cardiovascular Angiography and Interventions

Commentaries:

SCAI SHOCK: Update Refines Cardiogenic Shock Classification – TCTMD

SCAI Releases Updated Expert Consensus to SCAI SHOCK Classification – American College of Cardiology

 

Commentaries on Twitter

 

The Lancet Commission: Experts warn of the increasing overmedicalization of death, call for radical rethink of how society cares for dying people.

1 Feb, 2022 | 09:55h | UTC

News Release: THE LANCET: Experts warn of the increasing overmedicalization of death, call for radical rethink of how society cares for dying people

Homepage: Lancet Commission on the Value of Death (free registration required for all articles)

Report of the Lancet Commission on the Value of Death: bringing death back into life

The precariousness of balancing life and death

Ros Taylor: seeing palliative care as relational

Related: What would it take to die well? A systematic review of systematic reviews on the conditions for a good death – The Lancet Health Longevity

 

Commentary on Twitter (thread – click for more)

 

Observational study: Pharmacist involvement in the care of critically ill patients may reduce resource utilization, adverse drug events, and medical costs.

1 Feb, 2022 | 09:47h | UTC

PHarmacist Avoidance or Reductions in Medical Costs in CRITically Ill Adults: PHARM-CRIT Study – Critical Care Explorations

 

Commentary from the author on Twitter (thread – click for more)

 

RCT: Impact of portable normothermic blood-based machine perfusion on outcomes of liver transplant.

1 Feb, 2022 | 08:58h | UTC

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant: The OCS Liver PROTECT Randomized Clinical Trial – JAMA Surgery

Commentaries:

Normothermic Machine Perfusion Improves Outcomes in Liver Transplant Recipients – Physician’s Weekly

Machine Perfusion Cuts Early Graft Dysfunction in Liver Transplantation – MedPage Today (free registration required)

Related:

RCT: Hypothermic machine perfusion in liver transplantation

Transplantation of Discarded Livers Following Viability Testing with Normothermic Machine Perfusion

 

Commentaries on Twitter

 

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

1 Feb, 2022 | 08:56h | UTC

Transmission of SARS-CoV-2 Omicron VOC subvariants BA.1 and BA.2: Evidence from Danish Households – medRxiv

Commentaries:

Study suggests BA.2 COVID-19 subvariant more contagious – CIDRAP

‘Stealth Omicron’ spreads more than original strain: study – MedicalXpress

The new Omicron subtype BA.2 could prolong the current wave of COVID-19 infection, scientists say- Business Insider

 

Commentary from the author on Twitter (thread – click for more)

 

Does the world need an Omicron vaccine? What researchers say.

1 Feb, 2022 | 08:53h | UTC

Does the world need an Omicron vaccine? What researchers say – Nature

 

Will Omicron end the pandemic? Here’s what experts say.

1 Feb, 2022 | 08:54h | UTC

Will Omicron end the pandemic? Here’s what experts say – Nature

 

Randomized trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a scoping review.

1 Feb, 2022 | 08:51h | UTC

Randomised trials on non-pharmaceutical interventions for COVID-19 as of August 2021: a scoping review – BMJ Evidence-Based Medicine

Related:

Study ranks the most effective non-pharmaceutical interventions for reducing COVID-19 spread

Effect of Non-pharmaceutical Interventions to Contain COVID-19 in China

 

Commentary from the author on Twitter (thread – click for more)

 

The extraordinary success of Covid-19 vaccines, in two charts.

1 Feb, 2022 | 08:48h | UTC

The extraordinary success of Covid-19 vaccines, in two charts – Vox

 

Position Paper: Preventing heart failure.

30 Jan, 2022 | 14:53h | UTC

Preventing heart failure: a position paper of the Heart Failure Association in collaboration with the European Association of Preventive Cardiology

 

Studies show parental vaccination provided indirect protection of children from SARS-CoV-2 infection during the Delta wave.

30 Jan, 2022 | 14:52h | UTC

Indirect protection of children from SARS-CoV-2 infection through parental vaccination – Science

See also: Vaccination with BNT162b2 reduces transmission of SARS-CoV-2 to household contacts in Israel – Science

Commentary: COVID vaccine markedly cuts household transmission, studies show – CIDRAP

 

Commentary on Twitter

 

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