Critical Care & Emergencies (all articles)
Randomized Trial: Comparison of Different Blood Pressure Targets for Vasopressor Therapy in Older Critically Ill Patients with Vasodilatory Hypotension
13 Feb, 2020 | 08:04h | UTCEffect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Choosing the Best Blood Pressure Target for Vasopressor Therapy (free for a limited period)
Conference Presentation: Effect of Reduced Vasopressor Exposure on Mortality in Older Critically Ill Patients With Vasodilatory Hypotension (free)
Related Commentary on Twitter
No difference in mortality (as expected?) but higher incidence of severe acute renal failure with permissive hypotension in Older Critically Ill Patients With Vasodilatory Hypotension https://t.co/XyBy74WAPL congrats to the authors @JAMA_current
— Matthieu Legrand (@matthieulegrand) February 12, 2020
[Abstract Only] Randomized Trial: Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
13 Feb, 2020 | 08:00h | UTCPlasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Visual Abstract: Plasma Exchange and Glucocorticoids for ANCA-Associated Vasculitis (free)
Commentary: PEXIVAS: No benefit of plasma exchange in ANCA-associated vasculitis – Medicine Matters (free)
Randomized Trial: Among Patients with MRSA Bacteremia, the Addition of an Antistaphylococcal β-lactam to Standard Therapy Does Not Improve Outcomes
12 Feb, 2020 | 07:29h | UTCEffect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Combination Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: Not Ready for Prime Time (free for a limited period)
Commentaries: Trial pours cold water on combo treatment for MRSA bacteremia – CIDRAP (free) AND Trial shows using two drugs not better than one when treating MRSA blood infections – University of Melbourne (free)
Related Commentary on Twitter
Adding an antistaphylococcal β-lactam to standard #antibiotic therapy w vancomycin or daptomycin did not improve a primary composite outcome of mortality, persistent #bacteremia, relapse, or Tx failure in pts with #MRSA bacteremia https://t.co/UpyCz3Ss4F #VisualAbstract
— JAMA (@JAMA_current) February 12, 2020
[Abstract Only] Randomized Trial: Dexamethasone for the Treatment of Acute Respiratory Distress Syndrome
12 Feb, 2020 | 07:24h | UTCDexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related: Meta-Analysis: Assessment of Therapeutic Interventions and Lung Protective Ventilation in Patients with Moderate to Severe Acute Respiratory Distress Syndrome (free resources on the subject)
Related Commentary on Twitter
#Dexamethasone is associated with a substantial reduction in duration of mechanical #ventilation and all-cause 60-day #mortality in patients with #ARDS
New RCT from Jesús ViIlar and colleagues https://t.co/b4sW2K0RwG pic.twitter.com/MBbeSWBo55
— The Lancet Respiratory Medicine (@LancetRespirMed) February 10, 2020
Observational Study: Higher Risk of Death and Major Bleeding with Intravascular Microaxial Left Ventricular Assist Device vs. Intra-aortic Balloon Pump Among Patients with Acute MI Complicated by Cardiogenic Shock
12 Feb, 2020 | 07:27h | UTCAssociation of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock – JAMA (free for a limited period)
Editorial: Microaxial Left Ventricular Assist Devices: In Search of an Appropriate Indication (free for a limited period)
Commentary: High-tech pump may increase risk of death and bleeding, study finds – Yale News (free)
Related Commentary on Twitter (Thread – Click for More)
Major paper published by @JAMA_current today that uses real-world data to examine outcomes among patients undergoing PCI for AMI who received mechanical circulatory support, comparing the Impella to IABP (and to medical therapy) (1/9) https://t.co/EsoRfSj1eH
— Joseph Ross (@jsross119) February 10, 2020
Critical Care Management of Adults with Community-acquired Severe Respiratory Viral Infection
11 Feb, 2020 | 02:25h | UTC
Clinical Controversies in Anticoagulation Monitoring and Antithrombin Supplementation for ECMO
11 Feb, 2020 | 01:44h | UTC
Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children
9 Feb, 2020 | 20:50h | UTCExecutive Summary: Executive Summary: Surviving Sepsis Campaign International Guidelines for the Management of Septic Shock and Sepsis-Associated Organ Dysfunction in Children (free)
Related Commentary on Twitter
The #SurvivingSepsis Campaign has released NEW peds sepsis guidelines that recommend child-specific care for this deadly condition. Access the full guidelines published in @PedCritCareMed: https://t.co/Yjfa5kaXtb
More resources: https://t.co/R4bivYQWuA#SCCMSoMe #PedsICU pic.twitter.com/o9FslT2c6I
— SCCM (@SCCM) February 8, 2020
[Abstract Only] Meta-Analysis: Corticosteroids as Adjunctive Therapy in the Treatment of Influenza
9 Feb, 2020 | 20:13h | UTCCorticosteroids as Adjunctive Therapy in the Treatment of Influenza: An Updated Cochrane Systematic Review and Meta-analysis – Critical Care Medicine (link to abstract – $ for full-text)
[Abstract Only] Cohort Study: Blood Pressure Thresholds and Neurologic Outcomes After Endovascular Therapy for Acute Ischemic Stroke
9 Feb, 2020 | 20:16h | UTCBlood Pressure Thresholds and Neurologic Outcomes After Endovascular Therapy for Acute Ischemic Stroke: An Analysis of Individual Patient Data From 3 Randomized Clinical Trials – JAMA Neurology (link to abstract – $ for full-text)
Commentary: ‘Sweet Spot’ Identified for BP During Stroke Thrombectomy – TCTMD (free) AND Blood Pressure Key to Good Outcomes in Stroke Thrombectomy – Medscape (free registration required)
Related Commentary on Twitter
BP MAP < 70 mmHg for >10 min and > MAP 90 mmHg for > 45 min were associated with worse outcomes in this cohort study of endovascular #stroke patients (n=365). NNH 10.
Blood Pressure Thresholds in Endovascular Therapy for Acute Ischemic Stroke https://t.co/fBFPZcN5CG— Vivien Lee MD FAAN (@VivienHLee) January 29, 2020
[Abstract Only] Meta-Analysis: Epinephrine Improves Overall Survival but not Neurologic Outcomes for Out-of-Hospital Cardiac Arrest
9 Feb, 2020 | 20:12h | UTCEpinephrine for Out-of-Hospital Cardiac Arrest: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)
Related: A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free)
Mini-Review: Corticosteroids in Community-Acquired Pneumonia
7 Feb, 2020 | 08:16h | UTCCorticosteroids in Community-Acquired Pneumonia – JAMA (free for a limited period)
Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)
Related Cochrane Review: Is Treatment With Corticosteroids Beneficial for People With Pneumonia? (free)
Guideline Synopsis: Diagnosis and Treatment of Adults with Community-Acquired Pneumonia
7 Feb, 2020 | 08:17h | UTCDiagnosis and Treatment of Adults with Community-Acquired Pneumonia – JAMA (free for a limited period)
See also: Treatment Algorithm (free)
Original Article: ATS/IDSA Guideline: Diagnosis and Treatment of Adults with Community-acquired Pneumonia (free resources)
Related Guideline: NICE Guideline: Management of Pneumonia in Adults (free resources)
Nutrition Therapy in Critical Illness: A Review of the Literature for Clinicians
7 Feb, 2020 | 08:15h | UTCNutrition therapy in critical illness: a review of the literature for clinicians – Critical Care (free)
Management of HIV-infected Patients in the ICU
5 Feb, 2020 | 08:18h | UTCManagement of HIV-infected patients in the intensive care unit – Intensive Care Medicine (free)
Guidelines for the Management of Glucocorticoids During the Peri‐operative Period for Patients with Adrenal Insufficiency
5 Feb, 2020 | 08:23h | UTC
Related Commentary on Twitter
?Patients with adrenal insufficiency can be better identified and supplemented with glucocorticoids during the peri-operative period.
This is the first national guidance on this topic and of relevant to all.@AAGBI @RCPLondon @Soc_Endo
?https://t.co/eSg158Hjlh pic.twitter.com/1hdYjlJBYk
— Anaesthesia (@Anaes_Journal) February 4, 2020
Review: Vasopressin and its Analogues in Shock States
5 Feb, 2020 | 08:17h | UTCVasopressin and its analogues in shock states: a review – Annals of Intensive Care (free)
Review: Pathophysiological and Clinical Considerations in the Perioperative Care of Patients with a Previous Ischemic Stroke
4 Feb, 2020 | 08:52h | UTC
[Abstract Only] Study: Accuracy of Coronary CT Angiography to Exclude Significant CAD in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome
4 Feb, 2020 | 08:49h | UTCCommentaries: Coronary CT Angiography in NSTEACS Patients – Journal of the American College of Cardiology (free) AND CCTA to Avoid Invasive Cath in NSTE ACS? Clues From VERDICT – TCTMD (free)
Guideline: Enhanced Recovery After Lung Surgery
4 Feb, 2020 | 08:00h | UTCRelated: Guidelines for enhanced recovery after lung surgery: recommendations of the Enhanced Recovery After Surgery (ERAS®) Society and the European Society of Thoracic Surgeons (ESTS) – European Journal of Cardio-Thoracic Surgery (free) AND Enhanced recovery programs in lung cancer surgery: systematic review and meta-analysis of randomized controlled trials – Cancer Management and Research (free)
See also other Enhanced Recovery After Surgery (ERAS) Guidelines (free)
Meta-Analysis: Aspirin for Venous Thromboembolism Prophylaxis After Total Hip and Knee Replacement
4 Feb, 2020 | 07:55h | UTC
Critical Care Nephrology: Core Curriculum 2020
4 Feb, 2020 | 07:50h | UTCCritical Care Nephrology: Core Curriculum 2020 – American Journal of Kidney Diseases (free)
Source: Grupo UTIclínica – HCFMUSP
[Abstract Only] Randomized Trial: Electrical vs. Pharmacological Cardioversion for Emergency Department Patients with Acute Atrial Fibrillation
2 Feb, 2020 | 20:11h | UTCElectrical versus pharmacological cardioversion for emergency department patients with acute atrial fibrillation (RAFF2): a partial factorial randomised trial – The Lancet (link to abstract – $ for full-text)
Summary: Electrical vs Chemical Cardioversion in ED Patients With Atrial Fibrillation (RAFF2) – EMOttawa (free)
Related Study: Randomized Trial: Early vs. Delayed Cardioversion in Recent-Onset Atrial Fibrillation – New England Journal of Medicine (free study and commentaries)
Related Commentary on Twitter
Published in @TheLancet today, @EMO_Daddy et al. are at it again with the RAFF2 trial; showing immediate rhythm control in patients with acute atrial fibrillation is safe and effective.
Visual infographic below.
Summary: https://t.co/OyFeKjIyjc
Article: https://t.co/y983EWDOaK pic.twitter.com/22EofQFgnH— EM Ottawa (@emergmedottawa) January 31, 2020
Study Commentary: PEPTIC
2 Feb, 2020 | 19:47h | UTCPEPTIC – The Bottom Line (free)
Original Study: Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial – JAMA (link to abstract, commentaries and study presentation)
Perspective: CPR, by Default
2 Feb, 2020 | 19:45h | UTCCPR, by Default – The New York Times (10 articles per month are free)