Critical Care & Emergencies (all articles)
Understanding the Host in the Management of Pneumonia. An Official American Thoracic Society Workshop Report.
12 Jul, 2021 | 01:41h | UTC
RCT: Another study shows that non-antibiotic outpatient treatment in mild acute diverticulitis is safe.
12 Jul, 2021 | 01:29h | UTCEfficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)
Related: State of the Art Review: Management of colonic diverticulitis AND Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum AND Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial – Clinical Gastroenterology and Hepatology AND Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis
Commentary on Twitter
Another (final?) nail in the coffin for antibiotics in uncomplicated diverticulitis? DINAMO study from Spain – Outpatient treatment with antibiotics versus symptomatic Tx.
No difference in hospitalization rate or revisits to ER.https://t.co/wOc3tBGfxr @AnnalsofSurgery
— Ville Sallinen (@villesallinen) July 9, 2021
M-A: Comparative efficacy and safety of vancomycin, linezolid, tedizolid, and daptomycin in treating patients with suspected or proven complicated skin and soft tissue infections.
9 Jul, 2021 | 09:57h | UTC
Commentary on Twitter
🆕💥 Network Meta-Analysis @InfectDis_Ther
20 RCTs N=7804
Comparative Efficacy& Safety of Vancomycin,Linezolid,Tedizolid, and Daptomycin in Treating Patients with Suspected or Proven cSSTI
Linezolid was superior to vancomycin in improving clinical successhttps://t.co/qlZfXoWfaa pic.twitter.com/tO3sIoOMY4— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 20, 2021
Assessment and management of cardiovascular disease in the intensive care unit.
9 Jul, 2021 | 09:54h | UTCAssessment and management of cardiovascular disease in the intensive care unit – Heart
Case series: therapeutic plasma exchange in 3 patients with vaccine-induced immune thrombotic thrombocytopenia.
8 Jul, 2021 | 09:17h | UTC
Commentary on Twitter
Three patients with severe manifestations of VITT after #COVID19 vaccination had poor response to initial therapy with anticoagulants and intravenous immune globulin. Their condition improved after therapeutic plasma exchange was initiated.
— NEJM (@NEJM) July 7, 2021
Review: Non-invasive ventilatory support and high-flow nasal oxygen as first-line treatment of acute hypoxemic respiratory failure and ARDS.
8 Jul, 2021 | 09:01h | UTC
Commentary on Twitter
Physiology-to-bedside overview about non-invasive ventilatory support in AHRF & #ARDS
➡️spontaneous breathing: benefits/harms
➡️how to make spontaneous effort non‑injurious?
➡️optimizing HFNO & NIV
➡️monitoring to detect failure & be protective
➡️evidencehttps://t.co/KPW2u8akhA pic.twitter.com/yKVxrYaFmZ— Intensive Care Medicine (@yourICM) July 7, 2021
Predictors of death and new disability after critical illness: a multicenter prospective cohort study.
8 Jul, 2021 | 08:59h | UTC
Commentary on Twitter
Predicting death & new disability after #ICU admission: only 41% of pts requiring > 24h of mechanical ventilation are alive/free of new disability at 6 months. Potentially impacting? age, illness severity, diagnosis. Results #FOAMcc https://t.co/bpto5JUumB
Here visual abstract ⬇️ pic.twitter.com/hRqybdNpLa— Intensive Care Medicine (@yourICM) July 3, 2021
Study Commentary: Febrile Neutropenia – Procalcitonin vs. MASCC Score.
8 Jul, 2021 | 08:57h | UTCFebrile Neutropenia – Procalcitonin vs MASCC Score – Journal Feed
M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.
7 Jul, 2021 | 09:02h | UTCEditorial: IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? – JAMA
Commentaries: Interleukin-6 antagonists improve outcomes in hospitalised COVID-19 patients – King’s College London AND WHO advises 2 monoclonal antibodies for severe COVID – CIDRAP
Commentary on Twitter (thread – click for more)
https://twitter.com/msh_manu/status/1412473073715056645
A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.
7 Jul, 2021 | 09:03h | UTCA living WHO guideline on drugs for covid-19 – The BMJ
Commentary on Twitter
The latest version of this @WHO living guidance provides a strong recommendation for interleukin-6 (IL-6) receptor blockers (tocilizumab or sarilumab) in patients with severe or critical covid-19. Read the updated WHO guideline on drugs for #COVID19 https://t.co/FUb9yzFRwo
— The BMJ (@bmj_latest) July 6, 2021
WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – “These are the first drugs found to be effective against COVID-19 since corticosteroids were recommended by WHO in September 2020”.
7 Jul, 2021 | 09:00h | UTC
Commentary on Twitter (thread – click for more)
🆕 treatment recommendation from WHO:
WHO recommends life-saving interleukin-6 receptor blockers to treat #COVID19 and urges producers to join efforts to rapidly increase access.👉https://t.co/h4IcZad2VA pic.twitter.com/YXPkuBVwY4
— World Health Organization (WHO) (@WHO) July 6, 2021
SAEM Guidelines for reasonable and appropriate care in the emergency department (GRACE): Recurrent, low-risk chest pain in the emergency department.
7 Jul, 2021 | 08:48h | UTCNews release: SAEM publishes GRACE guidelines for recurrent, low-risk chest pain care in the ED – Society for Academic Emergency Medicine
Invited commentaries: GRACE-recurrent low-risk chest pain: A user’s guide AND Navigating uncertainty with GRACE: Society for Academic Emergency Medicine’s guidelines for reasonable and appropriate care in the emergency department
M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.
7 Jul, 2021 | 08:52h | UTC
RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.
6 Jul, 2021 | 10:16h | UTCCommentary: Ivermectin: balance of evidence shows no significant benefit against Covid-19 – MSN News
Related: Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”. AND Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”. AND Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials AND RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.
6 Jul, 2021 | 10:21h | UTC
Editorial | Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions.
6 Jul, 2021 | 10:14h | UTC
Commentary on Twitter
Shortcutting science perpetuates ineffective/unsafe treatments: with #COVID19 plethora of interventions (most next-to-no basis/inconsistent effects) trialled or given on compassionate grounds regardless risks. Will mistakes be acknowledged & lessons learnt?https://t.co/p53WyeMLEC pic.twitter.com/zUwlML8Pft
— Intensive Care Medicine (@yourICM) July 5, 2021
WSES position paper: Diagnosis and management of small bowel obstruction in virgin abdomen.
6 Jul, 2021 | 10:07h | UTC
Energetic dysfunction in sepsis: a narrative review.
6 Jul, 2021 | 10:06h | UTCEnergetic dysfunction in sepsis: a narrative review – Annals of Intensive Care
M-A of observational studies: the association between surgical fixation of hip fractures within 24 hours and mortality.
6 Jul, 2021 | 10:01h | UTCThe association between surgical fixation of hip fractures within 24 hours and mortality: a systematic review and meta-analysis – The Bone & Joint Journal (link to abstract – $ for full-text)
CDC Report: Underlying medical conditions and severe illness among 540,667 adults hospitalized with COVID-19, March 2020–March 2021.
5 Jul, 2021 | 02:40h | UTC
Commentary on Twitter
A new report finds that obesity, diabetes with complication, and the presence of multiple chronic conditions were the strongest chronic risk factors for death from #COVID19 among hospitalized adults. Learn more: https://t.co/KzsarYhHYA. pic.twitter.com/c0vd8ANqa0
— CDC (@CDCgov) July 1, 2021
RCT: Awake prone positioning in patients with hypoxemic respiratory failure due to COVID-19 – no difference in intubation rates compared to standard care.
5 Jul, 2021 | 02:24h | UTC
Seminar | Acute respiratory distress syndrome.
5 Jul, 2021 | 01:57h | UTCAcute respiratory distress syndrome – The Lancet
Review | Perioperative cardiac risk reduction in noncardiac surgery.
5 Jul, 2021 | 01:45h | UTCPerioperative Cardiac Risk Reduction in Noncardiac Surgery – Mayo Clinic Proceedings
Acute kidney injury in the critically ill: an updated review on pathophysiology and management.
5 Jul, 2021 | 01:49h | UTC
Commentary on Twitter
#AKI in #ICU
➡️phenotypes
➡️pathophysiology
➡️impact on acute & long-term prognosis
➡️update on nephrotoxicity
➡️organ cross‑talk
➡️prevention: fluids/vasopressors management & kidney perfusion pressure
➡️prediction from biomarkers to #AI
➡️approach
➡️#RRThttps://t.co/Qyb7BQPTUn pic.twitter.com/ClDaBZLPa4— Intensive Care Medicine (@yourICM) July 2, 2021
M-A: Decision-making authority during Tele-ICU care reduces mortality and length of stay.
5 Jul, 2021 | 01:18h | UTCDecision-Making Authority During Tele-ICU Care Reduces Mortality and Length of Stay—A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)