Critical Care & Emergencies (all articles)
Randomized Trial: Early Use of Norepinephrine in Septic Shock Resuscitation
16 Feb, 2019 | 13:58h | UTCEarly Use of Norepinephrine in Septic Shock Resuscitation (CENSER) : A Randomized Trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
See Commentary by Wellington ICU
“This is a promising result, and more and larger studies are needed to confirm the findings.” (from Wellington ICU)
Chinese Guidelines on the Management of Ascites and its Related Complications in Cirrhosis
16 Feb, 2019 | 13:49h | UTCNote: if the above link is not working, try this one
Related Guidelines: Evidence-based clinical practice guidelines for liver cirrhosis 2015 – Journal of Gastroenterology (free) AND Management of Adult Patients with Ascites Due to Cirrhosis: Update 2012 – American Association for the Study of Liver Diseases (free PDF) EASL clinical practice guidelines on the management of ascites, spontaneous bacterial peritonitis, and hepatorenal syndrome in cirrhosis (free) AND KASL clinical practice guidelines for liver cirrhosis: Ascites and related complications – Clinical and Molecular Hepatology (free) AND Cirrhosis in Over 16s: Assessment and Management – National Institute for Health and Care Excellence (free)
Meta-Analysis: Fever Control in Critically Ill Adults
16 Feb, 2019 | 13:54h | UTCNote: if the above link is not working, try this one
“Our findings do not support the hypothesis that more active fever management increases survival compared with less active fever management overall or in patients with limited physiological reserves.”
Does This Patient Have a Severe Snake Envenomation?
14 Feb, 2019 | 01:48h | UTCDoes This Patient Have a Severe Snake Envenomation? The Rational Clinical Examination Systematic Review – JAMA Surgery (free for a limited period)
Related: Global Mapping of Vulnerability to Snakebite Envenoming (free study and commentaries) AND Why Are So Many People Still Dying from Snake Bites? (free) AND Snakebite finally makes a WHO list of top global health priorities (free) AND Snakebites Make The List Of ‘Neglected Tropical Diseases’ (free)
Meta-Analysis: Hypotensive Resuscitation in Patients with Traumatic Hemorrhagic Shock
14 Feb, 2019 | 01:45h | UTCCommentary: Permissive hypotensive resuscitation in patients with traumatic hemorrhagic shock – Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine (free)
Severe Toxicity from Checkpoint Protein Inhibitors: What Intensive Care Physicians Need to Know?
13 Feb, 2019 | 02:02h | UTCRelated Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)
Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)
Randomized Trial: Intensive Blood Pressure Reduction Does Not Improve Outcomes in Patients with Acute Ischemic Stroke Treated with Thrombolytics
13 Feb, 2019 | 01:52h | UTCIntensive blood pressure reduction with intravenous thrombolysis therapy for acute ischaemic stroke (ENCHANTED): an international, randomised, open-label, blinded-endpoint, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Intensive Blood Pressure Lowering With Intravenous Thrombectomy for Acute Ischemic Stroke Did Not Improve Functional Outcomes – Practical Neurology (free) AND Tighter BP Control No Better in Acute Stroke – MedPage Today (free registration required)
Randomized Trial: Intense IV Blood Sugar Control Doesn’t Improve Stroke Outcomes
11 Feb, 2019 | 00:15h | UTCCommentaries: NIH study provides answer to long-held debate on blood sugar control after stroke – National Institute of Health (free) AND Stroke: Intensive Blood Sugar Control Did Not Improve Outcomes – MedicalResearch.com (free) AND Live from the ISC: Standard treatment of hyperglycaemia in acute ischaemic stroke outperforms an intensive approach – NeuroNews (free)
Related Cochrane Review: Insulin for glycaemic control in acute ischaemic stroke (free) AND Summary: Controlling high blood sugar levels with insulin in people who have had an acute ischaemic stroke (free)
“Intensive glucose control (80–130mg/dL) does not improve 90-day functional outcome and increases the risk of severe hypoglycaemia.” (from NeuroNews)
The Aftermath of Acute Kidney Injury: A Narrative Review of Long-term Mortality and Renal Function
10 Feb, 2019 | 14:26h | UTC
Review: Epidemiology and Antimicrobial Resistance in Intensive Care Units
10 Feb, 2019 | 13:54h | UTC
Expert Panel Recommendations: Fluid Administration for Acute Circulatory Dysfunction Using Basic Monitoring
7 Feb, 2019 | 23:26h | UTCFluid administration for acute circulatory dysfunction using basic monitoring: narrative review and expert panel recommendations from an ESICM task force – Intensive Care Medicine (free for a limited period)
Note: if the above link is paywalled, try this one
Related Commentary on Twitter
Fluid administration for acute circulatory failure: go back to the basics, thanks to the expert panel recommendations from an ESICM task force!
Read the full text article for free at https://t.co/VPtl6cD0aN @Dr_Cit @ESICM @ClinMedJournals pic.twitter.com/pBoJiKHihT— Intensive Care Medicine (@yourICM) February 1, 2019
Guideline: Best Practice Advice on Pre-hospital Emergency Anesthesia & Advanced Airway Management
7 Feb, 2019 | 23:20h | UTC
Podcast: Hyperkalemia Master Class
6 Feb, 2019 | 00:52h | UTC#137 Hyperkalemia Master Class with Joel Topf MD – The Curbsiders Internal Medicine Podcast (free)
International Consensus Guidelines for the Optimal Use of the Polymyxins
4 Feb, 2019 | 23:45h | UTCInternational Consensus Guidelines for the Optimal Use of the Polymyxins – Pharmacotherapy (free)
Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).
Editorial: Humanizing the Intensive Care Unit
3 Feb, 2019 | 15:51h | UTCHumanizing the intensive care unit – Critical Care (free)
Related Commentary on Twitter
Humanizing the intensive care unit#FOAMedhttps://t.co/PyQFWImRwe pic.twitter.com/b69IF9Anca
— Critical Care (@Crit_Care) January 29, 2019
Position Statement: Clear Fluids Fasting for Elective Pediatric Anesthesia
3 Feb, 2019 | 13:44h | UTC
Related Guidelines: Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration: Application to Healthy Patients Undergoing Elective Procedures: An Updated Report by the American Society of Anesthesiologists Task Force on Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration (free) AND Perioperative fasting in adults and children: guidelines from the European Society of Anaesthesiology (free)
Related Systematic Review: Practice Guideline Recommendations on Perioperative Fasting – Journal of Parenteral and Enteral Nutrition (free)
Related Narrative Review: Nothing by Mouth at Midnight: Saving or Starving? A Literature Review – Gastroenterology Nursing (free)
“‘It is safe and recommended for all children able to take clear fluids, to be allowed and encouraged to have them up to 1 h before elective general anaesthesia’.”
Review: Benefits of Non‐invasive Ventilation in Acute Hypercapnic Respiratory Failure
3 Feb, 2019 | 11:30h | UTCBenefits of non‐invasive ventilation in acute hypercapnic respiratory failure – Respirology (free)
Related Guidelines: BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free) AND The Japanese Respiratory Society Noninvasive Positive Pressure Ventilation (NPPV) Guidelines – Respiratory Investigation (free) AND Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline – European Respiratory Journal (free)
Related Reviews: Non‐invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease – Cochrane Library (free) AND Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)
10 Myths About Frusemide
30 Jan, 2019 | 23:31h | UTC10 myths about frusemide – Intensive Care Medicine (free)
Note: if the above link is paywalled, try this one
Perspective: Debates in Sepsis
30 Jan, 2019 | 23:20h | UTCDebates in sepsis – ACP Hospitalist (free)
Related: Point and Counterpoint: Should the Surviving Sepsis Campaign Guidelines Be Retired? (free commentaries) AND The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use (free commentaries)
Cohorty Study: Patient-reported Complications Related to Peripherally Inserted Central Catheters
28 Jan, 2019 | 23:55h | UTC
Related Commentary on Twitter
Three in four patients that receive a #PICC report a complication after discharge – yet very few are ever documented. Our new multicenter study in @BMJ_Qual_Saf exploring this issue is now out! #FOAMVa @AVATAR_grp @ISaveThatLine @ins1org #MAGIC https://t.co/sU3sL8aMGG
— Vineet Chopra (@vineet_chopra) January 26, 2019
Review: Cardiorenal Syndrome in Acute Kidney Injury
28 Jan, 2019 | 23:40h | UTCCardiorenal Syndrome in Acute Kidney Injury – Seminars in Nephrology (free)
French Guidelines of Intubation and Extubation of the ICU Patient
27 Jan, 2019 | 20:43h | UTC
Study: Incidence, Risk Factors, and Outcomes Associated With In-Hospital Acute Myocardial Infarction
27 Jan, 2019 | 20:22h | UTCCommentaries: In-Hospital Acute MI: Despite Numerous Predictors, Solutions Remain Elusive – TCTMD (free) AND In-Hospital Acute MI Common, Outcomes Poor – MedPage Today (free registration required)
Systematic Review: Early Discontinuation of Antibiotics for Febrile Neutropenia vs. Continuation Until Neutropenia Resolution in People with Cancer
24 Jan, 2019 | 00:17h | UTCEarly discontinuation of antibiotics for febrile neutropenia versus continuation until neutropenia resolution in people with cancer – Cochrane Library (free)
Study: Hospital Observation Upon Reversal (HOUR) With Naloxone
24 Jan, 2019 | 00:01h | UTCCommentary: Study confirms 1-hour discharge rule for patients given naloxone after opiate overdose – Society for Academic Emergency Medicine (free)