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Critical Care & Emergencies (all articles)

RCT | Sulbactam-durlobactam non-inferior to colistin in reducing 28-day mortality from carbapenem-resistant ABC

30 May, 2023 | 12:08h | UTC

Efficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) – The Lancet Infectious Diseases (link to abstract – $ for full-text)

News Release: Novel antibiotic succeeds in trial against hospital-acquired pneumonia – Rutgers University

 

RCT | Care bundle with intensive blood pressure control improves outcomes in acute cerebral hemorrhage

30 May, 2023 | 12:04h | UTC

The third Intensive Care Bundle with Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial (INTERACT3): an international, stepped wedge cluster randomised controlled trial – The Lancet

News Release: Tens of thousands of lives a year could be saved by new treatment protocol for brain hemorrhage – George Institute for Global Health

 

Review | Spurious electrolyte and acid-base disorders in the patient with cancer

30 May, 2023 | 11:43h | UTC

Spurious Electrolyte and Acid-Base Disorders in the Patient With Cancer: A Review – American Journal of Kidney Diseases

 

Commentary on Twitter

 

RCT | Preliminary evidence for right median nerve stimulation in awakening from acute traumatic coma

30 May, 2023 | 11:36h | UTC

Acute traumatic coma awakening by right median nerve electrical stimulation: a randomised controlled trial – Intensive Care Medicine

 

Commentary on Twitter

 

Review | Posterior circulation ischemic stroke diagnosis and management

30 May, 2023 | 11:30h | UTC

Posterior circulation ischaemic stroke diagnosis and management – Clinical Medicine Journal

 

AHA/ASA Guideline for the management of patients with aneurysmal subarachnoid hemorrhage

29 May, 2023 | 11:16h | UTC

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association – Stroke

Top Things to Know: 2023 Aneurysmal Subarachnoid Hemorrhage Guideline – American Heart Association

 

Commentary on Twitter

 

RCT | Communication-priming intervention boosts goals-of-care discussions for seriously ill patients

29 May, 2023 | 11:12h | UTC

Intervention to Promote Communication About Goals of Care for Hospitalized Patients With Serious Illness: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Conversations on Goals of Care With Hospitalized, Seriously Ill Patients – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Some Surrogate Endpoints Are Fine – By Dr John Mandrola

 

M-A | Hydrocortisone shows no significant impact on 90-day mortality in septic shock patients

29 May, 2023 | 11:06h | UTC

Patient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock – NEJM Evidence

News Release: Study examines the role of hydrocortisone in the management of adult patients with septic shock – University of California San Francisco Medical Center/News Medical

 

Consensus Paper | Cardiac arrest in the perioperative period

29 May, 2023 | 11:04h | UTC

Cardiac arrest in the perioperative period: a consensus guideline for identification, treatment, and prevention from the European Society of Anaesthesiology and Intensive Care and the European Society for Trauma and Emergency Surgery – European Journal of Anaesthesiology

 

Guideline | Investigation and management of acute transfusion reactions

29 May, 2023 | 11:02h | UTC

Guideline on the investigation and management of acute transfusion reactions – British Journal of Haematology

 

ISPD Catheter-related infection recommendations

29 May, 2023 | 11:00h | UTC

ISPD Catheter-related Infection Recommendations: 2023 Update – Peritoneal Dialysis International

 

Guideline | Targeted temperature management in intracerebral, subarachnoid hemorrhage and acute ischemic stroke

29 May, 2023 | 10:48h | UTC

Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: updated consensus guideline recommendations by the Neuroprotective Therapy Consensus Review (NTCR) group – British Journal of Anaesthesia

 

2023 Update on sepsis and septic shock in adult patients | Management in the emergency department

25 May, 2023 | 11:26h | UTC

2023 Update on Sepsis and Septic Shock in Adult Patients: Management in the Emergency Department – Journal of Clinical Medicine

 

Consensus Statement | Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit

24 May, 2023 | 13:15h | UTC

Rationale and clinical application of antimicrobial stewardship principles in the intensive care unit: a multidisciplinary statement – Journal of Anesthesia, Analgesia and Critical Care

 

M-A | Optimizing enteral nutrition delivery by implementing volume-based feeding protocol for critically ill patients

24 May, 2023 | 13:13h | UTC

Optimizing enteral nutrition delivery by implementing volume-based feeding protocol for critically ill patients: an updated meta-analysis and systematic review – Critical Care

 

Guideline | Assessment and early management of head injury

23 May, 2023 | 13:11h | UTC

Head injury: assessment and early management – NICE

Commentary: NICE head injury guidelines 2023: Now who do we scan? – St Emilyn’s

 

Ventilator associated tracheobronchitis and pneumonia: one infection with two faces

23 May, 2023 | 12:49h | UTC

Ventilator associated tracheobronchitis and pneumonia: one infection with two faces – Intensive Care Medicine

 

Review | Microcirculatory dysfunction in cardiogenic shock

23 May, 2023 | 12:50h | UTC

Microcirculatory dysfunction in cardiogenic shock – Annals of Intensive Care

 

Review | The esophageal balloon for respiratory monitoring in ventilated patients

23 May, 2023 | 12:40h | UTC

The oesophageal balloon for respiratory monitoring in ventilated patients: updated clinical review and practical aspects – European Respiratory Review

 

Digitally-enabled remote critical care: will it make problems of geography history?

22 May, 2023 | 13:36h | UTC

Digitally-enabled remote critical care: will it make problems of geography history? – British Journal of Anaesthesia

 

Editorial | Selective digestive decontamination – Pro

22 May, 2023 | 13:34h | UTC

Selective digestive decontamination – Pro – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 

Practice Guidance | Differential diagnosis of suspected COPD exacerbations in the acute care setting

15 May, 2023 | 13:26h | UTC

Differential Diagnosis of Suspected Chronic Obstructive Pulmonary Disease Exacerbations in the Acute Care Setting: Best Practice – American Journal of Respiratory and Critical Care Medicine

 

Commentary on Twitter

 

Guideline | Acute dizziness and vertigo in the emergency department

15 May, 2023 | 13:25h | UTC

Guidelines for reasonable and appropriate care in the emergency department 3 (GRACE-3): Acute dizziness and vertigo in the emergency department – Academic Emergency Medicine

News Release: New guideline for treatment of acute dizziness and vertigo in the emergency department – Society for Academic Emergency Medicine

 

RCT | Prophylactic antibiotics show no statistically significant survival improvement in severe alcohol-related hepatitis

15 May, 2023 | 13:21h | UTC

Summary: This multicenter, randomized, double-blind clinical trial aimed to determine the efficacy of amoxicillin-clavulanate combined with prednisolone compared to placebo combined with prednisolone on mortality in patients hospitalized with severe alcohol-related hepatitis. The study involved 284 patients from 25 centers in France and Belgium with biopsy-proven severe alcohol-related hepatitis, who were followed up for 180 days.

The primary outcome was all-cause mortality at 60 days, while secondary outcomes included mortality at 90 and 180 days, infection rates, hepatorenal syndrome, and changes in Model for End-stage Liver Disease (MELD) and Lille scores. The results showed no statistically significant difference in 60-day mortality between the two groups, with 17.3% in the amoxicillin-clavulanate group and 21.3% in the placebo group. However, infection rates at 60 days were significantly lower in the amoxicillin-clavulanate group compared to the placebo group.

It is worth noting that the study may have been underpowered, as the absolute risk difference of 4% did not achieve statistical significance. In conclusion, the combination of amoxicillin-clavulanate and prednisolone did not show a statistically significant improvement in 2-month survival in patients hospitalized with severe alcohol-related hepatitis compared to prednisolone alone. These findings do not support the use of prophylactic antibiotics to improve survival in this patient population, but the potential underpowered nature of the study should be considered.

Article: Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Therapeutic plasma exchange: Core curriculum 2023

15 May, 2023 | 13:14h | UTC

Therapeutic Plasma Exchange: Core Curriculum 2023 – American Journal of Kidney Diseases

 

Commentary on Twitter

 

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