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Critical Care & Emergencies (all articles)

Management of diabetes and hyperglycemia in the hospital

29 Jan, 2021 | 01:34h | UTC

Management of diabetes and hyperglycaemia in the hospital – The Lancet Diabetes & Endocrinology (free for a limited period)

 

Commentary on Twitter

https://twitter.com/TheLancetEndo/status/1354754451161100288

 

Acute Pancreatitis: A Review

28 Jan, 2021 | 01:20h | UTC

Acute Pancreatitis: A Review – JAMA (free for a limited period)

Podcast: Acute Pancreatitis Part 1 of 2: Diagnosis

Podcast: Acute Pancreatitis Part 2 of 2: Treatment

 

Meta-analysis: Beta-blockers for traumatic brain injury

28 Jan, 2021 | 01:18h | UTC

Beta-blockers for traumatic brain injury: a systematic review and meta-analysis – Journal of Trauma and Acute Care Surgery (link to abstract – $ for full-text)

 

[Preprint] Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19

28 Jan, 2021 | 01:49h | UTC

Efficacy of Colchicine in Non-Hospitalized Patients with COVID-19 – medRxiv

 

Commentary on Twitter

 

Duration of culturable SARS-CoV-2 in hospitalized patients with Covid-19

28 Jan, 2021 | 01:47h | UTC

Duration of Culturable SARS-CoV-2 in Hospitalized Patients with Covid-19 – New England Journal of Medicine

 

Editorial: Covid-19 controversies: the Tocilizumab chapter

28 Jan, 2021 | 01:46h | UTC

Covid-19 controversies: the tocilizumab chapter – The BMJ

Related: Contradicting earlier trials, Tocilizumab did not improve outcomes, with signs of harm, in patients with severe Covid-19 (studies and commentaries)

 

DEVT, SKIP Trials Add Support for Omitting IV tPA Before Stroke Thrombectomy

27 Jan, 2021 | 01:01h | UTC

DEVT, SKIP Trials Add Support for Omitting IV tPA Before Stroke Thrombectomy – TCTMD

Original studies and commentaries: Randomized trial: Endovascular treatment alone noninferior to intravenous alteplase plus endovascular treatment on functional independence in patients with acute ischemic stroke

 

Opinion: Monoclonal antibodies yet to show important clinical benefit in patients with Covid-19

27 Jan, 2021 | 01:23h | UTC

Monoclonal Antibodies Yet To Show Important Clinical Benefit In Patients With Covid-19. A Review Of What We Know, Including The Latest Clinical Trial Data – Brief19

See also: PulmCrit Wee – Follow-up Bamlanivimab study unmasks statistical chicanery

 

[Press release – not published yet] Neutralizing antibodies bamlanivimab and etesevimab together reduced risk of COVID-19 hospitalizations and death by 70 percent

27 Jan, 2021 | 01:22h | UTC

New data show treatment with Lilly’s neutralizing antibodies bamlanivimab (LY-CoV555) and etesevimab (LY-CoV016) together reduced risk of COVID-19 hospitalizations and death by 70 percent – Lilly

Commentary: Lilly antibody combo therapy cuts risk of COVID-19 deaths – Reuters

 

Commentary on Twitter

 

WHO Updated Guideline: COVID-19 clinical management

27 Jan, 2021 | 01:26h | UTC

COVID-19 Clinical management: living guidance – World Health Organization

News release: WHO recommends follow-up care, low-dose anticoagulants for COVID-19 patients

Commentary: WHO issues new clinical advice on treating COVID-19 patients – Reuters

 

[Press release – not published yet] REGENERON reports positive interim data with antibody cocktail used as passive vaccine to prevent COVID-19

27 Jan, 2021 | 01:21h | UTC

REGENERON REPORTS POSITIVE INTERIM DATA WITH REGEN-COV™ ANTIBODY COCKTAIL USED AS PASSIVE VACCINE TO PREVENT COVID-19

Commentaries: Regeneron’s antibody cocktail effective in preventing COVID-19 infection: study – Reuters AND Regeneron says monoclonal antibodies prevent Covid-19 in study – STAT AND Expert reaction to press release from Regeneron giving interim data from its REGEN-COV™ antibody cocktail trial for the prevention of COVID-19 in people at high risk of infection – Science Media Centre

 

Systematic review: Cardiopulmonary resuscitation in the prone position in the operating room or in the intensive care unit

27 Jan, 2021 | 01:14h | UTC

Cardiopulmonary Resuscitation in the Prone Position in the Operating Room or in the Intensive Care Unit: A Systematic Review – Anesthesia & Analgesia

 

Commentary on Twitter (thread – click for more)

https://twitter.com/IARS_Journals/status/1350827861016535043

 

[Press release – not published yet] Azithromycin and doxycycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial

26 Jan, 2021 | 01:03h | UTC

Azithromycin and doxcycline are not generally effective against COVID-19 in patients treated at home, shows PRINCIPLE trial – University of Oxford

See also: PRINCIPLE trial finds no benefit from antibiotics, azithromycin and doxycycline for COVID-19 patients – National Institute for Health Research

 

American Clinical Neurophysiology Society’s Standardized Critical Care EEG Terminology: 2021 Version

25 Jan, 2021 | 01:15h | UTC

American Clinical Neurophysiology Society’s Standardized Critical Care EEG Terminology: 2021 Version – Journal of Clinical Neurophysiology

 

[Press Release – Not Published Yet] Colchicine reduces the risk of COVID-19-related complications: Positive results from COLCORONA trial show that colchicine is the only effective oral medication for treating non-hospitalized patients

25 Jan, 2021 | 01:43h | UTC

Colchicine reduces the risk of COVID-19-related complications: Positive results from COLCORONA trial show that colchicine is the only effective oral medication for treating non-hospitalized patients – Montreal Heart Insititute

Study Protocol: Colchicine Coronavirus SARS-CoV2 Trial (COLCORONA) (COVID-19) – ClinicalTrials.gov

“Patients will receive study medication colchicine 0.5 mg per os (PO) twice daily for the first 3 days and then once daily for the last 27 days.”

Commentaries: ‘Major breakthrough’ | Large study shows effectiveness of colchicine to treat COVID-19 – The Canadian AND A gout drug shows promise for Covid-19, but skeptics worry about trusting science by press release – STAT

 

Commentary on Twitter

 

[Press Release – Not Published Yet] Full-dose blood thinners decreased need for life support and improved outcome in hospitalized COVID-19 patients

25 Jan, 2021 | 01:42h | UTC

Full-dose blood thinners decreased need for life support and improved outcome in hospitalized COVID-19 patients – National Institutes of Health

 

CDC Report: Allergic reactions including anaphylaxis after receipt of the first dose of Moderna COVID-19 vaccine

25 Jan, 2021 | 01:29h | UTC

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Moderna COVID-19 Vaccine — United States, December 21, 2020–January 10, 2021 – CDC Morbidity and Mortality Weekly Report

Commentary: CDC reports rare allergic reactions to Moderna’s Covid-19 vaccine – STAT

 

Systematic Review: Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation

25 Jan, 2021 | 01:05h | UTC

Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation – Cochrane Library

Summary: Topical antibiotics to help reduce death and respiratory infections in people in intensive care receiving mechanical ventilation – Cochrane Library

 

5 Important Things To Know About Extended Spectrum Beta-Lactamases (ESBL): Insights From A Clinical Microbiologist

25 Jan, 2021 | 00:58h | UTC

5 Important Things To Know About Extended Spectrum Beta-Lactamases (ESBL): Insights From A Clinical Microbiologist – IDStewardship

 

[News release – Not published yet] Lilly’s neutralizing antibody prevented COVID-19 at nursing homes, reducing risk by up to 80 percent for residents

22 Jan, 2021 | 08:40h | UTC

Lilly’s neutralizing antibody bamlanivimab (LY-CoV555) prevented COVID-19 at nursing homes in the BLAZE-2 trial, reducing risk by up to 80 percent for residents

Commentaries: Eli Lilly says its monoclonal antibody prevented Covid-19 infections in clinical trial – STAT AND Expert reaction to press release from Lilly about their neutralising antibody bamlanivimab and results from the BLAZE-2 trial looking at prevention of COVID-19 in nursing homes in the US – Science Media Centre

 

Clinical update: Allergic reactions including anaphylaxis after receipt of the first dose of Pfizer-BioNTech COVID-19 vaccine

22 Jan, 2021 | 08:35h | UTC

Allergic Reactions Including Anaphylaxis After Receipt of the First Dose of Pfizer-BioNTech COVID-19 Vaccine – JAMA

Author interview: COVID-19 Vaccine Safety–Anaphylaxis and Allergic Reactions

 

Large cohort study identifies the most common hospital complications associated with COVID-19

22 Jan, 2021 | 08:36h | UTC

Diagnosis-wide analysis of COVID-19 complications: an exposure-crossover study – Canadian Medical Association Journal

Commentaries: Analysis of patient data reveals most common complications of COVID-19 – Medical News Today AND Study confirms most common complications associated with COVID-19 – New Medical

 

Commentary on Twitter

 

Twenty articles that critical care clinicians should read about COVID-19

22 Jan, 2021 | 08:28h | UTC

Twenty articles that critical care clinicians should read about COVID-19 – Intensive Care Medicine

 

Commentary on Twitter

 

Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus

21 Jan, 2021 | 01:19h | UTC

Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus – Critical Care

 

Cohort study: Recipients of hematopoietic stem-cell transplantation who develop COVID-19 have poor overall survival

21 Jan, 2021 | 01:18h | UTC

Clinical characteristics and outcomes of COVID-19 in haematopoietic stem-cell transplantation recipients: an observational cohort study – The Lancet Haematology

 

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