Critical Care & Emergencies (all articles)
Community-acquired Pneumonia in Critically Ill Very Old Patients: A Growing Problem
23 Feb, 2020 | 22:06h | UTCEditorial: Natural enemy or friend? Pneumonia in the very elderly critically ill patient (free)
Position Statement: Antithrombotic Therapy in Patients with Acute Coronary Syndrome Complicated by Cardiogenic Shock or Out-of-hospital Cardiac Arrest
23 Feb, 2020 | 21:47h | UTC
Randomized Trial: Effect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients with Large Vessel Occlusion Ischemic Stroke
23 Feb, 2020 | 21:18h | UTCEffect of Intravenous Tenecteplase Dose on Cerebral Reperfusion Before Thrombectomy in Patients With Large Vessel Occlusion Ischemic Stroke: The EXTEND-IA TNK Part 2 Randomized Clinical Trial – JAMA (free for a limited period)
Commentary: No Need to Go to Higher Tenecteplase Dose for Acute Stroke – TCTMD (free)
Systematic Review: Transcranial Doppler Sonography for Detecting Stenosis or Occlusion of Intracranial Arteries in People with Acute Ischemic Stroke
21 Feb, 2020 | 08:37h | UTCTranscranial Doppler sonography for detecting stenosis or occlusion of intracranial arteries in people with acute ischaemic stroke – Cochrane Library (free)
Opinion – “It’s Insane to Keep Using Mortality as a Primary Endpoint in Critical Care Trials”
21 Feb, 2020 | 10:36h | UTCIt’s insane to keep using mortality as a primary endpoint in critical care trials – PulmCrit (free)
Source: Grupo UTIclínica – HCFMUSP
[Abstract Only] Observational Study: Effects of Pre-Hospital Administration of Epinephrine in Pediatric Patients with Out-of-Hospital Cardiac Arrest
20 Feb, 2020 | 08:21h | UTCPre-Hospital Administration of Epinephrine in Pediatric Patients With Out-of-Hospital Cardiac Arrest – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Epinephrine for Pediatric OHCA Mirrors PARAMEDIC2 – JournalFeed (free) AND Getting to the heart of epinephrine use in pediatric cardiac arrest patients – Osaka University (free)
Related Study: Randomized Trial: Epinephrine in Out-of-Hospital Cardiac Arrest (free study and commentaries)
[Abstract Only] Meta-Analysis: Clinical Pre‐test Probability Adjusted vs. Age‐adjusted D‐dimer Interpretation Strategy for DVT Diagnosis
20 Feb, 2020 | 08:36h | UTCClinical pre‐test probability adjusted versus age‐adjusted D‐dimer interpretation strategy for DVT diagnosis: A diagnostic individual patient data meta‐analysis – Journal of Thrombosis and Haemostasis (link to abstract – $ for full-text)
Commentary: Clinical Pre-test Prob vs. Age-adjusted D-dimer for DVT – The Meta Analysis – JournalFeed (free)
Related Studies: Diagnosis of Pulmonary Embolism with d-Dimer Adjusted to Clinical Probability – New England Journal of Medicine (link to abstract and commentary) AND Age-Adjusted D-Dimer Cutoff Levels to Rule Out Pulmonary Embolism: The ADJUST-PE Study – JAMA (free)
Meta-Analysis: Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease
19 Feb, 2020 | 10:21h | UTCEditorial: The ISCHEMIA Trial Meets the Rashomon Effect: Lessons for Clinical Practice (free for a limited period)
Related Commentary on Twitter
🔺meta-analysis on effects of percutaneous coronary intervention in stable & unstable CAD;includes ISCHEMIA trial
🔺PCI prevents death, cardiac death,&MI in pts w unstable CAD
🔺For pts w stable CAD,PCI shows🚫evidence of an effect on any of these outcomes https://t.co/zsEWWuVPmL pic.twitter.com/y0WLwIIVef— Circ: CQO (@CircOutcomes) February 18, 2020
China Releases Largest Study on COVID-19 Outbreak with Over 44.000 Patients – Elderly and Sick are Most at Risk
19 Feb, 2020 | 10:23h | UTCThe Epidemiological Characteristics of an Outbreak of 2019 Novel Coronavirus Diseases (COVID-19) – China, 2020 – China CDC Weekly (free PDF – link via Forbes)
Commentaries: Coronavirus: Largest study suggests elderly and sick are most at risk – BBC (free) AND New Chinese Study Finds That The Elderly Are Most At Risk From The Coronavirus [Infographic] – Forbes (free) AND Expert reaction to WHO Director General’s statement on new paper from China detailing over 44,000 of their cases – Science Media Centre (free)
Randomized Trial: Sodium Bicarbonate Prehydration Prior to Contrast-Enhanced Computed Tomography Does Not Prevent Postcontrast Acute Kidney Injury in Adults with Chronic Kidney Disease
18 Feb, 2020 | 08:18h | UTCRelated: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (free statement and commentary) AND Another Study Questions the Association of Contrast Use and Acute Kidney Injury (studies on the subject)
[Abstract Only] Randomized Trial: Nonsedation vs. Light Sedation in Critically Ill, Mechanically Ventilated Patients
18 Feb, 2020 | 08:22h | UTCNonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: No Sedation: An Option in Mechanically Ventilated ICU Patients – MedPage Today (free registration required)
Related Commentary on Twitter
In a randomized trial in 700 mechanically ventilated ICU patients, 90 day mortality was not different between no sedation compared to arousable sedation. There was a low rate of thromboembolic events but they were more numerous in the sedated group. #CCC49
— NEJM (@NEJM) February 16, 2020
Podcast – Things we Do for No Reason Episode 3: Potassium, Oxygen, and Antipsychotics
18 Feb, 2020 | 08:20h | UTC#195 TWDFNR 3: Potassium, Oxygen, and Antipsychotics – The Curbsiders Internal Medicine Podcast (free)
Related Podcasts: #109: Things We Do For No Reason: A High Value Episode (free) AND #165 Things We Do For No Reason™ Part 2 (free)
See also: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (free articles)
Observational Study: Empirical Anti-MRSA Antibiotic Therapy Does Not Improve Outcomes in Patients Hospitalized for Pneumonia
18 Feb, 2020 | 08:15h | UTCEmpirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia – JAMA Internal Medicine (free for a limited period)
Editorial: Overuse of Broad-Spectrum Antibiotics for Pneumonia (free for a limited period)
Related Commentary on Twitter
NEW 🔥⚡Retrospective multicenter cohort study @JAMA_current
Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia. #IDTwitter #medtwitter https://t.co/X0jWhMaUMT pic.twitter.com/FwNadOZrjx— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) February 17, 2020
Humanizing Intensive Care: Toward a Human-Centered Care ICU Model
18 Feb, 2020 | 08:09h | UTCHumanizing Intensive Care: Toward a Human-Centered Care ICU Model – Critical Care Medicine (free)
Source: Critical Care Reviews
Viewpoint – Nutritional Support in Sepsis: When Less may be More
18 Feb, 2020 | 08:06h | UTCNutritional support in sepsis: when less may be more – Critical Care (free)
Meta-Analysis: Subglottic Secretion Drainage for Preventing Ventilator-associated Pneumonia
18 Feb, 2020 | 08:01h | UTC
Guidelines for the Management of Adult Acute and Acute-on-Chronic Liver Failure in the ICU
16 Feb, 2020 | 21:42h | UTCNews Release: New guidelines for hepatic failure in the intensive care unit – Wolters Kluwer Health (free)
See also: Executive Summary (free)
Study Commentaries: The 65 Trial – Comparison of Different Blood Pressure Targets for Vasopressor Therapy
16 Feb, 2020 | 21:36h | UTC65 Trial – The Bottom Line (free) AND The 65 trial: Is 60 the new 65? – PulmCrit (free)
Original Study: Randomized Trial: Comparison of Different Blood Pressure Targets for Vasopressor Therapy in Older Critically Ill Patients with Vasodilatory Hypotension – JAMA (free)
Guidelines for Early Mobilization in the Intensive Care Unit
16 Feb, 2020 | 21:06h | UTC
Bloodstream Infections in Critically Ill Patients: An Expert Statement
16 Feb, 2020 | 21:03h | UTCBloodstream infections in critically ill patients: an expert statement – Intensive Care Medicine (free)
Meta-Analysis: Determining the Optimal Time for Liberation from Renal Replacement Therapy in Critically Ill Patients
16 Feb, 2020 | 21:19h | UTC
Extracorporeal Membrane Oxygenation for Refractory Cardiac Arrest: A Retrospective Multicenter Study
16 Feb, 2020 | 21:02h | UTC
Cohort Study: Association of Physician Orders for Life-Sustaining Treatment with ICU Admission Among Patients Hospitalized Near the End of Life
16 Feb, 2020 | 21:01h | UTCAssociation of Physician Orders for Life-Sustaining Treatment with ICU Admission Among Patients Hospitalized Near the End of Life – JAMA (free for a limited period)
Editorial: Physician Orders for Life-Sustaining Treatment and Limiting Overtreatment at the End of Life (free for a limited period)
Basic Point‐of‐care Ultrasound Framework Based on the Airway, Breathing, and Circulation Approach for the Initial Management of Shock and Dyspnea
16 Feb, 2020 | 20:46h | UTCSource: Grupo UTIclínica – HCFMUSP
Updated Nomenclature of Delirium and Acute Encephalopathy: Statement of Ten Societies
14 Feb, 2020 | 02:13h | UTC