Critical Care & Emergencies (all articles)
[Preprint] Open-label RCT: Baricitinib noninferior to Tocilizumab in hospitalized patients with severe COVID-19.
20 Jun, 2022 | 10:28h | UTCRelated:
WHO recommends two new drugs to treat COVID-19 – World Health Organization
Baricitinib plus Remdesivir for Hospitalized Adults with Covid-19 – New England Journal of Medicine
Commentary on Twitter
Preprint⚡⚡
Baricitinib Vs Tocilizumab open label RCT
Baricitinib was non-inferior to tocilizumab with regards to the composite outcome of mechanical ventilation or death by day 28 and the time to discharge by day 28 in patients with severe #COVID19 https://t.co/sQkhATkjEd— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) June 16, 2022
Brief Review: Helmet noninvasive support in hypoxemic respiratory failure.
20 Jun, 2022 | 01:13h | UTCHelmet noninvasive support in hypoxemic respiratory failure – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Helmet noninvasive support in hypoxemic respiratory failure:
⚙️ set‐up
⛑ physiology of helmet interface: from most relevant feature to major drawbacks
💨 clinical implications
Free to read #FOAMcc on @yourICM
🖇 https://t.co/qNE4Id5oBg pic.twitter.com/b2auLLlW9z— Intensive Care Medicine (@yourICM) June 18, 2022
RCT: Immune enhancement with Thymosin alpha 1 does not improve outcomes in patients with predicted severe acute necrotizing pancreatitis.
20 Jun, 2022 | 01:11h | UTCImmune enhancement in patients with predicted severe acute necrotising pancreatitis: a multicentre double-blind randomised controlled trial – Intensive Care Medicine (if the link is paywalled, try this one)
Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.
17 Jun, 2022 | 11:03h | UTCEndovascular Treatment Versus Best Medical Management in Acute Basilar Artery Occlusion Strokes: Results From the ATTENTION Multicenter Registry – Circulation (free for a limited period)
Commentary on Twitter
#ResearchLetter In 2134 patients with basilar artery occlusion #stroke, endovascular treatment was associated with improved functional capacity. The effect was more pronounced in patients with more debilitating symptoms #AHAJournals https://t.co/wy4uFocYlR pic.twitter.com/TIBRVAXRhE
— Circulation (@CircAHA) June 10, 2022
#CCR22 – RCT: High-flow nasal cannula therapy met criteria for noninferiority compared to CPAP for the liberation from respiratory support in acutely ill children in the ICU.
16 Jun, 2022 | 11:10h | UTCEffect of High-Flow Nasal Cannula Therapy vs Continuous Positive Airway Pressure Therapy on Liberation From Respiratory Support in Acutely Ill Children Admitted to Pediatric Critical Care Units: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
Among acutely ill children clinically assessed to require noninvasive respiratory support in a pediatric critical care unit, HFNC met the criterion for noninferiority compared with CPAP for time to liberation from respiratory support. https://t.co/WvU2fKLDOJ #CCR22
— JAMA (@JAMA_current) June 16, 2022
#CCR22 – RCT: Intravenous Vitamin C increases the risk of death or persistent organ dysfunction in adults with sepsis in the intensive care unit.
16 Jun, 2022 | 11:13h | UTCRelated:
Commentary on Twitter
https://twitter.com/NEJM/status/1536991910006468608
#CCR22 – RCT: Among critically ill patients undergoing tracheal intubation, administering a 500 ml fluid bolus did not decrease the incidence of severely low blood pressure, cardiac arrest, or death.
16 Jun, 2022 | 11:08h | UTCEffect of Fluid Bolus Administration on Cardiovascular Collapse Among Critically Ill Patients Undergoing Tracheal Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentary on Twitter
In this randomized clinical trial, among critically ill adults undergoing tracheal intubation, administration of a fluid bolus did not significantly decrease the incidence of cardiovascular collapse. https://t.co/vPkfgLBF1n #CCR22
— JAMA (@JAMA_current) June 16, 2022
Review: The physiological underpinnings of life-saving respiratory support.
16 Jun, 2022 | 11:03h | UTCThe physiological underpinnings of life-saving respiratory support – Intensive Care Medicine
Commentary on Twitter
Physiology of life-saving respiratory support:
➡️historical overview
➡️pathophysiology of respiratory failure
Invasive mechanical ventilation & extracorporeal support #ECLS #ECMO:
➡️rationale
➡️implementation
➡️iatrogenic consequences
➡️future#FOAMcc
📎 https://t.co/EEvfpqVKIa pic.twitter.com/4t7wl53Jpz— Intensive Care Medicine (@yourICM) June 12, 2022
Interventions in acute intracranial surgery: an evidence-based perspective.
16 Jun, 2022 | 10:59h | UTCInterventions in Acute Intracranial Surgery: An Evidence-Based Perspective – World Neurosurgery
M-A: Acute or subacute, the optimal timing for uncomplicated Type B aortic dissection.
16 Jun, 2022 | 10:46h | UTC
AHA Scientific Statement: Toward a better understanding of sex- and gender-related differences in endovascular stroke treatment.
15 Jun, 2022 | 11:26h | UTCNews Release: More data needed on stroke treatment and outcomes by sex, gender – American Heart Association
Commentary on Twitter
Toward a Better Understanding of Sex- and Gender-Related Differences in Endovascular Stroke Treatment: A Scientific Statement From the American Heart Association/American Stroke Associationhttps://t.co/oXrdiLZfNK pic.twitter.com/Z4kMZG4Ymm
— Let's Get Proof (@letsgetproof) June 13, 2022
Review: Sepsis management for the nephrologist.
15 Jun, 2022 | 11:23h | UTCSepsis Management for the Nephrologist – Clinical Journal of the American Society of Nephrology
Encephalopathy in cirrhosis: prevention and management.
15 Jun, 2022 | 10:39h | UTC
Review: Portal vein thrombosis in cirrhosis.
15 Jun, 2022 | 10:38h | UTCPortal Vein Thrombosis in Cirrhosis – Journal of Clinical and Experimental Hepatology
Cohort Study | Intermediate-risk pulmonary embolism: echocardiography predictors of clinical deterioration.
15 Jun, 2022 | 10:34h | UTC
Study Commentary: Dexamethasone should not be given to people with a chronic subdural hematoma.
15 Jun, 2022 | 10:28h | UTCDexamethasone should not be given to people with a chronic subdural haematoma
Original Study: Trial of Dexamethasone for Chronic Subdural Hematoma – New England Journal of Medicine
Guideline: Management of hyperglycemia in hospitalized adult patients in non-critical care settings.
14 Jun, 2022 | 11:22h | UTCCommentary: Endocrine Society Issues New Guidelines for Hospitalized Patients With Diabetes – Clinical Advisor
Related:
Podcast: #330 Inpatient Diabetes with Dr. Dave Lieb – The Curbsiders
Review: Managing hyperglycaemia in inpatients – Clinical Medicine Journal
Systematic Review: Janus kinase inhibitors for the treatment of COVID‐19.
14 Jun, 2022 | 11:14h | UTCJanus kinase inhibitors for the treatment of COVID‐19 – Cochrane Library
Review | Body packers, stuffers, and pushers: time bombs in our Eds.
14 Jun, 2022 | 10:50h | UTCBody Packers, Stuffers, and Pushers: Time Bombs in Our Eds – emDocs
BSH guideline for the hematological management of major hemorrhage.
13 Jun, 2022 | 10:53h | UTC
M-A: Respiratory viral co-infections in patients with COVID-19 and associated outcomes.
13 Jun, 2022 | 10:41h | UTC
NIH Updated Guideline: Oxygenation and ventilation for adults with Covid-19.
13 Jun, 2022 | 10:44h | UTCOxygenation and Ventilation for Adults – National Institutes of Health
RCT: Emergency vs. delayed coronary angiogram in survivors of out-of-hospital cardiac arrest.
13 Jun, 2022 | 10:42h | UTCEmergency vs Delayed Coronary Angiogram in Survivors of Out-of-Hospital Cardiac Arrest: Results of the Randomized, Multicentric EMERGE Trial – JAMA Cardiology (free for a limited period)
Commentary on Twitter
In this RCT, performing an emergency coronary angiogram (CAG) after an out-of-hospital cardiac arrest without ST-segment elevation showed no difference in the 180-day survival rate compared to a delayed CAG. https://t.co/gYwPdNV32v
— JAMA Cardiology (@JAMACardio) June 8, 2022
Brief Review: Mental health morbidity, self-harm, and suicide in ICU survivors and caregivers.
13 Jun, 2022 | 08:01h | UTCMental health morbidity, self-harm, and suicide in ICU survivors and caregivers – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
#ICU mental health outcomes? The more we discover, the more we realize we need to care for a vulnerable population!
🧠 mental health morbidity among survivors
🧠 mental health morbidity among caregivers
🧠 risk prediction/mitigation
🧠 future directions
🖇 https://t.co/wo8QdP8Mz9 pic.twitter.com/9jX6h9SdRz— Intensive Care Medicine (@yourICM) June 7, 2022
Brief Review: How to manage anticoagulation during extracorporeal membrane oxygenation.
13 Jun, 2022 | 08:03h | UTCHow to manage anticoagulation during extracorporeal membrane oxygenation – Intensive Care Medicine (if the link is paywalled, try this one)
Related: 2021 ELSO Adult and Pediatric Anticoagulation Guidelines – ASAIO Journal