Open access
Open access
Powered by Google Translator Translator

Editor's Choice

[News release – not published yet] New Sanofi and GSK vaccine demonstrates strong protection against severe Covid-19 in clinical trials.

8 Mar, 2022 | 08:53h | UTC

Commentary: New vaccine demonstrates strong protection against severe Covid-19 in clinical trials – CNN

News Release: Sanofi and GSK to seek regulatory authorization for COVID-19 vaccine

 

The next variant: three key questions about what’s after Omicron.

8 Mar, 2022 | 08:54h | UTC

The next variant: three key questions about what’s after Omicron – Nature

 

Nature is trialling transparent peer review — the early results are encouraging.

8 Mar, 2022 | 08:52h | UTC

Nature is trialling transparent peer review — the early results are encouraging – Nature

 

CDC, AAP update developmental milestones for surveillance program.

8 Mar, 2022 | 08:47h | UTC

News Release: CDC, AAP update developmental milestones for surveillance program – AAP News

See Guidance: Evidence-Informed Milestones for Developmental Surveillance Tools – Pediatrics

Commentaries:

Revised Developmental Milestone Guidelines For Infants And Toddlers: Explained Here – Forbes

Much Awaited – Development Milestone Checklists Updated by CDC & AAP – Pediatric OnCall

 

RCT: In patients with stable chest pain with intermediate pretest probability of obstructive coronary artery disease, an initial diagnostic imaging strategy based on CT angiography resulted in similar risks of major adverse cardiovascular events compared to invasive coronary angiography.

7 Mar, 2022 | 00:55h | UTC

CT or Invasive Coronary Angiography in Stable Chest Pain – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: DISCHARGE Hailed as a Big Step Forward for CTA in Stable Chest Pain – TCTMD

 

Commentary on Twitter

 

RCT: Anterior–lateral electrode position is more effective compared to anterior–posterior electrode position for cardioverting atrial fibrillation.

7 Mar, 2022 | 00:45h | UTC

Anterior–Lateral Versus Anterior–Posterior Electrode Position for Cardioverting Atrial Fibrillation – Circulation

Commentary: Anterior-Lateral or Anterior-Posterior Pads for A-fib Cardioversion? – JournalFeed

 

Commentary on Twitter

 

Systematic Review: Anticoagulants for people hospitalized with COVID‐19.

7 Mar, 2022 | 00:48h | UTC

Anticoagulants for people hospitalised with COVID‐19 – Cochrane Library

Summary: Do blood thinners prevent people who are hospitalised with COVID-19 from developing blood clots? – Cochrane Library

Related: Anticoagulation in Patients With COVID-19: JACC Review Topic of the Week.

 

COVID-19: How Omicron overtook Delta in three charts.

7 Mar, 2022 | 00:46h | UTC

COVID-19: How Omicron overtook Delta in three charts – Nature

 

Systematic Review: Prediction of good neurological outcome in comatose survivors of cardiac arrest.

7 Mar, 2022 | 00:40h | UTC

Prediction of good neurological outcome in comatose survivors of cardiac arrest: a systematic review – Intensive Care Medicine

 

Commentary on Twitter

 

Ten myths about albumin.

7 Mar, 2022 | 00:44h | UTC

Ten myths about albumin – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 

Review articles: Cutaneous manifestations of SARS-CoV-2 infection.

7 Mar, 2022 | 00:38h | UTC

Cutaneous Manifestations of SARS-CoV-2 Infection – American Journal of Clinical Dermatology

Common skin signs of COVID-19 in adults: An update – Cleveland Clinic Journal of Medicine

 

The Lancet Series: Ageing with HIV.

7 Mar, 2022 | 00:35h | UTC

Homepage: Ageing with HIV

Editorials:

Ageing with HIV

Time to tackle late diagnosis

Series:

Delayed presentation of HIV among older individuals: a growing problem

How health systems can adapt to a population ageing with HIV and comorbid disease

Biological ageing with HIV infection: evaluating the geroscience hypothesis

Intersectionality of stigmas and health-related quality of life in people ageing with HIV in China, Europe, and Latin America

 

New research finds breast cancer overdiagnosis not as common as previously thought.

7 Mar, 2022 | 00:36h | UTC

Estimation of Breast Cancer Overdiagnosis in a U.S. Breast Screening Cohort – Annals of Internal Medicine (link to abstract – $ for full-text)

How often is breast cancer overdiagnosed? New research finds true cases far outweigh false alarms – STAT

Breast cancer overdiagnosis may not happen as frequently as previously thought – ACP Internist

 

RCT: Efficacy and safety of switching to the 2-drug regimen Dolutegravir/Lamivudine vs. continuing a 3- or 4-Drug regimen for maintaining virologic suppression in adults living with HIV-1.

7 Mar, 2022 | 00:32h | UTC

Efficacy and Safety of Switching to the 2-Drug Regimen Dolutegravir/Lamivudine Versus Continuing a 3- or 4-Drug Regimen for Maintaining Virologic Suppression in Adults Living With HIV-1: Week 48 Results From the Phase 3, Non-inferiority SALSA Randomized Trial – Clinical Infectious Diseases

 

[Preprint] RECOVERY trial shows Baricitinib reduces deaths in patients hospitalized with COVID-19.

4 Mar, 2022 | 10:09h | UTC

News Release: RECOVERY trial shows Baricitinib reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Original study: Baricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis – medRxiv

Commentaries:

Arthritis drug reduces mortality in severe COVID-19, huge clinical trial finds – Science

Covid-19: Anti-inflammatory treatment baricitinib reduces deaths in patients admitted to hospital, finds trial – The BMJ

Another life-saving Covid drug identified – BBC

Related:

WHO recommends two new drugs (Baricitinib and Sotrovimab) to treat COVID-19.

RCT: Baricitinib reduced mortality in hospitalized adults with COVID-19.

Randomized trial: Baricitinib plus remdesivir reduce recovery time in patients with COVID-19

 

Commentary from the author on Twitter (thread – click for more)

 

Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis.

4 Mar, 2022 | 10:07h | UTC

Variation in the COVID-19 infection–fatality ratio by age, time, and geography during the pre-vaccine era: a systematic analysis – The Lancet

Invited Commentary: Understanding of COVID-19 from infection–fatality ratio – The Lancet

 

Quantifying the effects of the COVID-19 pandemic on gender equality on health, social, and economic indicators.

4 Mar, 2022 | 10:04h | UTC

Quantifying the effects of the COVID-19 pandemic on gender equality on health, social, and economic indicators: a comprehensive review of data from March, 2020, to September, 2021 – The Lancet

Commentaries:

Gender equality and COVID-19: act now before it is too late – The Lancet

Social and economic effects of the COVID-19 pandemic threaten to reverse progress towards gender equality: study – The Lancet

 

Commentary on Twitter (thread – click for more)

 

Updated WHO guidance conditionally recommends Molnupiravir for patients with non-severe covid-19 at highest risk of hospitalization.

4 Mar, 2022 | 09:57h | UTC

BMJ News Release: WHO recommends antiviral drug for patients with non-severe covid-19 at highest risk of hospital admission – BMJ

WHO News Release: WHO updates its treatment guidelines to include molnupiravir

See updated guidance: A living WHO guideline on drugs for covid-19 – BMJ

Related:

Editorial (just published): Molnupiravir’s authorisation was premature – The BMJ

RCT: Molnupiravir reduced the risk of hospitalization or death in at-risk (i.e., obesity, over 60 years, etc.) unvaccinated adults with Covid-19.

Merck’s COVID pill loses its luster: what that means for the pandemic – “Molnupiravir was initially heralded by public-health officials as a game-changer for COVID-19, but full clinical-trial data showed lower-than-expected efficacy”.

FDA panel narrowly recommends authorization of first antiviral pill to treat COVID.

[Press release – not published yet] Merck’s new Covid-19 pill Molnupiravir updated data shows reduced efficacy (30%) for preventing hospitalization and death compared to initial results (50%). Absolute risk reduction of hospitalization and death fell from 7% to 3%.

8 lingering questions about the new Covid pills from Merck and Pfizer.

COVID antiviral pills: what scientists still want to know – “Drugs like Molnupiravir and Paxlovid could change the course of the pandemic if clinical trial results hold up in the real world”.

[Press release – not published yet] RCT: Pfizer’s novel Covid-19 oral antiviral treatment candidate reduced risk of hospitalization or death by 89% in interim analysis of phase 2/3 EPIC-HR study.

A prominent virologist warns new COVID-19 pill could unleash dangerous mutants. Others see little cause for alarm.

The U.K. approves Merck’s COVID-19 antiviral pill, calling it a world first.

Merck to allow other nations to produce new COVID-19 antiviral.

Video: Merck’s Covid pill could transform treatment. Here’s how it works.

How antiviral pill Molnupiravir shot ahead in the COVID drug hunt.

What we know — and don’t know — about Merck’s new Covid-19 pill.

[Press release – not published yet] Merck announces oral antiviral Molnupiravir reduced the risk of hospitalization or death by approximately 50 Percent compared to placebo for patients with mild or moderate COVID-19.

Merck’s Covid-19 pill is great news but may not be a game-changer.

Video | A Pill For COVID? A Doctor Explains Molnupiravir.

 

M-A: Efficacy of covid-19 vaccines in immunocompromised patients.

4 Mar, 2022 | 10:01h | UTC

Efficacy of covid-19 vaccines in immunocompromised patients: systematic review and meta-analysis – The BMJ

News Release: Study suggests additional covid-19 vaccine doses for immunocompromised patients – BMJ Newsroom

Related: Response to additional COVID-19 vaccine doses in people who are immunocompromised: a rapid review.

 

Commentary on Twitter

 

Viewpoint: Understanding and communicating uncertainty in achieving diagnostic excellence.

4 Mar, 2022 | 09:56h | UTC

Understanding and Communicating Uncertainty in Achieving Diagnostic Excellence – JAMA (free for a limited period)

 

Cohort Study: Association between screen time exposure in children at 1 year of age and autism spectrum disorder at 3 years of age.

4 Mar, 2022 | 09:54h | UTC

Association Between Screen Time Exposure in Children at 1 Year of Age and Autism Spectrum Disorder at 3 Years of Age: The Japan Environment and Children’s Study – JAMA Pediatrics

Commentary: Screen Time Linked to Autism Spectrum Disorder in Boys – HealthDay

Related:

M-A: Global prevalence of meeting screen time guidelines among children 5 years and younger.

Media and Young Minds – American Academy of Pediatrics

Guidelines on Screen Time and Digital Wellness in Infants, Children and Adolescents – “children below 2 years age should not be exposed to any type of screen, whereas exposure should be limited to a maximum of one hour of supervised screen time per day for children 24-59 months age, and less than two hours per day for children 5-10 years age”.

 

Systematic Review: Arthroscopic surgery provides little or no clinically important benefit for patients with degenerative knee disease.

4 Mar, 2022 | 09:53h | UTC

Arthroscopic surgery for degenerative knee disease (osteoarthritis including degenerative meniscal tears) – Cochrane Library

Summary: Arthroscopic surgery for degenerative knee disease – Cochrane Library

Related:

Guideline: Arthroscopic Meniscal Surgery

Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline

Randomized Trial: Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears

Study: Adverse Outcomes After Arthroscopic Partial Meniscectomy

 

Pre-post study: The introduction of a text-message alert system to alert volunteers close to a cardiac arrest patient at home was associated with increased survival to hospital discharge.

4 Mar, 2022 | 09:44h | UTC

Alert system-supported lay defibrillation and basic life-support for cardiac arrest at home – European Heart Journal

Editorial: Volunteer first responders for out-of-hospital cardiac arrest at home: the missing link for improved survival? – European Heart Journal

 

Commentary on Twitter

 

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

4 Mar, 2022 | 09:41h | UTC

Clinic, Home, and Kiosk Blood Pressure Measurements for Diagnosing Hypertension: a Randomized Diagnostic Study – Journal of General Internal Medicine

Commentary: Home blood pressure monitoring may provide the basis for accurate diagnoses of hypertension – Kaiser Permanente

 

WHO: COVID-19 pandemic triggers a 25% increase in the prevalence of anxiety and depression worldwide.

3 Mar, 2022 | 09:44h | UTC

News Release: COVID-19 pandemic triggers 25% increase in prevalence of anxiety and depression worldwide – World Health Organization

Scientific Brief: Mental health and COVID-19: Early evidence of the pandemic’s impact – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Stay Updated in Your Specialty

Telegram Channels
Free

WhatsApp alerts 10-day free trial

No spam, just news.