Emergency Medicine
WSES consensus guidelines on sigmoid volvulus management
5 Jun, 2023 | 13:19h | UTCWSES consensus guidelines on sigmoid volvulus management – World Journal of Emergency Surgery
Review | Hypovolemia with peripheral edema: what is wrong?
5 Jun, 2023 | 13:18h | UTCHypovolemia with peripheral edema: What is wrong? – Critical Care
Review | Interventional therapies for pulmonary embolism
2 Jun, 2023 | 12:16h | UTCInterventional therapies for pulmonary embolism – Nature Reviews Cardiology (if the link is paywalled, try this one)
Commentary on Twitter
In our latest Review, @FelixMahfoud et al. discuss interventional therapies for pulmonary embolism. Check it out here: https://t.co/sBDfnZno1q pic.twitter.com/XNLclSbjmr
— Nature Reviews Cardiology (@NatRevCardiol) May 14, 2023
Expert Consensus | Nephrotoxic potential of 195 medications in the non-intensive care setting
1 Jun, 2023 | 12:14h | UTC
M-A | Noninvasive ventilation in patients with acute hypoxemic respiratory failure
1 Jun, 2023 | 12:11h | UTC
RCT | Prophylactic platelet transfusion reduces CVC-related bleeding in patients with platelets 10-50 K/mm³
31 May, 2023 | 14:20h | UTCPlatelet Transfusion before CVC Placement in Patients with Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.
— NEJM (@NEJM) May 27, 2023
Guidelines | Management of ascites in liver disease
31 May, 2023 | 14:08h | UTC
Review | How to approach acute thrombosis and thrombocytopenia
31 May, 2023 | 14:03h | UTCHow to approach acute thrombosis and thrombocytopenia – Clinical Medicine Journal
M-A | Diagnostic accuracy of point-of-care ultrasound for shock
31 May, 2023 | 13:51h | UTC
RCT | Care bundle with intensive blood pressure control improves outcomes in acute cerebral hemorrhage
30 May, 2023 | 12:04h | UTC
Review | Spurious electrolyte and acid-base disorders in the patient with cancer
30 May, 2023 | 11:43h | UTC
Commentary on Twitter
Spurious Electrolyte and Acid-Base Disorders in the Patient With Cancer: A Review https://t.co/i9jPRxBdkz (FREE)
@raad_chowdhury @NephroMD @bdubNephro @PITTRenal pic.twitter.com/FbhovMDHd7
— AJKD (@AJKDonline) May 27, 2023
Review | Posterior circulation ischemic stroke diagnosis and management
30 May, 2023 | 11:30h | UTCPosterior circulation ischaemic stroke diagnosis and management – Clinical Medicine Journal
AHA/ASA Guideline for the management of patients with aneurysmal subarachnoid hemorrhage
29 May, 2023 | 11:16h | UTCTop Things to Know: 2023 Aneurysmal Subarachnoid Hemorrhage Guideline – American Heart Association
Commentary on Twitter
2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association https://t.co/IHZRkTR25t@American_Heart @American_Stroke @AHAScience @BrianHoh1 @drdangayach @CPDerdeyn pic.twitter.com/I2JdXnHuXp
— Stroke AHA/ASA (@StrokeAHA_ASA) May 23, 2023
M-A | Hydrocortisone shows no significant impact on 90-day mortality in septic shock patients
29 May, 2023 | 11:06h | UTCPatient-Level Meta-Analysis of Low-Dose Hydrocortisone in Adults with Septic Shock – NEJM Evidence
Guideline | Investigation and management of acute transfusion reactions
29 May, 2023 | 11:02h | UTC
ISPD Catheter-related infection recommendations
29 May, 2023 | 11:00h | UTCISPD Catheter-related Infection Recommendations: 2023 Update – Peritoneal Dialysis International
Guideline | Targeted temperature management in intracerebral, subarachnoid hemorrhage and acute ischemic stroke
29 May, 2023 | 10:48h | UTC
2023 Update on sepsis and septic shock in adult patients | Management in the emergency department
25 May, 2023 | 11:26h | UTC
Guideline | Assessment and early management of head injury
23 May, 2023 | 13:11h | UTCHead injury: assessment and early management – NICE
Commentary: NICE head injury guidelines 2023: Now who do we scan? – St Emilyn’s
Practice Guidance | Differential diagnosis of suspected COPD exacerbations in the acute care setting
15 May, 2023 | 13:26h | UTC
Commentary on Twitter
Differential Diagnosis of Suspected Chronic Obstructive Pulmonary Disease Exacerbations in the Acute Care Setting: Best Practice
🔓 Open Access
🔗 https://t.co/aPiT06E2g4 pic.twitter.com/kF40aSS7Oo— ATS Blue Journal (@ATSBlueEditor) May 12, 2023
Guideline | Acute dizziness and vertigo in the emergency department
15 May, 2023 | 13:25h | UTC
RCT | Prophylactic antibiotics show no statistically significant survival improvement in severe alcohol-related hepatitis
15 May, 2023 | 13:21h | UTCSummary: This multicenter, randomized, double-blind clinical trial aimed to determine the efficacy of amoxicillin-clavulanate combined with prednisolone compared to placebo combined with prednisolone on mortality in patients hospitalized with severe alcohol-related hepatitis. The study involved 284 patients from 25 centers in France and Belgium with biopsy-proven severe alcohol-related hepatitis, who were followed up for 180 days.
The primary outcome was all-cause mortality at 60 days, while secondary outcomes included mortality at 90 and 180 days, infection rates, hepatorenal syndrome, and changes in Model for End-stage Liver Disease (MELD) and Lille scores. The results showed no statistically significant difference in 60-day mortality between the two groups, with 17.3% in the amoxicillin-clavulanate group and 21.3% in the placebo group. However, infection rates at 60 days were significantly lower in the amoxicillin-clavulanate group compared to the placebo group.
It is worth noting that the study may have been underpowered, as the absolute risk difference of 4% did not achieve statistical significance. In conclusion, the combination of amoxicillin-clavulanate and prednisolone did not show a statistically significant improvement in 2-month survival in patients hospitalized with severe alcohol-related hepatitis compared to prednisolone alone. These findings do not support the use of prophylactic antibiotics to improve survival in this patient population, but the potential underpowered nature of the study should be considered.
Article: Effect of Prophylactic Antibiotics on Mortality in Severe Alcohol-Related Hepatitis: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary on Twitter
Among patients with severe alcohol-related #hepatitis receiving prednisolone, amoxicillin-clavulanate did not improve survival at 60-day follow-up compared with placebo. https://t.co/4XkVL2CTsP #DDW pic.twitter.com/9sh5vennkK
— JAMA (@JAMA_current) May 9, 2023
Brief Review | Coagulation support during perioperative bleeding management
15 May, 2023 | 13:01h | UTCCoagulation support during perioperative bleeding management – Intensive Care Medicine
Commentary on Twitter
Coagulation & perioperative bleeding
🩸fibrinogen source/dose/time
🩸Ca++: just vs citrated blood products?
🩸PCCs/factor concentrates
🩸TXA
🩸plasma: volume or coagulation?
🩸PLTs as primary components
🩸RBCs not just DO2
🩸targeted coagulation support
🖇️ https://t.co/lv1i5GoHBg pic.twitter.com/8BtuAE6gt8— Intensive Care Medicine (@yourICM) May 13, 2023
M-A | Endovascular therapy for stroke presenting beyond 24 hours
12 May, 2023 | 13:44h | UTC
Commentary on Twitter
Endovascular therapy for stroke presenting at >24 hours was associated with favorable clinical, safety, and procedural outcomes in this meta-analysis of 569 patients. https://t.co/DjoDDcr1mf
— JAMA Network Open (@JAMANetworkOpen) May 4, 2023
Should my elderly hospitalized patient with acute onset of altered mental status undergo stat head CT?
12 May, 2023 | 13:38h | UTC