Emergency Medicine
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
5 Mar, 2021 | 08:53h | UTCCommentaries: Ivermectin: Yet Another Fad Runs Into The Brick Wall Known As “Actual Science” – Brief-19 AND Ivermectin doesn’t speed recovery from mild COVID-19, study shows – CIDRAP
Scientific Statement: Invasive management of acute myocardial infarction complicated by cardiogenic shock
5 Mar, 2021 | 08:33h | UTC
RCT: Mixed findings with Terlipressin plus Albumin for the treatment of Type 1 hepatorenal syndrome
4 Mar, 2021 | 08:35h | UTCTerlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: Albumin provides no benefit to hospitalized patients with decompensated cirrhosis
4 Mar, 2021 | 08:37h | UTCA Randomized Trial of Albumin Infusions in Hospitalized Patients with Cirrhosis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Albumin provides no benefit to hospitalized patients with advanced liver disease – University College London
NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms
3 Mar, 2021 | 08:55h | UTC
More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil
3 Mar, 2021 | 08:53h | UTCOriginal study (preprint): Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil
Commentaries: Covid Brazil variant ‘may spread more easily’ – BBC AND Brazil coronavirus variant: what is it and why is it a concern? An expert explains – The Conversation
RCT: High flow oxygen does not change the risk of mortality in patients with a suspected acute coronary syndrome
3 Mar, 2021 | 08:37h | UTC
Commentary on Twitter
Supplementary high flow oxygen given for ischaemic symptoms to patients with suspected acute coronary syndrome was not associated with a change in 30 day mortality, finds new #BMJResearchhttps://t.co/CDhfFyVL88
— The BMJ (@bmj_latest) March 2, 2021
M-A: Role of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage
3 Mar, 2021 | 08:16h | UTCRole of Cilostazol in prevention of vasospasm following aneurysmal subarachnoid hemorrhage – A systematic review, meta-analysis and trial sequential analysis – World Neurosurgery (link to abstract – $ for full-text)
Studies: Secondary infections in patients with severe COVID-19
2 Mar, 2021 | 02:05h | UTCSecondary Infections in Patients with Severe COVID-19 – NEJM Journal Watch
Scaling up COVID-19 rapid antigen tests: promises and challenges
2 Mar, 2021 | 02:09h | UTCScaling up COVID-19 rapid antigen tests: promises and challenges – The Lancet Infectious Diseases
Review: Cardiovascular biomarkers in patients with COVID-19
2 Mar, 2021 | 02:07h | UTC
Commentary on Twitter
Cardiovascular #biomarkers in patients with #COVID19 – review article by @escardio Study Group on Biomarkers in Cardiology of the Acute Cardiovascular Care Association #ACVC_ESC https://t.co/9Mcx24fX8y#EHJACVC #cardiotwitter #medtwitter pic.twitter.com/y7kD2Oylrj
— European Society of Cardiology Journals (@ESC_Journals) March 1, 2021
Consensus Document: Venous thromboembolism prophylaxis in the trauma intensive care unit
2 Mar, 2021 | 01:52h | UTC
Guideline: Treatment of methicillin-resistant Staphylococcus aureus (MRSA)
2 Mar, 2021 | 01:50h | UTC
Commentary on Twitter
We're delighted to publish the first update of UK #MRSA guidelines in more than a decade. Please share with your contacts & colleagues .
Treatment of methicillin-resistant Staphylococcus aureus (MRSA): updated guidelines from the UKhttps://t.co/3o3OVIdLuB #JACAMRNews #IDtwitter pic.twitter.com/GGlv1C1T1g
— JAC-AMR (@jac_amr) February 4, 2021
Cohort study: Recovery of consciousness and functional outcome in moderate and severe traumatic brain injury
2 Mar, 2021 | 01:34h | UTCRecovery of Consciousness and Functional Outcome in Moderate and Severe Traumatic Brain Injury – JAMA Neurology (free for a limited period)
Editorial: Holding Out Hope After Traumatic Brain Injury (free for a limited period)
Commentary on Twitter
In this study in @JAMANeuro:
most individuals who became comatose after moderate/severe traumatic brain injury recovered consciousness and ~50% regained functional independence, cautioning early decisions to withdraw/withhold treatment in these patients. https://t.co/jIz38AwCXO— Saleh Almenawer, MD (@SalehAlmenawer) March 1, 2021
Teleneurology-enabled determination of death by neurologic criteria after cardiac arrest or severe neurologic injury
2 Mar, 2021 | 01:32h | UTCTeleneurology-Enabled Determination of Death by Neurologic Criteria After Cardiac Arrest or Severe Neurologic Injury – Neurology (link to abstract – $ for full-text)
RCT: Prescribed light exercise vs. standard management for emergency department patients with acute mild traumatic brain injury
2 Mar, 2021 | 01:30h | UTCA randomized trial comparing prescribed light exercise to standard management for emergency department patients with acute mild traumatic brain injury – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentary: Exercise After Concussion in Adults? – Journal Feed
M-A: Treatment with convalescent plasma is not associated with better outcomes in patients with Covid-19
28 Feb, 2021 | 21:51h | UTCEditorial: Emerging Lessons From COVID-19 for the US Clinical Research Enterprise
Commentary on Twitter
Just out: Our meta-analysis in @JAMA_current
"Among patients with COVID-19, treatment with convalescent plasma compared with control was not associated with improved survival or other positive clinical outcomes"https://t.co/tRqpd9v67m
— Lars G. Hemkens (@LGHemkens) February 26, 2021
CDC Study: Suspected SARS-CoV-2 reinfections in a skilled nursing facility
28 Feb, 2021 | 21:55h | UTCCommentaries: Possible SARS-CoV-2 Reinfection Described at Skilled Nursing Facility – HealthDay AND Reinfections could be more likely among those with a mild first case of COVID-19: case study – CTV News
Commentary on Twitter (thread – Click for more)
📌CDC report: Asymptomatic or mildly symptomatic infections don't always produce sufficient immune response to prevent reinfection. Report of nursing facility found 5 people reinfected ~3 months after initial infection. All 5 had more severe symptoms 2nd time around, one death🧵 pic.twitter.com/m9ix9XJolA
— Dr. Ali Nouri (@AliNouriPhD) February 28, 2021
Identification of 3 clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19
28 Feb, 2021 | 21:45h | UTCInvited Commentary: Anticipating outcomes for patients with COVID-19 and identifying prognosis patterns
Commentary on Twitter
Identification and validation of clinical phenotypes with prognostic implications in patients admitted to hospital with COVID-19 https://t.co/kLtzmF5ZWI 📣 These results might help to better classify patients for clinical management #COVID@SPAIN #COVID@HULP pic.twitter.com/ZVaMuUDfnL
— Alberto M. Borobia (@borobia_am) February 24, 2021
Editorial | Twenty Lessons from 2020: With a Focus on the ICU Perspective
28 Feb, 2021 | 21:44h | UTCTwenty Lessons from 2020: With a Focus on the ICU Perspective – ICU Management & Practice
RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates
28 Feb, 2021 | 20:59h | UTCSafety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
M-A: Risk predictors of progression to severe disease during the febrile phase of dengue
28 Feb, 2021 | 20:57h | UTC
Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19
26 Feb, 2021 | 08:48h | UTC
Commentary on Twitter
Why do 2 randomized trials of tocilizumab, an interleukin-6 blocker, for severe covid-19, have opposite results?
Today @NEJMhttps://t.co/g8LCrhhpLyhttps://t.co/BcN3wOwsl0 pic.twitter.com/sLrQUYI1pf— Eric Topol (@EricTopol) February 25, 2021
PRO-CON Debate: Are Carbapenems necessary for all infections caused by ceftriaxone-resistant Enterobacterales?
28 Feb, 2021 | 20:43h | UTCEditorial: Navigating treatment approaches for presumed ESBL-producing infections
Commentary on Twitter (thread – click for more)
🔥NEW🔥 PRO-CON Debate on the role of carbapenems in infections caused by Enterobacterales resistant to ceftriaxone. #AMR @BSACandJAC @IDdocAdi @ABsteward
— JAC-AMR (@jac_amr) February 24, 2021
Cohort study: A single conventional Troponin combined with HEART score may be as good as serial measurements for safe discharge of patients with chest pain in the ED
26 Feb, 2021 | 08:32h | UTCEditorial: Troponin Testing in the Emergency Department—When 2 Become 1
Commentary: Single Troponin Test May Be Enough for Safe Discharge of Chest Pain Patients – TCTMD