Critical Care & Emergencies (all articles)
Studies suggest apneic oxygenation reduces hypoxemia during emergency intubation
17 Jul, 2017 | 01:34h | UTCStudies suggest apneic oxygenation reduces hypoxemia during emergency intubation:
Meta-analysis 1: Apneic oxygenation during intubation in the emergency department and during retrieval: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)
Meta-analysis 2: Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full text)
Source: Apneic Oxygenation Prevents Desaturation During Intubation – Journal Watch ($ resource to find articles of interest)
Guideline: Nutrition Support Therapy in the Pediatric Critically Ill Patient
16 Jul, 2017 | 12:46h | UTC
Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of COPD
16 Jul, 2017 | 12:48h | UTCNon-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease – Cochrane Library (free)
NIV reduces mortality and endotracheal intubation in patients with acute hypercapnic respiratory failure secondary to an acute exacerbation COPD.
The future of mechanical ventilation: lessons from the present and the past
13 Jul, 2017 | 20:56h | UTCThe future of mechanical ventilation: lessons from the present and the past – Critical Care (free)
Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke
12 Jul, 2017 | 20:13h | UTCBlood pressure and in-hospital outcomes in patients presenting with ischaemic stroke – European Heart Journal (link to abstract – $ for full-text)
Commentary: Blood Pressure and Outcomes After Ischemic Stroke – American College of Cardiology, Latest in Cardiology (free)
Related article: Editorial: Blood Pressure in Acute Stroke Still No Answer for Management – Stroke (free PDF)
Observational analysis of over 300.000 patients suggests a J-shaped, or U-shaped relationships between BP and outcomes (both lower and higher BP levels detrimental). Among patients submitted to thrombolytic therapy, there were fewer complications with lower blood pressure.
Advances in the causes and management of community acquired pneumonia in adults
12 Jul, 2017 | 15:51h | UTCState of The Art Review: Advances in the causes and management of community acquired pneumonia in adults – The BMJ (free)
Meta-analysis: Dual Versus Triple Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention
11 Jul, 2017 | 21:26h | UTCMeta-analysis: Safety and Efficacy of Dual Versus Triple Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention – American Journal of Medicine (link to abstract – $ for full-text)
Source: EvidenceAlerts (free resource to find articles of interest)
“In patients receiving anticoagulant therapy, a strategy of single antiplatelet therapy confers a benefit of less major bleeding with no difference in all-cause mortality, cardiovascular mortality, major adverse cardiac events, myocardial infarction, stent thrombosis, or thromboembolic event rate compared with dual antiplatelet therapy”.
Post-Surgical Complications
11 Jul, 2017 | 16:45h | UTCPost-Surgical Complications – emDocs (free)
Practical review of this common problem in the emergency department.
Direct oral anticoagulants for treatment of Heparin-induced Thrombocytopenia
9 Jul, 2017 | 00:35h | UTCDirect oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review – Blood (link to abstract – $ for full-text)
Source: Direct Oral Anticoagulants for Heparin-Induced Thrombocytopenia – Journal Watch ($)
This literature review and observational study suggest direct oral anticoagulants (rivaroxaban, apixaban, dabigatran) are safe and effective for the treatment of Heparin-induced Thrombocytopenia.
Guidelines for the investigation and management sepsis in pregnancy
7 Jul, 2017 | 14:07h | UTC
The use of high-frequency ventilation during general anaesthesia
7 Jul, 2017 | 13:40h | UTCReview: The use of high-frequency ventilation during general anaesthesia: an update – F1000 research (free)
Peri-operative blood management
7 Jul, 2017 | 13:43h | UTCReview: Peri-operative blood management – Indian Journal of Anesthesia (free)
Common ED Medication Errors: Polypharmacy
4 Jul, 2017 | 21:17h | UTCCommon ED Medication Errors: Polypharmacy – emDocs (free)
Related: Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)
The practice of tracheostomy decannulation
3 Jul, 2017 | 18:01h | UTCThe practice of tracheostomy decannulation-a systematic review – Journal of Intensive Care (free)
Perioperative Management of Neurological Conditions
3 Jul, 2017 | 17:33h | UTCPerioperative Management of Neurological Conditions – Health Services Insights (free)
Direct oral anticoagulants in patients with chronic kidney disease
3 Jul, 2017 | 17:27h | UTC
Treatment of severe alcoholic hepatitis
3 Jul, 2017 | 17:17h | UTCSource: Critical Care Reviews Newsletter
CABG vs DES for Non–ST-Elevation Acute Coronary Syndrome and left main or multivessel CAD
29 Jun, 2017 | 16:12h | UTCComparison of Outcome of Coronary Artery Bypass Grafting Versus Drug-Eluting Stent Implantation for Non–ST-Elevation Acute Coronary Syndrome – The American Journal of Cardiology (link to abstract – $ for full-text)
Source: EvidenceAlerts
In patients with Non–ST-Elevation Acute Coronary Syndrome and left main or multivessel CAD, CABG significantly reduced the risk of death from any causes, myocardial infarction, or stroke compared with PCI with drug-eluting stents
Recognizing Sepsis as a Global Health Priority
29 Jun, 2017 | 13:03h | UTCPerspective: Recognizing Sepsis as a Global Health Priority: A WHO Resolution – New England Journal of Medicine (free)
Cardiovascular Testing and Clinical Outcomes in Emergency Department Patients With Chest Pain
28 Jun, 2017 | 22:04h | UTCCardiovascular Testing and Clinical Outcomes in Emergency Department Patients With Chest Pain – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Cardiac Tests in ED Patients Not Tied to Better Outcomes – Medscape (free registration required) AND Cardiac Testing for Slight ACS Risk Just Means More Procedures – MedPage Today (free registration required) AND Cardiac Testing in Emergency Room Chest Pain Patients – American College of Cardiology, Latest in Cardiology (free)
Contact Precautions for Endemic MRSA and VRE: Time to Retire Legal Mandates
26 Jun, 2017 | 19:41h | UTCViewpoint: Contact Precautions for Endemic MRSA and VRE: Time to Retire Legal Mandates – JAMA (free)
“Contact precautions are easy to use w a single patient, but burdensome when applied to an entire hospital” (RT @JAMA_current see Tweet)
This viewpoint suggests a more selective use of contact precautions for the control of endemic pathogens.
Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection
26 Jun, 2017 | 17:52h | UTCSource: EvidenceAlerts (free resource to find articles of interest)
In this meta-analysis including 19 randomized trials, probiotics given within 2 days of the first antibiotic dose (more effective than if started later) reduced the risk of Clostridium difficile infection (CDI) by >50% in hospitalized adults. 1 case of CDI would be prevented for every 23−144 patients treated with probiotics when antibiotics are started. “There was no convincing evidence of superior efficacy for any of the tested probiotic formulations, delivery methods (drink or capsule), or probiotic doses”.
Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis
25 Jun, 2017 | 16:34h | UTCEffect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)
Source: No Benefit of Nebulized Hypertonic Saline for Acute Bronchiolitis – Journal Watch ($ resource to find articles of interest)
Hypertonic saline clearly does not have any benefit for bronchiolitis (RT @JAMAPeds see Tweet)
Targeted temperature management in the ICU
23 Jun, 2017 | 20:36h | UTC
Time-to-Furosemide Treatment and Mortality in Acute Heart Failure
23 Jun, 2017 | 01:51h | UTCTime-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentary: Door-to-Furosemide Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)
“God help us if this sort of observational data leads to “door to furosemide time” being adopted as a quality measure” (RT @adamcifu see Tweet)