Critical Care & Emergencies (all articles)
Guidelines for the Prevention and Treatment of Frostbite
23 Jul, 2019 | 01:54h | UTC
[Abstract Only] Randomized Trial: Interventions to Prevent Dry Eye in Critically Ill Patients Compared
23 Jul, 2019 | 01:14h | UTCEffectiveness of Nursing Interventions to Prevent Dry Eye in Critically Ill Patients – American Journal of Critical Care (link to abstract – $ for full-text)
Source: Medscape
[Abstract Only] Pilot Study Suggests High-dose Spironolactone May Be Effective in Diuretic-Resistant Heart Failure
21 Jul, 2019 | 20:47h | UTCHigh-Dose Spironolactone When Patients With Acute Decompensated Heart Failure Are Resistant to Loop Diuretics: A Pilot Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: High-Dose Spironolactone Effective in Diuretic-Resistant Heart Failure – NEJM Journal Watch (free)
Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline
20 Jul, 2019 | 18:35h | UTCBuffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
“The three ongoing studies once published and assessed may alter the conclusions of the review.”
Guideline Synopsis: Management of Patients with Acute Ischemic Stroke
19 Jul, 2019 | 09:48h | UTCManagement of Patients with Acute Ischemic Stroke – JAMA (free for a limited period)
Original Guideline: 2018 AHA/ASA Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free)
Related Guidelines: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)
Cohort Study: State-Mandated Protocolized Sepsis Care Linked to Lower Mortality
17 Jul, 2019 | 10:36h | UTCAssociation Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis – JAMA (free for a limited period)
Editorial: Government Regulation of Sepsis Care (free for a limited period)
Commentaries: First Ever State Sepsis Regulation in U.S. Tied to Lower Death Rates – University of Pittsburg (free) AND Regulations That Mandate Sepsis Care Appear To Have Worked In New York – NPR (free)
Cohort Study: Shorter Time to Endovascular Recanalization in Acute Ischemic Stroke is Associated with Better Outcomes
17 Jul, 2019 | 10:46h | UTCAssociation Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)
Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)
Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)
News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)
Randomized Trial: Flexible Family Visitation Hours in The ICU Do Not Reduce the Incidence of Delirium Compared with Restricted Visitation
17 Jul, 2019 | 10:23h | UTCEffect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families (free for a limited period)
Author Interview: Do Flexible Family Visitation Hours Reduce Delirium in ICU Patients? – MedicalResearch.com (free)
Related Commentary on Twitter
In this 1685-patient cluster-crossover RCT, flexible family visitation did not significantly reduce @ICU_delirium compared with restricted visitation. https://t.co/Wg2QoXvu0F pic.twitter.com/thFJ4WqsS1
— Delirium in the ICU (@ICU_delirium) July 16, 2019
Post‐intensive Care Syndrome: Its Pathophysiology, Prevention, and Future Directions
17 Jul, 2019 | 08:59h | UTCPost‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)
Related Reviews: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free) AND Optimizing Post-Intensive Care Unit Rehabilitation – Turkish Thoracic Journal (free)
Review: Coronary Microvascular Obstruction in ST-Elevation Myocardial Infarction
14 Jul, 2019 | 20:03h | UTCOptimized Treatment of ST-Elevation Myocardial Infarction: The Unmet Need to Target Coronary Microvascular Obstruction as Primary Treatment Goal to Further Improve Prognosis – Circulation Research (free) (via @gonzaeperez)
Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared
14 Jul, 2019 | 19:41h | UTCRelated reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free) AND Managing the toxicities of CAR T‐cell therapy – Hematological Oncology (free)
Source: Critical Care Reviews Newsletter
A Current Appraisal of Evidence for the Approach to Sepsis and Septic Shock
14 Jul, 2019 | 19:43h | UTCSource: Critical Care Reviews Newsletter
[Abstract Only] Meta-Analysis: Balanced Crystalloids Do Not Improve Outcomes When Compared with Normal Saline in Critically Ill Patients
14 Jul, 2019 | 19:13h | UTCChoice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
Source: Hospital Medicine Virtual Journal Club
Editorial: How I Manage Intracranial Hypertension
14 Jul, 2019 | 19:01h | UTCHow I manage intracranial hypertension – Critical Care (free)
Related Commentary on Twitter
https://twitter.com/Crit_Care/status/1148602481028583424
[Abstract Only] Study: The Benefits of Clopidogrel-aspirin Combination after Minor Stroke/TIA occurs Predominantly Within the First 21 Days
12 Jul, 2019 | 08:03h | UTCTime Course for Benefit and Risk of Clopidogrel and Aspirin after Acute Transient Ischemic Attack and Minor Ischemic Stroke: A Secondary Analysis from the POINT Randomized Trial – Circulation (link to abstract – $ for full-text)
Commentary: Clopidogrel-Aspirin in Minor Stroke/TIA of Maximum Benefit in First 21 Days – TCTMD (free)
Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)
[Abstract Only] Randomized Trial: C-Reactive Protein Can Guide Antibiotics for COPD Exacerbations
11 Jul, 2019 | 11:18h | UTCC-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: CRP Testing Can Safely Reduce Antibiotic Use for COPD Exacerbations – NEJM Journal Watch (free) AND Fingerprick Biomarker Test Can Reduce Use of Antibiotics in COPD Flares – MedicalResearch.com (free)
Review: Management of Acute Variceal Hemorrhage
10 Jul, 2019 | 02:31h | UTCManagement of acute variceal hemorrhage – F1000Research (free)
ERS Statement on Chest Imaging in Acute Respiratory Failure
9 Jul, 2019 | 10:26h | UTCERS statement on chest imaging in acute respiratory failure – European Respiratory Journal (free PDF)
[Abstract Only] Randomized Trial: Prophylactic Vena Cava Filters Do Not Improve Outcomes After Major Trauma
9 Jul, 2019 | 10:10h | UTCA Multicenter Trial of Vena Cava Filters in Severely Injured Patients – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Liberal IVC Filter Use Not Warranted in Severe Trauma Patients – TCTMD (free)
Related Commentary on Twitter
Early prophylactic placement of a vena cava filter after major trauma does not result in a lower incidence of symptomatic pulmonary embolism or death at 90 days than no placement of a filter. #ISTH2019 https://t.co/ZjMqDcaOL5 pic.twitter.com/7jXvYAW5hx
— NEJM (@NEJM) July 8, 2019
Observational Study Suggests Point-of-Care Ultrasound in the Emergency Department May Result in Care Delays and Increased In-hospital Mortality
5 Jul, 2019 | 02:44h | UTCImpact of Point-of-Care Ultrasound in the Emergency Department on Care Processes and Outcomes in Critically Ill Nontraumatic Patients – Critical Care Explorations (free) (via @f_g_zampieri)
Related Commentary on Twitter
https://twitter.com/POCUS_Society/status/1145789677544230912
Perspective: Wide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence
4 Jul, 2019 | 10:54h | UTCWide Interest in a Vitamin C Drug Cocktail for Sepsis Despite Lagging Evidence – JAMA (free for a limited period)
Related: The Effect of Vitamin C on Clinical Outcome in Critically Ill Patients: A Systematic Review With Meta-Analysis of Randomized Controlled Trials – Critical Care Medicine (link to abstract – $ for full-text)
Review: Infections in the Elderly Critically-Ill Patients
3 Jul, 2019 | 06:05h | UTCInfections in the Elderly Critically-Ill Patients – Frontiers in Medicine (free)
Review: The Use of Activated Charcoal to Treat Intoxications
30 Jun, 2019 | 17:46h | UTCThe Use of Activated Charcoal to Treat Intoxications – Deutsches Arzteblatt International (free)
Guidelines for the Provision of Intensive Care Services
28 Jun, 2019 | 07:46h | UTCGuidelines for the Provision of Intensive Care Services – Edition 2 – Intensive Care Society (free PDF)
Serial High-Sensitivity Troponin Measurements to Estimate the Probability of Myocardial Infarction
28 Jun, 2019 | 07:45h | UTCApplication of High-Sensitivity Troponin in Suspected Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: High-Sensitivity Troponin in Suspected MI – American College of Cardiology (free) AND Risk Stratification Using Serial High-Sensitivity Troponin Measurements – NEJM Journal Watch (free)
See also: Compass MI Calculator