Critical Care & Emergencies (all articles)
Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure
21 Jan, 2021 | 01:16h | UTCLower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Even though supplemental oxygen is used for the treatment of patients with hypoxemic respiratory failure, the most effective oxygenation targets are not known. In this randomized trial, a lower oxygenation target did not result in lower mortality than a higher target.
— NEJM (@NEJM) January 21, 2021
Allocating scarce intensive care resources during the COVID-19 pandemic: practical challenges to theoretical frameworks
21 Jan, 2021 | 01:22h | UTC
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb
21 Jan, 2021 | 01:10h | UTCSummary: Thrombolysis for treatment of acute deep vein thrombosis – Cochrane Library
Randomized trial: In pediatric acute CNS infections, 3% Hypertonic saline is superior to 20% Mannitol for reducing intracranial pressure
21 Jan, 2021 | 01:08h | UTCRandomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections – Pediatric Critical Care Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Feature w/#VisualAbstract
RCT of 20% mannitol vs. 3% hypertonic saline in children w/raised ICP due to acute CNS infections: Which is superior?
Rameshkumar, @drarunbansal, Jayashree 🇮🇳: https://t.co/ZGWaPMhPvr
Editorial by Argent 🇿🇦: https://t.co/BsbZKsEG03#PedsICU @WFPICCS pic.twitter.com/5asM9HNQaN
— Pediatric Critical Care Medicine (@PedCritCareMed) December 21, 2020
Managing code status conversations for seriously ill older adults in respiratory failure
21 Jan, 2021 | 00:55h | UTC
Case series: Portable Magnetic Resonance Imaging for ICU Patients
21 Jan, 2021 | 00:54h | UTCPortable Magnetic Resonance Imaging for ICU Patients – Critical Explorations
Critical analysis of a randomized controlled trial
21 Jan, 2021 | 00:52h | UTCCritical Analysis of a Randomized Controlled Trial – Indian Journal of Critical Care Medicine
Randomized trial: No benefit from discontinuing ACE Inhibitors and ARBs in patients admitted with COVID-19
20 Jan, 2021 | 01:55h | UTCCommentary: Discontinuing vs. Continuing ACEIs, ARBs in Patients Admitted With COVID-19 – American College of Cardiology
Related study (study and commentary): Randomized trial: Renin–angiotensin system inhibitors can be safely continued in patients admitted to hospital with COVID-19
Study: Crowded ICUs linked to increased mortality from COVID-19
20 Jan, 2021 | 01:53h | UTCCommentaries: Intensive Care Unit Strain and Mortality Risk Among Critically Ill Patients With COVID-19—There Is No “Me” in COVID – JAMA Network Open AND Crowded ICUs tied to higher risk of COVID-19 death – CIDRAP
Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke
20 Jan, 2021 | 01:35h | UTCEffect of Endovascular Treatment Alone vs Intravenous Alteplase Plus Endovascular Treatment on Functional Independence in Patients With Acute Ischemic Stroke: The DEVT Randomized Clinical Trial – JAMA (free for a limited period)
Related study: Effect of Mechanical Thrombectomy Without vs With Intravenous Thrombolysis on Functional Outcome Among Patients With Acute Ischemic Stroke: The SKIP Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Intravenous Thrombolysis Before Endovascular Thrombectomy for Acute Ischemic Stroke – JAMA (free for a limited period)
Video: Thrombolysis Before Thrombectomy for Stroke
Meta-analysis: Early initiation of renal replacement therapy is not associated with survival benefit in critically ill patients with acute kidney injury
20 Jan, 2021 | 01:25h | UTC
Meta-analysis: Inconclusive evidence regarding a benefit of systematic early mobilization in mechanically ventilated adult ICU patients
20 Jan, 2021 | 01:24h | UTC
Post-resuscitation shock: Recent advances in pathophysiology and treatment
20 Jan, 2021 | 01:18h | UTC
Meta-analysis: Corticosteroid use in COVID-19 patients
19 Jan, 2021 | 01:56h | UTCRelated meta-analysis: Corticosteroids for Patients With Coronavirus Disease 2019 (COVID-19) With Different Disease Severity: A Meta-Analysis of Randomized Clinical Trials – Journal of Cardiothoracic and Vascular Anesthesia
Evidence summary and clinical decision algorithm to guide clinicians in the care of the hypoxemic, non-intubated patients with suspected Covid-19
19 Jan, 2021 | 01:57h | UTC
After return of spontaneous circulation in patients with out-of-hospital cardiac arrest, too early ECG acquisition (7 minutes or less) is associated with false-positive findings for STEMI
19 Jan, 2021 | 01:44h | UTCCommentary: Delaying Electrocardiography in Cardiac Arrest: A Pause for the Cause – JAMA Network Open
RECOVERY trial: No Benefit from convalescent plasma in hospitalized patients with Covid-19
17 Jan, 2021 | 22:26h | UTCCommentary: Covid: ‘Convalescent plasma no benefit to hospital patients’ – BBC
Randomized trial: In patients hospitalized with community-acquired pneumonia, adjunctive oral dexamethasone reduced the length of stay and ICU admissions, with no difference in mortality rates
17 Jan, 2021 | 21:58h | UTCAdjunctive treatment with oral dexamethasone in non-ICU patients hospitalised with community-acquired pneumonia: A randomised clinical trial – European Respiratory Journal (link to abstract – $ for full-text)
Meta-analysis: Safety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation
17 Jan, 2021 | 21:42h | UTCSafety and efficacy of dexmedetomidine in acutely ill adults requiring non-invasive ventilation: a systematic review and meta-analysis of randomized trials – CHEST (link to abstract – $ for full-text)
Meta-analysis: Effect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation
17 Jan, 2021 | 21:41h | UTCEffect of ultra-short-acting β-blockers on mortality in patients with persistent tachycardia despite initial resuscitation: a systematic review and meta-analysis of randomized controlled trials – CHEST (link to abstract – $ for full-text)
Observational study: Among patients hospitalized with Covid-19 not receiving mechanical ventilation, transfusion of plasma with higher anti–SARS-CoV-2 IgG antibody levels is linked to lower risk of death than transfusion of plasma with lower antibody levels
15 Jan, 2021 | 08:59h | UTCEditorial: (A Little) Clarity on Convalescent Plasma for Covid-19 – New England Journal of Medicine
Commentaries: Expert reaction to study looking at convalescent plasma antibody levels and risk of death from COVID-19 – Science Media Centre AND Antibody-rich convalescent plasma may lower risk of COVID death – CIDRAP
Opinion: RCTs don’t justify using convalescent plasma or antibody cocktails
15 Jan, 2021 | 08:58h | UTCRCTs don’t justify using convalescent plasma or antibody cocktails – PulmCrit
Perspective: Ivermectin for COVID-19 — Breakthrough Treatment or Hydroxychloroquine Redux?
15 Jan, 2021 | 08:51h | UTCRelated video: Ivermectin For COVID-19 | A Doctor Explains – ZDoggMD
NIH Guideline Statement: “there are insufficient data to recommend either for or against the use of ivermectin for the treatment of COVID-19”
15 Jan, 2021 | 08:53h | UTC
Covid-19: When to start invasive ventilation is “the million dollar question”
15 Jan, 2021 | 08:48h | UTCCovid-19: When to start invasive ventilation is “the million dollar question” – The BMJ
Commentary on Twitter
Options for ventilating covid-19 patients have expanded since the first wave of the pandemic, but doctors are unsure of the best management pathway because evidence is lacking, reports @ingridtorjesenhttps://t.co/iKldASmahF
— The BMJ (@bmj_latest) January 14, 2021